Clinical Trials Sponsored by Exicure, Inc.

Total 35403 results

Exicure, Inc.

Terminated

Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid Tumors

Advanced or Metastatic Solid Tumors | Advanced or Metastatic Merkel Cell Carcinoma | Advanced or Metastatic Cutaneous Squamous Cell Carcinoma | Advanced or Metastatic Melanoma | Advanced or Metastatic Head and Neck Squamous Cell Carcinoma

United States
Exicure, Inc.

Completed

A Study of AST-008 in Healthy Subjects

Healthy Volunteer Study

United Kingdom
NextCure, Inc.

Completed

A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors

Melanoma | Breast Cancer | Lung Cancer | Cholangiocarcinoma | Endometrial Cancer | Head and Neck Squamous Cell Carcinoma | Urothelial Carcinoma | Advanced or Metastatic Solid Tumors | CRC

United States
NextCure, Inc.

Terminated

A Safety and Tolerability Study of NC410 in Subjects With Advanced or Metastatic Solid Tumors

Gastric Cancer | Ovarian Cancer | Colo-rectal Cancer | Advanced or Metastatic Solid Tumors

United States
NextCure, Inc.

Withdrawn

A Safety and Tolerability Study of NC318 in Combination With Chemotherapy for Subjects With Advanced or Metastatic NSCLC

Non-Small Cell Lung Cancer | Advanced or Metastatic Solid Tumors
NextCure, Inc.

Recruiting

A Safety, Tolerability and Efficacy Study of NC525 in Subjects With Advanced Myeloid Neoplasms

Relapsed or Refractory Acute Myeloid Leukemia | Relapsed or Refractory Chronic Myelomonocytic Leukemia | Relapsed or Refractory Myelodysplastic Syndrome

United States
NextCure, Inc.

Terminated

A Safety and Tolerability Study of NC762 in Subjects With Advanced or Metastatic Solid Tumors

Breast Cancer | Ovarian Cancer | Non-small Cell Lung Cancer | Advanced or Metastatic Solid Tumors

United States
Icure Pharmaceutical Inc.

Completed

A Multinational, Multi-center, Randomized, Double-blind, Active Comparator, Phase III Clinical Trial to Evaluate the Efficacy and Safety of Donepezil Transdermal Patch in Patients With Alzheimer's Disease

Alzheimer Disease

Korea, Republic of
Icure Pharmaceutical Inc.

Completed

A Phase I Clinical, Dose Escalation Study of the Safety, Tolerability and Pharmacokinetics of Donepezil Patch in Healthy Male Subjects

Alzheimer Disease

Korea, Republic of
Medicure

Terminated

Safety and Efficacy of Pyridoxal 5' -Phosphate in the Treatment of Tardive Dyskinesia

Tardive Dyskinesia

Canada, India
Medicure

Completed

A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG

Myocardial Ischemia | Reperfusion Injury | Coronary Artery Bypass Graft Surgery

Canada, United States
Icure Pharmaceutical Inc.

Completed

A Phase I Clinical Study, Randomized, Single-blind, Placebo-controlled, Multiple Doses, Dose Escalation Study of the Safety, Tolerability and Pharmacokinetics of Donepezil Patch in Healthy Male Subjects.

Alzheimer Disease

Korea, Republic of
Medicure

Recruiting

Oral Pyridoxal 5'-Phosphate for the Treatment of Patients With PNPO Deficiency (MEND-PNPO)

Pyridox(am)Ine 5'-Phosphate Oxidase Deficiency

United States, Australia
Medicure

Completed

Pharmacokinetic Evaluation of Tirofiban Using a Single High-Dose Bolus In Subjects With Varying Degrees of Renal Function

Renal Insufficiency

United States
Medicure

Completed

MATCHED (MC-1 and ACE Therapeutic Combination for Hypertensive Diabetics)

Hypertension | Metabolic Syndrome | Diabetes Mellitus Type 2

Canada
Medicure

Completed

MEND-CABG (MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery)

Myocardial Ischemia | Reperfusion Injury | Coronary Artery Bypass Graft Surgery | Myocardial Revascularization

Canada, United States
Eximore Ltd.

