Clinical Trials Sponsored by Rhythmia Medical, Inc.

Total 2812 results

Rhythm Pharmaceuticals, Inc.

Recruiting

A Study of RM-718 in Healthy Subjects and in Patients With HO

Hypothalamic Obesity

United States
Rhythm Pharmaceuticals, Inc.

Active, not recruiting

DAYBREAK: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

Genetic Obesity

United States, Spain, Netherlands, Germany, United Kingdom, Canada, Israel, Greece
Rhythm Pharmaceuticals, Inc.

Completed

Open-Label Study of Setmelanotide in Hypothalamic Obesity

Hypothalamic Obesity

United States
Rhythm Pharmaceuticals, Inc.

Completed

Phase 1b/2a Study to Evaluate Safety and Efficacy of Setmelanotide in Obese Patients

Overweight and Obesity

United States
Rhythm Pharmaceuticals, Inc.

Completed

Setmelanotide for the Treatment of Leptin Receptor (LEPR) Deficiency Obesity

Leptin Receptor Deficiency Obesity

Netherlands, Germany, United Kingdom, Canada, France, Réunion
Rhythm Pharmaceuticals, Inc.

Approved for marketing

An Expanded Access Protocol for Setmelanotide for Treatment of Bardet-Biedl Syndrome (BBS)

Obesity | Bardet-Biedl Syndrome (BBS)
Rhythm Pharmaceuticals, Inc.

Completed

Setmelanotide in a Single Patient With Partial Lipodystrophy

Obesity | Hypertriglyceridemia

United States
Rhythm Pharmaceuticals, Inc.

Completed

An Observational,Prospective Natural History Study of Early-Onset Extreme Obesity Due to Bi-Allelic Loss-of-Function Mutations in the POMC, PCSK1 or LEPR Genes (NHS)

POMC Deficiency Obesity | PCSK1 Deficiency Obesity | LEPR Deficiency Obesity

Turkey
Rhythm Pharmaceuticals, Inc.

Completed

A Phase 1 Study to Evaluate the Pharmacokinetics of Setmelanotide in Subjects With Varying Degrees of Renal Impairment

Renal Insufficiency

United States
Rhythm Pharmaceuticals, Inc.

Completed

The TEMPO (Tracing the Effect of the MC4 Pathway in Obesity) Registry

Genetic Forms of Extreme Obesity

United States, Canada
Rhythm Pharmaceuticals, Inc.

Completed

Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RM-493 Administered to Healthy, Obese, Non-diabetic Volunteers

Overweight | Obese
Rhythm Pharmaceuticals, Inc.

Active, not recruiting

Long Term Extension Trial of Setmelanotide

Obesity Associated With Defects in Leptin-melanocortin Pathway

United States, Netherlands, Canada, Germany, United Kingdom, France, Greece, Spain
Rhythm Pharmaceuticals, Inc.

Completed

Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Participants With Moderate to Severe Obesity

Bardet Biedl Syndrome (BBS) | Alström Syndrome (AS)

United States, United Kingdom, France, Canada, Puerto Rico, Spain
Rhythm Pharmaceuticals, Inc.

Completed

Setmelanotide in Pediatric Patients With Rare Genetic Diseases of Obesity

Bardet-Biedl Syndrome | POMC Deficiency Obesity | PCSK1 Deficiency Obesity | LEPR Deficiency Obesity

United States, Australia, Spain, United Kingdom
Rhythm Pharmaceuticals, Inc.

Completed

Setmelanotide for the Treatment of Early-Onset Pro-Opiomelanocortin (POMC) Deficiency Obesity

Pro-opiomelanocortin (POMC) Deficiency Obesity

Belgium, United States, Canada, France, Germany, Spain, United Kingdom
Rhythm Pharmaceuticals, Inc.

Completed

Setmelanotide Phase 2 Treatment Trial in Participants With Rare Genetic Disorders of Obesity

Obesity | Genetic Obesity | Obesity Due to Melanocortin 4 Receptor Deficiency

United States, United Kingdom, Germany, Netherlands, France, Canada, Greece, Israel, Spain
Rhythm Pharmaceuticals, Inc.

Recruiting

EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

Obesity | Genetic Obesity

United States, Spain, Germany, Netherlands, United Kingdom, Greece, Puerto Rico, Canada, France, Israel
Rhythm Pharmaceuticals, Inc.

