Clinical Trials Sponsored by Riaan Research Initiative

Total 163 results

Ontario Neurodegeneration Disease Research Initiative

Completed

The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

Stroke | Parkinson Disease | Amyotrophic Lateral Sclerosis | Alzheimer Disease | Frontotemporal Dementia

Canada
University of Iowa
Tinnitus Research Initiative

Completed

Zinc to Treat Tinnitus in the Elderly

Tinnitus

United States
Community Research Initiative of New England

Completed

Efficacy Study of Substitution of Darunavir/Ritonavir (DRV/r) for Dual-boosted Protease Inhibitors (DVD)

HIV Infections

United States
Community Research Initiative of New England

Completed

BRAVO: Background Regimen of Raltegravir on Virologic Outcome (BRAVO)

HIV Infections

United States
VA Quality Enhancement Research Intiative

Withdrawn

Melodica Orchestra for Dyspnea: Safety and Feasibility Pilot (MELODY)

Chronic Obstructive Pulmonary Disease | Emphysema | COPD | Chronic Bronchitis | Dyspnea | Breathlessness

United States
VA Quality Enhancement Research Intiative

Completed

Participatory Music Program for Homeless Veterans

Quality of Life

United States
Community Research Initiative of New England
Abbott

Terminated

BOOST: Study of Increased Dosage of Lopinavir/Ritonavir (LPV/r)

HIV Infections

United States
CMV Research Foundation
International AIDS Vaccine Initiative

Completed

Safety Study of Four Chimera Cytomegalovirus (CMV) Vaccines in Healthy Adult Males 30-50 Years of Age

Cytomegalovirus

United States
Ontario Neurodegeneration Disease Research Initiative
Ontario Brain Institute

Terminated

Health in Aging, Neurodegenerative Diseases and Dementias In Ontario (HANDDS-ONT)

Dementia | Neuro-Degenerative Disease

Canada
Community Research Initiative of New England
Gilead Sciences

Completed

A Pilot Study of Treating HCV at a Psychiatrist-staffed Outpatient Addiction Clinic

Hepatitis C | Hepatitis C, Chronic | Opiate Dependence

United States
Alternative Research Initiative
Foundation for a Smoke-Free World

Not yet recruiting

Electronic Cigarettes and Nicotine Pouches for Smoking Cessation

Role of Tobacco Harm Reduction in Smoking Cessation | Efficiency and Efficacy of E-cigarettes and Nicotine Pouches | Adverse Effect of E-cigarettes and Nicotine Pouches

Pakistan
UMC Utrecht
Janssen Research & Development, LLC; Innovative Medicines Initiative

Completed

Study to Collect Information About Invasive Disease Caused by Extraintestinal Pathogenic Escherichia Coli-2 (EXPECT-2) (EXPECT-2)

E. Coli Infection

United States, Italy, United Kingdom, Canada, France, Germany, Japan, Spain
Community Research Initiative of New England
Tibotec Pharmaceutical Limited

Completed

Lopinavir/r or Fosamprenavir/r Switch to Atazanavir/r or Darunavir/r (LARD)

HIV Infections

United States
Community Research Initiative of New England
The Campbell Foundation

Completed

FOTO: Five Consecutive Days on Treatment With Efavirenz, Tenofovir, and Emtricitabine Followed by Two Days Off Treatment Versus Continuous Treatment

HIV Infections

United States
Wiseman Research Initiatives LLC

Terminated

Vaccine Therapy in Treating Patients With HER2/Neu Positive or Negative Stage IV Breast Cancer or Other HER2/Neu Positive Cancers

Breast Cancer | Unspecified Adult Solid Tumor, Protocol Specific

United States
International AIDS Vaccine Initiative
Biomedical Advanced Research and Development Authority

Active, not recruiting

Evaluation of Safety and Immunogenicity of rVSVΔG-SEBOV-GP Vaccine in Adults With Good General Health

Ebola Sudan Virus Disease

United States
McGill University
Ethiopian Health and Nutrition Research Institute; Micronutrient Initiative

Completed

The Effects of Iodized Salt on Cognitive Development in Ethiopia

Goiter | Iodine Deficiency | Cretinism

Canada
Community Research Initiative of New England
Merck Sharp & Dohme LLC

Withdrawn

A Pilot Study to Determine if Raltegravir Eradicates HIV From Peripheral Blood Mononuclear Cells

HIV Infections | Acquired Immune Deficiency Syndrome
University of Waterloo
Ottawa Heart Institute Research Corporation; Canadian Tobacco Control Research...

