Clinical Trials Sponsored by Roche Foundation

Total 18618 results

Hoffmann-La Roche
Foundation Medicine

Recruiting

A Study to Evaluate the Impact of Liquid Biopsy in Participants With a Clinical Diagnosis of Advanced Cancer (L1st)

Metastatic Lung Cancer | Metastatic Gastrointestinal Cancer

Spain, France, Italy, Germany, Netherlands
Hoffmann-La Roche
Foundation Medicine, Inc.

Active, not recruiting

A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site (CUPISCO)

Cancer of Unknown Primary Site

United Kingdom, Korea, Republic of, France, Australia, Germany, Austria, Croatia, Denmark, Finland, Greece, Hungary, Italy, Portugal, Spain, Japan, Brazil, Colombia, Mexico, Romania, Czechia, Norway, Thailand, Switzerland, Turkey, Nethe... and more
Pacific Health Foundation
Hoffmann-La Roche

Completed

Pegasys and Copegus for Asian Patients With Treatment-naive Hepatitis C Genotypes 6, 7, 8, 9

Chronic Hepatitis C | Treatment | Asian Americans | Novel Genotypes

United States
Columbus Research Foundation
Hoffmann-La Roche

Completed

Remote Management of Diabetic Patients Via Data Transmission by Accu-Chek 360 Software

Diabetes

United States
ETOP IBCSG Partners Foundation
Hoffmann-La Roche

Active, not recruiting

BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural Mesothelioma (BEAT-meso)

Pleural Mesothelioma Malignant Advanced

Switzerland, United Kingdom, Belgium, Spain, France, Italy
ETOP IBCSG Partners Foundation
Hoffmann-La Roche

Terminated

ALEctinib for the Treatment of Pretreated RET-rearranged Advanced Non-small Cell Lung Cancer (ALERT-lung)

Non-small Cell Lung Cancer | Non-small Cell Lung Cancer Metastatic | Non-small Cell Lung Cancer Recurrent

Ireland, Spain, Belgium, Italy, Netherlands, Switzerland
Foundation for Liver Research
Hoffmann-La Roche

Completed

PEG-interferon Alfa-2a add-on Study in HBeAg Negative Chronic Hepatitis B Patients (PAS)

Chronic Hepatitis B

Netherlands, Canada
ETOP IBCSG Partners Foundation
Roche Pharma AG

Active, not recruiting

ABC-lung: Atezolizumab, Bevacizumab and Chemotherapy in EGFR-mutant Non-small Cell Lung Carcinoma (ABC-lung)

EGFRmutant Stage IIIB/C or IV Non-squamous NSCLC

Singapore, Spain, Korea, Republic of, Switzerland, Germany
Foundation for Liver Research
Hoffmann-La Roche

Terminated

High-dose Ribavirin in Treatment of Chronic Hepatitis C Genotype 1 or 4 (VIRID)

Chronic Hepatitis C

Netherlands
PETHEMA Foundation
Roche Pharma AG; Celgene Corporation

Terminated

SIMIDIS: Azacitidine and Beta Erythropoietin Treatment in Patients With Myelodysplastic Syndrome (SIMIDIS)

Myelodysplastic Syndrome

Spain
ETOP IBCSG Partners Foundation
Hoffmann-La Roche

Recruiting

A Window-of-Opportunity Trial of Giredestrant +/- Triptorelin vs. Anastrozole + Triptorelin in Premenopausal Patients With ER-positive/HER2-negative Early Breast Cancer (PREcoopERA)

Breast Cancer

Ireland, Italy, Germany, Spain, Hungary, France, Sweden, Switzerland
Spanish Foundation of Rheumatology
Roche Farma, S.A

Unknown

Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis

Arthritis, Rheumatoid

Spain
University of Cambridge
Hoffmann-La Roche; Roche Foundation of Anemia Research (RoFAR, Switzerland)

Completed

Erythropoietin Therapy for Subarachnoid Hemorrhage

Aneurysmal Subarachnoid Hemorrhage

United Kingdom
Nykode Therapeutics ASA
Roche Pharma AG; GOG Foundation

Not yet recruiting

Efficacy and Safety of VB10.16 Alone or in Combination With Atezolizumab in Patients With Advanced Cervical Cancer.

