Search clinical trials for: PF-05212377 (SAM-760)

Total 80 results

Pfizer
Yale University

Completed

This Study Will Evaluate The Relationship Between Plasma Drug Levels And Receptor Binding In Brain Using PET (Positron Emission Tomography) In Healthy Volunteers

Healthy

United States
Pfizer

Completed

Multiple Ascending Dose Study To Assess Safety, Tolerability And Pharmacokinetics Of PF-05212377 (SAM-760) (MAD)

Healthy

France
Pfizer

Terminated

Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On Donepezil

Alzheimer's Disease

United States, Spain, Canada, United Kingdom, Germany, Chile, France
Pfizer
Yale University

Completed

To Evaluate The Relationship Between Plasma Drug Levels And Receptor Binding In Brain Using PET (Positron Emission Tomography) In Healthy Volunteers (3193A1-1103)

Healthy

United States
Pfizer

Completed

A Study To Examine The Distribution Of PF-05212377 In The Brain Of Healthy Volunteer Subjects Using Positron Emission Tomography And A Radioactive Tracer Following Oral Administration Of One Dose Of PF-05212377

Healthy

United States
Pfizer

Completed

A First In Human Study In Healthy People To Evaluate Safety, Toleration And Time Course Of Plasma Concentration Of Single Inhaled Doses Of PF-05212372.

Pharmacokinetics | Safety | Phase 1 | Single Dose | Toleration

Belgium
Pfizer

Withdrawn

A Study Of Gastrointestinal Tolerability Of PF05212389 In Obese Subjects

Obesity
Wyeth is now a wholly owned subsidiary of Pfizer
Pfizer

Completed

Study Evaluating Multiple Doses Of GSI-953 Within The Elderly Population

Healthy

United States
Antev Ltd.

Completed

A Study of Parenterally-administered Teverelix TFA in Healthy Male Volunteers

Healthy

United Kingdom
Pfizer

Completed

Study To Evaluate Safety, Tolerability, And Pharmacokinetics Of PF-06473871 In Normal Healthy Adults

Healthy

Belgium
Pfizer

Completed

Investigation Of The Metabolism, And Excretion Of [14c]-PF-05212384 In Healthy Male Volunteers

Healthy

United Kingdom
Institut Curie
National Cancer Institute, France; Fondation ARC

Terminated

PF-05212384 (PKI-587) for t-AML/MDS or de Novo Relapsed or Refractory Acute Myeloid Leukemia (AML) (LAM-PIK)

Acute Myeloid Leukemia, in Relapse | Therapy-related Acute Myeloid Leukemia and Myelodysplastic Syndrome | de Novo Acute Myeloid Leukemia at Diagnostic

France
Pfizer

Withdrawn

A Trial Of PF-04856884 In Patients With Recurrent Glioblastoma

Glioblastoma
Pfizer

Completed

Study of PF-05212384 (Also Known as PKI-587)Administered Intravenously To Subjects With Solid Tumors (B2151001)

Neoplasms

United States, Spain, United Kingdom
Pfizer

Completed

A Study to Compare Two Different Forms of PF-07081532 in Adults Who Are Overweight or Obese

Obesity | Overweight

United States
Pfizer

Terminated

A Study Of Two Dual PI3K/mTOR Inhibitors, PF-04691502 And PF-05212384 In Patients With Recurrent Endometrial Cancer

Endometrial Neoplasms

United States, Canada, Spain, United Kingdom, Japan, Russian Federation, Poland, Australia
Dana-Farber Cancer Institute
Pfizer

Recruiting

Study of the CDK4/6 Inhibitor Palbociclib (PD-0332991) in Combination With the PI3K/mTOR Inhibitor Gedatolisib (PF-05212384) for Patients With Advanced Squamous Cell Lung, Pancreatic, Head & Neck and Other Solid Tumors

Pancreatic Cancer | Solid Tumors | Lung Cancer Squamous Cell | Head & Neck Cancer

