Clinical Trials Sponsored by ERCR SPURBO

Total 36 results

University Hospital, Brest
ERCR SPURBO

Completed

Cardiovascular Disease Prevention in Europe and Sub-Saharan Africa (Spices_phase_2)

Cardiovascular Risk Factors

France
University Hospital, Brest
ERCR SPURBO

Completed

Scaling-up Packages of Interventions for Cardiovascular Disease Prevention in Selected Sites in Europe and Sub-Saharan Africa: An Implementation Research (SPICES_PHASE_1)

Cardiovascular Disease

France
University Hospital, Brest
ERCR SPURBO

Completed

The Reported Frequency of FP Visits and Family Difficulties Should Alert FPs and Help Them to Prevent Severe Outcomes in Multimorbid Outpatients

Multimorbidity
University Hospital, Brest
ERCR SPURBO; Unité INSERM 1078, SFR 148 ScInBioS, Brest

Completed

Preventing Decompensation Among Multimorbid Outpatients in Residential Care. A Cohort Study With a Six-month Follow-up. (FDPM)

Multimorbidity
Spero Therapeutics

Completed

A Study to Evaluate the Effect of Co-administration on the Pharmacokinetics of SPR720, Azithromycin, and Ethambutol in Healthy Participants

Healthy Volunteers

United States
Spero Therapeutics

Completed

Study to Examine the Effect of Antacid and Omeprazole on the Single-Dose Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects

Healthy Volunteers

United States
Spero Therapeutics

Recruiting

A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of SPR720 as Compared With Placebo for the Treatment of Participants With Mycobacterium Avium Complex (MAC) Pulmonary Disease

Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD)

United States
Spero Therapeutics

Completed

A Study to Assess the Intrapulmonary Pharmacokinetics (PK) of SPR719 by Comparing the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations Following the Oral Administration of Multiple Doses of SPR720 in Healthy Volunteers.

Healthy Volunteer

United States
Spero Therapeutics

Completed

A Study to Compare Two Bioanalytical Assays for Tebipenem

Healthy Volunteers

United States
Spero Therapeutics

Completed

Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) (ADAPT-PO)

Acute Pyelonephritis | Complicated Urinary Tract Infection

Bulgaria, Georgia, United States, Czechia, Estonia, Hungary, Latvia, Moldova, Republic of, Poland, Romania, Russian Federation, Serbia, Slovakia, South Africa, Ukraine
Spero Therapeutics

Terminated

Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease

Mycobacterium Avium Complex | Non-tuberculous Mycobacterium Pulmonary Disease

United States
Spero Therapeutics

Completed

Phase 1 Study of PK and Safety of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Subjects With Various Degrees Of Renal Function

Renal Impairment

United States
Spero Therapeutics

Completed

Bioequivalence Study Comparing Two Tablet Formulations of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects

Healthy Volunteers

United States
Spero Therapeutics
GlaxoSmithKline

Recruiting

A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) (PIVOT-PO)

Urinary Tract Infection | Acute Pyelonephritis

Moldova, Republic of, Georgia, United States, Serbia, Bulgaria, Romania, South Africa
Spero Therapeutics
Covance

Completed

Study of the Absorption, Metabolism, and Excretion of [14C]-Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) Following a Single Oral Dose in Healthy Male Subjects

Healthy Volunteers

United States
German Resuscitation Registry
European Resuscitation Council (ERC)

Completed

A Multi-centre Survey of Epidemiology, Treatment and Outcome of Patients Suffering an Out-of-hospital Cardiac Arrest (EuReCaONE)

Out of Hospital Cardiac Arrest

Germany
Spero Therapeutics
Clinartis

Completed

Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking Volunteers

Healthy Volunteers

United States
Spero Therapeutics
Celerion

Completed

A Single-Dose, Randomized, Placebo- and Active-Control, Four-Way, Cross-Over Study for the Evaluation of the Effect of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) on the QT/QTc Intervals in Adult Healthy Subjects