Completed

Integrating Smoking Cessation Into Routine Primary Care Practice

Smoking Cessation
MRC/UVRI and LSHTM Uganda Research Unit
International AIDS Vaccine Initiative

Recruiting

Feasibility of Identifying, Enrolling and Following Acute and Early HIV-1 Infected Individuals. (KILGORIS)

Acute Human Immunodeficiency Virus Type I Infection

Uganda
MJM Bonten
Janssen Research & Development, LLC; Innovative Medicines Initiative

Completed

Study to Collect Information About Invasive Disease Caused by Extraintestinal Pathogenic Escherichia Coli (EXPECT-1) (EXPECT-1)

E.Coli Infections

United States, United Kingdom, Canada, France, Germany, Italy, Japan, Spain
International AIDS Vaccine Initiative
University of Nairobi; Medical Research Council-Oxford

Completed

A Phase IIA Trial to Evaluate the Safety and Immunogenicity of a DNA HIV-1 Vaccine Followed by an MVA HIV-1 Vaccine in HIV-uninfected Volunteers

HIV Infections

United Kingdom, Kenya
Seattle Children's Research Institute (SCRI)
The PATH Malaria Vaccine Initiative (MVI)

Completed

Reproducibility of Malaria Challenge in Healthy Volunteers

Healthy

United States
Duke University
Duke Clinical Research Institute; Clinton Health Access Initiative, Nigeria

Active, not recruiting

COVID Quick Start - Test and Treat in Africa

COVID-19

United States
Emory University
International AIDS Vaccine Initiative; Zambia-Emory HIV Research Project

Completed

Zambia SiVET MMR Tdap-IPV (SiVET)

High Risk for HIV

Zambia
University of Manitoba
Canada Manitoba Agri-Food Research and Development Initiative

Withdrawn

Effects of Vitamin D Fortification on Vitamin D Metabolite Profiles and Status in Vitamin D Insufficient Individuals (VITD-2013)

Vitamin D Deficiency

Canada
Centre for Addiction and Mental Health
Canadian Tobacco Control Research Initiative

Terminated

Baclofen for Smoking Cessation in a Non-Psychiatric Population (Baclofen)

Nicotine Dependence

Canada
Centre for Addiction and Mental Health
Canadian Tobacco Control Research Initiative

Terminated

Testing a Full Substitution Therapy Approach As Treatment of Tobacco Dependence

Nicotine Dependence

Canada
International Food Policy Research Institute
Cornell University; World Vision; Micronutrient Initiative

Completed

Feasibility and Effectiveness of Distributing Micronutrient Sprinkles to Reduce Prevalence of Anemia

Anemia

Haiti
European Society for Blood and Marrow Transplantation
European Research Initiative on CLL

Completed

Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in 17p- Chronic Lymphocytic Leukemia (CLL) (17p-CLL)

CLL

Germany, United Kingdom, Netherlands, Finland, Sweden, Denmark, Israel
Sir Mortimer B. Davis - Jewish General Hospital
Canadian Tobacco Control Research Initiative

Suspended

The Safety of Transdermal Nicotine Immediately Following an Acute Coronary Syndrome (STADIA)

Smoking Cessation

Canada
International AIDS Vaccine Initiative
ModernaTX, Inc.; AURUM Tembisa Clinical Research; Center for Family Health Research

Active, not recruiting

A Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644)

HIV-1-infection

Rwanda, South Africa
Didier Jutras Aswad
Canadian Institutes of Health Research (CIHR)

Completed

A Pragmatic Randomized Control Trial Comparing Models of Care in the Management of Prescription Opioid Misuse (OPTIMA)

Opioid Use Disorder

Canada
International AIDS Vaccine Initiative
University of Rochester; Aaron Diamond AIDS Research Center

Completed

Safety and Immunogenicity of a Modified Vaccinia Ankara (MVA) HIV Vaccine in HIV Uninfected Adults

HIV Infection

United States
Community Research Initiative of New England

Completed

An Evaluation of Pentoxifylline in HIV-Positive Persons With Symptomatic HIV Infection and a Karnofsky Score > 40 Percent and < 100 Percent

HIV Infections

United States
International AIDS Vaccine Initiative
University of Rochester; Aaron Diamond AIDS Research Center

Completed

Safety and Immunogenicity of a Plasmid HIV Vaccine in HIV Uninfected Adults (C001)

HIV Infection

United States
Community Research Initiative of New England

Completed

A Study to Evaluate the Effect of Cimetidine on CD4 Lymphocyte Counts in HIV Infection

HIV Infections

United States
International AIDS Vaccine Initiative
Massachusetts General Hospital; GlaxoSmithKline; Fred Hutchinson Cancer Research... and other collaborators

Completed

A Randomized, Double-blinded, Placebo-controlled, Dose-escalation Phase 1 Clinical Trial to Evaluate the Safety and Immunogenicity of Recombinant HIV Envelope Protein BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, in Healthy, HIV-1 Uninfected Adults

HIV Infections

United States, Kenya
Nepal Health Research Council
Microbe Literacy Initiative; Partnership for Sustainable Development Nepal...

