Search clinical trials for: Avelumab

Total 299 results

Merck KGaA, Darmstadt, Germany

Completed

Phase I/Ib Multiple Ascending Dose Study in China

Metastatic Solid Tumors

China
Clinique Neuro-Outaouais

Completed

Avelumab in Patients With Newly Diagnosed Glioblastoma Multiforme (SEJ)

Glioblastoma Multiforme of Brain

Canada
Promontory Therapeutics Inc.
Pfizer; EMD Serono

Completed

A Dose Escalation and Confirmation Study of PT-112 in Advanced Solid Tumors in Combination With Avelumab (PAVE-1)

Non-Small Cell Lung Cancer (NSCLC)

United States, Switzerland
Vaccinex Inc.
University of Rochester

Recruiting

Trial of Immunotherapy With Avelumab and Pepinemab As Second Line For Patients With Metastatic Pancreatic Adenocarcinoma

Metastatic Pancreatic Adenocarcinoma

United States
4SC AG
Merck KGaA, Darmstadt, Germany

Withdrawn

Domatinostat in Combination With Avelumab in Patients With Treatment-naïve Metastatic Merkel Cell Carcinoma (MERKLIN 1)

Merkel Cell Carcinoma
Samsung Medical Center
Merck KGaA, Darmstadt, Germany

Active, not recruiting

Avelumab in Relapsed or Refractory Extranodal Natural Killer/T-cell Lymphoma[AVENT STUDY]

Lymphoma, Extranodal NK-T-Cell

Korea, Republic of
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in Metastatic or Locally Advanced Solid Tumors (JAVELIN Solid Tumor JPN)

Solid Tumors

Germany
AHS Cancer Control Alberta
EMD Serono; Alberta Cancer Foundation

Recruiting

The UNSCARRed Study: UNresctable Squamous Cell Carcinoma Treated With Avelumab and Radical Radiotherapy (UNSCARRed)

Squamous Cell Carcinoma of the Skin

Canada
McGill University Health Centre/Research Institute...

Recruiting

mDCF + Avelumab in Resectable Esophago-gastric Adenocarcinoma (EGA)

Gastric Adenocarcinoma | Esophageal Adenocarcinoma

Canada
Pfizer

Not yet recruiting

A Study to Learn About the Effect of Avelumab First-Line Maintenance in Canadian People With Advanced Bladder Cancer

Urinary Bladder Neoplasms | Bladder Cancer | Urothelial Carcinoma | Bladder Tumors

Canada
Vaccinex Inc.
Merck KGaA, Darmstadt, Germany

Completed

VX15/2503 in Combination With Avelumab in Advanced Non-small Cell Lung Cancer (CLASSICAL-Lung)

Carcinoma, Non-Small-Cell Lung

United States
4SC AG

Active, not recruiting

Domatinostat in Combination With Avelumab in Patients With Advanced Merkel Cell Carcinoma Progressing on Anti-PD-(L)1 (MERKLIN2)

Merkel Cell Carcinoma

Spain, Netherlands, Belgium, Germany, France, Italy
Groupe Oncologie Radiotherapie Tete et Cou
UNICANCER

Active, not recruiting

Randomized Trial of Avelumab-cetuximab-radiotherapy Versus SOCs in LA SCCHN (REACH) (REACH)

HNSCC

France
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Terminated

A Phase Ib Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) of Avelumab in Combination With M9241(NHS-IL12) (JAVELIN IL-12) (COMBO)

Advanced Solid Tumors

Spain, United States, Netherlands, Hungary, Italy, France, Belgium
Johannes Gutenberg University Mainz
Ipsen; Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA...

Active, not recruiting

Cabozantinib in Combination With Avelumab in Patients Refractory to Standard Chemotherapy With Advanced Neuroendocrine Neoplasias G3 (NEN G3)

Cancer

Germany
Hospices Civils de Lyon

Completed

Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias (TROPHIMMUN)

Gestational Trophoblastic Neoplasias (GTN)

France
Vall d'Hebron Institute of Oncology

Active, not recruiting

Phase II Study of Avelumab Plus Chemotherapy in the Peri-operative Treatment for Patients With Resectable Gastric Cancer (GC) or Gastroesophageal Junction Cancer (GEJC) (MONEO)

Stomach Neoplasms | Gastroesophageal Junction Adenocarcinoma

Spain
The Netherlands Cancer Institute
Merck KGaA, Darmstadt, Germany

Completed

Bioimmunoradiotherapy (Cetuximab/RT/Avelumab)

Carcinoma, Squamous Cell of Head and Neck

Netherlands
Verastem, Inc.

