Search clinical trials for: Metformin

Total 2160 results

National Cancer Institute (NCI)

Completed

Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI

Obesity | Colorectal Cancer | Adenomatous Polyp

Canada, United States
Massachusetts General Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Unknown

Metformin Treatment in Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Syndrome
University of Hawaii
National Institute of General Medical Sciences (NIGMS)

Unknown

Metformin for HIV Inflammation

Coronary Artery Disease | HIV

United States
Torrent Pharmaceuticals Limited

Completed

Study to Evaluate the Bioequivalence of a Test Tablet Formulation of Metformin HCl (1000 mg), Compared to an Equivalent Dose of a Commercially Available Reference Drug Product (Glucophage®, Bristol-Myers Squibb Company) in Fasted, Healthy, Adult Subjects

Healthy

United States
Torrent Pharmaceuticals Limited

Completed

Study to Evaluate the Bioequivalence of a Test Tablet Formulation of Metformin HCl (1000 mg), Compared to an Equivalent Dose of a Commercially Available Reference Drug Product (Glucophage®, Bristol-Myers Squibb Company) in Fed, Healthy, Adult Subjects

Healthy

United States
Shanghai 10th People's Hospital

Not yet recruiting

SGLT2 Inhibitors in Treating Patients With PCOS

Polycystic Ovary Syndrome
Woman's
Novo Nordisk A/S

Completed

Combined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM)

Type 2 Diabetes Mellitus | Metabolic Syndrome | Impaired Glucose Tolerance | Gestational Diabetes Mellitus | Disorder of Glucose Regulation

United States
Rutgers University
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome

Metabolic Syndrome

United States
Boehringer Ingelheim
Eli Lilly and Company

Completed

Bioequivalence of a Fixed Dose Combination Tablet of Empagliflozin/Metformin Extended Release Compared With Mono Compound Tablets in Healthy Subjects

Healthy

Germany
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Assess the Bioequivalence of 2 Fixed Dose Combination (FDC) Tablets of Canagliflozin and Metformin Immediate Release (IR) (150 mg/850 mg) With Respect to the Individual Components of Canagliflozin (1 x 300 mg) and Metformin IR Tablets (2 x 850 mg) in Healthy Volunteers

Healthy

United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Bioequivalence of Fixed Dose Combination (FDC) Tablets of Canagliflozin and Metformin Immediate Release (IR) With Respect to the Individual Components of Canagliflozin and Metformin IR Tablets in Healthy Volunteers

Healthy

United States
Bangabandhu Sheikh Mujib Medical University, Dhaka...
Department of Genetic Engineering and Biotechnology, Dhaka University

Recruiting

Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS

Polycystic Ovary Syndrome | Metformin

Bangladesh
Istituto Ortopedico Rizzoli

Recruiting

Metformin as Maintenance Therapy in Patients With Bone Sarcoma and High Risk of Relapse (Metform-Bone)

Osteosarcoma | Ewing Sarcoma

Italy
Cairo University

Completed

Efficacy of Metformin as add-on Therapy in Non-Diabetic Heart Failure Patients

Heart Failure

Egypt
Kyongtae Ty Bae, M.D., Ph.D.
University of Maryland, Baltimore; United States Department of Defense; University... and other collaborators

Completed

Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease (TAME)

Polycystic Kidney, Autosomal Dominant

United States
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Completed

A Study of DBPR108 and Metformin Hydrochloride Combination Therapy in Patients With T2DM

Type 2 Diabetes Mellitus

China
National Center of Cardiology and Internal Medicine...

Completed

The Influence of Metformin on Chronic Heart Failure Clinical Course in Patients With Prediabetes

Coronary Artery Disease | PreDiabetes | Chronic Heart Failure

Kyrgyzstan
Shenzhen People's Hospital

Completed

Effect of Metformin on Gut Microbiota Changes and Glycemic Control of Newly Diagnosed Type 2 Diabetes

Type 2 Diabetes

China
Chongqing Medical University

Completed

Metformin SR Tablet (DuLeNing) and Glucophage in Patients With Type 2 Diabetes (CQM-2016)

Diabetes Mellitus

China
British Columbia Cancer Agency
BC Cancer Foundation; Pancreatic Cancer Canada

Unknown

The Effects of Neoadjuvant Metformin on Tumour Cell Proliferation and Tumour Progression in Pancreatic Ductal Adenocarcinoma (Metformin 001)

Resectable Pancreatic Ductal Adenocarcinoma

Canada
Takeda

Terminated

Safety and Efficacy of TAK-559 in Combination With Metformin in Patients With Type 2 Diabetes Mellitus.

Diabetes Mellitus
Laboratorios Silanes S.A. de C.V.