Cervical Cancer | HPV-Related Malignancy | HPV-Related Cervical Carcinoma
ETOP IBCSG Partners Foundation
Pfizer; Hoffmann-La Roche

Completed

To Reduce the Use of Chemotherapy in Postmenopausal Patients With ER-positive and HER2-positive Breast Cancer (TOUCH) (TOUCH)

Breast Cancer | HER2-positive Breast Cancer | Estrogen Receptor Positive Tumor

France, Switzerland, Belgium, Italy
Konkuk University Medical Center
Foundation Medicine; Roche Diagnostics

Recruiting

Impact of Concomitant Genetic Alterations in EGFR Mutated Adenocarcinoma by NGS Analysis: A Multicenter Study

Adenocarcinoma of Lung | EGFR Activating Mutation

Korea, Republic of
NSABP Foundation Inc
Hoffmann-La Roche; Genentech, Inc.

Active, not recruiting

Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed After Surgery by Atezolizumab or Placebo

Triple Negative Breast Cancer

United States, Canada
Royal Free Hospital NHS Foundation Trust
Roche Diagnostics

Completed

SARS-CoV-2 (COVID-19) Antibody PrevalencE in an Adult London HIV Cohort (SCAPE-HIV)

Covid19 | SARS-CoV Infection | HIV-1-infection

United Kingdom
Royal Marsden NHS Foundation Trust
Roche Pharma AG

Completed

Capecitabine and Oxaliplatin Plus Bevacizumab as Neoadjuvant Treatment for Untreated Unresectable Liver-only Metastases From Colorectal Cancer

Metastatic Colorectal Cancer

United Kingdom
ETOP IBCSG Partners Foundation
Hoffmann-La Roche; AstraZeneca

Active, not recruiting

Osimertinib and Bevacizumab Versus Osimertinib Alone as Second-line Treatment in Stage IIIb-IVb NSCLC With Confirmed EGFRm and T790M (BOOSTER) (BOOSTER)

Non Small Cell Lung Cancer Metastatic

Ireland, Singapore, Spain, Switzerland, Korea, Republic of, Netherlands
Royal Marsden NHS Foundation Trust
Hoffmann-La Roche

Terminated

R-CHOP-B Bevacizumab for Diffuse Large B Cell Lymphoma

B-cell Lymphoma | Non-Hodgkin's Lymphoma

United Kingdom
Hoffmann-La Roche
NSABP Foundation Inc; German Breast Group

Active, not recruiting

A Study of Trastuzumab Emtansine Versus Trastuzumab as Adjuvant Therapy in Patients With HER2-Positive Breast Cancer Who Have Residual Tumor in the Breast or Axillary Lymph Nodes Following Preoperative Therapy (KATHERINE)

Breast Cancer

United States, Italy, United Kingdom, Canada, Czechia, Argentina, Austria, Belgium, Brazil, China, France, Germany, Guatemala, Ireland, Panama, Spain, Sweden, Taiwan, Turkey, Colombia, Hong Kong, Peru, Switzerland, South Africa, Israel, G... and more
University Hospital Southampton NHS Foundation...
Hoffmann-La Roche

Terminated

Atezolizumab, Rituximab, Gemcitabine and Oxaliplatin in Patients With Relapsed or Refractory DLBCL Not Suitable for High-dose Therapy (ARGO)

Diffuse Large B Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Relapsed Diffuse Large B-Cell Lymphoma

United Kingdom
Hoffmann-La Roche
Roche Diagnostics

Completed

A Study Evaluating the Perception of Insertion Pain With Accu-Chek FlexLink and FlexLink Plus Insulin Pump Devices Under Real Life Conditions in Diabetic Patients.

