Clinical Trials Sponsored by Norlien Foundation

Total 15772 results

Norgine

Completed

Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus MOVIPREP® Using 2-Day Split-Dosing and 1-Day Morning Split-Dosing Regimen in Adults. (MORA)

Colorectal Cancer | Colorectal Carcinoma | Colon Cleansing

United Kingdom, Spain, Belgium, France, Germany, Italy, Poland
Norgine

Completed

A Multi-centre, Phase II, Double-blind, Randomised, Placebo-controlled, Parallel Group, Dose-ranging Study in Patients With Faecal Incontinence; to Evaluate the Efficacy, Safety and Tolerability of Locally Applied NRL001 Over an 8 Week Treatment Period

Faecal Incontinence

Spain, Poland, United Kingdom, Czech Republic, France, Germany, Hungary, Italy, Sweden
Norgine

Completed

Evaluation of the Pharmacokinetics of Ulimorelin in Subjects With Hepatic Impairment and Healthy Subjects

Digestive System Disorders

Slovakia
Norgine

Completed

Study to Examine the Effect of Ulimorelin on the Pharmacokinetics of Midazolam in Healthy Volunteers

Digestive System Disorders

United Kingdom
Norgine

Completed

Safety, Tolerability, Pharmacodynamic and Pharmacokinetics of 7.5, 10, 12.5 or 15 mg NRL001 in a 2 g Suppository for 14 Days

Fecal Incontinence

United Kingdom
Norgine

Completed

Effect of Chronic Viral Hepatitis on the Pharmacokinetics of NRL972.

Hepatitis, Viral, Human

Bulgaria, Romania
Norgine

Completed

Multi-national Cirrhosis Study to Characterise the Association Between the Pharmacokinetics of NRL972 and Disease Severity.

Hepatic Cirrhosis

Germany
Norgine

Completed

Effects of Oral PEG 3350 on Electrolyte Balance

Chronic Constipation

Romania
Norgine

Completed

MOVIPREP® Versus NaP Pivotal Phase III Study

Colonoscopy

France
Norgine

Completed

Real World Outcomes Study of Hepatic Encephalopathy Patients' Experience on Rifaximin (PROSPER) (PROSPER)

Hepatic Encephalopathy

United Kingdom
Norgine

Completed

Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus a Sodium Picosulfate and Magnesium Salt Solution Using Day Before-Only Dosing Regimen in Adults.

Colorectal Cancer | Colorectal Carcinoma | Colon Cleansing

Netherlands, United Kingdom, Spain, Germany, Italy, Poland
Norgine

Completed

Performance of NER1008 Enema Compared With Fleet® Enema in Bowel Cleansing

Colorectal Cancer

United Kingdom
Norgine

Completed

Pharmacokinetics of NRL972 in Patients With Nonalcoholic Steatohepatitis (NASH) and Non-Alcoholic Fatty Liver Disease (NAFLD)

Nonalcoholic Steatohepatitis | Non-Alcoholic Fatty Liver Disease

United States
Norgine

Completed

Pharmacodynamic and Clinical Evaluation of Dose and Taste-optimised Low Volume PEG-based Bowel Cleansing Solutions Using the Split-dosing Intake Regimen in Healthy Subjects and in Subjects Undergoing Screening Colonoscopy

Colon Cancer

Germany
Norgine

Completed

A Clinical Investigation to Demonstrate the Performance of a New Enema (TF037) in Distal Bowel Cleansing Compared With Fleet Enema

Colonoscopy

United Kingdom
Norgine

Completed

Effect of 7 Days of Dosing With a 10 mg Rectal Suppository of NRL001in Patients With Faecal Incontinence

Fecal Incontinence

United Kingdom
Norgine

Completed

A Three-Period Study to Investigate the Relative Bioavailability and Pharmacodynamic Profiles of a Zegerid 20mg Capsule, Zegerid 20mg Powder for Oral Suspension and Losec 20mg Capsule in Healthy Adult Volunteers Under Fasting Conditions

Acid Reflux | Gastro Oesophageal Reflux Disease

United Kingdom
Norgine

Completed

Study to Assess the Tolerability, Safety and Efficacy of an Adapted Gut Cleansing Solution in Routine Colon Cleansing Prior to Colonoscopies

Colon Cancer

Germany
Norgine

Completed

Study to Investigate Safety and Response to 1 or 2 g Rectal Suppositories Containing 5 or 10 mg NRL001.

