Clinical Trials Sponsored by Epicentro

Total 75 results

Epicentre

Completed

Reducing the Frequency of Follow up and Task Sharing in the Treatment of Uncomplicated Severe Acute Malnutrition

Severe Acute Malnutrition

Nigeria
Epicentre

Completed

Comparative Study of Two Tetanus Toxoid Vaccination Strategies: Cold Chain Versus Controlled Temperature Chain

Tetanus | Tetanus Vaccine

Chad
EpicentRx, Inc.

Terminated

RRx-001 Sequentially With a Platinum Doublet or a Platinum Doublet in Third-Line or Beyond in Patients With Small Cell Lung Cancer (REPLATINUM)

Carcinoma, Small Cell Lung

United States
EpicentRx, Inc.

Completed

RRx-001 + Radiation + Temozolomide In Newly Diagnosed Glioblastoma and Anaplastic Gliomas (G-FORCE-1)

Glioblastoma | Oligodendroglioma | Anaplastic Oligodendroglioma

United States
EpicentRx, Inc.

Completed

A Phase 2 Randomized, Open-Label Study of RRx-001 vs Regorafenib in Subjects With Metastatic Colorectal Cancer (ROCKET)

Colorectal Neoplasms

United States
EpicentRx, Inc.

No longer available

Expanded Access for PSV Personalized Oncolytic Viruses (PSV)

Cancer
EpicentRx, Inc.

Recruiting

A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors (BETA-PRIME)

Sarcoma | Neoplasms | Cancer | Chondrosarcoma | Solid Tumor, Adult | Sarcoma,Soft Tissue

United States
EpicentRx, Inc.

Completed

RRx-001 in Lung Cancer, Ovarian Cancer and Neuroendocrine Tumors Prior to Re-administration of Platinum Based Doublet Regimens (QUADRUPLE THREAT)

Carcinoma, Non-Small-Cell Lung | Ovarian Epithelial Cancer | Neuroendocrine Tumors | Small Cell Carcinoma

United States
EpicentRx, Inc.

Terminated

RRx-001 in Combination With Irinotecan in Metastatic or Advanced Cancer (PAYLOAD) (PAYLOAD)

Metastatic Cancer | Advanced Cancer | Malignant Solid Tumor

United States
EpicentRx, Inc.

Completed

Dose-Escalation Study of RRx-001 in Combination With Whole Brain Radiation in Subjects With Brain Metastases (BRAINSTORM)

Brain Metastases

United States
EpicentRx, Inc.

Recruiting

RRx-001 for Reducing Oral Mucositis in Patients Receiving Chemotherapy and Radiation for Head and Neck Cancer (KEVLARx)

Oral Mucositis

United States
EpicentRx, Inc.

Completed

A Phase I, Open-Label, Multiple Ascending Dose Study of RRx-001 and Nivolumab (PRIMETIME)

Lymphoma | Malignant Solid Tumor

United States
EpicentRx, Inc.

Terminated

RRx-001 in Second Line Treatment of Advanced Cholangiocarcinoma Prior to Readministration of First-Line Therapy (EPIC)

Cholangiocarcinoma

United States
EpicentRx, Inc.

Terminated

A Phase 1 Pilot Study of the Subcutaneous (s.c.) Route to Facilitate the Administration of RRx-001

Lymphomas | Malignant Solid Tumor

United States
EpicentRx, Inc.

Completed

Safety and Pharmacokinetic Study of RRx-001 in Cancer Subjects (DINAMIC)

Lymphomas | Malignant Solid Tumor

United States
Epicentre
Medecins Sans Frontieres, Netherlands

Completed

Ciprofloxacin for the Prevention of Meningococcal Meningitis

Meningitis, Meningococcal

Niger
Epicentre
Medecins Sans Frontieres, Netherlands

Withdrawn

Non-inferiority Trial of Two Snake Antivenoms in CAR (PAVES) (PAVES)

Snake Bites
Epicentre
Kenya Medical Research Institute

Completed

Immunogenicity and Safety of Fractional Doses of Yellow Fever Vaccines (YEFE) (YEFE)

