Search clinical trials for: Imipenem

Total 78 results

Tunis University

Completed

Effect of Aerosolised Colistin in Ventilator Associated Pneumonia

Pneumonia, Ventilator-Associated

Tunisia
Sutep Jaruratanasirikul
Prince of Songkla University

Completed

The Population Pharmacokinetics of Imipenem in Patients With Ventilator-associated Pneumonia

Ventilator-Associated Pneumonia

Thailand
Assistance Publique - Hôpitaux de Paris

Completed

Impact of Imipenem With Amikacin Pharmacokinetic and Pharmacodynamic (IMPACT)

Ventilator Associated Pneumonia

France
Central Hospital, Nancy, France

Terminated

Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli (COLIFOX)

Urinary Tract Infections

France
Institute of Liver and Biliary Sciences, India

Completed

Imipenem Versus Cefepime in Spontaneous Bacterial Peritonitis and to Evaluate the Risk Factors for Treatment Failure

Spontaneous Bacterial Peritonitis

India
Amsterdam UMC, location VUmc
ZonMw: The Netherlands Organisation for Health Research and Development; Fo...

Completed

Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO (SHORT)

Febrile Neutropenia | Hematological Malignancy

Netherlands
University Hospital Rijeka
University of Rijeka

Completed

Imipenem Prophylaxis in Patients With Acute Pancreatitis (IMPROWE)

Acute Pancreatitis

Croatia
Juan A. Arnaiz

Completed

Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis

Infective Endocarditis

Spain
Merck Sharp & Dohme LLC

Completed

Efficacy and Safety of Imipenem+Cilastatin/Relebactam (MK-7655A) Versus Colistimethate Sodium+Imipenem+Cilastatin in Imipenem-Resistant Bacterial Infection (MK-7655A-013) (RESTORE-IMI 1)

Bacterial Infections
Johnson & Johnson Pharmaceutical Research & Development...

Terminated

To Compare Safety and Efficacy of Doripenem Versus Imipenem-Cilastatin in Patients With Ventilator-Associated Pneumonia

Ventilator-Associated Pneumonia

United States, Australia, Germany, France, Spain, Argentina, Mexico, Portugal, India, Romania, Turkey, Ukraine, Canada, Belgium, Brazil, Philippines, Russian Federation, Hungary, Israel, Thailand, Guatemala
Assistance Publique - Hôpitaux de Paris
Groupe Hospitalier Paris Saint Joseph; French National Network of Clinical...

Completed

Temocillin Versus a Carbapenem as Initial Intravenous Treatment for ESBL Related Urinary Tract Infections (TEMO-CARB)

Urinary Tract Infections

France
University of Puerto Rico

Unknown

Polymyxin B Monotherapy vs Combination Therapy in Critically Ill Patients With Multi-drug Resistant Pathogens (MUSEUM)

Critical Illness | Trauma | Resistant Infection

Puerto Rico
Entasis Therapeutics

Completed

Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complex (ATTACK)

Bacteremia | Ventilator-associated Bacterial Pneumonia | Acinetobacter Baumannii-calcoaceticus Complex | Hospital-acquired Bacterial Pneumonia | Colistin Resistant ABC

United States, Belarus, Brazil, China, Greece, Hungary, India, Israel, Korea, Republic of, Lithuania, Mexico, Peru, Puerto Rico, Russian Federation, Taiwan, Thailand, Turkey
Pfizer

Completed

Complicated Skin and Skin Structure Infections

Abscess | Cellulitis | Skin Infection
Mahidol University

Unknown

Ertapenem Versus Meropenem/Imipenem for ESBL+ Gram-negative Infections

Drug Safety

Thailand
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

A Trial of Intravenous HRS-8427 in the Treatment of Adults With Complicate Urinary Tract Infection, Including Acute Pyelonephritis

Patients With Complicated Urinary Tract Infection(cUTI), Including Acute Pyelonephritis(AP)
Evopoint Biosciences Inc.

