Search clinical trials for: rhNGF

Total 49 results

Dompé Farmaceutici S.p.A
Covance

Completed

Study to Evaluate Safety, Tolerability and Pharmacokinetics of rhNGF Eye Drops in Healthy Volunteers (NGF0112)

Healthy

Switzerland, United Kingdom
Dompé Farmaceutici S.p.A

Recruiting

A Study to Evaluate Safety and Efficacy of a New Formulation of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution in Patients With Dry Eye Disease (REDUCO)

Dry Eye Disease

United States, Italy
Dompé Farmaceutici S.p.A

Completed

A Study to Evaluate Safety and Efficacy of rhNGF Eye Solution vs Vehicle in Patients With Moderate to Severe Dry Eye

Dry Eye Syndrome

United States
Dompé Farmaceutici S.p.A

Completed

A 8 Weeks Study to Evaluate Efficacy & Safety of rhNGF vs Vehicle in Patients After Cataract and Refractive Surgery

Ocular Discomfort

Italy
Dompé Farmaceutici S.p.A
Cromsource

Completed

Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma (NGF-Glaucoma)

Glaucoma

United States
Daewoong Pharmaceutical Co. LTD.

Unknown

The Clinical Study for Evaluation of Efficacy and Safety of EGF on Oral Mucositis in Radiation Therapy Patients

Stomatitis

Korea, Republic of
Dompé Farmaceutici S.p.A
Cromsource

Completed

Study to Evaluate Safety, Tolerability & PK of rhNGF in Healthy Volunteers

Healthy Volunteers

United States
Dompé Farmaceutici S.p.A
Cross Research S.A.

Completed

Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye

Dry Eye Syndrome

Austria
Daewoong Bio Inc.

Completed

Pharmacokinetics, Safety, and Tolerability of rhEGF Eye Drops in Healthy Male Subjects

Dry Eye Syndromes

Korea, Republic of
Dompé Farmaceutici S.p.A

Completed

Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NK

Neurotrophic Keratitis

United States
The Catholic University of Korea

Unknown

Preventive Effect of EGF Cream for Cutaneous Adverse Event of EGFR Inhibitors

Drug-Related Side Effects and Adverse Reactions | Epidermal Growth Factor

Korea, Republic of
The Catholic University of Korea

Unknown

Therapeutic Effect of EGF Cream for Cutaneous Adverse Event of EGFR Inhibitors

Drug-Related Side Effects and Adverse Reactions | Epidermal Growth Factor

Korea, Republic of
PT. Daewoong Infion
Equilab International

Completed

Efficacy and Safety Evaluation of EASYEF® in Acute Wound (Split-thickness Skin Graft Donor Site)

Skin Graft Scar | Split-Thickness Skin Graft (STSG)

Indonesia
Insmed Incorporated

Completed

IGF-I/IGFBP-3 Therapy in Children and Adolescents With Growth Hormone Insenitivity Syndrome (GHIS) Such as Laron Syndrome

Laron Syndrome | Growth Hormone Insensitivity Syndrome (GHIS)

United States, Argentina, Australia, Brazil, China, Egypt, Germany, Israel, Italy, Norway, Peru, Slovakia, Turkey, United Kingdom
Dompé Farmaceutici S.p.A

Completed

Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. (REPARO)

Keratitis | Neurotrophic Keratitis | Corneal Ulcer

Germany, Italy, France, Poland, Spain, United Kingdom
Insmed Incorporated

Terminated

Research Study Using Recombinant Human Insulin-Like Growth Factor-1/Recombinant Human Insulin-Like Growth Factor Binding Protein-3 for Children With Noonan Syndrome

Noonan Syndrome

United States
Daewoong Pharmaceutical Co. LTD.

Completed

Efficacy and Safety of rhEGF in Diabetic Foot Ulcer Patients With Uncontrolled Diabetic Mellitus

Diabetic Foot Ulcer Patients With Uncontrolled Diabetes Mellitus

Korea, Republic of
Insmed Incorporated
Muscular Dystrophy Association

Completed

Safety and Efficacy Study of Recombinant Human Insulin-Like Growth Factor-I/Recombinant Human Insulin-Like Growth Factor Binding Protein-3 (rhIGF-I/rhIGFBP-3) In Myotonic Dystrophy Type 1

Myotonic Dystrophy Type 1

United States
SVS Institute of Dental Sciences

Unknown

RhEGF Incorporated in An Absorbable Collagen Membrane for The Management Of Gingival Recession Defects

Periodontitis

India
Dompé Farmaceutici S.p.A

Completed

A Dose Ranging Study to Evaluate the Safety and Potential Efficacy of rhNGF in Patients With Retinitis Pigmentosa (RP) (Lumos)

Retinitis Pigmentosa

Italy
Nationwide Children's Hospital
Tercica

Terminated

Effect of Increlex® on Children With Crohn Disease

Crohn Disease

United States
Ospedale San Raffaele
Dompé Farmaceutici S.p.A

Completed

Nerve Growth Factor Eye Drops Treatment in Patients With Retinitis Pigmentosa and Cystoid Macular Edema (NEMO)

Retinitis Pigmentosa | Cystoid Macular Edema

Italy
Boston Children's Hospital
Autism Speaks; International Rett Syndrome Foundation

Completed

Treatment of Rett Syndrome With rhIGF-1 (Mecasermin [rDNA]Injection)

Rett Syndrome

United States
Children's Hospital Medical Center, Cincinnati

Completed

IGF-1 Treatment for Individuals With Short Stature Due to PAPP-A2 Deficiency

Short Stature
G. d'Annunzio University

Completed

An 8-week Follow-up to Evaluate the Renewal of Corneal Nerves Structure and Function in Patients With Neurotrophic Keratopathy Treated With Recombinant Human Nerve Growth Factor (rhNGF) Eyedrops

Neurotrophic Keratopathy

Italy
Ipsen

Completed

Prepubertal Children With Growth Failure Associated With Primary Insulin-Like Growth Factor-1 (IGF-1) Deficiency

Growth Disorders | Insulin-Like Growth Factor-1 Deficiency

United States
Shire

Completed

Long-term Safety and Efficacy Outcome Study Comparing Children Previously Enrolled in Study ROPP-2008-01 for the Prevention of Retinopathy of Prematurity (ROP) (PEDAL)

Retinopathy of Prematurity (ROP)

United States, Italy, Netherlands, Poland, Sweden, United Kingdom
National Institute of Neurological Disorders and...

