Clinical Trials Sponsored by North American Brain Tumor Consortium

Total 70 results

Pediatric Brain Tumor Consortium

Active, not recruiting

Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma (PBTC-047)

Glioma

United States
Hoffmann-La Roche
Pediatric Brain Tumor Consortium

Completed

A Study of Capecitabine (Xeloda®) and Concomitant Radiation Therapy in Children With Newly Diagnosed Brainstem Gliomas

Brainstem Glioma

United States
University of Florida
American Brain Tumor Association

Withdrawn

Peptide Vaccine for Glioblastoma Against Cytomegalovirus Antigens (PERFORMANCE)

Glioblastoma
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI); North American Brain Tumor Consortium

Completed

Risk Factors for Developing a Blood Clot in Patients Who Are Undergoing Cancer Treatment for Newly Diagnosed Gliomas

Brain and Central Nervous System Tumors | Thromboembolism

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors

Malignant Glioma | Recurrent Childhood Ependymoma | Recurrent Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Atypical Teratoid/Rhabdoid Tumor | Refractory Diffuse Intrinsic Pontine Glioma | CNS Embryonal Tumor, Not Otherwise Specified

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors

Glioblastoma | Gliosarcoma | Medulloblastoma | Anaplastic Astrocytoma | Choroid Plexus Neoplasms | Anaplastic Oligodendroglioma | Giant Cell Glioblastoma | Neuroectodermal Tumor, Primitive | Brainstem Tumors | Teratoid Tumor, Atypical

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Capecitabine and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Nonmetastatic Brain Stem Glioma or High-Grade Glioma

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors

Lymphoma | Unspecified Childhood Solid Tumor, Protocol Specific | Leukemia | Brain and Central Nervous System Tumors | Carcinoma of Unknown Primary

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

SCH 66336 in Treating Children With Recurrent or Progressive Brain Tumors

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Busulfan in Treating Children and Adolescents With Refractory CNS Cancer

Sarcoma | Lymphoma | Leukemia | Brain and Central Nervous System Tumors | Metastatic Cancer | Retinoblastoma | Childhood Germ Cell Tumor

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI); North American Brain Tumor Consortium

Completed

Tumor DNA and MRI/CT Scan Findings in Patients With Grade III or Grade IV Malignant Glioma

High Grade Glioma
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI); North American Brain Tumor Consortium

Completed

Study of Blood Samples and Risk of Infection in Patients With Newly Diagnosed Malignant Supratentorial Astrocytoma

Brain and Central Nervous System Tumors | Infection
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Peginterferon Alfa-2b in Younger Patients With Craniopharyngioma That is Recurrent or Cannot Be Removed By Surgery

Childhood Craniopharyngioma

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors

Glioblastoma | Gliosarcoma | Ependymoma | Anaplastic Astrocytoma | Oligodendroglioma | Anaplastic Ependymoma | Giant Cell Glioblastoma | Astrocytoma, Grade II | Brainstem Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors

Brain and Central Nervous System Tumors | Neuroblastoma

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Genetic Study of Brain Tumors in Young Children

Central Nervous System Tumor, Pediatric

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

TP-38 Toxin in Treating Young Patients With Recurrent or Progressive Supratentorial High-Grade Glioma

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Carmustine Implants and O(6)-Benzylguanine in Treating Children With Recurrent Malignant Glioma

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors

Recurrent Childhood Medulloblastoma | Childhood Choroid Plexus Tumor | Childhood Ependymoblastoma | Childhood Grade III Meningioma | Childhood High-grade Cerebellar Astrocytoma | Childhood High-grade Cerebral Astrocytoma | Childhood Medulloepithelioma | Recurrent Childhood Anaplastic Astrocytoma | Recurrent... and other conditions

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Withdrawn

Biomarkers in Blood Samples From Young Patients With Newly Diagnosed Brain Tumors Undergoing Standard Radiation Therapy and Chemotherapy

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade Glioma That Can Be Removed By Surgery

Recurrent Childhood Anaplastic Astrocytoma | Recurrent Childhood Anaplastic Oligoastrocytoma | Recurrent Childhood Anaplastic Oligodendroglioma | Recurrent Childhood Giant Cell Glioblastoma | Recurrent Childhood Glioblastoma | Recurrent Childhood Gliomatosis Cerebri | Recurrent Childhood Gliosarcoma

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Withdrawn

Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Nervous System Tumors

Brain and Central Nervous System Tumors

United States
Baylor College of Medicine
Pediatric Brain Tumor Consortium

Completed

Karenitecin in Pediatric Patients With Refractory or Recurrent Solid Tumors N10010) (KTN10010)

