Search clinical trials for: Oxycodone/Naloxone Controlled-release

Total 206 results

Purdue Pharma LP

Completed

Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain

Low Back Pain

United States, Poland, Czech Republic, Italy
Purdue Pharma LP

Completed

A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

Low Back Pain

United States
Mundipharma Research GmbH & Co KG

Completed

OXN PR Compared to OxyPR to Demonstrate Non-inferiority in Pain & Locomotor Function & Improvement in Symptoms of Constipation in OA Subjects

Chronic Osteoarthritis

Spain, Belgium, Finland, Czechia, Germany, Hungary
Purdue Pharma LP

Completed

Efficacy and Safety of Oxycodone/Naloxone Controlled-release Tablets (OXN) Compared to Placebo in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

Low Back Pain

United States
Mundipharma Research GmbH & Co KG

Completed

A Study to Demonstrate Improvement in Symptoms of Constipation in Subjects That Require Around-the-clock Opioid Pain Killer Therapy

Pain | Constipation

United Kingdom
Mundipharma Research GmbH & Co KG

Completed

A Randomised, Double Blind, Placebo and Active Controlled, Double Dummy,Parallel Group Study to Determine the Safety and Efficacy of Oxycodone/Naloxone Prolonged Release Tablets in Subjects With Moderate to Severe, Chronic Nonmalignant Pain

Subjects With Moderate to Severe, Chronic Nonmalignant Pain
Mundipharma (China) Pharmaceutical Co. Ltd

Completed

Targin for Non-cancer Pain

Non Cancer Pain

China
Pfizer

Completed

A Randomized, Two-way, Crossover Study to Estimate the Relative Bioavailability of a Controlled-release Formulation of Oxycodone (40 mg) With Sequestered Naltrexone Compared With Immediate-release Oxycodone Tablets (20 mg) in Healthy Volunteers

Healthy

United States
Mundipharma Research GmbH & Co KG

Completed

Oxycodone-naloxone Prolonged Release Tablets in Relieving Opioid-related Constipation

Pain
Kati Järvelä

Completed

A Comparison of PR Oxycodone/Naloxone and PR Oxycodone After Cardiac Surgery

Postoperative Pain | Opioid Related Disorders

Finland
Mundipharma Research GmbH & Co KG

Completed

OXN PR vs Placebo in Opioid-naive Subjects Suffering From Severe Pain Due to Bladder Pain Syndrome (BPS)

Pain | Interstitial Cystitis | Painful Bladder Syndrome

Poland, Germany, Hungary, Czechia, United Kingdom
Mundipharma Research GmbH & Co KG

Completed

A Randomised Placebo Controlled Study of OXN PR for Severe Parkinson's Disease Associated Pain

Parkinson's Disease With Severe Pain

United Kingdom, Spain, Germany, Hungary, Czech Republic, Poland, Romania
Mundipharma Research GmbH & Co KG

Completed

Oxycodone/Naloxone Prolonged Release (OXN PR) Compared to Placebo to Demonstrate Improvement in Symptoms of Restless Legs Syndrome (RLS) in Subjects With Moderate to Severe Idiopathic RLS With Daytime Symptoms

Moderate to Severe Idiopathic RLS With Daytime Symptoms

Spain, Sweden, Germany
Mundipharma Pharmaceuticals B.V.

Completed

Oxycodone/Naloxone (OXN) Combination in Moderate to Severe Non-malignant Pain

Pain

Netherlands
Grünenthal GmbH

Completed

Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component.

Back Pain | Low Back Pain | Neuropathic Pain

Germany, Spain, Austria, Italy
Mundipharma SAS

Terminated

Efficacy of Oxycodone/Naloxone(OXN), Versus Oxycodone (OXY), for the Reduction of Intensity of Opioid-induced Constipation in Pain Patients (OXN3505)

Pain | Constipation

France
Mario Negri Institute for Pharmacological Research

Completed

GREAT - Good Response With Appropriate Treatment

Neoplasms | Cancer Pain

Italy
Purdue Pharma LP

Completed

Pharmacokinetics and Safety of ORF Tablets in Pediatric Patients

Opioid Analgesia

United States, Australia, Finland, New Zealand
Ullevaal University Hospital
Mundipharma AB

Completed

A Comparison of Oxycodone/Naloxone and Oxycodone After Laparoscopic Hysterectomy

Postoperative Pain | Opioid Induced Constipation

Norway
Mundipharma Research GmbH & Co KG

Completed

Oxycodone-naloxone in Relieving Opioid-related Constipation

Pain
Purdue Pharma LP

Completed

Long-Term Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Children Who Completed OTR3001

Pain

United States, Israel
Mundipharma Research GmbH & Co KG

Completed

A Study Comparing Oxycodone to Oxycodone/Naloxone in Moderate to Severe, Chronic Cancer Pain

Pain | Cancer | Constipation

United Kingdom
Kuopio University Hospital

Completed

Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery (oksineukir)

Constipation

Finland
Mundipharma Korea Ltd

Completed

A Study to Evaluate Efficacy and Safety of Oxycodone/Naloxone Compared to OxyContin in Korean Cancer Patients (TOP)

Cancer

Korea, Republic of
Mundipharma Pharmaceuticals B.V.