Active, not recruiting

Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B

Ocular Inflammation | Dry Eye | Keratoconjunctivitis Sicca

Mexico
Eyecure Therapeutics Inc.
Beijing Tongren Hospital

Unknown

Treatment of RP and LCA by Primary RPE Transplantation

Leber Congenital Amaurosis, Retinitis Pigmentosa

China
NextCure, Inc.
Merck Sharp & Dohme LLC

Recruiting

A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants With Advanced Unresectable or Metastatic Solid Tumors

Cervical Cancer | Gastric Cancer | Esophageal Cancer | Ovarian Cancer | Lung Cancer | Endometrial Cancer | Colo-rectal Cancer | Advanced or Metastatic Solid Tumors | Microsatellite Instability Low | Microsatellite Instability High | Microsatellite Stable | Head Neck Cancer

United States
AiCure
Montefiore Medical Center

Completed

Using Artificial Intelligence to Measure and Optimize Adherence in Patients on Anticoagulation Therapy.

Stroke

United States
Medicure
SCRI Development Innovations, LLC

Completed

Shortened Aggrastat® Versus Integrilin in Percutaneous Coronary Intervention (SAVI-PCI)

Myocardial Infarction | Unstable Angina | Acute Coronary Syndromes

United States
Medicure
SCRI Development Innovations, LLC

Withdrawn

Aggrastat Truncated Length Against Standard Therapies in Percutaneous Coronary Intervention (ATLAST-PCI)

Myocardial Infarction | Percutaneous Coronary Intervention | Unstable Angina | Acute Coronary Syndromes
Eucure (Beijing) Biopharma Co., Ltd

Recruiting

Study of YH004 (4-1BB Agonist Antibody) in Advanced Solid Tumors And Relapsed Or Refractory Non-Hodgkin Lymphoma

Advanced Solid Tumors | Relapsed Or Refractory Non-Hodgkin Lymphoma

China
Eucure (Beijing) Biopharma Co., Ltd

Recruiting

A Study to Assess YH003 in Combination With Pebolizumab and Albumin Paclitaxel Injection in Subjects With Unresectable/Metastatic Mucosal Melanoma

Mucosal Melanoma

China
Eucure (Beijing) Biopharma Co., Ltd

Completed

Study of YH004 (4-1BB Agonist Antibody) in Advanced or Metastatic Malignancy

Cancer

Australia
Eucure (Beijing) Biopharma Co., Ltd

Completed

A Study to Assess YH001 in Combination With Toripalimab Injection in Subjects With Advanced Solid Tumors

Advanced Solid Tumor

Australia
Eucure (Beijing) Biopharma Co., Ltd

Active, not recruiting

A Study to Assess YH003 in Combination With Toripalimab(Anti-PD-1 mAb) Injection in Patients With Cancers

Melanoma | Pancreatic Ductal Adenocarcinoma

United States, Australia
Eucure (Beijing) Biopharma Co., Ltd

Withdrawn

A Study to Evaluate YH001 in Combination With Toripalimab in Subjects With Advanced NSCLC and HCC (YH001)

HCC | NSCLC Stage IV | NSCLC Stage IIIB

China, Australia, Taiwan, Armenia, Austria
Eucure (Beijing) Biopharma Co., Ltd

Completed

A Study to Evaluate the Safety, Tolerability and How YH002 Enters, Moves Through and Exits the Body in Subjects With Advanced Solid Malignancies

Advanced Solid Malignancies

Australia
Eucure (Beijing) Biopharma Co., Ltd

Recruiting

A Study to Evaluate the Combination of YH003, YH001 and Pembrolizumab in Subjects With Advanced Solid Tumors

Solid Tumor

Australia
Eucure (Beijing) Biopharma Co., Ltd

Recruiting

A Study to Assess YH002 in Combination With YH001 in Subjects With Advanced Solid Tumors

Advanced Solid Tumor

China, Australia
Eucure (Beijing) Biopharma Co., Ltd

Completed

A Study to Evaluate YH003 in Subjects With Advanced Solid Tumors

Advanced Solid Tumors

China
Eucure (Beijing) Biopharma Co., Ltd

Completed

A Study to Evaluate YH001 in Subjects With Advanced Solid Tumors

Advanced Solid Tumors

China
Eucure (Beijing) Biopharma Co., Ltd

Completed

A Study to Evaluate YH003 in Combination With Toripalimab (Anti-PD-1 mAb) in Subjects With Advanced Solid Tumors

Advanced Solid Tumors

Australia
Yale University
National Cancer Institute (NCI); Merck Sharp & Dohme LLC; NextCure, Inc.