Completed

A 48-Week (24-Week Baseline Followed by a 24-Week Treatment) Phase II Pilot Study of the Tolerability and Effect/Efficacy of Subcutaneously Administered Insulin-Like Growth Factor-1 (rhIGF) (CEP-151) in Multiple Sclerosis (MS) Patients

Multiple Sclerosis

United States
Ipsen

Completed

Recombinant Human Insulin-Like Growth Factor (rhIGF-1) Treatment of Short Stature Associated With IGF-1 Deficiency

Growth Disorders | Insulin-Like Growth Factor-1 Deficiency

United States
EMD Serono Research & Development Institute, Inc.
Nordic Bioscience A/S

Completed

A Study to Investigate the Safety and Effectiveness of Different Doses of Sprifermin in Participants With Osteoarthritis of the Knee (FORWARD)

Osteoarthritis, Knee

Estonia, Romania, Hong Kong, Czechia, Denmark, Poland, Argentina, United States
Massachusetts General Hospital
Tercica

Completed

Safety Profile of Insulin Like Growth Factor-1 (IGF-I) Administration in Adolescents

Anorexia Nervosa

United States
University Hospital Southampton NHS Foundation...

Completed

A Study to Assess Safety and Efficacy of a Novel Treatment, Keratinocyte Growth Factor (KGF), in Asthmatic Patients

Bronchial Asthma

United Kingdom
Merck KGaA, Darmstadt, Germany

Completed

A Multicenter Study of rhFGF 18 in Patients With Knee Osteoarthritis Not Requiring Surgery

Knee Osteoarthritis

Germany, Croatia, Bulgaria, Canada, Finland, Poland, Serbia, South Africa, Sweden
The Immunobiological Technology Institute (Bio-Manguinhos)...

Active, not recruiting

Efficacy and Safety Evaluation of the Intralesional Recombinant Human Epidermal Growth Factor (rhEGF) in Subjects With Diabetic Foot Ulcer.

Foot Ulcer, Diabetic | Epidermal Growth Factor
University College Cork

Completed

Evaluation of the Safety and Efficacy of Using Insulin-like Growth Factor-1 in Patients With a Heart Attack (RESUS-AMI)

Myocardial Infarction | Heart Failure

Ireland, Netherlands
Shire

Completed

IGF-1/IGFBP3 Prevention of Retinopathy of Prematurity

Retinopathy of Prematurity (ROP)

United States, Italy, Netherlands, United Kingdom, Sweden, Poland
Universidade Federal Fluminense

Completed

Regeneration of Human Intrabony Defects With rhFGF-2/HA

Periodontitis
Ipsen

Terminated

rhGH and rhIGF-1 Combination Therapy in Children With Short Stature Associated With IGF-1 Deficiency

Insulin-like Growth Factor-1 Deficiency

United States
Massachusetts General Hospital

Completed

IGF-1 and Bone Loss in Women With Anorexia Nervosa

Anorexia Nervosa | Osteoporosis | Osteopenia

United States
Massachusetts General Hospital

Completed

Effects of rhIGF-1 on Bone Metabolism in Adolescent Girls With Anorexia Nervosa (814)

Disorder of Bone Density and Structure, Unspecified

United States
Martin, Paul
National Cancer Institute (NCI)

Completed

Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer

Primary Myelofibrosis | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma and other conditions

United States
Boston Children's Hospital
International Rett Syndrome Foundation

Completed

Treatment of Rett Syndrome With Recombinant Human IGF-1

Rett Syndrome

United States
Children's Oncology Group
National Cancer Institute (NCI)

Withdrawn

Palifermin in Preventing Oral Mucositis Caused by Chemotherapy and/or Radiation Therapy in Young Patients Undergoing Stem Cell Transplant

Malignant Neoplasm | Gastrointestinal Mucositis
Seoul National University Hospital
Daewoong Pharmaceutical Co. LTD.

Completed

Study of Epidermal Growth Factor on Oral Mucositis Induced by Intensive Chemotherapy for Hematologic Malignancies (EGFOM)

Oral Mucositis

Korea, Republic of
Massachusetts General Hospital

Completed

Effects of Anorexia Nervosa on Peak Bone Mass

Anorexia Nervosa

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Secondary Acute Myeloid Leukemia | Myelodysplastic Syndrome

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Withdrawn

Melphalan, Total Marrow Irradiation, and Autologous Stem Cell Transplantation in Treating Patients With High-Risk Multiple Myeloma

Plasma Cell Myeloma | Plasma Cell Leukemia in Remission

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Human Lysozyme Goat Milk for the Prevention of Graft Versus Host Disease in Patients With Blood Cancer Undergoing a Donor Stem Cell Transplant

Hematopoietic and Lymphoid Cell Neoplasm | Allogeneic Hematopoietic Stem Cell Transplant Recipient

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Withdrawn

Human Lysozyme Goat Milk in Treating Patients With Blood Cancer Undergoing Donor Stem Cell Transplant

Hematopoietic and Lymphoid Cell Neoplasm | Hematopoietic Cell Transplantation Recipient

United States

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