Yellow Fever

Uganda, Kenya
Epicentre
Medecins Sans Frontieres, Netherlands

Completed

Evaluation of PCR Using DNA Extract From Slides and Filter Paper for the Detection of Tuberculosis and MDR-tuberculosis

Tuberculosis | Multi Drug Resistant Tuberculosis

Uganda
Epicentre
Medecins Sans Frontieres, Netherlands

Completed

Time to Become Negative of Three Rapid Diagnostic Tests for Malaria

Malaria, Falciparum

Uganda
Epicentre
Medecins Sans Frontieres, Netherlands

Completed

Malaria Survey in Mbarara District, Uganda 2010

Malaria

Uganda
Médecins Sans Frontières, Kenya
Epicentre

Not yet recruiting

Diagnostic Performance of a Novel Lipoarabinomannan. (FUJILAM)

HIV Primary Infection
EpicentRx, Inc.
Prothex Pharma, Inc.

Completed

Safety and Efficacy of RRx-001 in the Attenuation of Oral Mucositis in Patients Receiving Chemoradiation for the Treatment of Oral Cancers (PREVLAR)

Oral Mucositis

United States
Epicentre
Médecins Sans Frontières, France

Completed

Reduced Visit Frequency in the Treatment of Uncomplicated Severe Acute Malnutrition: Evaluation of Operational Feasibility and Safety

Severe Acute Malnutrition
Epicentre
Medecins Sans Frontieres, Netherlands

Withdrawn

Ciprofloxacin for the Prevention of Meningococcal Meningitis 2018

Meningitis, Meningococcal

Niger
Epicentre
Médecins Sans Frontières, France

Completed

Non-routine Use of Antibiotics (Amoxi-light)

Severe Acute Malnutrition
Epicentre
Medecins Sans Frontieres, Netherlands

Completed

Providing Additional Information on the Safety and Effectiveness of an Ebola Vaccine

Ebola Virus Disease

Uganda, Congo, The Democratic Republic of the
Epicentre
Medecins Sans Frontieres, Netherlands

Completed

SAM: Discharge Based on the Use of a MUAC-based Criterion to

Severe Acute Malnutrition
Epicentre
Medecins Sans Frontieres, Spain

Withdrawn

Efficacy of Artesunate-amodiaquine (AS-AQ) in Children With Malaria and Severe Acute Malnutrition, Madaoua, Niger 2010

Child | Malnutrition | Malaria, Falciparum

Niger
Epicentre
Medecins Sans Frontieres, Spain

Completed

Efficacy Study of Amodiaquine-Artesunate and Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria

Malaria, Falciparum

Congo, The Democratic Republic of the
Epicentre
Médecins Sans Frontières, France

Terminated

Eflornithine + Nifurtimox Late-Stage Human African Trypanosomiasis (HAT)in West Nile, Uganda (NECS)

Trypanosomiasis, African

Uganda
EpicentRx, Inc.
Texas Children's Cancer Center

Active, not recruiting

RRx-001 Given With Irinotecan and Temozolomide for Pediatric Patients With Recurrent or Progressive Malignant Solid and Central Nervous System Tumors (PIRATE)

Unspecified Childhood Solid Tumor, Protocol Specific | Central Nervous System Neoplasms | Brain Tumor, Recurrent | Brain Tumor, Pediatric

United States
Epicentre
Boston University; University of Florida

Completed

SMF to Improve Performance of Microscopy for the Diagnosis of PTB in a High HIV Prevalence Setting (PTB)

Tuberculosis

Uganda
Epicentre
Brown University; Medecins Sans Frontieres, Netherlands

Withdrawn

Regional Anaesthesia for Painful Injuries After Disasters (RAPID)

Fracture | Lower Limb Injuries
Epicentre
United Nations World Food Programme (WFP)

Completed

Different Strategies for Preventing Severe Acute Malnutrition in Niger

Malnutrition

Niger
Epicentre
Medecins Sans Frontieres, Netherlands; Ipas; Guttmacher Institute

Active, not recruiting

Abortion-related Morbidity and Mortality in Conflict-affected and Fragile Settings Study (AMoCo)

Abortion Complication

Central African Republic, Congo, The Democratic Republic of the, Nigeria
EpicentRx, Inc.
Sciclone Pharmaceuticals (China) Co., Ltd.