United States
Pfizer

Terminated

Clinical Study Of PI3K/mTOR Inhibitors In Combination With An Oral MEK Inhibitor Or Irinotecan In Patients With Advanced Cancer

Advanced Cancer

Italy, United States, Canada, Spain
Pfizer

Completed

A Study Of PF-05212384 In Combination With Other Anti-Tumor Agents and in Combination With Cisplatin in Patients With Triple Negative Breast Cancer in an Expansion Arm (TNBC)

Neoplasm

United States, Spain, Canada, Italy, United Kingdom
Wyeth is now a wholly owned subsidiary of Pfizer
Pfizer

Completed

Study Evaluating The Coadministration of Begacestat And Donepezil

Healthy Subjects

United States
Pfizer

Completed

Study Evaluating The Safety And Tolerability Of Administration Of Single Oral Doses Of SAM-760 To Healthy Subjects

Healthy

France
King's College Hospital NHS Trust

Recruiting

RCT Comparing Intravaginal Laser Therapy to Sham in Post-menopausal Women With Recurrent Urinary Tract Infections (UTIEXTERMINATE)

Recurrent Urinary Tract Infection | Genitourinary Syndrome of Menopause

United Kingdom
Pfizer

Terminated

A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of PF-05180999 In Healthy Adults

Migraine

United States
Cristiana Sessa

Completed

Dose Finding Study Of PF-05212384 With Paclitaxel And Carboplatin In Patients With Advanced Solid Tumor (IOSI-NDU-001)

Breast Cancer | NSCLC | Endometrial Cancer | Ovary Cancer | Small Cell Lung Cancer (SCLC) | Head and Neck (HNSCC)

Switzerland
Unity Health Toronto

Unknown

Revascularization StrategIes for ST Elevation Myocardial Infarction Trial (ASSIST-MI)

ST Elevation Myocardial Infarction | Coronary Stenting | Primary Angioplasty
Pfizer

Completed

Scopolamine Challenge Study

Healthy

France
Temple University

Completed

Foot Reflexology in Ocular Hypertensive and Glaucoma Patients

Ocular Hypertension | Glaucoma

United States
Pfizer

Terminated

A Study Of PF-05212384 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI In Metastatic Colorectal Cancer

Metastatic Colorectal Carcinoma

United States, Canada, Spain
Pfizer

Terminated

A Study Of PF-05212384 Plus Irinotecan Vs Cetuximab Plus Irinotecan In Patients With KRAS And NRAS Wild Type Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

Korea, Republic of, United States, Japan, Spain
University of Florida
Pfizer

Terminated

Study of Paclitaxel, Carboplatin, and PF-05212384 in Advanced or Metastatic NSCLC (UF-STO-LUNG-002)

Non-Small Cell Lung Cancer

United States
Mehmet Sönmez

Completed

The Effects of Non-Immersive Virtual Reality Exercises on Muscle Excitability in Knee Osteoarthritis

Knee Osteoarthritis | Virtual Reality

Turkey
University of Colorado, Denver
Pfizer

Active, not recruiting

Study of Efficacy, Safety and Tolerability of Crisaborole and PF-07038124 With and Without NBUVB in Vitiligo

Vitiligo

United States
Impax Laboratories, LLC

Completed

A Study to Assess the PK and Pharmacodynamics of IPX203 in Patients With Advanced Parkinson's Disease

Parkinson's Disease

United States
Pfizer

Terminated

A Phase 2, Multi-Center Study To Compare The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist With Ranibizumab In Adults With Diabetic Macular Edema

Macular Edema, Diabetic

United States, Israel, Germany, Hungary, Bulgaria, Czech Republic, Moldova, Republic of, Poland, Romania
Alfredo Gamboa
Vanderbilt University Medical Center

Withdrawn

Breathing Device for Orthostatic Hypotension (OH)

Orthostatic Hypotension

United States
University of Southern California
National Cancer Institute (NCI)