Terminated

Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Clinical Activity of Defactinib in Combination With Avelumab in Epithelial Ovarian Cancer

Epithelial Ovarian Cancer

United States
Institut Bergonié
Bayer; Merck KGaA, Darmstadt, Germany

Recruiting

A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors (REGOMUNE)

Hepatocellular Carcinoma | Triple Negative Breast Cancer | Non-small Cell Lung Cancer | Soft-tissue Sarcoma | Urothelial Carcinoma | Thyroid Cancer | Gastro-enteropancreatic Neuroendocrine Tumor | Biliary Tract Cancer | HPV-Related Carcinoma | Solid Tumor, Adult | Mesotheliomas Pleural | GIST | Renal Carcinoma | Colorectal... and other conditions

France
Radboud University Medical Center
Merck KGaA, Darmstadt, Germany

Completed

PD-L1 Imaging in Non Small Cell Lung Cancer' (PINNACLE) (PINNACLE)

Non Small Cell Lung Cancer

Netherlands
Pfizer

Completed

An Observational Chart Review Study To Describe The Real-World Outcomes And Use Of Avelumab In Combination With Axitinib For Treatment Of Patients With aRCC In The UK

Advanced Renal Cell Carcinoma

United Kingdom
4D pharma plc

Withdrawn

Study of MRx0518 and Avelumab in Patients With Urothelial Carcinoma (AVENU)

Urothelial Carcinoma

United States
Pfizer

Completed

Current Treatment Outcomes in Japanese RCC Patients Treated With Avelumab Plus Axitinib as First-line Therapy: Retrospective Study (J-DART)

Renal Cell Carcinoma

Japan
Centre Hospitalier Universitaire de Besancon
Pfizer

Recruiting

Maintenance Avelumab Immunotherapy in Patients With Locally Advanced or Metastatic Squamous Cell Penile Carcinoma (PULSE)

Penile Cancer | Penile Neoplasms | Penile Squamous Cell Carcinoma

France
National Cancer Institute (NCI)

Recruiting

A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma After Progression on Platinum-Based Chemotherapy

Thymic Carcinoma | Thymoma

United States
Consorzio Oncotech

Completed

Avelumab as Single Agent in Metastatic or Locally Advanced Urothelial Cancer in Patients Unfit for Cisplatin. The ARIES Study (ARIES)

Metastatic or Locally Advanced PD-L1 Positive Urothelial Cancer

Italy
Yonsei University
Merck KGaA, Darmstadt, Germany

Active, not recruiting

K-Basket, Avelumab, Biomarker-driven, Advanced Solid Tumor

PD-L1 Positive Mutation Tumor | EBV Positive Mutation Tumor | MSI-H Mutation Tumor | POLE/POLD1 Mutation Tumor

Korea, Republic of
Andrew J. Armstrong, MD

Completed

PD-L1 Inhibition as ChecKpoint Immunotherapy for NeuroEndocrine Phenotype Prostate Cancer (PICK-NEPC)

Prostate Cancer

United States
Centre Francois Baclesse
Pfizer

Recruiting

TALazoparib and Avelumab as Maintenance Therapy in Platinum-Sensitive Metastatic or Locally Advanced URothelial Carcinoma (TALASUR)

Urothelial Carcinoma

France
Pfizer

Terminated

Safety And Efficacy Study Of Avelumab Plus Chemotherapy With Or Without Other Anti-Cancer Immunotherapy Agents In Patients With Advanced Malignancies

Non-small Cell Lung Cancer | Urothelial Cancer

Spain, Czechia, United States, Australia, United Kingdom, Italy, Canada, Hungary
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Treatment Outcomes in Japanese RCC Patients Treated With Avelumab Plus Axitinib as First-line Therapy: Retrospective Study (J-DART2)

Renal Cell Carcinoma

Japan
Pfizer

Completed

A Study Of Avelumab In Combination With Axitinib In Advanced Renal Cell Cancer (JAVELIN Renal 100)

Renal Cell Cancer

United States, United Kingdom, Japan
Andrew Sharabi
Pfizer

Terminated

Stereotactic Body Radiation Therapy (SBRT) Combined With Avelumab (Anti-PD-L1) for Management of Early Stage Non-Small Cell Lung Cancer (NSCLC)

