Search clinical trials for: Risdiplam

Total 22 results

Hoffmann-La Roche

Recruiting

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy (HINALEA 2)

Muscular Atrophy, Spinal

United States
Hoffmann-La Roche

Completed

A Study Investigating the Excretion Balance, Pharmacokinetics and Metabolism of a Single Oral Dose of [14C]-Labeled Risdiplam (RO7034067) in Healthy Male Participants

Healthy

Netherlands
Hoffmann-La Roche

Recruiting

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy (HINALEA 1)

Muscular Atrophy, Spinal

United States
Clinic for Special Children
Genentech, Inc.

Active, not recruiting

Risdiplam in Patients With Spinal Muscular Atrophy Previously Treated With Nusinersen (RISE)

Spinal Muscular Atrophy

United States
Hoffmann-La Roche

Not yet recruiting

A Study to Investigate the Pharmacokinetics and Safety of Risdiplam in Infants With Spinal Muscular Atrophy (PUPFISH)

Muscular Atrophy, Spinal
Hoffmann-La Roche

Active, not recruiting

A Study of Risdiplam in Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy (Rainbowfish)

Muscular Atrophy, Spinal

United States, Belgium, Brazil, Russian Federation, Australia, Taiwan, Poland
Hoffmann-La Roche

Completed

Investigate Safety, Tolerability, PK, PD and Efficacy of Risdiplam (RO7034067) in Infants With Type1 Spinal Muscular Atrophy (FIREFISH)

Muscular Atrophy, Spinal

Belgium, United States, China, Spain, Japan, France, Brazil, Croatia, Italy, Russian Federation, Saudi Arabia, Serbia, Switzerland, Turkey, Ukraine, Poland
Hoffmann-La Roche

Completed

A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function

Muscular Atrophy, Spinal

United States
Genentech, Inc.

Approved for marketing

An Expanded Access Program for Risdiplam in Participants With Spinal Muscular Atrophy (SMA)

Muscular Atrophy, Spinal

United States
Bakri Elsheikh
Genentech, Inc.

Recruiting

Investigating NMJ Defects in SMA Following Central and Peripheral SMN Restoration

Spinal Muscular Atrophy

United States
Hoffmann-La Roche

Completed

Bioavailability and Bioequivalence of Two Risdiplam Tablets in Healthy Participants

Muscular Atrophy, Spinal

United States
Genentech, Inc.

Recruiting

Long-Term Follow-Up Study of Risdiplam in Participants With Spinal Muscular Atrophy (SMA) (WeSMA)

Spinal Muscular Atrophy

United States, Puerto Rico
Hoffmann-La Roche

Active, not recruiting

A Study of Risdiplam (RO7034067) in Adult and Pediatric Participants With Spinal Muscular Atrophy (Jewelfish)

Spinal Muscular Atrophy

Belgium, United States, United Kingdom, France, Poland, Italy, Switzerland, Netherlands, Germany
Hoffmann-La Roche

Completed

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) in Healthy Japanese Participants

Healthy Volunteers

United States
Hoffmann-La Roche

Recruiting

A Study to Investigate the Safety and Efficacy of RO7204239 in Combination With Risdiplam (RO7034067) in Participants With Spinal Muscular Atrophy (MANATEE)

Spinal Muscular Atrophy (SMA)

Belgium, United States, Croatia, Japan, Netherlands, Spain, Canada, Poland, United Kingdom, Italy, Portugal, Australia
Hoffmann-La Roche

Completed

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of Risdiplam (RO7034067) in Type 2 and 3 Spinal Muscular Atrophy (SMA) Participants (SUNFISH)

Muscular Atrophy, Spinal

Belgium, United States, China, Spain, Japan, Canada, France, Poland, Brazil, Croatia, Italy, Russian Federation, Turkey, Germany, Serbia, United Kingdom
Genesis Health System

Unknown

The Use of Coconut Oil for the Prevention and Treatment of Diaper Dermatitis in the NICU Population

Dermatitis, Contact

United States
University Hospital, Basel, Switzerland
Heffter Research Institute

Completed

Pharmacological Interaction Between Pindolol and MDMA (3,4-Methylenedioxymethamphetamine)

Substance-Related Disorders | Amphetamine-Related Disorders | Mood Disorder

Switzerland
Hoffmann-La Roche

Completed

A Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants

Spinal Muscular Atrophy

United States
Ohr Pharmaceutical Inc.

Withdrawn

Effect of Squalamine Lactate Ophthalmic Solution, 0.2% in Subjects With Neovascular Age-Related Macular Degeneration

Age-Related Macular Degeneration

United States
Shionogi
Hormos Medical; QuatRx Pharmaceuticals

Completed

A Clinical Study to Evaluate Ospemifene in the Treatment of Vulvar and Vaginal Atrophy in Postmenopausal Women

Atrophy | Vaginal Diseases
Hoffmann-La Roche

Completed

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) Given by Mouth in Healthy Volunteers

Spinal Muscular Atrophy

Netherlands

3

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