Not yet recruiting

Impact of Microbe Literacy Initiative on Improved Vaccine Uptake in Peri-urban Slum Areas in Kathmandu, Nepal

Vaccine Acceptance

Nepal
U.S. Army Medical Research and Development Command
The PATH Malaria Vaccine Initiative (MVI)

Withdrawn

A Phase I Clinical Trial Immunizing Healthy Adults With the NMRC-M3V-Ad-PfCA Vaccine to Generate Biologic Reagents (AdBa)

Healthy | Malaria

United States
Community Research Initiative of New England
Bristol-Myers Squibb; Merck Sharp & Dohme LLC

Completed

BATAR: Individuals Currently Taking Boosted Atazanavir as Part of an HIV Treatment Regimen Will be Evaluated to See if Substituting Raltegravir for Nucleoside Transcriptase Inhibitors Will be Safe and Well Tolerated. (BATAR)

HIV

United States
Søren H. Sindrup
Danish Pain Research Center; Innovative Medicines Initiative

Completed

Oxcarbazepine for the Treatment of Chronic Peripheral Neuropathic Pain (IMIOXC)

Postherpetic Neuralgia | Peripheral Nerve Injury | Polyneuropathy

Denmark
European Vaccine Initiative
University of Oxford; Malaria Research and Training Center, Bamako, Mali

Not yet recruiting

Assessment of Safety, Immunogenicity and Efficacy of R21/Matrix-M1 Malaria Vaccine in Healthy WOCBP in Mali

Healthy Women of Child Bearing Potential
Centre for Addiction and Mental Health
Canadian Institutes of Health Research (CIHR); Canadian Tobacco Control Research...

Completed

Study of Varenicline (Champix) for Smoking Cessation/Reduction in Patients With Bipolar Disorder

Nicotine Dependence

Canada
Crucell Holland BV
The PATH Malaria Vaccine Initiative (MVI); Seattle Children's Research Institute...

Completed

A Study to Assess the Immunogenicity, Tolerability and Safety of a Malaria Vaccine and Also Its Protective Efficacy in a Malaria Challenge Model

Malaria

United States
Pfizer
Biomedical Advanced Research and Development Authority; Innovative Medicines...

Completed

A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria. (REVISIT)

Ventilator Associated Pneumonia | Complicated Intra-abdominal Infection | Hosptial Acquired Pneumonia

Spain, China, Korea, Republic of, Philippines, United States, Romania, Taiwan, Italy, Malaysia, Mexico, India, Israel, Turkey, Greece, Thailand, Czechia, Croatia, Argentina, Russian Federation, Bulgaria, Ukraine
GlaxoSmithKline
Walter Reed Army Institute of Research (WRAIR); The PATH Malaria Vaccine Initiative...

Completed

Efficacy, Safety and Immunogenicity Study of GlaxoSmithKline(GSK) Biologicals' Candidate Malaria Vaccine 257049 in the Sporozoite Challenge Model in Healthy Malaria-naïve Adults

Malaria

United States
University of Calgary
Alberta Centre for Child, Family & Community Research; Alberta Family Wellness...

Completed

Mindfulness Based Cognitive Therapy for Psychological Distress in Pregnancy

Depression | Stress | Anxiety

Canada
European Malaria Vaccine Initiative
Radboud University Medical Center; GlaxoSmithKline; Biomedical Primate Research... and other collaborators

Completed

Assessment of Three Formulations of the Candidate Vaccine AMA 1 in Healthy Dutch Adult Volunteers

Plasmodium Falciparum Malaria

Netherlands
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI); QIMR Berghofer Medical Research...

Completed

Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2 (CHMI-trans2)

Transmission | Malaria,Falciparum | Controlled Human Malaria Infection | Gametocytes

Netherlands

Clinical Trials Sponsored by Riaan Research Initiative

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Papua New Guinea

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Rare Diseases

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