Clinical Trials Sponsored by Portola Pharmaceuticals, LLC (a wholly owned subsidiary of Alexion Pharmaceuticals)

Total 86 results

Alexion Pharmaceuticals, Inc.
Portola Pharmaceuticals, LLC (a wholly owned subsidiary of Alexion Pharmaceuticals)

Terminated

Study Evaluating Betrixaban in Pediatric Participants

VTE Prophylaxis

United States, United Kingdom, Russian Federation, Ukraine
Alexion Pharmaceuticals
Population Health Research Institute; Portola Pharmaceuticals, LLC (a wholly...

Completed

A Study in Participants With Acute Major Bleeding to Evaluate the Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Direct and Indirect Oral Anticoagulants (Extension Study)

Bleeding

United States, Belgium, Canada, France, Germany, Japan, Netherlands, Spain, United Kingdom
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Study of the Drug Interactions Between Danicopan and Cyclosporine, Tacrolimus, Antacids, and Omeprazole in Healthy Adults

Healthy

United States
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

Study of a Single Dose of Danicopan in Healthy Participants

Healthy

New Zealand
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

Study of Radiolabeled Danicopan in Healthy Male Participants

Healthy

New Zealand
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Terminated

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ACH-0137171 in Participants With Chronic Hepatitis C Infection

HCV Infection

United States, Germany, Netherlands
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

Study of Danicopan in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United Kingdom, New Zealand, Korea, Republic of, Italy
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Proof-of-Mechanism Study to Determine the Effect of Danicopan on C3 Levels in Participants With C3G or IC-MPGN

C3 Glomerulopathy | C3 Glomerulonephritis | Dense Deposit Disease | Immune Complex Mediated Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis Types I, II, and III

Netherlands, Australia, Belgium
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Study of Multiple Doses of ALXN2050 in Healthy Adults

Healthy

New Zealand
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Study of the Cardiac Effects of Danicopan in Healthy Adults

Healthy

United States
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

Study of Danicopan in Participants With Hepatic Impairment

Hepatic Impairment

United States
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Drug Interaction Study Between Danicopan and Midazolam, Fexofenadine, and Mycophenolate Mofetil in Healthy Participants

Healthy

New Zealand
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Study of Single-dose ALXN2050 in Healthy Adults

Healthy

New Zealand
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Study of Modified Release Formulations of Danicopan in Healthy Adult Participants

Healthy

United Kingdom
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

Study of Different Forms of Danicopan (Tablet, Softgel Capsule, Liquid-filled Capsule) in Healthy Participants

Healthy

New Zealand
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

Study of Danicopan in Participants With Normal Kidney Function and Participants With Kidney Dysfunction

Healthy | Renal Dysfunction

United States
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

Study of Multiple Doses of Danicopan in Healthy Participants

Healthy

New Zealand
Alexion Pharmaceuticals
Celerion; Achillion, a wholly owned subsidiary of Alexion

Completed

A Drug Interaction Study of ACH-0145228

Healthy

United States
Alexion Pharmaceuticals
Celerion; Achillion, a wholly owned subsidiary of Alexion

Completed

A Drug Interaction Study of Danicopan

Healthy

United States
Alexion Pharmaceuticals, Inc.
Achillion, a wholly owned subsidiary of Alexion

Completed

Study of Danicopan in Participants With Paroxysmal Nocturnal Hemoglobinuria With Inadequate Response to Eculizumab (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United Kingdom, United States, Italy
Rempex Pharmaceuticals (a wholly owned subsidiary...

Completed

Evaluating the Plasma, Epithelial Lining, and Alveolar Macrophage Concentrations of Intravenous Carbavance™ (RPX2014/RPX7009) in Healthy Adult Subjects

Healthy Subjects

United States
Allergan
MAP Pharmaceuticals, Inc., a wholly owned subsidiary of Allergan

Completed

Study of MAP0010 in Asthmatic Children and Adolescents

Asthma

United States
Allergan
MAP Pharmaceuticals, Inc., a wholly owned subsidiary of Allergan

Completed

QT Intervals Study to Compare the Acute Effects of Orally Inhaled Dihydroergotamine (DHE), Oral Moxifloxacin, and Placebo

Healthy

United States
Allergan
MAP Pharmaceuticals, Inc., a wholly owned subsidiary of Allergan

Completed

Tolerability and PK of Submicron Budesonide in Children 4 to 11 Years Old With Mild-To-Moderate Stable Asthma

Asthma

United States
Allergan
MAP Pharmaceuticals, Inc., a wholly owned subsidiary of Allergan

Completed

Pharmacokinetics & Tolerability Study of MAP0004 Co-administered With Ketoconazole

Healthy

United Kingdom
Allergan
MAP Pharmaceuticals, Inc., a wholly owned subsidiary of Allergan

Completed

Phase 3 Study of MAP0004 in Adult Migraineurs (FREEDOM301)

Migraine Disorders

United States
Allergan
MAP Pharmaceuticals, Inc., a wholly owned subsidiary of Allergan

Completed

Pharmacodynamic Study to Compare Acute Effects of Dihydroergotamine Mesylate (DHE) on Pulmonary Arterial Pressure

Healthy

United States
Rempex Pharmaceuticals (a wholly owned subsidiary...