Recruiting

Oral Combination of Glimepiride/Vildagliptin/Metformin in Patients With T2D and Dual Treatment Failure

Type 2 Diabetes

Mexico
GlaxoSmithKline

Completed

A Type 2 Diabetes Study of the Longer-Term Glycemic Effect of AVANDAMET vs. Metformin

Diabetes Mellitus, Type 2

United States, Taiwan, Argentina, Canada, Philippines, Korea, Republic of, Mexico, Brazil, Pakistan
Services Hospital, Lahore

Completed

Comparison of Hypoglycaemic Regimens During Ramadan Fasting in Type 2 Diabetes

Diabetes, Type 2

Pakistan
Boehringer Ingelheim
Eli Lilly and Company

Completed

Relative Bioavailability of 2 Fixed Dose Combinations of Linagliptin/Metformin Compared With Single Tablets

Healthy

United States
Merck Sharp & Dohme LLC

Completed

A Study to Demonstrate the Bioequivalence of Sitagliptin/Metformin Combination Tablets and Co-administration of Sitagliptin and Metformin as Individual Tablets (0431A-095)

Type 2 Diabetes
RenJi Hospital

Not yet recruiting

The Effect of Henagliflozin and Metformin on Myocardial Tissue-level Characteristics

Myocardial Fibrosis | Obesity | Type 2 Diabetes | Magnetic Resonance Imaging | Sodium-glucose Co-transporter-2 Inhibitor
University of Minnesota

Not yet recruiting

Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia

Oral Leukoplakia

United States
Sun Yat-sen University

Not yet recruiting

The Effect of Metformin in Patients With Metastatic Castration-resistant Prostate Cancer

Metastatic Prostate Cancer

China
Dana-Farber Cancer Institute
National Cancer Institute (NCI)

Recruiting

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma

United States
Garvan Institute of Medical Research
National Health and Medical Research Council, Australia

Recruiting

Preventing Cognitive Decline With Metformin (MetMemory)

Cognitive Decline

Australia
National Cancer Institute (NCI)

Terminated

Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma

Renal Cell Carcinoma | Renal Cell Cancer | Hereditary Leiomyomatosis

United States
Cynthia Calkin
Stanley Medical Research Institute

Completed

Treating Insulin Resistance as a Strategy to Improve Outcome in Refractory Bipolar Disorder (TRIO-BD)

Bipolar Disorder

United States, Canada
University of Virginia

Completed

Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome (EJB044)

Metabolic Syndrome | Insulin Sensitivity

United States
Lars Christian Gormsen

Completed

Effects of Metformin on Hepatic FFA Metabolism

Type 2 Diabetes | Dyslipidemia
Virginia Commonwealth University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Pharmacogenetics of Metformin Action in PCOS

Polycystic Ovary Syndrome

United States
Novo Nordisk A/S

Completed

Comparison of the Blood Sugar Lowering Effect Between Repaglinide Plus Metformin and Repaglinide Alone in Type 2 Diabetics Not Previously Treated With Oral Sugar-lowering Drugs

Diabetes Mellitus, Type 2 | Diabetes

China
Novo Nordisk A/S

Completed

Efficacy and Safety of Repaglinide and Metformin Combination Therapy in Type 2 Diabetes Failing on Oral Anti-diabetic Drugs

Diabetes Mellitus, Type 2 | Diabetes

China
National Cancer Institute (NCI)

Completed

Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus

Esophageal Cancer | Barrett Esophagus

United States, Puerto Rico, Canada
Government Dental College and Research Institute...

Unknown

Locally Delivered 1% Metformin Gel in the Treatment of Intrabony Defects in Chronic Periodontitis

Intrabony Defects in Chronic Periodontitis

India
Odense University Hospital

Completed

The Effect of Metformin in Overweight Patients With Dysregulated Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

Denmark
Jiangsu HengRui Medicine Co., Ltd.

Active, not recruiting

Clinical Study of Retagliptin Phosphate Combined With Metformin in the Treatment of Type 2 Diabetes

Type 2 Diabetes

China
Wake Forest University Health Sciences
University of South Florida; National Institute on Aging (NIA)

Recruiting

Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction (Met-PEF)

Heart Failure With Preserved Ejection Fraction

United States
PT. Pyridam Farma Tbk
PT Pharma Metric Labs

Completed

Bioequivalence Study of Metformin Hydrochloride 500 mg Film-Coated Tablets in Indonesia Healthy Subject

Drug Use

Indonesia
Sunovion

Completed

A Clinical Trial Study to Determine the Effect of an Investigational Drug (SEP-363856) Has on the Way That the Drug Metformin Travels Through the Body in People With Schizophrenia.

Schizophrenia

United States
Hager salah el din

Completed

Evaluation of the Effect of Metformin on Metastatic Breast Cancer as Adjuvant Treatment

Metastatic Breast Cancer

Egypt
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Dual Add-on Therapy in Type 2 Diabetes Poorly Controlled With Metformin Monotherapy

Diabetes Mellitus, Type II
Kristian Karstoft
University of Copenhagen

Completed

The Interaction Between Metformin and Acute Exercise

Diabetes Mellitus, Type 2 | Impaired Glucose Tolerance

Denmark
National Cheng-Kung University Hospital

Terminated

Metformin in Stage IV Lung Adenocarcinoma

Non-small Cell Lung Cancer

Taiwan
GlaxoSmithKline

Completed

Study Of AVANDAMET® With Or Without Insulin In Type II Diabetes Mellitus Patients. AVANDAMET® is a Registered Trademark of the GSK Group of Companies.

Diabetes Mellitus, Type 2

Spain, Germany, France, Austria, Italy

3

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