Clinical Trials Sponsored by Big Leap Research

Total 141 results

Sao Thai Duong Joint Stock Company
Big Leap Clinical Research Joint Stock Company

Completed

Safety and Efficacy of KOVIR in the Combination Regimen With Background Treatment in COVID-19 Patients (KOVIR) (KOVIR)

COVID-19

Vietnam
Sao Thai Duong Joint Stock Company
Big Leap Clinical Research Joint Stock Company

Not yet recruiting

Efficacy of KOVIR Capsule in the Combination Regimen With Background Treatment in COVID-19 Patients

COVID-19

Vietnam
Holterman, Ai-Xuan, M.D.
T Rose Clinical, Inc.; Big Leap Research; Prometheus USA

Recruiting

Part II: Granulocyte-Colony Stimulating Factor Adjunct Therapy for Biliary Atresia (BA_GCSF2b)

Biliary Atresia

United States, Vietnam, Pakistan
Sao Thai Duong Joint Stock Company
Big Leap Clinical Research Joint Stock Company

Completed

A Trial of TD0019 in Treatment of Cervical Scapulohumeral Syndrome

Syndrome Pain

Vietnam
Maple Leaf Research

Recruiting

Drug-Drug Interaction Study in Trans Women Living With HIV (T-DDI)

Hiv | Transgenderism

Canada
Sao Thai Duong Joint Stock Company
Big Leap Clinical Research Support Joint Stock Company

Recruiting

To Evaluate the Efficacy and Safety of Shampoo TD03 and TD07 in Scalp Diseases (TD0307)

Scalp Dermatitis

Vietnam
Leap Therapeutics, Inc.
Cancer Research Institute, New York City

Completed

Trial of TRX518 (Anti-GITR mAb) in Stage III or IV Malignant Melanoma or Other Solid Tumors (TRX518-001)

Unresectable Stage III or Stage IV Malignant Melanoma or Other Solid Tumor Malignancies

United States
Holterman, Ai-Xuan, M.D.
Children's National Health System; T. Rose Clinical, Inc., United States; Big...

Completed

GCSF Adjunct Therapy for Biliary Atresia (BA_GCSF)

Biliary Atresia

United States, Vietnam
Ottawa Hospital Research Institute
LEAF Weight Loss Clinic

Not yet recruiting

Correlating Improvement in PCOS Symptoms to the Percentage of Body Weight Lost in Females Also Living With Obesity (FLOWERS-PCOS)

Obesity | Polycystic Ovary Syndrome

Canada
University of Toronto
Unity Health Toronto; Maple Leaf Research

Completed

Effects of Intensive cART During Acute/Early HIV Infection

Acute HIV Infection

Canada
David VanderWeele

Terminated

Neoadjuvant Androgen Deprivation, Darolutamide, and Ipatasertib in Men With Localized, High Risk Prostate Cancer (ADDItion)

Castrate Resistant Prostate Cancer

United States
ModernaTX, Inc.
Lead Scientific and Operating Center: Julius Clinical Research

Active, not recruiting

A Study on the Clinical Course, Outcomes and Risk Factors of Myocarditis and Pericarditis After Moderna COVID-19 Vaccine

Myocarditis, Pericarditis

Denmark, Norway, Spain, United Kingdom
Sherif Farag

Withdrawn

Azacitidine Plus Nivolumab Following Reduced-intensity Allogeneic PBSC Transplantation for Patients With AML and High-risk Myelodysplasia

Aml | AML, Adult
European Organisation for Research and Treatment...
Hoffmann-La Roche; Leap Therapeutics, Inc.

Withdrawn

Combination of Targeted and Immunotherapy for Advanced Biliary Tract and Esophagogastric Gastric Cancer (DYNAMIC)

Esophageal Cancer | Hepatobiliary Neoplasm | Biliary Tract Cancer | GastroEsophageal Cancer
Bio-Medical Research, Ltd.

Completed

Validation Study in Healthy Female Volunteers: A Comparison of Two Neurotech Vital Devices Set up to Provide Different Types of Electrical Stimulation

Healthy Female Volunteers

United States
Bio-Medical Research, Ltd.

Completed

Determination of the Efficacy of Slendertone® Face to Tone the Muscles of the Face and Reduce the Signs of Facial Aging (Face)

Facial Muscle Toning

Ireland
Ottawa Hospital Research Institute
The Ottawa Hospital; LEAF Weight Loss Clinic

Not yet recruiting

BLOOM Forward: Investigating Weight Loss Impact on TJAC Patients

Obesity | Knee Osteoarthritis | Hip Osteoarthritis | Arthroplasty Complications
Muhammad Furqan
AstraZeneca

Recruiting

Chemo-Immunotherapy Followed by Durvalumab and Ceralasertib in Treatment Naïve Patients With Extensive Stage Small Cell Lung Cancer

Extensive Stage Small Cell Lung Cancer

United States
Nelson Yee
Ipsen

Active, not recruiting

Liposomal Irinotecan in Combination With Oxaliplatin, Leucovorin, and 5-fluorouracil for Patients With Locally Advanced Pancreatic Carcinoma:

Locally Advanced Pancreatic Carcinoma(LAPC)

United States
Bio-Medical Research, Ltd.