Recruiting

Evaluation of the Efficacy and Safety of Intravenous Imipenem/Cilastatin/XNW4107 in Comparison With Recarbrio in Adults With HABP /VABP (REITAB-2)

Hospital Acquired Bacterial Pneumonia or Ventilator-Associated Bacterial Pneumonia

United States, Spain, France, Israel
Spero Therapeutics
GlaxoSmithKline

Recruiting

A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) (PIVOT-PO)

Urinary Tract Infection | Acute Pyelonephritis

Moldova, Republic of, Georgia, United States, Serbia, Bulgaria, Romania, South Africa
GlaxoSmithKline

Terminated

GSK2251052 in Complicated Urinary Tract Infection

Infections, Urinary Tract

France, United States, Russian Federation, Spain, Greece, Canada
Hartford Hospital
Merck Sharp & Dohme LLC

Completed

Imipenem-Relebactam Pharmacokinetics in Augmented Renal Clearance

Sepsis

United States
Evopoint Biosciences Inc.

Completed

Pharmacokinetics of XNW4107 in Subjects With Various Degrees of Renal Function

Bacterial Infections

United States
Evopoint Biosciences Inc.

Completed

Intrapulmonary Pharmacokinetics of XNW4107, Imipenem and Cilastatin in Healthy Subjects

Bacterial Infections

United States
Merck Sharp & Dohme LLC

Completed

Efficacy and Safety of Imipenem+Cilastatin/Relebactam (MK-7655A) in Japanese Participants With Complicated Intra-abdominal Infection or Complicated Urinary Tract Infection (MK-7655A-017)

Complicated Intra-abdominal Infection | Complicated Urinary Tract Infection

Japan
Xiangya Hospital of Central South University

Unknown

Second-generation Sequencing Guides the Treatment of Severe Pneumonia (NGS)

Pneumonia | Metagenomic Next Generation Sequencing

China
Ruijin Hospital
Pfizer

Unknown

Linezolid Alone or Combined With Carbapenem Against Methicillin-resistant Staphylococcus Aureus (MRSA) in Ventilator-associated Pneumonia

Pneumonia, Ventilator-Associated | Methicillin-resistant Staphylococcus Aureus
Wake Forest University Health Sciences
Merck Sharp & Dohme LLC

Withdrawn

Imipenem/Cilastatin/Relebactam (IMI/REL) in Treatment of CRE Infections

Gram-Negative Bacterial Infections | Antibiotic Resistant Infection | Carbapenem-Resistant Enterobacteriaceae Infection | KPC

United States
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia

Pneumonia | Bacterial Infections | Pneumonia, Bacterial | Abdominal Abscess | Pneumonia, Ventilator-Associated
Entasis Therapeutics

Completed

Evaluation of Safety and Efficacy of Intravenous Sulbactam-ETX2514 in the Treatment of Hospitalized Adults With Complicated Urinary Tract Infections

Acute Pyelonephritis | Complicated Urinary Tract Infection

Bulgaria
Prince of Songkla University

Unknown

PK/PD and Clinial Outcomes of Beta-lactams in ICU Patients

Critical Illness | Bacterial Infections

Thailand
Evopoint Biosciences Inc.

Completed

To Evaluate the Pharmacokinetics of XNW4107 in Healthy Adult Young Females and in Healthy Adult Elderly Males and Females.

Bacterial Infections

United States
Pfizer

Completed

A Study To Determine The Efficacy And Safety Of Tigecycline Compared With Imipenem/Cliastatin to Treat Complicated Intra-Abdominal Infection

Intra-abdominal Infection

China
Pfizer

Terminated

Study Evaluating Safety and Efficacy of Tigecycline Versus Imipenem/Cilastatin Subjects With Hospital-Acquired Pneumonia

Pneumonia, Bacterial

Canada, United States, Argentina, Australia, Brazil, Chile, Colombia, Croatia, France, Hungary, Korea, Republic of, Latvia, Russian Federation, Taiwan
Nanfang Hospital of Southern Medical University

Unknown

Antibacterial Prophylaxis vs no Prophylaxis for Hematological Malignancies Patients Before Allo-HSCT

