Clinical Trials Sponsored by Alliance Foundation Trials (AFT)

Total 44 results

Alliance Foundation Trials, LLC.

Completed

Atezolizumab Immunotherapy in Patients With Advanced NSCLC

Carcinoma, Non-Small-Cell Lung

United States
Alliance Foundation Trials, LLC.
Pfizer

Active, not recruiting

Phase II Palbociclib +Ibrutinib in Mantle Cell Lymphoma

B Cell Lymphoma | Mantle Cell Lymphoma

United States
Alliance Foundation Trials, LLC.
Bayer

Recruiting

Androgen Receptor Directed Therapy on Cognitive Function in Patients Treated With Darolutamide or Enzalutamide (ARACOG)

Prostate Cancer | Metastatic Prostate Cancer | Prostate Cancer Metastatic | Castrate Resistant Prostate Cancer

United States
Alliance Foundation Trials, LLC.
AstraZeneca

Active, not recruiting

CHIO3 Trial: CHemotherapy Combined With Immune Checkpoint Inhibitor for Operable Stage IIIA/B Non-Small Cell Lung Cancer

Stage IIIA Non-small Cell Lung Cancer | Stage IIIB Non-small Cell Lung Cancer

United States
Alliance Foundation Trials, LLC.
Pharmacyclics LLC.

Active, not recruiting

Study of Ibrutinib in Combination With Revlimid/Dexamethasone in Relapsed/Refractory Multiple Myeloma

Multiple Myeloma | Refractory Multiple Myeloma | Multiple Myeloma in Relapse

United States
Alliance Foundation Trials, LLC.
Genentech, Inc.

Recruiting

Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC

NSCLC

United States
Gilead Sciences
Alliance Foundation Trials, LLC.

Recruiting

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05)

Triple Negative Breast Cancer

United States
Alliance Foundation Trials, LLC.
Bristol-Myers Squibb

Terminated

Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease

Multiple Sclerosis | Autoimmune Diseases | Rheumatoid Arthritis | Systemic Lupus Erythematosus | Psoriasis | Crohn Disease | Ulcerative Colitis | Non-small Cell Lung Cancer | Giant Cell Arteritis | Polymyalgia Rheumatica

United States
Alliance Foundation Trials, LLC.
Celgene; Janssen, LP

Withdrawn

Study of Combination POM, BTZ, Low-Dose DEX, and DARA (PVD-DARA) in Patients With RRMM

Relapsed or Refractory Multiple Myeloma
Alliance Foundation Trials, LLC.
Merck Sharp & Dohme LLC

Terminated

Pembrolizumab vs Topotecan in Patients With Small Cell Lung Cancer

Small Cell Lung Cancer

United States
Alliance Foundation Trials, LLC.
Merck Sharp & Dohme LLC

Completed

Optimal Sequencing of Pembrolizumab (MK-3475) and Standard Platinum-based Chemotherapy in First-Line NSCLC

Non-Small Cell Lung Cancer

United States
Alliance Foundation Trials, LLC.
Janssen Research & Development, LLC

Active, not recruiting

A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer

Prostate Cancer

United States
Novartis Pharmaceuticals
Alliance Foundation Trials, LLC.; RTOG Foundation, Inc.

Active, not recruiting

An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With SoC, Versus SoC Alone, in Adult Male Patients With mHSPC (PSMAddition)

Prostatic Neoplasms

United States, China, Canada, Spain, United Kingdom, Belgium, Japan, Taiwan, Germany, Singapore, Austria, Netherlands, Korea, Republic of, France, Switzerland, Denmark, Sweden, Poland, Czechia
Alliance Foundation Trials, LLC.
Bristol-Myers Squibb; Celgene Corporation

Terminated

A Study of Nivolumab +/- Nab-paclitaxel in Non-small Cell Lung Cancer

Nonsmall Cell Lung Cancer | Non Small Cell Lung Cancer Recurrent | Non-Small Cell Carcinoma of Lung, TNM Stage 4 | Non-Small-Cell Lung Cancer Metastatic

United States
Alliance Foundation Trials, LLC.
Patient-Centered Outcomes Research Institute

Completed

Optimizing the Effectiveness of Routine Post-treatment Surveillance in Prostate Cancer Survivors

Prostate Cancer | Cancer of the Prostate | Prostatic Cancer | Cancer of Prostate
Alliance Foundation Trials, LLC.
Patient-Centered Outcomes Research Institute

Completed

Direct Oral Anticoagulants (DOACs) Versus LMWH +/- Warfarin for VTE in Cancer (CANVAS)

Cancer | Venous Thromboembolism | Deep Vein Thrombosis (DVT) | Pulmonary Embolism (PE) | Blood Clot

United States
SOLTI Breast Cancer Research Group
Novartis; Alliance Foundation Trials, LLC.