Early Stage Non-Small Cell Lung Cancer

United States
Seoul National University Hospital
Merck KGaA, Darmstadt, Germany

Completed

Phase II Study of Avelumab in Patients With Advanced Hepatocellular Carcinoma After Prior Sorafenib Treatment (AvelumabHCC)

Carcinoma, Hepatocellular

Korea, Republic of
Assuntina Sacco, M.D.
Pfizer

Terminated

Avelumab for Recurrent/Metastatic Nasopharyngeal Cancer

Nasopharyngeal Cancer

United States
Effector Therapeutics
Pfizer; Merck KGaA, Darmstadt, Germany

Completed

A Study to Evaluate eFT508 Alone and in Combination With Avelumab in Subjects With MSS Colorectal Cancer

Microsatellite Stable Relapsed or Refractory Colorectal Cancer

United States
National Cancer Institute, Slovakia
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in Refractory Testicular Germ Cell Cancer.

Neoplasms | Gonadal Disorders | Neoplasms, Germ Cell and Embryonal | Testicular Neoplasms | Testicular Diseases | Antineoplastic Agents | Molecular Mechanisms of Pharmacological Action

Slovakia
AIO-Studien-gGmbH

Completed

Avelumab and Cetuximab in Combination With FOLFOX in Patients With Previously Untreated Metastatic Colorectal Cancer - The Phase II AVETUX-CRC Trial. (AVETUX)

Metastatic Colorectal Cancer

Germany
Pfizer

Completed

A Study Of Avelumab In Combination With Axitinib In Advanced HCC (VEGF Liver 100)

Carcinoma, Hepatocellular

Japan
Pfizer
Merck KGaA, Darmstadt, Germany

Active, not recruiting

A NON-INTERVENTIONAL STUDY ON AVELUMAB USE IN PATIENTS WITH ADVANCED OR METASTATIC UROTHELIAL CARCINOMA (AVENANCE)

Urothelial Carcinoma

France
Pfizer

Terminated

A Study of Avelumab in Real-World Treatment for Patients With Advanced or Metastatic Urothelial Cancer

Bladder Cancer

Brazil, Argentina
Sunnybrook Health Sciences Centre
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in G3 NEC (NET-001)

Neuroendocrine Carcinoma

Canada
Merck KGaA, Darmstadt, Germany
Pfizer

Approved for marketing

Expanded Access to Avelumab for Treatment of Metastatic Merkel Cell Carcinoma (mMCC)

Metastatic Merkel Cell Carcinoma

France
Pfizer

Terminated

A Study of Avelumab in Combination With Axitinib In Non-Small Cell Lung Cancer (NSCLC) or Urothelial Cancer (Javelin Medley VEGF)

Non-Small Cell Lung Cancer | Urothelial Cancer

Korea, Republic of, United States, Taiwan, Poland, Spain, Russian Federation, Italy, Hungary
Transgene
Pfizer; EMD Serono Research & Development Institute, Inc.; Merck KGaA, Darmstadt...

Active, not recruiting

Phase Ib/II of TG4001 and Avelumab in HPV16 Positive R/M Cancers

HPV-Related Carcinoma | HPV-Related Cervical Carcinoma | HPV-Related Anal Squamous Cell Carcinoma | HPV-Related Penile Squamous Cell Carcinoma | HPV-Related Vulvar Squamous Cell Carcinoma

United States, France, Spain
Erasmus Medical Center
Merck KGaA, Darmstadt, Germany

Recruiting

Chemotherapy and Sequential Immunotherapy for Locally Advanced Urothelial Cancer (CHASIT)

Urothelial Carcinoma

Netherlands
Spanish Oncology Genito-Urinary Group
Adknoma Health Research

Completed

SOGUG-AVELUMAB_RWD (SOGUG)

Metastatic Urothelial Carcinoma

Spain
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Active, not recruiting

Avelumab Program Rollover Study

Solid Tumors

Korea, Republic of, United States, Spain, United Kingdom, Russian Federation, Argentina, Australia, Italy, Japan, Belgium, Brazil, Czechia, France, Germany, Hungary, Romania, Turkey, Bulgaria, Mexico, Poland, Thailand, Ukraine
National Taiwan University Hospital

Enrolling by invitation

The Ave-CRT Study for Newly Diagnosed Metastatic Esophageal Squamous Cell Carcinoma

Metastatic Esophageal Squamous Cell Carcinoma | Esophageal Tumor

Taiwan

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