Search clinical trials for: TH-302

Total 2758 results

Threshold Pharmaceuticals

Terminated

A Phase 2 Biomarker - Enriched Study of TH-302 in Subjects With Advanced Melanoma

Metastatic Melanoma

United States, Canada
Sarcoma Alliance for Research through Collaboration
Threshold Pharmaceuticals

No longer available

SARC021C: A Continuation Study of TH-CR-406/SARC021

Soft Tissue Sarcoma
Threshold Pharmaceuticals

Unknown

A Cardiac Safety Study of TH-302 in Patients With Advanced Solid Tumors

Solid Tumors

United States
Threshold Pharmaceuticals

Completed

A Phase I Study of the Safety, Pharmacokinetics, and Anti-Tumor Activity of TH-302 in Patients With Advanced Solid Tumors

Hypoxia | Tumors

United States
Threshold Pharmaceuticals

Completed

Study of Hypoxia-Activated Prodrug TH-302 to Treat Advanced Leukemias

Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | High-risk Myelodysplastic Syndrome | Advanced Myelofibrosis

United States
Seoul National University Hospital
Threshold Pharmaceuticals

Completed

Study of TH-302 Monotherapy as Second-line Treatment in Advanced Biliary Tract Cancer

Biliary Tract Cancer

Korea, Republic of
Herbert Hurwitz, MD
GlaxoSmithKline; National Comprehensive Cancer Network; Threshold Pharmaceuticals

Completed

Dose Escalation Study of Pazopanib Plus TH-302 (PATH)

Solid Tumors

United States
Merck KGaA, Darmstadt, Germany
Threshold Pharmaceuticals

Completed

A Phase 1 TH-302 Mass Balance Trial

Solid Tumor

Germany
Threshold Pharmaceuticals

Completed

Dose-Escalation Study of TH-302 in Combination With Doxorubicin to Treat Patients With Advanced Soft Tissue Sarcoma

Soft Tissue Sarcoma

United States
Threshold Pharmaceuticals

Unknown

Dose-Escalation Study of TH-302 in Combination With Sunitinib to Treat Patients With Advanced Renal Cell Carcinoma,Gastrointestinal Stromal Tumors and Pancreatic Neuroendocrine Tumors (TH-CR-410)

Gastrointestinal Stromal Tumors | Advanced Renal Cell Carcinoma | Pancreatic Neuroendocrine Tumors

United States
Threshold Pharmaceuticals

Completed

Dose-Escalation Study of TH-302 in Combination With A) Gemcitabine or B) Docetaxel or C) Pemetrexed to Treat Advanced Solid Tumors

Pancreatic Cancer | Non-Small Cell Lung Cancer | Prostate Cancer

United States
Grupo Espanol de Tumores Neuroendocrinos
Pfizer; Threshold Pharmaceuticals

Completed

A Study to Assess the Safety and the Efficacy of the Combination of TH-302 and Sunitinib in Neuroendocrine Pancreatic Tumours

Pancreatic Neoplasms | Neuroendocrine Tumors

Spain
Ding Ma
Shandong University; Huazhong University of Science and Technology; Zhejiang...

Active, not recruiting

The Safety of Ovarian Preservation in Stage IA Endometrial Carcinoma (EC-02)

Endometrial Neoplasms

China
Threshold Pharmaceuticals

Unknown

Open-label Study of TH-302 and Dexamethasone With or Without Bortezomib or Pomalidomide in Subjects With Relapsed/Refractory Multiple Myeloma

Multiple Myeloma

United States
Northwestern University
Brain & Behavior Research Foundation; Neurocentria, Inc.

Completed

Effect of MMFS-202-302 on Cognitive Enhancement in Schizophrenia

Schizophrenia | Schizoaffective Disorder

United States
Tesu Saglik Teknolojileri A.S.

Recruiting

Efficacy and Safety of Digital Therapeutic in Adults With Prediabetes

PreDiabetes

Turkey
Jinling Hospital, China
Jiangsu Topcel-KH Pharmaceutical Co., Ltd.

Enrolling by invitation

A Study of TH-SC01 for Treating Complex Perianal Fistula in Perianal Crohn's Disease.

Crohn's Disease

China
Children's Specialized Hospital
University of Medicine and Dentistry of New Jersey

Completed

The Effect of FES on Children With Spinal Cord Injury

Spinal Cord Injury
The University of Texas Health Science Center at...

Completed

Safety and Efficacy Study of TH-302 CNS Penetration in Recurrent High Grade Astrocytoma Following Bevacizumab

HIGH GRADE GLIOMA

United States
Merck KGaA, Darmstadt, Germany
Threshold Pharmaceuticals

Terminated

A Japanese Trial of TH-302 in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Soft Tissue Sarcoma

Japan
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Threshold Pharmaceuticals

Completed

Sorafenib Tosylate and Hypoxia-Activated Prodrug TH-302 in Treating Patients With Advanced Kidney Cancer or Liver Cancer That Cannot Be Removed By Surgery

Kidney Cancer | Liver Cancer

United States
SWOG Cancer Research Network
National Cancer Institute (NCI)

Recruiting

Study to Test AKR1C3-Activated Prodrug OBI-3424 (OBI-3424) in Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Refractory T Acute Lymphoblastic Leukemia | Recurrent T Acute Lymphoblastic Leukemia

United States
Rain Oncology Inc

Terminated

Study for Treatment of Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck or Skin

Metastatic Head-and-neck Squamous-cell Carcinoma

United States, Australia
Jiangsu Topcel-KH Pharmaceutical Co., Ltd.
Changhai Hospital

Not yet recruiting

A Study of Human TH-SC01 Cell Injection for Treating Perianal Fistulas in Patients With Crohn's Disease

Crohn's Disease | Perianal Fistula
The University of Texas Health Science Center at...

Completed

TH-302 in Combination With Bevacizumab for Glioblastoma

Glioblastoma

United States
Theraclion

Active, not recruiting

Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)

Breast Fibroadenoma

Bulgaria
Rutgers, The State University of New Jersey
Michael J. Fox Foundation for Parkinson's Research

Completed

Telephone-Based Counseling for Depression in Parkinson's Disease (TH-CBT)

Depression | Parkinson's Disease

United States
Theraclion

Completed

High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma

Breast Fibroadenoma

France
Icahn School of Medicine at Mount Sinai
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Informatics Framework for Pulmonary Rehabilitation (CHIEF-PR)

COPD

United States
Maastricht Radiation Oncology
Threshold Pharmaceuticals; Zuyderland Medical Centre

Withdrawn

Testing TH-302, in Combination With Preoperative Chemoradiotherapy, in Esophageal Cancer.

Esophageal Cancer
Tel-Aviv Sourasky Medical Center

Unknown

Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections

Spinal Stenosis
Hookipa Biotech GmbH

Recruiting

HB-302/HB-301 Therapy in Participants With Metastatic Castration-Resistant Prostate Cancer

Prostate Cancer Metastatic

United States
Jinling hospital Nanjing, Jiangsu, China
Jiangsu Topcel-KH Pharmaceutical Co., Ltd.

Recruiting

A Study of TH-SC01 in the Treatment of Radiation-induced Rectal Injury

Rectal Injury

China
Threshold Pharmaceuticals
Sarcoma Alliance for Research through Collaboration (SARC)

Completed

A Trial of TH-302 in Combination With Doxorubicin Versus Doxorubicin Alone to Treat Patients With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Soft Tissue Sarcoma

United States, France, Canada, Spain, Germany, Belgium, Poland, Austria, Denmark, Hungary, Israel, Italy, Russian Federation
Swiss Tropical & Public Health Institute
Pevion Biotech Ltd; Mymetics Corporation

Completed

Phase Ib Trial of Two Virosome Formulated Malaria Vaccine Components (PEV 301, PEV 302) in Tanzania (PMAL03)

Falciparum Malaria

Tanzania
Threshold Pharmaceuticals
EMD Serono

Terminated

Study of TH-302 or Placebo in Combination With Pemetrexed in Patients With Non-squamous Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

United States, Germany, Spain, Poland, Greece, Czechia, Hungary, Italy, Romania, Russian Federation
VA Office of Research and Development
Department of Veterans Affairs, New Jersey; Rutgers Robert Wood Johnson Medical...

Completed

Telehealth Cognitive Behavioral Therapy for Depression in Parkinson's Disease (PD) (TH-CBT)

Depression | Parkinson's Disease

United States
Rain Oncology Inc

Terminated

Study for Treatment With TH-4000 (Tarloxotinib) in Epidermal Growth Factor Receptor (EGFR) Mutant, T790M-negative Non-small Cell Lung Cancer (NSCLC) Patients (TH-4000)

NSCLC | Non-small Cell Lung Cancer | Non-squamous NSCLC

United States, Australia
Theraclion

Withdrawn

Efficacy and Safety of High Intensity Focused Ultrasound (HIFU) Device to Treat Secondary Hyperparathyroidism

End Stage Renal Disease | Secondary Hyperparathyroidism | Parathyroid Hyperplasia

Spain, Italy
Ian Boggero, PhD
National Institute of Dental and Craniofacial Research (NIDCR)

Recruiting

K23- Physical Self Regulation vs Placebo

Temporomandibular Disorder

United States
Threshold Pharmaceuticals

Completed

Clinical Trial Testing TH-302 in Combination With Gemcitabine in Previously Untreated Subjects With Metastatic or Locally Advanced Unresectable Pancreatic Adenocarcinoma (MAESTRO)

Metastatic or Locally Advanced Unresectable Pancreatic Adenocarcinoma

United States, Germany
IRCCS San Raffaele Roma
Istituto Nazionale di Ricovero e Cura per Anziani

Active, not recruiting

TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios (HYDROKNEERVANA)

Knee Osteoarthritis | Total Knee Replacement

Italy
Virginia Polytechnic Institute and State University
University of Virginia; Autism Speaks; National Center for Advancing Translational...

Completed

Providing Accessible Diagnostic Evaluations and Psychoeducation for Autism Spectrum Disorder in Rural Southwest Virginia

Autism Spectrum Disorder

United States
Oxford University Hospitals NHS Trust
Theraclion

Terminated

High Intensity Focused Ultrasound (HIFU) for Parathyroid Adenoma

Parathyroid Adenomas

United Kingdom
Anika Therapeutics, Inc.

Completed

Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain

Osteoarthritis, Knee

United States
Theraclion

Completed

Observation of Histological Changes in Parathyroid Adenomas Following High Intensity Focused Ultrasound (HIFU) Treatment Procedure

Primary Parathyroid Adenomas

France
Shenzhen Xbiome Biotech Co., Ltd.
Beijing Improve-Quality Tech.Co., Ltd.

Recruiting

Safety and Tolerability of FMT Capsules in Healthy Volunteers

Acute-graft-versus-host Disease

China
Jiangsu Topcel-KH Pharmaceutical Co., Ltd.
Xiangya Hospital of Central South University

Not yet recruiting

The Purpose of This Study is to Evaluate the Safety and Efficacy of Human TH-SC01 Cell Injection in the Treatment of Complex Perianal Fistula

Complex Perianal Fistulas

China
Bispebjerg Hospital
Malmö University

Completed

Safty and Feasibility Study of Therapeutic Cooling in Acute Ischemic Stroke (COOLAID Øresund)

Cerebral Infarction

Denmark
GE Healthcare
Quintiles, Inc.; Covance; ABX CRO; Examination Management Services Inc.; Averion...

Terminated

Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Computed Tomography

Diabetes Mellitus | Renal Insufficiency

United States, United Kingdom

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