Recruiting

Ribociclib vs. Palbociclib in Patients With Advanced Breast Cancer Within the HER2-Enriched Intrinsic Subtype (HARMONIA)

Metastatic Breast Cancer

United States, Spain, Portugal
Alliance Foundation Trials, LLC.
Eli Lilly and Company; Pfizer; Genentech, Inc.; Foundation Medicine

Recruiting

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer (EndoMAP)

Endometrial Cancer

United States
Hoffmann-La Roche
Breast International Group; Frontier Science & Technology Research Foundation... and other collaborators

Completed

A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer (IMpassion030)

Triple Negative Breast Cancer

Russian Federation, United States, Israel, Italy, Spain, France, Korea, Republic of, United Kingdom, Denmark, Taiwan, Hungary, Argentina, Australia, Austria, Belgium, Brazil, China, Germany, Hong Kong, Japan, Mexico, Romania, Switze... and more
Alliance Foundation Trials, LLC.
Takeda; Janssen Scientific Affairs, LLC; Celgene Corporation

Active, not recruiting

Study of Lenalidomide/Ixazomib/Dexamethasone/Daratumumab in Transplant-Ineligible Patients With Newly Diagnosed MM

Myeloma, Multiple

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Sky Foundation

Active, not recruiting

Combination Chemotherapy With or Without Hypofractionated Radiation Therapy Before Surgery in Treating Patients With Pancreatic Cancer

Pancreatic Adenocarcinoma | Borderline Resectable Adenocarcinoma of the Head of the Pancrease

United States, Canada
ETOP IBCSG Partners Foundation
Alliance for Clinical Trials in Oncology; Canadian Cancer Trials Group; Breast...

Active, not recruiting

Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer (POSITIVE)

Early Breast Cancer

Korea, Republic of, United States, France, Canada, Spain, Lebanon, Belgium, Switzerland, Israel, Ireland, Japan, Italy, Denmark, Austria, Australia, Greece, Hungary, Netherlands, Norway, Portugal, Serbia, Slovenia
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); NSABP Foundation Inc

Completed

Correlation of Menstrual Cycle Phase at Time of Primary Surgery With 5-Year Disease-Free Survival in Women With Stage I or Stage II Breast Cancer

Breast Cancer | Perioperative/Postoperative Complications

United States, Canada
Alliance Foundation Trials, LLC.
Pfizer; Breast International Group; NSABP Foundation Inc; Austrian Breast & Colorectal... and other collaborators

Active, not recruiting

PALbociclib CoLlaborative Adjuvant Study (PALLAS)

Breast Cancer

United States, Spain, Italy, Ireland, United Kingdom, Australia, Germany, Japan, Portugal, Taiwan, Canada, Israel, Netherlands, Switzerland, Belgium, Austria, Hungary, Korea, Republic of, Mexico, Poland, Sweden
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); GlaxoSmithKline; Genentech, Inc.; Brain Science...

Recruiting

Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

Intracranial Meningioma | Recurrent Meningioma | NF2 Gene Mutation

United States
University of Sydney
Northern Care Alliance NHS Foundation Trust; Waitemata District Health Board; Australasian Kidney Trials Network

Recruiting

Better Evidence and Translation for Calciphylaxis (BEAT-Calci)

Calciphylaxis

Australia, New Zealand
Sanofi
European Organisation for Research and Treatment of Cancer - EORTC; Alliance... and other collaborators

Terminated

Study of Amcenestrant (SAR439859) Versus Tamoxifen for Patients With Hormone Receptor-positive (HR+) Early Breast Cancer, Who Have Discontinued Adjuvant Aromatase Inhibitor Therapy Due to Treatment-related Toxicity (AMEERA-6)

Breast Cancer

Chile, China
University of Manchester
Northern Care Alliance NHS Foundation Trust; National Institute for Health... and other collaborators

Active, not recruiting

SC IL-1Ra in SAH - Phase III Trial (SCIL) (SCIL)

Subarachnoid Hemorrhage

United Kingdom
Alliance Foundation Trials, LLC.
Pfizer; Syneos Health; UNICANCER; German Breast Group; SOLTI Breast Cancer Research... and other collaborators

Active, not recruiting

Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer (PATINA)

HER-2 Positive Breast Cancer | Estrogen Receptor Positive Breast Cancer

United States, Spain, France, Italy, Germany, Australia, Portugal, New Zealand
Karolinska University Hospital
Karolinska Institutet; The Swedish Research Council; Region Stockholm; Swedish... and other collaborators

Active, not recruiting

Safety and Efficacy of Hyperbaric Oxygen Therapy for Long COVID Syndrome (HOT-LoCO)

COVID-19 | Post COVID-19 Condition | Post-COVID Syndrome | Post COVID-19 Condition, Unspecified | Post COVID Condition | Post-Acute COVID-19 Syndrome