Recruiting

The Study of NC318 Alone or in Combination With Pembrolizumab in Patients With Advanced Non-small Cell Lung Cancer

Advanced Non-small Cell Lung Cancer

United States
Shanghai General Hospital, Shanghai Jiao Tong University...
Eyecure Therapeutics Inc.

Unknown

Clinical Research of Human Retinal Pigment Epithelial (HuRPE) Cell Injection on Atrophy of High Myopia Macular Area

Degenerative Myopia With Macular Hole
AiCure
Montefiore Medical Center; Orexo AB

Completed

Using Artificial Intelligence To Monitor Medication Adherence in Opioid Replacement Therapy

Addiction | Opioid Dependence | Opiate Addiction | Medication Non-adherence

United States
Albert Einstein College of Medicine
Merck Sharp & Dohme LLC; AiCure

Completed

Smartphone Based aDOT Treatment With Fixed-Dose Elbasvir and Grazoprevir in PWIDs

Hepatitis C | Medication Adherence

United States
IND Diagnostic Inc.

Unknown

Evaluation of the IND One Step Strep A Rapid Test vs. Culture

Strep Throat

United States
University of Alberta
Alberta Innovates Health Solutions; University Hospital Foundation; EPICORE Centre

Not yet recruiting

Autologous Whole Blood Management for Transfusion Reduction in Adult Cardiac Surgery Patients

Postoperative Hemorrhage | Postoperative Anemia | Postoperative Blood Loss

Canada
Public Health Foundation Enterprises, Inc.
National Institute of Mental Health (NIMH); Emory University; San Francisco Department... and other collaborators

Completed

DOT Diary Mobile App for Pre-Exposure Prophylaxis Adherence in Young Men

Risk Behavior | HIV Prevention | Adherence, Medication | Pre-Exposure Prophylaxis

United States
Public Health Foundation Enterprises, Inc.
National Institute of Mental Health (NIMH); Emory University; San Francisco Department... and other collaborators

Completed

DOT Diary Optimization Pilot: A Pilot Study to Optimize the DOT Diary App to Measure PrEP Adherence

Risk Behavior | HIV Prevention | Adherence, Medication | Pre-Exposure Prophylaxis

United States
University of California, San Francisco
National Institute of Mental Health (NIMH); RTI International; AiCure

Recruiting

Youth Ending the HIV Epidemic (YEHE)

HIV/AIDS | Mobile Health | Young Adults

United States
UNC Lineberger Comprehensive Cancer Center
Genentech, Inc.; Oncoceutics, Inc.

Recruiting

ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer

Metastasis | Endometrial Cancer

United States
NC Medial Research Inc

Recruiting

A Study of NCS-01 in Patients With Acute Ischemic Stroke

Ischemic Stroke

United States
IC-IT Sciences Inc.

Unknown

Comparison of the Natural Frequencies Technology Sleep Patches to Sham Patches During Sleep in the Home Environment

Sleep Disturbance

United States
Zhengzhou Gensciences Inc
Haimen Gensciences lnc

Completed

An Open Label Study to Determine the Safety and Efficacy of Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection in Adolescent and Adult Patients With Hemophilia A.

Hemophilia A

China
Zhengzhou Gensciences Inc
Jiangsu Gensciences lnc.

Completed

Phase III Expansion Trial for Determining the Safety and Efficacy of Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection in Adolescent and Adult Patients With Hemophilia A (RH-107-III02)

Hemophilia A

China
UNC Lineberger Comprehensive Cancer Center
Seagen Inc.

Completed

Induction Chemo w/ABVD Followed by Brentuximab Vedotin Consolidation in Newly Diagnosed, Non-Bulky Stage I/II Hodgkin Lymphoma

Hodgkin Lymphoma, Adult

United States
UNC Lineberger Comprehensive Cancer Center
Genentech, Inc.

Terminated

Efalizumab in Treating Patients With Graft-Versus-Host Disease of the Skin That Did Not Respond to Previous Steroids (NRR)

Graft Versus Host Disease

United States

Clinical Trials Sponsored by Exicure, Inc.

Sponsors and Collaborators

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