Completed

Oxycodone/Naloxone (OXN) Combination in Moderate to Severe Non-malignant Pain

Pain

Belgium
Mundipharma Korea Ltd

Completed

An Interventional Study to Compare the Efficacy and Tolerability With Targin® in Non-malignant Chronic Pain (GLORY)

Chronic Pain

Korea, Republic of
Purdue Pharma LP

Completed

Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Children With Moderate to Severe Malignant and/ or Nonmalignant Pain Requiring Opioids

Pain

United States, Israel, Spain, United Kingdom, Greece, Hungary, New Zealand, Romania
University Health Network, Toronto
Canadian Society of Hospital Pharmacists

Withdrawn

Dosing Intervals of Opioid Medication for Chronic Pain

Chronic Pain

Canada
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A 5-treatment, Study in Healthy Volunteers to Assess The Safety, Tolerability, and Pharmacokinetics of Four Controlled Release (CR) Pregabalin Tablet Formulations and the Immediate Release (IR) Formulation Administered Fasted

Healthy

Belgium
Mundipharma Korea Ltd

Completed

PROspective Non-interventional Open laBEl Trial for TARGIN in Korean Patients With Cancer Pain (PROBE)

Cancer

Korea, Republic of
Mundipharma Korea Ltd

Completed

An Interventional Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Spinal Disorders (TALENT)

Spinal Disorders
Kuopio University Hospital
Admescope Ltd

Active, not recruiting

Opioid Induced Bowel Dysfunction in Patients Undergoing Cesarean Section (oksisektio)

Pain, Postoperative | Constipation

Finland
Fujian Cancer Hospital

Withdrawn

Change the Dose Frequency of Controlled-Release Oxycodone to Refractory Pain

Cancer Pains
Sun Yat-sen University

Unknown

Comparison of Oxycodone to Control Moderate or Severe Oral Mucositis Pain Induced by Chemoradiotherapy

Nasopharyngeal Carcinoma

China
Mundipharma (China) Pharmaceutical Co. Ltd

Completed

Determine the Safety and Efficacy of Oxy/Nal Tablets Compared to Oxy PR in Subjects With Cancer Pain

Pain | Cancer

China
University of Edinburgh

Completed

A Comparison of Targinact vs. Oxycodone on Gut Function After Colorectal Surgery (TACS)

Postoperative Pain | Postoperative Nausea and Vomiting

United Kingdom
Mundipharma CVA

Completed

A Non-interventional, Observational Study for Targinact® Treatment in Patients With Severe Pain.

Severe Pain

Belgium
Ensysce Biosciences
Dr. Vince Clinical Research

Completed

A Study to Evaluate the Oral Abuse Potential of PF614 in Non-Dependent Recreational Opioid Users

Recreational Drug Use

United States
Instituto Nacional de Cancer, Brazil

Completed

Safety and Tolerability of Controlled-release Oxycodone on Postoperative Pain in Oncologic Head and Neck Surgery

Pain | Adverse Effects | Postoperative Nausea | Opioid Analgesic Adverse Reaction

Brazil
Mundipharma CVA

Completed

A Non-interventional, Observational Study for Targinact® Treatment in Patients With Chronic Severe Pain

Chronic Severe Pain

Belgium
Mallinckrodt

Completed

Fed Study of Controlled-Release Oxycodone Hydrochloride 40 mg Tablets and OxyContin® 40 mg Tablets

Healthy

United States
University of British Columbia
Vancouver Coastal Health; International Collaboration on Repair Discoveries; Purdue...

Completed

Targin® for Chronic Pain Management in Patients With Spinal Cord Injury

Chronic Pain

Canada
Egalet Ltd

Completed

Efficacy and Safety of Egalet-002 in Patients With Moderate-to-Severe Chronic Low Back Pain

Moderate-to-severe Chronic Low Back Pain

United States
Mundipharma Korea Ltd

Completed

A Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy (CIPN)

Cancer

Korea, Republic of
University of Rochester

Terminated

Open-Label Trial Comparing Oxycodone Medications (OUTCOMES)

Chronic Pain

United States
Mundipharma Research GmbH & Co KG

Completed

A Study to Demonstrate the Analgesic Efficacy of Oxycodone/Naloxone Prolonged Release Tablets in Addition to Pregabalin Compared to Pregabalin Alone in Opioid-naïve Subjects Treated With Pregabalin Suffering From Moderate to Severe Pain Due to Diabetic Polyneuropathy

Moderate to Severe Pain Due to Diabetic Polyneuropathy

Germany
Mallinckrodt

Completed

Fasting Study of Controlled-Release Oxycodone Hydrochloride 40 mg Tablets and OxyContin® 40 mg Tablets

Healthy

United States
University Hospital Inselspital, Berne

Completed

Early Postoperative Administration of Oxycodone +/- Naloxone and Duration of Epidural Analgesia

Epidural Analgesia | Radical Cystectomy | Postoperative Pain Management | Oral Oxycodone With/Without Naloxone | Return of the Bowel Function

Switzerland
Mundipharma Oy

Completed

OXN PR Compared to OXY PR in Subjects With Postoperative Pain After Knee Arthroplasty (OXN4505)

Post Operative Pain

Finland
University of Parma

Terminated

Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery

Pain, Postoperative | Anesthesia Recovery Period

Italy

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