Enrolling by invitation

A Trial of Setmelanotide in Acquired Hypothalamic Obesity

Hypothalamic Obesity

United States, Canada, United Kingdom, Germany, Netherlands
Rhythm Pharmaceuticals, Inc.

Completed

Phase 3 Crossover Trial of Two Formulations of Setmelanotide in Patients With Specific Gene Defects in the MC4R Pathway

Bardet-Biedl Syndrome | POMC Deficiency

Netherlands, United States, Germany, Canada, Puerto Rico, United Kingdom
Rhythm Pharmaceuticals, Inc.

Completed

Phase 2 Study to Evaluate Safety and Efficacy of RM-493 in Obese Participants

Overweight

United States
Rhythm Pharmaceuticals, Inc.

Completed

Phase 2 Trial to Evaluate Safety and Efficacy of Setmelanotide (RM-493) in Obese Participants With Prader-Willi Syndrome

Prader-Willi Syndrome

United States
Rhythm Pharmaceuticals, Inc.

Completed

Study of Setmelanotide Effects on QTc (Corrected QT) Interval in Healthy Subjects

Healthy

United States
Rhythm Pharmaceuticals, Inc.

Completed

Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers

Pro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene Mutations

United States, Israel, Canada, Germany, Greece, Italy, Portugal
Kansas City Heart Rhythm Research Foundation
Texas Cardiac Arrhythmia Research Foundation; Munson Medical Center

Recruiting

Feasibility and Safety of IV Sotalol Administered as a Loading Dose to Initiate Oral Sotalol Therapy (DASH-AF)

Atrial Fibrillation | Arrhythmias, Cardiac

United States
University of Copenhagen
Rhythm Pharmaceuticals, Inc.

Completed

Melanocortin 4 Receptor Mutations and Obesity-associated Diseases (Mc4Obes)

Obesity

Denmark
Rhythm AI Ltd
Biosense Webster, Inc.

Withdrawn

RandOmised Controlled Trial of STAR Mapping™ Guided Ablation for AF. (ROC-STAR)

Atrial Fibrillation
Kansas City Heart Rhythm Research Foundation
Montefiore Medical Center; Texas Cardiac Arrhythmia Research Foundation; Kansas... and other collaborators

Not yet recruiting

The ORCHESTRATE-Myocarditis Registry

Ischemia | Chest Pain | Myocarditis

United States
Altamira Medica Ltd.

Completed

Efficacy and Safety of AM-301 on Allergic Symptoms of Perennial Allergic Rhinitis Sufferers

Rhinitis, Allergic | Perennial Allergic Rhinitis

Canada
NC Medial Research Inc

Recruiting

A Study of NCS-01 in Patients With Acute Ischemic Stroke

Ischemic Stroke

United States
Kansas City Heart Rhythm Institute
Biosense Webster, Inc.

Terminated

Catheter Ablation of Arrhythmias to Improve CRT Response (ABLATE-CRT)

Arrhythmia, Cardiac

United States
CSA Medical, Inc.
Reset Medical, Inc.

Withdrawn

CryoSpray Ablation(tm)Thoracic Patient Registry

Asthma | Emphysema | Lung Cancer | Mesothelioma | COPD | Sarcoidosis | Chronic Bronchitis
Texas Cardiac Arrhythmia Research Foundation
California Pacific Medical Center

Unknown

Does Atrial Fibrillation (AF) Termination Without Additional Ablation Influence Outcome? (TARGET)

Atrial Fibrillation

United States
Texas Cardiac Arrhythmia Research Foundation
California Pacific Medical Center

Unknown

PV Reconnection After PVAI at Different Power Settings and Adenosine Provocation (ZODIAC)

Paroxysmal Atrial Fibrillation

United States
Broncus Medical Inc
Uptake Medical Technology, Inc.

Unknown

Post-Market Optimization Study of the EMPOWER® RF Catheter to Ablate Soft Tissue Lesions in the Lung

Lung Diseases

Germany
Broncus Medical Inc
Uptake Medical Technology, Inc.

Terminated

Feasibility Study of the RF Ablation Catheter to Ablate Lung Tumors

Lung Cancer | Lung Cancer Metastatic | Lung Cancer, Non-small Cell

China
Rolfs Consulting und Verwaltungs-GmbH (RCV)
Rhythm Pharmaceuticals, Inc.