Completed

Safety, Tolerability, Pharmacokinetics of Intravenous RPX2014 and RPX7009 in Healthy Adult Subjects

Bacterial Infections | Healthy Volunteers

Australia
Allergan
MAP Pharmaceuticals, Inc., a wholly owned subsidiary of Allergan

Completed

A Study of 2 Doses of MAP0010 in Adult Asthmatics (P202)

Asthma

United States
Allergan
MAP Pharmaceuticals, Inc., a wholly owned subsidiary of Allergan

Completed

Pharmacokinetics & Tolerability Study of MAP0004 in Smoking and Non-Smoking Adult Volunteers

Healthy Subjects

United Kingdom
Allergan
MAP Pharmaceuticals, Inc., a wholly owned subsidiary of Allergan

Terminated

A Study of 2 Doses of MAP0010 in Asthmatic Children

Asthma
Rempex Pharmaceuticals (a wholly owned subsidiary...

Completed

Safety Study of Intravenous Biapenem (RPX2003) and RPX7009 Given Alone and in Combination

Bacterial Infections | Healthy Volunteers

Australia
Perosphere Pharmaceuticals Inc, a wholly owned...

Recruiting

Study of Ciraparantag for Reversal of Anticoagulation Induced by Edoxaban, Apixaban or Rivaroxaban in Healthy Adults

Healthy

United States
Perosphere Pharmaceuticals Inc, a wholly owned...

Completed

Evaluation of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PER977 Following Heparin

Healthy

United States
Perosphere Pharmaceuticals Inc, a wholly owned...

Completed

PK and PD of Single, Escalating Doses of PER977 Following Enoxaparin (PER977)

Healthy

United States
Perosphere Pharmaceuticals Inc, a wholly owned...

Completed

Phase 2 Study of Rivaroxaban Reversal by Ciraparantag as Measured by WBCT

Healthy

United States
Hospira, now a wholly owned subsidiary of Pfizer
Maruishi Pharmaceutical

Completed

Post-Marketing Clinical Study to Assess Efficacy and Safety of Dexmedetomidine in Post-Operative Patients

Conscious Sedation

Japan
Hospira, now a wholly owned subsidiary of Pfizer
Maruishi Pharmaceutical

Completed

Clinical Study to Investigate the Efficacy and the Safety of DA-9501 in Sedation During the Surgery or Medical Procedure Without Intubation

Sedation

Japan
Hospira, now a wholly owned subsidiary of Pfizer
Maruishi Pharmaceutical

Completed

Long-term Clinical Study Evaluating the Safety and Efficacy of Dexmedetomidine in ICU Subjects

Sedation

Japan
Rempex Pharmaceuticals (a wholly owned subsidiary...

Completed

The Safety and Pharmacokinetics of Carbavance™ (RPX2014/RPX7009) in Subjects With Renal Insufficiency

Subjects With Varying Degrees of Renal Insufficiency and | Subjects With Normal Renal Function

United States
Allergan
MAP Pharmaceuticals, Inc., a wholly owned subsidiary of Allergan

Completed

A Study of 2 Doses of MAP0010 and Placebo in Asthmatic Children

Asthma
Rempex Pharmaceuticals (a wholly owned subsidiary...

Completed

Safety, Tolerability, Pharmacokinetics of Intravenous RPX7009 in Healthy Adult Subjects

Bacterial Infections | Healthy Volunteers

Australia
Rempex Pharmaceuticals (a wholly owned subsidiary...

Completed

Safety, Tolerability, Pharmacokinetics of Intravenous RPX2003 (Biapenem) in Healthy Adult Subjects

Bacterial Infections | Healthy Volunteers

United States
Perosphere Pharmaceuticals Inc, a wholly owned...

Completed

Phase 2 Study of Apixaban Reversal by Ciraparantag as Measured by WBCT

Healthy

United States
Perosphere Pharmaceuticals Inc, a wholly owned...

Completed

Effects of a Double-Blind, Single Dose of PER977 Administered Alone, and Following a Single Dose of Edoxaban (PER977-P1)

Anticoagulant Reversal | Reversal of Edoxaban Induced Anticoagulation

United States
Acura Pharmaceuticals Inc.
King Pharmaceuticals is now a wholly owned subsidiary of Pfizer

Completed

Study of the Relative Abuse Potential of Acurox Tablets in Non-Dependent Recreational Opioid Users

Opioid Abuse

United States
Vascular Solutions LLC
King Pharmaceuticals is now a wholly owned subsidiary of Pfizer

Completed

Evaluation of an Absorbable Surgical Hemostatic Agent: Thrombi-Gel® Versus Gelfoam-Thrombin (Control)

Operation Site Bleed

United States
Wyeth is now a wholly owned subsidiary of Pfizer
Solvay Pharmaceuticals

Terminated

Study Evaluating Safety and Tolerability of Ascending Multiple Dose of SLV-313 in Schizophrenia Patients

Healthy
Wyeth is now a wholly owned subsidiary of Pfizer
Solvay Pharmaceuticals

Completed

Study Evaluating Bifeprunox in Bipolar Depression

Depression Bipolar

United States
Wyeth is now a wholly owned subsidiary of Pfizer
Solvay Pharmaceuticals

Completed

Study Evaluating Bifeprunox in Bipolar Depression

Bipolar Disorder

United States

Clinical Trials Sponsored by Portola Pharmaceuticals, LLC (a wholly owned subsidiary of Alexion Pharmaceuticals)

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Morocco

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations