Search clinical trials for: aerosolized DNase

Total 69 results

Region Skane

Recruiting

Aerosoliserat DNase for Treatment of Respiratory Failure in Severe COVID-19

COVID-19

Sweden
Protalix

Unknown

Study to Evaluate the Safety,Tolerability, Pharmacokinetics and Exploratory Efficacy Parameters of AIR DNase™in Patients With Cystic Fibrosis Previously Treated With Pulmozyme®

Cystic Fibrosis

Israel
Protalix

Completed

Safety, Tolerability and Pharmacokinetics Study of AIR DNAse Administered by Inhalation to Healthy Adult Volunteers

Cystic Fibrosis (CF)

Israel
Nicole Hamblett
University of Washington; Dartmouth-Hitchcock Medical Center; Cystic Fibrosis...

Completed

Impact of Discontinuing Dornase Alfa in People With CF on Highly Effective CFTR Modulator Therapy-A SIMPLIFY Sub-Study (SIMPLIFY-DN)

Cystic Fibrosis

United States
McMaster University
Canadian Institutes of Health Research (CIHR)

Recruiting

Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI) (IDEALSepsisI)

Sepsis | Critical Illness

Canada
Jiangsu Province Centers for Disease Control and...

Active, not recruiting

Heterologous Prime-boost Immunization With an Aerosolised Adenovirus Type-5 Vector-based COVID-19 Vaccine (Ad5-nCoV) After Priming With an Inactivated SARS-CoV-2 Vaccine

COVID-19

China
Jon Simmons
University of South Alabama

Recruiting

Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure (DAMPENCOVID)

Covid19

United States
Nicole Hamblett
University of Washington; Dartmouth-Hitchcock Medical Center; Cystic Fibrosis...

Completed

Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy (SIMPLIFY)

Cystic Fibrosis

United States
University of Melbourne

Recruiting

Improving Early Reperfusion With Adjuvant Dornase Alfa in Large Vessel Ischemic Stroke (EXTEND-IA DNase)

Ischemic Stroke

Australia
University of Illinois at Chicago
Genentech, Inc.; Research to Prevent Blindness

Terminated

DNase Treatment for Dry Eyes

Dry Eye

United States
Kafrelsheikh University
Damietta University

Unknown

Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment (Antibodies)

COVID-19
Prisma Health-Midlands

Withdrawn

Early Intrapleural TPA Instillation Versus Late (ELEVATE)

Tissue Plasminogen Activator

United States
Dr. Michael Flavin

Withdrawn

Treating Wheezing in Children With Hypertonic Saline (TWICS) (TWICS)

Wheeze
National University of Malaysia

Completed

Short Duration High Intensity Intrapleural Alteplase With Pulmozyme in Pleural Infection Management

Loculated Empyema

Malaysia
University of Medicine and Dentistry of New Jersey

Completed

Impact of Nebulized Dornase Alpha on Mechanically Ventilated Patients

Atelectasis | Ventilation, Mechanical

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Aerosolized Aldesleukin in Treating Patients With Lung Metastases

Sarcoma | Metastatic Melanoma | Metastatic Renal Cell Cancer | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Stage IV Osteosarcoma AJCC v7 | Metastatic Osteosarcoma | Stage IV Renal Cell Cancer AJCC v7 | Metastatic Malignant Neoplasm in the Lung

United States
Jiangsu Province Centers for Disease Control and...
Hunan Provincial Center for Disease Control and Prevention; Yunnan Center for... and other collaborators

Active, not recruiting

Heterologous Boost Immunization With an Aerosolised Ad5-nCoV After Two-dose Priming With an Inactivated SARS-CoV-2 Vaccine

COVID-19

China
Wright State University

Terminated

Aerosolized Antibiotics in the Treatment of Ventilator Associated Pneumonia (AAINTVAP)

Pneumonia, Ventilator-Associated

United States
Denver Health and Hospital Authority

Completed

Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication

Coagulopathy | Empyema, Pleural | Parapneumonic Effusion

United States
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Recruiting

SARS-CoV-2 Infection Among Healthcare Workers

COVID-19

China
Nationwide Children's Hospital
Genentech, Inc.

Completed

Effectiveness of Pulmozyme in Infants With Cystic Fibrosis

Cystic Fibrosis

United States
National Cancer Institute (NCI)

Recruiting

Study of Aerosolized Antibiotics and Pembrolizumab in Advanced Non-small Cell Lung Cancer

Advanced Non Small Cell Lung Cancer

United States
ONY

Terminated

Infasurf®(Calfactant) Aerosol for Infants With Bronchiolitis-AERO-04

Bronchiolitis

United States
Heidelberg University

Completed

Iloprost-Study: Comparison of Nitric Oxide to Iloprost (Ventavis) for Treatment of Pulmonary Hypertension in Children After Cardiopulmonary Bypass Surgery

Pulmonary Hypertension

Germany
Pari Pharma GmbH

Terminated

Long-term Safety Follow-up Study in the Prevention of Bronchiolitis Obliterans Syndrome (BOS)

Bronchiolitis Obliterans

Germany
Windtree Therapeutics

Terminated

Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants

Respiratory Distress Syndrome

United States
Vancouver Coastal Health

Unknown

123I-MIBG Scintigraphy in Patients Being Evaluated for Neuroendocrine Tumors

Neuroblastoma | Pheochromocytoma | Paraganglioma | Medullary Thyroid Carcinoma | Carcinoid Tumors

Canada
Hannover Medical School

Terminated

Combination Therapy of Bosentan and Aerosolized Iloprost in Idiopathic Pulmonary Arterial Hypertension (IPAH)

Hypertension

Germany
University of Vermont
Genentech, Inc.

Completed

Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis

Sinusitis | Cystic Fibrosis

United States
Jiangsu Province Centers for Disease Control and...

Not yet recruiting

Effectiveness of a Second COVID-19 Vaccine Booster in Chinese Adults

COVID-19

China
Kafrelsheikh University

Unknown

Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19 (Isotretinoin)

Covid19

Egypt
Foundation IRCCS San Matteo Hospital
Ministero della Salute, Italy

Recruiting

HCMV Breakthrough Infections During Letermovir Prophylaxis (CMVbreak)

Cytomegalovirus Infections | Hematopoietic Stem Cell Transplantation | Cytomegalovirus Viremia

Italy
Bayer
Nektar Therapeutics

Completed

Inhaled Amikacin Solution BAY41-6551 as Adjunctive Therapy in the Treatment of Gram-Negative Pneumonia (INHALE 1)

Pneumonia, Bacterial

Korea, Republic of, Taiwan, United States, Canada, Philippines, Turkey, Thailand, Australia, Mexico, Colombia, Czechia, Brazil
Jiangsu Province Centers for Disease Control and...

Active, not recruiting

Heterologous Boost Immunization With Ad5-nCoV After Three-dose Priming With an Inactivated SARS-CoV-2 Vaccine

COVID-19

China
Seattle Children's Hospital

Completed

Improving Sedation of Children Undergoing Procedures in the Emergency Department

Anxiety
Hat Yai Medical Education Center

Terminated

Aerosolized Plus Intravenous vs. Intravenous Colistin for VAP Due to Pandrugs-resistant A. Baumannii in Neonates

Pneumonia, Ventilator-Associated | Colistin Adverse Reaction | Infection Due to Multidrug Resistant Acinetobacter | Infection Resistant to Multiple Drugs

Thailand
Case Western Reserve University
Cystic Fibrosis Foundation

Withdrawn

Pharmacokinetics of Vancomycin for Inhalation in Cystic Fibrosis

Cystic Fibrosis | Methicillin-resistant Staphylococcus Aureus

United States
M.D. Anderson Cancer Center
Gateway for Cancer Research; James B. and Lois R. Archer Charitable Foundation

Recruiting

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

Malignant Neoplasms of Female Genital Organs | Malignant Neoplasms of Lip Oral Cavity and Pharynx | Melanoma and Other Malignant Neoplasms of Skin | Malignant Neoplasm of Bone and Articular Cartilage | Malignant Neoplasms of Independent (Primary) Multiple Sites | Malignant Neoplasm of Male... and other conditions

United States
Pinnacle Health System

Completed

Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic

Pain, Postoperative | Morbid Obesity

United States
Sir Charles Gairdner Hospital
The University of Western Australia

Terminated

The Safety and Tolerability of Intra-abdominal t-PA and DNase on Peritonitis in Peritoneal Dialysis Patients

Peritoneal Dialysis | Peritoneal Dialysis, Continuous Ambulatory

Australia
Kafrelsheikh University
Ministry of Health, Saudi Arabia; Foshan University Laboratory of Emerging... and other collaborators

Not yet recruiting

Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.

Post COVID-19 Anosmia (Loss of Smell)

China, Egypt, Saudi Arabia
University of Florida

Completed

Fibrinolytic Therapy Versus Medical Thoracoscopy

Pleural Diseases

United States
ONY

Completed

Comparison of Aerosol Delivery of Infasurf to Usual Care in Spontaneously Breathing RDS Patients

Respiratory Distress Syndrome

United States
Kafrelsheikh University
1-Foshan University Laboratory of Emerging Infectious Disease Institute of... and other collaborators

Not yet recruiting

Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) (Isotretinoin)

COVID19

Egypt
NICHD Neonatal Research Network
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Terminated

Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF)

Respiratory Insufficiency | Pulmonary Hypertension | Respiratory Distress Syndrome, Newborn | Prematurity

United States
Eastern Regional Medical Center

Recruiting

Combination Tissue Plasminogen Activator (Tpa) and Dornase Alfa (Dnase) Administration Through Intrapleural Catheters for the Treatment of Loculated or Non-Draining Malignant Pleural Effusions

Loculated or Non-draining Malignant Pleural Effusions

United States
Stony Brook University
Nektar Therapeutics

Completed

Aerosolized Antibiotics and Respiratory Tract Infection in Patients on Mechanical Ventilation

Ventilator Associated Pneumonia | Respiratory Infection | Tracheobronchitis

United States
Tulane University

Completed

Fibrinolysis Compared to Thoracoscopy for Pleural Infection

Pleural Diseases | Pleural Infection | Empyema | Parapneumonic Effusion

United States
Cardeas Pharma

Completed

Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative Pneumonia (IASIS)

Pneumonia, Bacterial

Spain, United States, Greece, Hungary, Turkey, Puerto Rico, France
Beth Israel Deaconess Medical Center
National Institute of Nursing Research (NINR)

Completed

Aerosol Inhalation Treatment for Dyspnea - Patients

Dyspnea

United States

Search clinical trials for: aerosolized DNase

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