Clinical Trials Sponsored by GlaxoSmithKline

Total 4844 results

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GlaxoSmithKline

Not yet recruiting

A Phase 3 Study to Assess the Immune Response And Safety Of Rmenb+Omv Nz In Primed Healthy Participants (10 To 20 Years Old)

Meningitis
GlaxoSmithKline

Not yet recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of GSK3862995B Administered as a Single Dose to Healthy Participants of Chinese, Japanese, and European Ancestry

Pulmonary Disease, Chronic Obstructive
GlaxoSmithKline

Recruiting

Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2) (ENDURA-2)

Pulmonary Disease, Chronic Obstructive

United States
GlaxoSmithKline

Recruiting

Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA -1) (ENDURA -1)

Pulmonary Disease, Chronic Obstructive

United States
GlaxoSmithKline

Not yet recruiting

A Study to Evaluate the Safety of Dostarlimab in Adult Participants in India With Recurrent or Advanced Endometrial Cancer (EC)

Neoplasms, Endometrial
GlaxoSmithKline

Recruiting

A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age

Chickenpox

United States
GlaxoSmithKline

Not yet recruiting

A Trial to Evaluate the Safety of Niraparib Tablets in Adult Female Participants With Advanced or Relapsed Epithelial Ovarian Cancer

Ovarian Neoplasms
GlaxoSmithKline

Recruiting

A First-time in Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK4528287 in Healthy Participants

Colitis, Ulcerative

United Kingdom
GlaxoSmithKline

Recruiting

Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN (OBSErve-LN)

Lupus Nephritis

United States
GlaxoSmithKline

Recruiting

A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

Melanoma | Hodgkin Lymphoma | Hepatocellular Carcinoma (HCC) | Osteosarcoma | Ependymoma | Rhabdomyosarcoma | Hepatoblastoma | Fibrolamellar Carcinoma | Hepatic Tumors | Glioblastoma Multiforme (GBM) | Diffuse Intrinsic Pontine Glioma (DIPG) | High and Low Grade Glioma

United States, Spain, Italy, Czechia, Denmark
GlaxoSmithKline

Recruiting

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis (ODYSSEY)

Primary Myelofibrosis | Myelofibrosis; Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis

United States
GlaxoSmithKline

Not yet recruiting

Evaluation of Programmed Death Ligand 1 (PDL1) Response to Treatment in Extracellular Vesicles (EVs), Patient-derived Organoid (PDOs)s and Immune-marker Positron Emission Tomography (PET) Scanning in Non-small Cell Lung Cancer (NSCLC)

Lung Cancer, Non-Small Cell

United Kingdom
GlaxoSmithKline

Recruiting

A Study to Find and Confirm the Dose and Assess Safety, Reactogenicity and Immune Response of a Vaccine Against Pandemic H5N1 Influenza Virus in Healthy Younger and Older Adults

Influenza, Human

United States
GlaxoSmithKline

Recruiting

A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)

Neoplasms

United States, Spain, Korea, Republic of
GlaxoSmithKline

Recruiting

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma (JADE)

Neoplasms, Head and Neck

United States, Japan, Norway, Spain, Taiwan, Australia, United Kingdom, Belgium, Greece, Romania, Sweden, Turkey, Canada, Korea, Republic of, China, Argentina, India, Poland, Israel, Portugal, Italy, Germany, Czechia, France, Hungary, Mexico and more
GlaxoSmithKline

Recruiting

A Study on the Immune Response and Safety of a Vaccine Against N. Meningitidis Serogroup B Infection in Healthy Infants From 2 Months of Age

Meningitis, Meningococcal

Korea, Republic of
GlaxoSmithKline

Recruiting

Dose Exploration Study of GSK4532990 in. Participants With NASH or Suspected NASH (SKYLINE)

Non-alcoholic Fatty Liver Disease

United States
GlaxoSmithKline

Recruiting

Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA) (OCEAN)

Eosinophilic Granulomatosis With Polyangiitis

Canada, France, Spain, Belgium, Korea, Republic of, United States, Israel, Japan, Portugal, Italy, Poland, Netherlands, United Kingdom, China, Austria, Argentina, Brazil, Germany, Hungary, Sweden, Czechia
GlaxoSmithKline

Recruiting

Study to Assess Demographic, Pharmacologic, Biomarker, Clinical Features and Quality of Life (QoL) of Participants With Lupus Nephritis

Systemic Lupus Erythematosus

United Arab Emirates
GlaxoSmithKline

Active, not recruiting

Study of Belantamab Mafodotin Plus Standard of Care (SoC) in Newly Diagnosed Multiple Myeloma (DREAMM 9)