Recruiting

Early Genetic Identification of Obesity (WEGIO)

Cognitive Impairment | Hyperphagia | Obesity, Childhood | Bardet-Biedl Syndrome | Polydactyly | Retinopathy | Syndactyly | POMC Deficiency

Germany
Kansas City Heart Rhythm Research Foundation
Kansas City Heart Rhythm Institute; St. Bernards Medical Center; Sarasota Medical...

Recruiting

Observational Study to Examine the Procedural and Outcomes of AF Ablation Assisted by STAR Apollo™ Mapping System

Persistent Atrial Fibrillation

United States
Vivani Medical, Inc
Medpace, Inc.

Not yet recruiting

Assessment of Safety, Tolerability and Drug Levels of NPM-119 in Participants With Type 2 Diabetes (LIBERATE-1)

Type 2 Diabetes
Neovasc Inc.
Shockwave Medical, Inc.

Recruiting

Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II (COSIRA-II)

Refractory Angina

United States, Canada
Synchron Medical, Inc.

Withdrawn

SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis

Paralysis | Amyotrophic Lateral Sclerosis | Muscular Dystrophies | Neurologic Disorder | Spinal Muscular Atrophy | Spinal Cord Injury | Stroke, Lacunar | Upper Limb Injury | Paralysis; Stroke | Stroke, Brainstem

Australia
Calibra Medical, Inc.
Medpace, Inc.

Completed

Glycemic Control and Treatment Satisfaction Using Finesse Versus Pen for Initiating Bolus Insulin Dosing in Type 2 Diabetes Patients

Diabetes Mellitus, Type 2

United States, France, United Kingdom, Germany
University of Pennsylvania
Biosense Webster, Inc.; Texas Cardiac Arrhythmia Research Foundation

Active, not recruiting

First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Persistent Atrial Fibrillation Treatment (RAAFT-3) (RAAFT-3)

Atrial Fibrillation

United States
Neovasc Inc.
Shockwave Medical, Inc.

Active, not recruiting

REDUCER-I: An Observational Study of the Neovasc Reducer™ System

Angina Pectoris | Chronic Stable Angina | Angina Pectoris, Stable

Netherlands, Spain, United Kingdom, Germany, Italy, Switzerland, Belgium, France, Austria
Checkable Medical Inc
Curebase Inc.

Completed

Clinical Performance of the Checkable Medical At-Home Strep A Test

Respiratory Tract Infections | Pharyngitis | Streptococcus Pyogenes Infection

United States
Synchron Medical, Inc.

Active, not recruiting

COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis

Paralysis | Amyotrophic Lateral Sclerosis | Muscular Dystrophies | Spinal Cord Injuries | Neurologic Disorder | Spinal Muscular Atrophy | Cervical Spinal Cord Injury | Stroke, Lacunar | Paralysis; Stroke | Stroke Brainstem | Tetraplegic; Paralysis | Quadriplegia/Tetraplegia

United States
Kansas City Heart Rhythm Research Foundation
Kansas City Heart Rhythm Institute, Overland Park, Kansas; Texas Cardiac Arrythmia... and other collaborators

Recruiting

Left Atrial Appendage Closure With WATCHMAN FLX Device in Recurrent Gastrointestinal Bleeding: The GI-FLX Registry

Atrial Fibrillation | GI Bleeding

United States
ReCor Medical, Inc.

Not yet recruiting

Global Paradise System US Post Approval Study (US GPS)

Cardiovascular Diseases | Vascular Diseases | Hypertension
Episurf Medical Inc.

Recruiting

Clinical Investigation on the Outcome of Episealer Talus Post-operation for Treatment of Focal Osteochondral Defects

Osteochondral Defect

Germany, Sweden
Concept Medical Inc.

Not yet recruiting

Sirolimus Coated BALloon Versus Standard Balloon Angioplasty in The Treatment of Below The Knee Arterial Disease (MAGICAL BTK)

Arterial Disease of Legs
Microbot Medical, INC

Not yet recruiting

Assessment of Clin. Capabilities of LIBERTY® Endovascular Robotic System's Performance & Safety in Periph. Vasc. Interv. (ACCESS-PVI)

Peripheral Vascular Interventions

Clinical Trials Sponsored by Rhythmia Medical, Inc.

Sponsors and Collaborators

Medical Conditions

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CROs in Kenya

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Rare Diseases

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