Search clinical trials for: SC Methylnaltrexone (MNTX)

Total 1087 results

Bausch Health Americas, Inc.

Completed

Pharmacokinetics and Bioavailability of Single Subcutaneous Doses of Methylnaltrexone Versus Intravenous Dose

Healthy Subjects

United States
University Medicine Greifswald

Completed

Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects (LOP-MNTX-2009)

Intestinal Obstruction

Germany
Bausch Health Americas, Inc.

Completed

Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone in Volunteers With Impaired Hepatic Function

Liver Dysfunction

United States
Bausch Health Americas, Inc.

Completed

Open-Label Treatment Extension of Protocol MNTX 301

Terminal Illness

United States
Bausch Health Americas, Inc.

Completed

Methylnaltrexone in Patients With Opioid-Induced Bowel Dysfunction

Bowel Dysfunction

United States
Bausch Health Americas, Inc.
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study of Methylnaltrexone (MNTX) for the Relief of Constipation

Advance Illness Patients With OIC

United States
Bausch Health Americas, Inc.
Pfizer

Completed

A a Single Dose Efficacy Study in Inducing Laxation in Advance Illness Patients

Advanced Illness Patients With Opioid Induced Constipation

United States
Bausch Health Americas, Inc.

Completed

Effects of MNTX on CYP450 2D6 in Metabolizers of Dextromethorphan

Healthy Adults

United States
Bausch Health Americas, Inc.

Completed

Open-Label Treatment Extension of Protocol MNTX 302

Terminal Illness

United States
Bausch Health Americas, Inc.

Completed

Study of the Pharmacokinetics of Intravenous Administered 14C-MNTX

Healthy Male Volunteers

United States
Bausch Health Americas, Inc.

Completed

Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone (MNTX) in Subjects With Impaired Renal Function

Renal Impairment

United States
Bausch Health Americas, Inc.

Completed

Intravenous (IV) Methylnaltrexone (MNTX) in the Prevention of Post-Operative Ileus

Postoperative Ileus

United States
Beth Israel Medical Center
Wyeth is now a wholly owned subsidiary of Pfizer

Withdrawn

Can Methylnaltrexone Safely Treat Opioid Related Constipation in the Emergency Department?

Colonic Inertia
Bausch Health Americas, Inc.

Completed

Naloxone and Intravenous Methylnaltrexone Effects on Bladder Function

Healthy Males

United States
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Unknown

Study of Methylnaltrexone in Opioid-Induced Constipation Patients

Opioid-induced Constipation

China
Bausch Health Americas, Inc.

Withdrawn

An Extension Study of Methylnaltrexone Bromide (MNTX) in Participants With Advanced Pancreatic Cancer

Pancreatic Cancer
Bausch Health Americas, Inc.

Completed

Pharmacokinetics and Bioavailability Comparison of Two Different Formulations of MNTX Tablets

Normal Volunteers

United States
Mayo Clinic
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Effect of Methylnaltrexone on GI Transit in Healthy Volunteers

Gastric Motility Disorder

United States
Bausch Health Americas, Inc.
Progenics Pharmaceuticals, Inc.

Completed

Study Evaluating the Efficacy and Safety of Subcutaneous Methylnaltrexone (MOA-728) for the Treatment of Opioid-Induced-Constipation

Constipation

Korea, Republic of, Taiwan
Bausch Health Americas, Inc.
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study of Intravenous (IV) Methylnaltrexone Bromide (MNTX) in the Treatment of Post-Operative Ileus (POI)

Post-Operative Ileus (POI)

United States
Bausch Health Americas, Inc.

Completed

Effect of Methylnaltrexone (MNTX) on Electrocardiogram (ECG) Parameters and Cardiac Repolarization

Healthy Volunteers

United States
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Safety and Efficacy of IBI306 in Chinese Subjects With Non-familial Hypercholesterolemia

Hypercholesterolemia

China
University of California, San Diego
University of Oklahoma; University of Southern California; Children's Bureau... and other collaborators

Completed

Evaluating Trauma-Informed, Evidence-Informed Interventions for Latino Families Experiencing Domestic Violence

Interpersonal Relations

United States
argenx

Active, not recruiting

A Study to Evaluate the Efficacy and Safety of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia (ADVANCE SC)

Primary Immune Thrombocytopenia

United States, France, Georgia, Germany, Italy, Japan, Poland, Russian Federation, Spain, Turkey, United Kingdom, Argentina, Australia, Bulgaria, Chile, China, Denmark, Greece, Ireland, Israel, Jordan, Korea, Republic of, Mexico, New... and more
StemCells, Inc.

Terminated

Study of Human Central Nervous System (CNS) Stem Cell Transplantation in Cervical Spinal Cord Injury

Cervical Spinal Cord Injury | Spine Injury | Cervical Spine Injury

United States, Canada
Bausch Health Americas, Inc.

Completed

Safety and Gastrointestinal Effects of Intravenous Methylnaltrexone

Healthy Volunteers

United States
argenx

Recruiting

A Study of Efgartigimod PH20 SC Given by Prefilled Syringe in Adults With Thyroid Eye Disease.

Thyroid Eye Disease

United States
Hangzhou Sumgen Biotech Co., Ltd.