Completed

Effectiveness of Kneehab in Strengthening Quadriceps in Rehabilitation Post Anterior Cruciate Ligament (ACL) Reconstruction (NMES)

Anterior Cruciate Ligament Reconstruction

Germany
Bio-Medical Research, Ltd.

Completed

Effect of a Transcutaneous Electrical Nerve Stimulation (TENS) Device on Overall Facial Appearance

Ageing

United States
Bio-Medical Research, Ltd.

Completed

A Pilot Study to Evaluate Safety and Performance of Neuromuscular Electrical Stimulation With the Inko RS Device for the Treatment of Stress Urinary Incontinence

Stress Urinary Incontinence

Germany
Bio-Medical Research, Ltd.

Completed

User Evaluation in Healthy Volunteers to Verify no Pelvic Floor Contraction is Stimulated When the Modified Neurotech Vital Device is Used Compared to the Neurotech Vital Device (BMR-12-1002)

Contraction of Pelvic Floor Muscle Using EMS
Bio-Medical Research, Ltd.

Completed

Effectiveness of Kneehab in Strengthening the Quadriceps of Patients Post Anterior Cruciate Ligament (ACL) Reconstruction (NMES)

Anterior Cruciate Ligament Reconstruction

Germany
Cooperative International Neuromuscular Research...
Carolinas Medical Center lead study site

Completed

Evaluation of Limb-Girdle Muscular Dystrophy

Becker Muscular Dystrophy | Limb-Girdle Muscular Dystrophy, Type 2A (Calpain-3 Deficiency) | Limb-Girdle Muscular Dystrophy, Type 2B (Miyoshi Myopathy, Dysferlin Deficiency) | Limb-Girdle Muscular Dystrophy, Type 2I (FKRP-deficiency)

United States
Dwight Owen
Genentech, Inc.

Recruiting

Temozolomide and Atezolizumab as Second or Third Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Extensive Stage Lung Small Cell Carcinoma | Metastatic Lung Small Cell Carcinoma | Recurrent Lung Small Cell Carcinoma

United States
John Quigley
Pfizer; AbbVie

Active, not recruiting

Study of the Safety and Efficacy of Gemtuzumab Ozogamicin (GO) and Venetoclax in Patients With Relapsed or Refractory CD33+ Acute Myeloid Leukemia:Big Ten Cancer Research Consortium BTCRC-AML17-113

Acute Myeloid Leukemia

United States
Monika Joshi, MD
AstraZeneca

Active, not recruiting

Durvalumab And Radiation Therapy Followed by Adjuvant Durvalumab in Patients With Urothelial Cancer (T2-4 N0-2 M0) of the Bladder (DUART)

Urothelial Cancer

United States
H Scott Boswell
Takeda

Terminated

Study Augmenting TAK-659 Action in Relapsed/Refractory AML by Addition Ofthe Proteasome Inhibitor Ixazomib

AML | AML, Adult

United States
Nasser Hanna
Genentech, Inc.

Terminated

Carboplatin Plus Pemetrexed Plus Atezolizumab Plus Bevacizumab in Chemotherapy and Immunotherapy-naïve Patients With Stage IV Non-squamous Non-small Cell Lung Cancer

NSCLC Stage IV | NSCLC, Recurrent

United States
Palo Alto Veterans Institute for Research
Big Health Inc.

Active, not recruiting

A Pilot Study of Digital Cognitive Behavioral Therapy for Veterans

Insomnia

United States
BGI-research
Shenzhen Children's Hospital

Not yet recruiting

Safety and Efficacy Evaluation of β-globin Restored Autologous Hematopoietic Stem Cells in β-thalassemia Major Patients

β-Thalassemia Major

China
Nasser Hanna
Genentech, Inc.