Multiple Myeloma

Spain, Italy, Germany, United States, Australia, Canada, Korea, Republic of, United Kingdom, France, Poland
GlaxoSmithKline

Active, not recruiting

Long-Term Study (AtDvance) to Evaluate GSK1070806 in Atopic Dermatitis. (AtDvance)

Dermatitis, Atopic

United States, Japan, China, Argentina, Greece, Korea, Republic of, Mexico, Panama, Spain, Bulgaria, Germany, Italy, Poland, Canada, Czechia, France
GlaxoSmithKline

Active, not recruiting

All Japanese Population: Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma (DREAMM 8)

Multiple Myeloma

Japan
GlaxoSmithKline

Active, not recruiting

Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (DREAMM-3)

Multiple Myeloma

United States, Australia, Spain, Bulgaria, Italy, Poland, Belgium, France, Hungary, United Kingdom, Greece, Russian Federation, Brazil, China, Korea, Republic of, Germany, Japan, Canada, Netherlands
GlaxoSmithKline

Withdrawn

A Study to Investigate the Safety and Pharmacological Effect of a Single Intravenous Infusion of Belantamab in Male and Female Participants Aged 18 to 75 With Autoimmune Disease

Autoimmune Diseases

Spain, France, United States
GlaxoSmithKline

Active, not recruiting

Placebo-controlled Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (ZEAL-1L)

Lung Cancer, Non-Small Cell

Spain, Italy, Belgium, France, United States, Hungary, Sweden, Turkey, Ireland, Greece, Russian Federation, Netherlands, Bulgaria, Germany, Romania, Mexico, Korea, Republic of, United Kingdom, Poland, Australia, Colombia, Peru, Swit... and more
GlaxoSmithKline

Completed

A Safety and Immune Response Study to Evaluate Varying Doses of an mRNA Vaccine Against Coronavirus Disease 2019 (COVID-19) in Healthy Adults

COVID-19

United States
GlaxoSmithKline

Completed

A Study on the Safety, Tolerability and Immune Response of Meningococcal Combined ABCWY Vaccine in Healthy Infants

Infections, Meningococcal

Finland, Poland, Spain, United Kingdom, Dominican Republic, Honduras, South Africa, Germany
GlaxoSmithKline

Completed

Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK3858279 in Healthy Caucasian, Chinese and Japanese Participants

Pain

Australia
GlaxoSmithKline

Active, not recruiting

A Study on the Immune Response and Safety of an RSV Vaccine When Given to Adults 18 Years of Age and Above Who Received Lung or Kidney Transplant and Are at an Increased Risk of Respiratory Syncytial Virus Lower Respiratory Tract Disease and Compared to Healthy Adults 50 Years of Age and Above (RSV OA=ADJ-023)

Respiratory Syncytial Virus Infections

Spain, Japan, United States, Australia, Canada, Korea, Republic of, Germany, Italy
GlaxoSmithKline

Completed

Immunogenicity, Reactogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Rotarix Porcine Circovirus (PCV)-Free Liquid Compared to Rotarix Liquid Given in 2-doses in Healthy Chinese Infants Starting at Age 6-16 Weeks

Gastroenteritis

China
GlaxoSmithKline

Active, not recruiting

Japan Expansion Cohort: Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma (DREAMM 7)

Multiple Myeloma

Japan
GlaxoSmithKline

Active, not recruiting

Study of Subcutaneous (SC) Belimumab in Pediatric Participants With Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus

Netherlands, United States, Germany, Spain, Japan, Argentina, Mexico
GlaxoSmithKline

Terminated

A Study on the Safety and Immune Response to an Unadjuvanted RSV Maternal Vaccine, in High Risk Pregnant Women Aged 15 to 49 Years and Infants Born to the Vaccinated Mothers

Respiratory Syncytial Virus Infections

United States, Spain, Canada, Finland, India, Panama, Italy, Brazil, South Africa
GlaxoSmithKline

Terminated

A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain (MARS-17)

Pain | Osteoarthritis, Knee

Germany, Japan, Korea, Republic of, United States, Canada, South Africa, Spain, China, France, Australia, United Kingdom, Mexico, Argentina
GlaxoSmithKline

Completed

A Study on the Immune Response and Safety of Vaccine Against Respiratory Syncytial Virus (RSV) Given to Adults 18 to 49 Years of Age at Increased Risk for Respiratory Syncytial Virus Disease, Compared to Older Adults 60 Years of Age and Above

Respiratory Syncytial Virus Infections

United States, Germany, South Africa, Australia, Canada, Japan
GlaxoSmithKline

Active, not recruiting

Study in Pediatrics With HypEREosinophilic Syndrome (SPHERE) (SPHERE)