Active, not recruiting

Axitinib With or Without Anti-OX40 Antibody PF-04518600 in Treating Patients With Metastatic Kidney Cancer

Clear Cell Renal Cell Carcinoma | Metastatic Renal Cell Cancer | Recurrent Renal Cell Carcinoma | Stage IV Renal Cell Cancer

United States
Hoffman Oncology
DSCS CRO

Active, not recruiting

Phase I Study of Combination of Gedatolisib With Palbociclib and Faslodex in Patients With ER+/HER2- Breast Cancer

Breast Cancer

United States
Pfizer

Completed

Study Of Safety And Efficacy Of PF-04991532 In Subjects With Type 2 Diabetes Mellitus

Diabetes, Type 2

Canada, United States, Korea, Republic of, Taiwan, Mexico, Hungary, Slovakia
Celcuity, Inc.

Recruiting

Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer (VIKTORIA-1) (VIKTORIA-1)

Breast Cancer

Korea, Republic of, United States, Belgium, United Kingdom, Taiwan, France, Italy, Australia, Singapore, Argentina, Canada, India, Mexico, Czechia, Spain, Austria, Bulgaria, Germany, Hungary, Poland, Brazil, Greece, Romania
Universidade Estadual Paulista Júlio de Mesquita...

Completed

Low Power Laser in Mandibular Third Molar Surgery

Laser Therapy, Low-Level
University Hospital Inselspital, Berne
Deka Medical, Inc.

Active, not recruiting

Effect of Treatment With the Ablative Fractional Carbodioxide Laser in Vulvar Lichen Sclerosis

Lichen Sclerosus Et Atrophicus of the Vulva

Switzerland
Pierre Fabre Medicament

Completed

PERmixon® in LUTS Evaluation Study (PERLES) (PERLES)

Benign Prostatic Hyperplasia (BPH)

France, Italy, Germany, Spain, Czech Republic
Poznan University of Physical Education
David C. Nieman; Tomasz Cisoń; Joanna Szurkowska; Mirosława Gałęcka; Dariusz Sitkowski and other collaborators

Completed

Effect of a 4-week Post-exercise Sauna Bathing on Targeted Gut Microbiota

Healthy Males

Poland
University of Helsinki

Completed

Combination Therapy With Fluoroquinolone in Staphylococcus Aureus Bacteremia (FINLEVO)

Sepsis | Bacteremia | Staphylococcus Aureus | Endocarditis

Finland
Karin Palmblad
Karolinska Institutet

Unknown

NEMOS in Normal Volunteer and JIA Study

Inflammatory Response

Sweden
Sun Protection Foundation

Enrolling by invitation

Natural Sunlight Protection and Simulated Sunlight Protection Offered by Sunscreens and Fabrics

Sunburn | Sun Damaged Skin | Overexposure to Sun Rays

United States, Chile, Peru
Pierre Fabre Medicament

Completed

Exploratory Study of L.S.E.S.r. (LipidoSterolic Extract of Serenoa Repens)(PERMIXON® 160 mg Hard Capsule) Versus Tamsulosine LP Activity on Inflammation Biomarkers in Urinary Symptoms Related to BPH (Benign Prostatic Hyperplasia) (PERMIN)

Benign Prostatic Hyperplasia (BPH)

France, Spain, Portugal, Italy
Universidad Metropolitana de Ciencias de la Educacion

Recruiting

Effect of tACS on the Recovery of Motor Control of the Upper Limb and Cerebral Connectivity in Chronic Stroke Patients (tACS)

Rehabilitation | Chronic Stroke

Chile
University of Chicago
Michael J. Fox Foundation for Parkinson's Research

Completed

Long-term Effect of Low Frequency Stimulation on Aspiration and Freezing of Gait in PD With STN DBS

Parkinson's Disease

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

Anatomic Stage IV Breast Cancer AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Breast Carcinoma

United States

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