Recruiting

A Phase 3, Controlled, Open-label, Global Randomized Study of RRx-001 With a Platinum Doublet or a Platinum Doublet in Small Cell Lung Cancer (REPLATINUM)

Carcinoma, Small Cell Lung

United States
Institut Pasteur de Dakar
Epicentre; Ministry of Health, Senegal

Not yet recruiting

Clinical Diagnostic Performance Evaluation of a Measles Rapid Test in Senegal

Measles
Epicentre
Medecins Sans Frontieres, Netherlands; Ministry of Health, Niger

Completed

Sentinel Surveillance of Malnutrition, Niger

Malnutrition
Epicentre
Medecins Sans Frontieres, Netherlands; Minisitry of Public Health, Niger

Completed

Prevention of Nosocomial Infections (CleanKids) (CleanKids)

Severe Acute Malnutrition | Health Care Associated Infection | Multi Drug Resistant Organisms
Epicentre
Centre de Recherche Médicale et Sanitaire (Cermes), Niamey

Completed

Efficacy of Three ACTs for the Treatment of Falciparum Malaria in Maradi Niger

Malaria

Niger
Epicentre
Epicentre, Niger; National Nutrition Direction, Niger; Ministry of Public Health... and other collaborators

Completed

Acceptability of a Microbiome-directed Food in Young Children With Acute Malnutrition

Malnutrition, Child

Niger
MRC/UVRI and LSHTM Uganda Research Unit
Epicentre, Paris, France.; Janssen Pharmaceutica N.V., Belgium; Coalition for... and other collaborators

Completed

ZEBOVAC (Ebola Vaccine Trial, Ad26.ZEBOV/MVA-BN-Filo)

Ebola Virus Disease

Uganda
Epicentre
Mbarara University of Science and Technology; Medecins Sans Frontieres, Netherlands

Completed

An Open Cohort of Childhood Tuberculosis in Mbarara National Referral Hospital, Uganda

Tuberculosis
Epicentre
Mbarara University of Science and Technology; Medecins Sans Frontieres, Netherlands

Completed

Screening of Children in Household Contact With Adult TB Patients in Mbarara Hospital, Uganda (TBcontact)

Tuberculosis
Epicentre
Mbarara University of Science and Technology; Medecins Sans Frontieres, Netherlands

Completed

Evaluation Of The Performance Of The Nitrate Reductase And Resazurin Titre Assay For The Detection of Mycobacterium Tuberculosis Complex From Sputum In A High Tb and Hiv Setting (NRA RETA)

HIV Infections | HIV | Tuberculosis | AIDS

Uganda
Epicentre
Kenya Medical Research Institute; LSHTM; Universite Abdou Moumouni de Niamey UAM

Active, not recruiting

Mass Campaigns With Fractional Dose Pneumococcal Vaccines in Sub-Saharan Africa (fPCV) (fPCV)

Pneumococcal Carriage

Niger
Epicentre
Massachusetts General Hospital; Médecins Sans Frontières, Belgium; Ministry of...

Active, not recruiting

Immune Response to a Delayed Second Dose of Oral Cholera Vaccine

Cholera | Vibrio Cholerae Infection

Guinea
Epicentre
University of Cape Town; Malaria Research and Training Center, Bamako, Mali

Completed

Efficacy and Bio-availability of Artemether-Lumefantrine in Severely Malnourished Children (MAL-NUT)

Malaria | Severe Acute Malnutrition

Mali, Niger
Epicentre
University of Cape Town; Medecins Sans Frontieres, Netherlands; Shoklo Malaria...

Completed

Quinine vs. Artemether/Lumefantrine in Uncomplicated Malaria During Pregnancy

Malaria

Uganda

Clinical Trials Sponsored by Epicentro

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