Fecal Incontinence

United Kingdom
Norgine

Completed

Study of Escalating Doses of NRL001 Given in Slow-release Rectal Suppositories of Different Weights

Incontinence

United Kingdom
Norgine

Completed

Scintigraphic Assessment Following Klean-Prep® or Moviprep®

Healthy | Gastric Emptying

United Kingdom
Norgine

Completed

Evaluation of the PK of NRL972 Following Pre- and co-Administration of Ursodeoxycholic Acid and Cloxacillin

Hepatic Cirrhosis

Bulgaria
Norgine

Completed

Comparison of 2L NRL994 With NaP Preparation in Colon Cleansing Prior to Colonoscopies for Colon Tumor Screening

Colonoscopy

Germany
Norgine

Completed

Movicol in Childhood Constipation (ProMotion Study)

Chronic Constipation

United Kingdom
Norgine

Completed

Study to Examine the Efficacy and Safety of Movicol in the Treatment of Chronic Constipation in Children

Chronic Constipation

United Kingdom
Norgine

Completed

Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus Trisulfate Solution Using 2-Day Split-Dosing Regimen in Adults (NOCT)

Colon Cancer | Colorectal Carcinoma | Colon Cleansing

United States
Norgine

Completed

Sensitivity of Alternative NRL972 Detection Methods in Healthy Subjects

Cirrhosis

Hungary
Norgine

Completed

A Multi-centre Study Comparing the Polyp Detection Rate of Two Different Types of Bowel Preparation: a 2-litre Solution (MOVIPREP®) Versus a Hyperosmotic and Stimulant Combined Low Volume Bowel Preparation (Sodium Picosulfate and Magnesium Citrate)

Colorectal Cancer

Germany
Norgine

Completed

Phase III Study Comparing Zegerid® With Losec® for the Relief of Heartburn Associated With Gastroesophageal Reflux Disease

Gastroesophageal Reflux

Poland
Norgine

Completed

A Study to Evaluate the Safety of TZP-101 (IV Ulimorelin) Administered Post-Operatively in Patients Who Have Undergone Partial Bowel Resection

Postoperative Ileus
Norgine

Completed

Comparator Study of PEG 3350 Versus Prucalopride in Females With Chronic Constipation

Constipation

Romania
Norgine

Completed

A Study in Healthy Male Subjects Designed to Assess the Mass Balance Recovery and Pharmacokinetics of 14C TZP-101

Postoperative Ileus

United Kingdom
Norgine

Completed

Evaluation of the Main Determinants of Patient Acceptability of the Bowel Cleansing Procedure, and of Success of Bowel Cleansing and Caecal Intubation

Routine Colonoscopy

Italy
Norgine

Completed

Safety and Tolerability of a Single Intra-anal Dose of NRL001 in Healthy Volunteers

Fecal Incontinence

Bulgaria
Norgine

Completed

Safety, Tolerability, Pharmacodynamic and Pharmacokinetics of a Single Rectal Application of 10 mg NRL001 in Elderly Subjects

Fecal Incontinence

United Kingdom
Norgine

Completed

Reproducibility of Child-Turcotte-Pugh (CTP) Rating and NRL972 Pharmacokinetics in Patients With Cirrhosis

Hepatic Cirrhosis

Romania
Norgine

Completed

Constipation Associated With Irritable Bowel Syndrome (IBS-C)

Constipation

United Kingdom, Italy, Czech Republic, France, Germany, Poland, Sweden
Norgine

Completed

Effect of Single Doses of 10 mg NRL001 Applied as a Suppository to the Anal Canal or Rectum

Fecal Incontinence

United Kingdom
Norgine

Completed

Evaluation of the Pharmacokinetics of NRL972 Following Pre-Administration of Rifampicin and Cyclosporine

Pharmacokinetics

Bulgaria
Norgine

Completed

Clearance of NRL972 in Patients With Cirrhosis, Nonalcoholic Steatohepatitis (NASH) and in Healthy Volunteers

Nonalcoholic Steatohepatitis | Hepatic Cirrhosis

Bulgaria
Norgine

Completed

Clearance of NRL972 in Patients With Cirrhosis and in Healthy Volunteers

Hepatic Cirrhosis

Bulgaria
Norgine

Completed

Clinical Evaluation of a New Reduced Volume Bowel Preparation

Colonoscopy

France
Norgine

Completed

A Phase III Trial to Assess the Efficacy, Acceptability and Safety of Moviprep® Versus a 4L PEG+E Standard Solution

Colonoscopy

Germany
Norgine

Completed

An Open Single Centre Study To Assess Treatment of Chronic Constipation in Children

Chronic Constipation

Australia
Norgine

Completed

MOVIPREP® Versus PICOLAX® Pilot Study

Colonoscopy

United Kingdom
Norgine

Completed

Movicol in Childhood Constipation (ProMotion Study)

Feces, Impacted

United Kingdom
University of Alberta
Women and Children's Health Research Institute, Canada; Norlien Foundation

Completed

Pilot Study of a Computer-Based Intervention for Alcohol Misuse in the Emergency Department

Alcohol Consumption

Canada
University of Calgary
Women and Children's Health Research Institute, Canada; Norlien Foundation

Unknown

Integrated Maternal Psychosocial Assessment to Care Trial (IMPACT) Full Trial

Depression | Anxiety

Canada
Corline Biomedical AB

Unknown

Heparinized Islets in Clinical Islet Transplantation

Type 1 Diabetes Mellitus

Sweden
Takeda
Norgine BV

Completed

Evaluation of the Efficacy, Safety and Tolerance of Experimental Morning-only MOVIPREP® Bowel Preparation in Comparison With Split-dose With Nocturnal Pause MOVIPREP® Bowel Preparation

Bowel Preparation Prior to Endoscopic, Radiological and Other Examinations as Well as to Surgical Procedures Which Require Empty Bowel.

Russian Federation, Kazakhstan

3

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