Recruiting

Adjuvant Treatment With Cisplatin-based Chemotherapy Plus Concomitant Atezolizumab in Patients With Stage I (Tumors ≥ 4cm), IIA, IIB, and Select Stage III [Any T1-3 N1-2 and T4N0-2] Resected Non-small Cell Lung Cancer (NSCLC) and the Clearance of Circulating Tumor DNA (ctDNA)

NSCLC | Lung Cancer

United States
Oana Danciu, MD
Pfizer; Big Ten Cancer Research Consortium

Active, not recruiting

Palbociclib in Combination With Tamoxifen as First Line Therapy for Metastatic Hormone Receptor Positive Breast Cancer

Metastatic Breast Cancer | Hormone Receptor Positive Malignant Neoplasm of Breast | Human Epidermal Growth Factor 2 Negative Carcinoma of Breast | Estrogen Receptor Positive Breast Cancer | Progesterone Receptor Positive Tumor

United States
Ajjai Alva, MD
AstraZeneca; Big Ten Cancer Research Consortium

Active, not recruiting

Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer

Kidney Cancer | Clear Cell Renal Cell Carcinoma | Advanced Kidney Cancer

United States
Kari Wisinski
Pfizer; Celcuity Inc

Active, not recruiting

Gedatolisib Plus Talazoparib in Advanced Triple Negative or BRCA1/2 Positive, HER2 Negative Breast Cancers

TNBC - Triple-Negative Breast Cancer

United States
Weill Medical College of Cornell University
The New Venture Fund / Foundation for OCD Research; The Wellcome Leap Fund

Recruiting

Accelerated TMS for Depression and OCD

Depression | OCD

United States
Centre for Addiction and Mental Health
University Health Network, Toronto; Maple Leaf Research

Active, not recruiting

PrEP and Alcohol - Enhancing HIV Pre-Exposure Prophylaxis (PrEP)

Hazardous Alcohol Use

Canada
Kathy Miller
Millennium Pharmaceuticals, Inc.; Big Ten Cancer Research Consortium

Terminated

MLN0128 Compared to Sorafenib in Advanced or Metastatic Hepatocellular Carcinoma

HCC | Hepatocellular Carcinoma | Liver Cancer

United States
Natalie Callendar
Bristol-Myers Squibb

Withdrawn

Phase II Study of Immunomaintenance Using POmalidomide With Elotuzumab afteR Second Autologous Transplant (Immuno-POWER)

Multiple Myeloma
Chandrikha Chandrasekhara
TerSera Therapeutics LLC

Withdrawn

Prospective Assessment of Patients With Neuroendocrine Tumors and Current or Prior History of Carcinoid Syndrome or Diarrhea Undergoing Peptide Receptor Radionuclide Therapy With or Without Telotristat Ethyl (NET-PACS)

Diarrhea | Neuroendocrine Tumors | Carcinoid Syndrome

United States
Q32 Bio Inc.
Innovaderm Research Inc.

Recruiting

Randomized, Double-Blind, Placebo-Controlled Phase 2a, Proof-of-Concept Trial of ADX-914 Phase 2a Trial for the Treatment of Severe Alopecia Areata (SIGNAL-AA)

Alopecia Areata

United States
Tetra Bio-Pharma
Cognitive Research Corporation

Recruiting

Inhaled Cannabinoids Versus Immediate-release Oral Opioids for the Management of Breakthrough Cancer Pain (REBORN)

Cancer | Breakthrough Cancer Pain

United States
Arava Bio Tech Ltd.
Cato Research

Unknown

Safety and Efficacy of AR/101 in Accelerating Re-epithelialization of Split Thickness Wounds

Wounds and Injuries

United States
Nataliya Uboha
Eli Lilly and Company

Terminated

Abemaciclib and Pembrolizumab in Locally Advanced Unresectable or Metastatic Gastroesophageal Adenocarcinoma: Big Ten Cancer Research Consortium BTCRC-GI18-149

Adenocarcinoma | Gastroesophageal Cancer

United States
Greg Durm, MD
Bristol-Myers Squibb; Big Ten Cancer Research Consortium

Active, not recruiting

Unresectable Stage IIIA/IIIB Non-small Cell Lung Cancer (NSCLC)

Non-small Cell Lung Cancer

United States
Monika Joshi, MD
Pfizer; Eisai Inc.; Big Ten Cancer Research Consortium

Terminated

A Study Combining Eribulin Mesylate With Avelumab in Cisplatin Ineligible Metastatic Urothelial Cell Cancer Patients

Metastatic Urothelial Cell Cancer

United States
Baudax Bio
Lotus Clinical Research, LLC

Completed

Placebo-Controlled Evaluation of Intranasal Dexmedetomidine for Postoperative Analgesia Following Bunionectomy Surgery

Pain, Post-operative

United States
Baudax Bio
Lotus Clinical Research, LLC

Terminated

Placebo-Controlled Evaluation of Intranasal Dexmedetomidine for Postoperative Analgesia Following Bunionectomy

Pain, Post-operative

United States
Atlantic Therapeutics
Bio-Medical Research, Ltd.

Completed

Neurotech Vital Compact Versus Itouch Sure Pelvic Floor Exerciser US

Stress Urinary Incontinence

United States

Clinical Trials Sponsored by Big Leap Research

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