Hematological Malignancies | Imipenem | Antibacterial Prophylaxis | Allogenetic Hematopoietic Stem Cell Transplantation

China
Coordinación de Investigación en Salud, Mexico
Instituto Mexicano del Seguro Social; Hospital Infantil de Mexico Federico... and other collaborators

Completed

Efficacy of Betalactam Antibiotics in Prolonged Infusion Compared to Intermittent in Pediatric Patients With Sepsis

Sepsis

Mexico
University Hospital, Basel, Switzerland

Completed

DetectAB - Detecting Antibiotics (DetectAB)

Antibiotic Drug Concentration in Sweat

Switzerland
Southeast University, China

Completed

The Analysis of Factors Influencing the Vd of Imipenem in Septic Shock Patients

Septic Shock

China
University of Illinois at Chicago
Merck Sharp & Dohme LLC

Enrolling by invitation

Impact of Obesity on the Pharmacokinetics of Imipenem-Relebactam in ICU Patients

Obesity | Critical Illness

United States
Shionogi

Completed

A Study of Efficacy and Safety of Intravenous Cefiderocol (S-649266) Versus Imipenem/Cilastatin in Complicated Urinary Tract Infections (APEKS-cUTI)

Urinary Tract Infections
Prince of Songkla University
Merck Sharp & Dohme LLC

Completed

Pharmacodynamics Study of Imipenem in Patients With Ventilator Associated Pneumonia

Ventilator Associated Pneumonia

Thailand
Evopoint Biosciences Inc.

Not yet recruiting

Evaluation of the Efficacy and Safety of Intravenous Imipenem/Cilastatin/XNW4107 in Comparison With Meropenem in Hospitalized Adults With cUTI Including AP (EudraCT no. 2022-000061-40)

Complicated Urinary Tract Infection Including Acute Pyelonephritis

United States
Hartford Hospital
Merck Sharp & Dohme LLC; University of Texas Southwestern Medical Center; University... and other collaborators

Recruiting

Imipenem/Cilastatin/Relebactam Pharmacokinetics, Safety, and Outcomes in Adults and Adolescents With Cystic Fibrosis

Pneumonia, Bacterial | Cystic Fibrosis

United States
Pfizer

Completed

Comparative Study of NXL104/Ceftazidime Versus Comparator in Adults With Complicated Urinary Tract Infections

Complicated Urinary Tract Infection

United States, Lebanon, Jordan
Prince of Songkla University
Merck Sharp & Dohme LLC

Completed

Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia

Patients With Febrile Neutropenia

Thailand
Entasis Therapeutics

Completed

Evaluation of the Safety, Tolerability and Pharmacokinetics of Intravenous ETX2514 Administered in Healthy Subjects

Acinetobacter Baumannii Infection

Australia
Joseph L. Kuti, PharmD
Merck Sharp & Dohme LLC

Completed

Imipenem/Cilastatin/Relebactam PK in ECMO

Sepsis

United States
Prince of Songkla University

Unknown

Imipenem in Critically Ill Patients

Critically Ill Patients With ECMO

Thailand
Merck Sharp & Dohme LLC

Completed

Study of the Safety, Tolerability, and Efficacy of Relebactam (MK-7655) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone to Treat Complicated Intra-Abdominal Infection [cIAI] (MK-7655-004)

Intra-abdominal Infections
Emilio Bouza
Merck Sharp & Dohme LLC

Unknown

In Vitro Activity of Ceftolozane/Tazobactam and Imipenem/Relebactam in Clinical Isolates of Pseudomonas Aeruginosa and Enterobacterales Collected From Hematology and Oncology Patients (ACTHEON)

Ceftolozane/Tazobactam | Imipenem/Relebactam | Hematology and Oncology

Spain
Southeast University, China
Merck Sharp & Dohme LLC

Unknown

Preliminary Research On Two-step Dosing Of Imipenem/Cilastatin (PROTDOI)

Sepsis

China
Merck Sharp & Dohme LLC

Completed

A De-Escalating Strategy for Antibiotic Treatment of Pneumonia in The Medical Intensive Care Unit (0787B-092)

Pneumonia | Infection

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