Sweden
Gustav Stalhammar
The Swedish Society of Medicine; Swedish Cancer Society; Karolinska Trial Alliance and other collaborators

Recruiting

Adjuvant Melatonin for Uveal Melanoma (AMUM)

Uveal Melanoma | Uveal Melanoma, Posterior, Medium/Large Size | Eye Cancer, Intraocular Melanoma

Sweden
Alliance Foundation Trials, LLC.
Patient-Centered Outcomes Research Institute; M.D. Anderson Cancer Center; Washington... and other collaborators

Active, not recruiting

Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS (COMET)

Ductal Carcinoma in Situ | DCIS

United States
Alliance Foundation Trials, LLC.
Patient-Centered Outcomes Research Institute; Mayo Clinic; Dana-Farber Cancer... and other collaborators

Active, not recruiting

Electronic Patient Reporting of Symptoms During Cancer Treatment (PRO-TECT)

Metastatic Cancer

United States
Peter MacCallum Cancer Centre, Australia
United States Department of Defense; Advanced Accelerator Applications; Australian... and other collaborators

Active, not recruiting

In Men With Metastatic Prostate Cancer, What is the Safety and Benefit of Lutetium-177 PSMA Radionuclide Treatment in Addition to Chemotherapy (UpFrontPSMA)

Metastatic Hormone Naive Prostate Cancer

Australia
University of Alabama at Birmingham
Susan G. Komen Breast Cancer Foundation; Daiichi Sankyo UK Ltd.; Triple Negative...

Completed

Abraxane With or Without Tigatuzumab in Patients With Metastatic, Triple Negative Breast Cancer

Breast Cancer | Metastatic Breast Cancer | Triple Negative Breast Cancer | Stage IV Breast Cancer

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Cancer Research UK; European Organisation for... and other collaborators

Active, not recruiting

Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors

Seminoma | Teratoma | Choriocarcinoma | Germinoma | Germ Cell Tumor | Yolk Sac Tumor | Mixed Germ Cell Tumor | Childhood Teratoma | Malignant Germ Cell Neoplasm | Extragonadal Seminoma | Non-seminomatous Germ Cell Tumor

United States, Germany, France, Spain, Netherlands, Australia, Belgium, Switzerland, United Kingdom, Italy, Denmark, Ireland
PENTA Foundation
Institut National de la Santé Et de la Recherche Médicale, France; Program... and other collaborators

Active, not recruiting

A Randomised Trial of Dolutegravir (DTG)-Based Antiretroviral Therapy vs. Standard of Care (SOC) in Children With HIV Infection Starting First-line or Switching to Second-line ART

HIV Infection

United Kingdom, Spain, Portugal, South Africa, Thailand, Uganda, Germany, Zimbabwe
Massachusetts General Hospital
Mayo Clinic; University of Pennsylvania; University of South Florida; University... and other collaborators

Completed

Healthy Mind Healthy You: A Study of Mindfulness

Stress

United States
Copenhagen University Hospital at Herlev
Zealand University Hospital; University of Copenhagen; Bispebjerg Hospital; Herning... and other collaborators

Terminated

Intermediate Care - Effect on Mortality Following Emergency Abdominal Surgery (InCare)

Emergency Abdominal Surgery

Denmark
Universitätsklinikum Hamburg-Eppendorf
UMC Utrecht; Hotchkiss Brain Institute, University of Calgary; Kompetenznetz... and other collaborators

Not yet recruiting

Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE (EAST-STROKE)

Atrial Fibrillation | Acute Ischemic Stroke
The University of Texas Health Science Center at...
Northern Care Alliance NHS Foundation Trust; Maastricht University Medical... and other collaborators

Completed

Multinational Survey of Epidemiology, Morbidity, and Outcomes in Intracerebral Hemorrhage (MNEMONICH)

Intracerebral Hemorrhage
Public Health Foundation Enterprises, Inc.
National Institute on Drug Abuse (NIDA); Eunice Kennedy Shriver National Institute... and other collaborators

Completed

Comparison of Men's Prevention Apps to Research Efficacy (COMPARE)

Sexually Transmitted Diseases | HIV/AIDS | Risk Reduction | Pre-exposure Prophylaxis

United States
University of Pennsylvania
The Hospital for Sick Children; Mayo Clinic; National University Hospital, Singapore and other collaborators

Active, not recruiting

Osteochondritis Dissecans of Knee Prospective Cohort

Osteochondritis Dissecans

United States
PENTA Foundation
Karolinska Institutet; Centre Hospitalier Universitaire Saint Pierre; Centro... and other collaborators

Active, not recruiting

European Pregnancy and Paediatric Infections Cohort Collaboration: Paediatric Protocol (EPPICC)

HIV Infections | Covid19 | Hepatitis C | Tuberculosis Infection

Clinical Trials Sponsored by Alliance Foundation Trials (AFT)

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in South Korea

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

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