Solid Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children

Central Nervous System Embryonal Neoplasm

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

VNP40101M in Treating Young Patients With Recurrent, Progressive, or Refractory Primary Brain Tumors

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Withdrawn

Immunotoxin Therapy in Treating Children With Recurrent Malignant Gliomas

Brain and Central Nervous System Tumors
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

SU5416 in Treating Children With Recurrent or Progressive Brain Tumors

Brain and Central Nervous System Tumors

United States
Memorial Sloan Kettering Cancer Center
Pediatric Brain Tumor Consortium

Terminated

A Study of the Effect of Blood Stem Cell Transplant After Chemotherapy Alone in Patients With Fanconi Anemia

Fanconi Anemia | Myelodysplastic Syndrome (MDS) | Acute Myelogenous Leukemia (AML)

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); American Lebanese Syrian Associated Charities...

Recruiting

A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

Low Grade Glioma (LGG) of Brain With BRAF Aberration | High Grade Glioma (HGG) of the Brain With BRAF Aberration | Low Grade Glioma of Brain With Neurofibromatosis Type 1

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); American Lebanese Syrian Associated Charities...

Suspended

Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

Medulloblastoma, Childhood

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); American Lebanese Syrian Associated Charities...

Active, not recruiting

INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

Glioblastoma Multiforme | Anaplastic Astrocytoma | Anaplastic Oligodendroglioma | DIPG | High-grade Astrocytoma NOS | CNS Primary Tumor, NOS (Malignant Glioma)

United States
Day One Biopharmaceuticals, Inc.
SIOPe Brain Tumor Group LOGGIC Consortium

Recruiting

DAY101 vs. Standard of Care Chemotherapy in Pediatric Patients With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

Low-grade Glioma

United States, Korea, Republic of, France, Germany, Spain, United Kingdom, Belgium, Denmark, Canada, Italy, Finland, Australia, Ireland, Switzerland, Netherlands, Czechia, Greece, New Zealand, Slovenia, Sweden, Hungary, Singapore, A... and more
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); PTC Therapeutics

Completed

PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors

Brain and Central Nervous System Tumors

United States
North American Consortium for Histiocytosis
Histiocyte Society

Recruiting

LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis

Langerhans Cell Histiocytosis

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); NovoCure Ltd.; American Lebanese Syrian Associated...

Recruiting

Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG

Malignant Glioma | Ependymoma | Diffuse Intrinsic Pontine Glioma

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); Treovir, LLC; American Lebanese Syrian Associated...

Not yet recruiting

HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma

Neoplasms | Malignant Glioma of Brain | Glioblastoma Multiforme | High Grade Glioma | Giant Cell Glioblastoma | High-grade Glioma | Anaplastic Astrocytoma of Brain | Anaplastic Glioma

United States
Children's Oncology Group
National Cancer Institute (NCI); Pediatric Brain Tumor Consortium

Active, not recruiting

Pilot Study to Enable Electronic Laboratory Data Transfer From Participating Institutions to MediData/RAVE

Accurate and Complete Data Acquisition for Clinical Trials

United States
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

Pharmacologic Study of Methotrexate in Patients Undergoing Stereotactic Biopsy for Recurrent High-Grade Glioma

Brain and Central Nervous System Tumors
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

Immunotoxin Therapy in Treating Patients With Malignant Glioma

Brain and Central Nervous System Tumors

United States
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

Irinotecan in Treating Patients With Recurrent Malignant Glioma

Brain and Central Nervous System Tumors

United States
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

Radiation Therapy in Treating Patients With Progressive or Recurrent Malignant Brain Tumors

Brain and Central Nervous System Tumors

United States
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

Chemotherapy in Treating Patients With Progressive or Recurrent Brain Tumors

Brain and Central Nervous System Tumors

United States
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

Carmustine Implants in Treating Patients With Brain Metastases

Unspecified Adult Solid Tumor, Protocol Specific | Metastatic Cancer

United States
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

EMD 121974 in Treating Patients With Progressive or Recurrent Glioma

Brain and Central Nervous System Tumors

United States
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

Methotrexate and Thiotepa in Treating Patients With Newly Diagnosed Primary CNS Lymphoma

Lymphoma

United States
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

COL-3 in Treating Patients With Progressive or Recurrent Brain Tumors

Brain and Central Nervous System Tumors

United States
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

Procarbazine in Treating Patients With Recurrent Brain Tumor

Brain and Central Nervous System Tumors

United States
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

Efaproxiral Plus Carmustine in Treating Patients With Progressive or Recurrent Malignant Glioma

Brain and Central Nervous System Tumors

United States

Clinical Trials Sponsored by North American Brain Tumor Consortium

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