TQT Study

United States
University Hospital, Bordeaux
Grant Agreement ERC SMHEART

Not yet recruiting

Validation of Multi-contrast, High-resolution Cardiac Magnetic Resonance Imaging (CARDIO-IRM)

Cardiac Disease

France
Hartford Hospital
Spero Therapeutics

Completed

Tebipenem (SPR994) Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis

Diabetes | ABSSSI | Healthy Volunteers | Wound Infection

United States
Spero Therapeutics
Simbec Research

Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of SPR720 in Healthy Volunteers

Healthy Volunteers

United Kingdom
Hartford Hospital
Spero Therapeutics

Completed

Bioavailability of Tebipenem (SPR994) Crushed Tablet

Relative Bioavailability

United States
Spero Therapeutics
Iqvia Pty Ltd

Completed

Effect of Tebipenem on Normal Human Intestinal Microbiota

Healthy Volunteers

Sweden
Semmelweis University
Purgo Biologics Inc.; FORM-Lab

Completed

Evaluation of a Novel Horizontal Ridge Augmentation Technique in Dentistry

Bone Augmentation | Bone Loss, Alveolar

Hungary
University of Connecticut
BHSAI; Harvard-NIOSH Education and Research Center (ERC)

Completed

Comparison of Bi-environmental Conditions During Occupational Related Activity (COBRA)

Hyperthermia | Hypothermia

United States
Spero Therapeutics
United States Department of Defense

Completed

Study to Assess the Intrapulmonary Pharmacokinetics of SPR206 in Healthy Volunteers

Healthy Volunteers

United Kingdom
Spero Therapeutics
Simbec Research; QPS Holdings LLC

Completed

Phase 1 Study to Evaluate DDI, PK, Safety, Tolerability of SPR741

Healthy Volunteers

United Kingdom
Spero Therapeutics
United States Department of Defense

Completed

Phase 1 Study of PK and Safety of SPR206 in Subjects With Various Degrees Of Renal Function

Renal Impairment

New Zealand
Spero Therapeutics
CPR Pharma Services Pty Ltd, Australia

Completed

Phase 1 Study of Safety, Tolerability and Pharmacokinetics of SPR994

Healthy Volunteers

Australia
Spero Therapeutics
CPR Pharma Services Pty Ltd, Australia

Completed

A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of SPR741 in Healthy Volunteers

Healthy Volunteers

Australia
Spero Therapeutics
Clinical Network Services (CNS) Pty Ltd

Completed

A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of SPR206 in Healthy Volunteers

Healthy Volunteers

Australia
University Hospital, Bordeaux
Grant Agreement ERC n°715093; University of Bordeaux - mission UB-C19

Completed

Prevalence of Myocardial Scars on CMR After COVID-19 Infection (COVID-CMR)

COVID-19 | Virus Disease

France
University of Chicago
Wuhan University; Gilead Sciences; Guangzhou 8th People's Hospital; Social Entrepreneurship...

Active, not recruiting

A Promotion and Implementation Project of HIV Pre-Exposure Prophylaxis Among High Risk Population

HIV Preexposure Prophylaxis

China
University Hospital, Grenoble
EFCR Department and Sleep Laboratory, Grenoble Alpes University Hospital; Pneumology... and other collaborators

Recruiting

Integrated Management of Chronic Respiratory Diseases (eMEUSE-SANTE)

Sleep Apnea, Obstructive | Chronic Obstructive Pulmonary Disease

France
University of Oklahoma
Brown University; University Hospital, Limoges; Technical University of Munich; Institute of Tropical Medicine, Belgium and other collaborators

Completed

EFECAB: Improving Pig Management to Prevent Epilepsy in Burkina Faso (EFECAB)

Cysticercosis

Burkina Faso
University of North Carolina, Chapel Hill
London School of Hygiene and Tropical Medicine; National Institute of Allergy... and other collaborators

Completed

Pay-it-forward RCT for Gonorrhea and Chlamydia Testing

Gonorrhea Male | Chlamydia;M

China

3

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