Recruiting

SG301-SC Injection Safety Study in Subjects With Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE)

China
Eli Lilly and Company

Completed

A Study of LY3461767 in Healthy Participants

Healthy

United States, Singapore
Federal University of Health Science of Porto Alegre
Irmandade Santa Casa de Misericórdia de Porto Alegre

Unknown

Pelvic Physiotherapy in the Prevention of Vaginal Stenosis Secondary to the Radiotherapy (PPPVSSR)

Gynecologic Cancer | Pathological Constriction

Brazil
Bausch Health Americas, Inc.

Completed

Study of Pharmacokinetics, Safety and Tolerability of Intravenous Methylnaltrexone Bromide

Healthy Adults

United States
argenx

Recruiting

A Study of Efgartigimod PH20 SC Given by Prefilled Syringe in Adults With Thyroid Eye Disease

Thyroid Eye Disease

United States
Eli Lilly and Company

Completed

A Safety Study of LY3493269 Given as a Single Injection in Healthy Participants

Healthy

Singapore
Bausch Health Americas, Inc.

Completed

Tolerance and Pharmacokinetics Study of MNTX Tablets

Normal Healthy Volunteers

United States
Eli Lilly and Company

Terminated

A Study of LY3478006 in Healthy Participants

Healthy

United States
Eli Lilly and Company

Completed

A Study of LY3375880 in Healthy Participants

Healthy

United States
GlaxoSmithKline

Completed

Efficacy and Safety Study of Mepolizumab Adjunctive Therapy in Subjects With Severe Uncontrolled Refractory Asthma

Asthma

United States, Argentina, Australia, Canada, France, Germany, Japan, Russian Federation, Spain, Ukraine, Belgium, Chile, Korea, Republic of, Mexico, Italy, United Kingdom
Eli Lilly and Company

Completed

A Study of LY3200327 in Healthy Participants

Healthy

United States
argenx

Recruiting

A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia (ADVANCE SC+)

Primary Immune Thrombocytopenia

United States, Australia, Bulgaria, China, Georgia, Greece, Italy, Japan, Poland, Portugal, Romania, Russian Federation, Thailand, Turkey, Argentina, Chile, Ireland, Jordan, Tunisia, Korea, Republic of, Mexico, New Zealand, South Africa and more
Implandata Ophthalmic Products GmbH
CRO Dr. med. Kottmann GmbH & Co. KG

Active, not recruiting

Long-term Safety and Performance of the ARGOS-SC Suprachoroidal Pressure Sensor System in Patients With Glaucoma Underwent Non-penetrating Glaucoma Surgery

Glaucoma | Open Angle Glaucoma

Germany, Switzerland
Bayer

Recruiting

A Study to Learn How Safe the Study Treatment BAY2701250 is, How it Affects the Body and How it Moves Into, Through and Out of the Body in Healthy Male Participants When a Single Amount is Given as an Injection Into the Vein (Intravenous Infusion) or Under the Skin (Subcutaneous Injection)

Pulmonary Hypertension Due to Left Heart Disease

Germany
Alexion Pharmaceuticals, Inc.
Syneos Health

Completed

Study of ALXN1820 in Healthy Adult Participants

Healthy

Australia, United Kingdom
Eli Lilly and Company

Completed

A Safety Study of LY3462817 in Healthy Japanese and Non-Japanese Participants

Healthy

United States
Eli Lilly and Company

Completed

A Study of LY3361237 in Healthy Participants

Healthy

United States
ViiV Healthcare
GlaxoSmithKline

Not yet recruiting

First Time in Human Study of Long Acting VH4524184 Formulations

HIV Infections

United States
Hoffmann-La Roche
Pfizer

Completed

A Study to Evaluate the Efficacy and Safety of PF-06480605 in Adults With Moderate to Severe Ulcerative Colitis

Moderate to Severe Ulcerative Colitis

United States, Australia, Thailand, Poland, Russian Federation, Japan, Colombia, Spain, Turkey, Romania, India, Slovakia, France, Hungary, South Africa, Belgium, Bulgaria, Germany, Italy, Mexico, Serbia, Ukraine, United Kingdom
Mitchell Scheiman
Children's Hospital of Philadelphia; University of Alabama at Birmingham; Boston... and other collaborators

Not yet recruiting

Interventions for Convergence Insufficiency in Concussed Children (ICONICC)

Concussion | Convergence Insufficiency

United States
Bausch Health Americas, Inc.

Completed

Effect of Cimetidine on the Single-Dose PK of IV- Administered MNTX

Healthy Adult Subjects

United States
Bausch Health Americas, Inc.

Completed

Study Evaluating IV Methylnaltrexone for the Treatment of Post Operative Ileus

Post Operative Bowel Dysfunction

Germany, Italy, United States, Hungary, Korea, Republic of, South Africa, Poland, Australia, Romania, Former Serbia and Montenegro
Biogen

Completed

Phase 1 Subcutaneous Single and Multiple Ascending Dose Study of BG00010 (Neublastin)

Healthy | Painful Lumbar Radiculopathy

Netherlands

Search clinical trials for: SC Methylnaltrexone (MNTX)

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