Hypereosinophilic Syndrome

United States, Netherlands, Argentina, Turkey, Israel, Brazil
GlaxoSmithKline

Completed

A Study on Safety and Immune Response of Investigational RSV OA Vaccine in Combination With Herpes Zoster Vaccine in Healthy Adults (RSV-OA=ADJ-020)

Respiratory Syncytial Virus Infections | Respiratory Syncytial Viruses

United States, Canada
GlaxoSmithKline

Withdrawn

A Pharmacokinetics and Safety Study of Augmentin ES-600 in Children With CAP and ABRS

Infections, Bacterial

Brazil
GlaxoSmithKline

Completed

A Study to Evaluate the Safety and Efficacy of Fluticasone Furoate (FF)/Umeclidinium(UMEC)/Vilanterol (VI) in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

India
GlaxoSmithKline

Active, not recruiting

Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma (DREAMM 8)

Multiple Myeloma

United States, Australia, Japan, Spain, Italy, Poland, France, Israel, Turkey, Korea, Republic of, Greece, Russian Federation, China, United Kingdom, New Zealand, Brazil, Czechia, Germany
GlaxoSmithKline

Completed

A Study to Evaluate the Efficacy and Safety of Belimumab Administered in Combination With Rituximab to Adult Subjects With Systemic Lupus Erythematosus (SLE) - BLISS-BELIEVE

Systemic Lupus Erythematosus

United States, Russian Federation, France, Spain, Korea, Republic of, Germany, Brazil, Netherlands, Canada, Mexico, Argentina
GlaxoSmithKline

Completed

A Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 50-59 Years of Age, Including Adults at Increased Risk of Respiratory Syncytial Virus Lower Respiratory Tract Disease, Compared to Older Adults 60 Years of Age and Above

Respiratory Syncytial Virus Infections

Argentina, United States, Germany, Spain, Poland, Canada, Japan, Netherlands
GlaxoSmithKline

Completed

A Study of Belantamab Mafodotin to Investigate Safety, Tolerability, Pharmacokinetics, Immunogenicity and Clinical Activity in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

Multiple Myeloma

China
GlaxoSmithKline

Completed

A Mechanistic Study of GSK3228836 With Fine Needle Aspiration (FNA) in Participants With Chronic Hepatitis B (B-Fine)

Hepatitis B

United States, Netherlands, United Kingdom, Canada
GlaxoSmithKline

Terminated

A Phase III, Double-blind Study to Assess Safety and Efficacy of an RSV Maternal Unadjuvanted Vaccine, in Pregnant Women and Infants Born to Vaccinated Mothers (GRACE)

Respiratory Syncytial Virus Infections

United States, Australia, Finland, Taiwan, Spain, Argentina, Philippines, Belgium, Panama, Thailand, France, Canada, Korea, Republic of, India, New Zealand, Mexico, Italy, United Kingdom, Bangladesh, Colombia, Dominican Republic, ... and more
GlaxoSmithKline

Active, not recruiting

A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study

Breast Neoplasms | Ovarian Neoplasms

United States, Austria, Spain, Denmark, Canada, Israel, France, Italy
GlaxoSmithKline

Completed

A Follow-up Study to Describe the Safety of Study Participants Who Received RSVPreF3 Maternal Vaccination (Any Dose) or Controls From Previous RSV MAT Studies During Any Pregnancy Conceived Post Vaccination/Control

Respiratory Syncytial Virus Infections

United States, Finland, Germany, Taiwan, Spain, Argentina, Philippines, Canada, Belgium, Panama, Australia, Thailand, France, Korea, Republic of, India, Bangladesh, Colombia, Dominican Republic, Honduras, South Africa, New Zealand, Ita... and more
GlaxoSmithKline

Completed

A Study to Evaluate the Safety, Tolerability and Blood Levels of GSK3915393 Administered to Healthy Participants of Chinese, Japanese and European Ancestry and to Assess Effects of GSK3915393 on Nintedanib

Idiopathic Pulmonary Fibrosis

United States
GlaxoSmithKline

Completed

Oral LGD-4665 Versus Placebo in Adults With Immune Thrombocytopenic Purpura (ITP) for 6 Weeks Plus Open Treatment Continuation

Immune Thrombocytopenic Purpura

United States
GlaxoSmithKline

Completed

Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN)

Pruritus

United States, Spain, Italy, Israel, Belgium, Canada, Czechia, United Kingdom, China, Japan, Poland, Russian Federation, France, Greece, Argentina, Bulgaria, Brazil, Germany, Mexico

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