Diabetes Mellitus Type 2, Diabetes Mellitus Type 1

Germany
Royal Marsden NHS Foundation Trust
Pfizer; Hoffmann-La Roche

Recruiting

Fulvestrant, Ipatasertib and CDK4/6 Inhibition in Metastatic ER+/HER2- Breast Cancer Patients Without ctDNA Suppression (FAIM)

Advanced Breast Cancer | Metastatic Breast Cancer | ER+ Breast Cancer

United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
Hoffmann-La Roche

Completed

An RCT of Metformin Vs Orlistat in Obese Anovulatory Women

Obesity | Anovulation

United Kingdom
University of Minnesota
Hoffmann-La Roche; Minnesota Medical Foundation

Completed

Controlled Trial of Valacyclovir in Infectious Mononucleosis

Infectious Mononucleosis

United States
Cambridge University Hospitals NHS Foundation Trust
Roche Pharma AG

Completed

Pilot Study of Rituximab Therapy for Systemic Lupus Erythematosus (SLE) and Vasculitis

Systemic Lupus Erythematosus | ANCA Associated Vasculitis

United Kingdom
Hoffmann-La Roche
nv Roche sa

Completed

An Observational Study to Evaluate the Clinical Effectiveness, Quality of Life, Safety and Tolerability of Tocilizumab (TCZ) in Patients With Rheumatoid Arthritis (RA) in Daily Clinical Practice

Rheumatoid Arthritis

Belgium, Luxembourg
Hoffmann-La Roche
Roche Pharma AG

Completed

Influence of Ribavirin on the Initial Virological Response in Treatment Naïve Patients With Hepatitis C Genotype 1 Infection

Hepatitis C, Chronic

Germany
Hoffmann-La Roche
Roche Pharma AG

Terminated

Comparison of Ibandronate - Zoledronate Regarding Nephrotoxicity in Multiple Myeloma (COMPARE)

Multiple Myeloma

Germany
Birmingham Women's and Children's NHS Foundation...
Roche Pharma AG

Terminated

A Pilot Trial of Pediatric Liver Transplantation Without Steroids

Evidence of Liver Transplantation

United Kingdom
University of Chicago
Roche Pharma AG; Breast Cancer Research Foundation

Terminated

Capecitabine as NeoAdjuvant Therapy in Locally Advanced Breast Cancer

Breast Cancer

United States, Nigeria
Hoffmann-La Roche
Roche Pharma AG

Completed

A Study of Trastuzumab Emtansine (Trastuzumab-MCC-DM1, T-DM1) in Combination With Pertuzumab Administered to Patients With Human Epidermal Growth Factor Receptor-2 (HER2)-Positive Locally Advanced or Metastatic Breast Cancer Who Have Previously Received Trastuzumab

Metastatic Breast Cancer

Italy, Spain, Canada, United States, Belgium, France, Germany
Brooke Army Medical Center
Hoffmann-La Roche; The Geneva Foundation

Completed

Study for the Treatment of Significant Steatosis With Xenical Followed by Treatment of Hepatitis C With Pegasys/Copegus (HCVNASH)

Hepatitis C | Fatty Liver

United States
National Bone Health Alliance
Roche Pharma AG; National Osteoporosis Foundation

Unknown

Changes in Biochemical Markers of Bone Turnover (Serum CTX and PlNP) After Initiation of a "Drug Holiday" From Bisphosphonates

Osteoporosis

United States
Roche Sequencing Solutions
Perinatal Quality Foundation: Nuchal Translucency Quality Review

Completed

Non-invasive Chromosomal Examination of Trisomy Study (NEXT)

Trisomy 21

United States, Belgium, Netherlands, Sweden, Italy, Canada
University of Minnesota
Juvenile Diabetes Research Foundation; Roche Pharma AG

Completed

Delayed Mycophenolate Mofetil in Single-Donor Islet Allotransplantation in Type 1 Diabetes

Hypoglycemia | Type 1 Diabetes

United States
University of Bern
Hoffmann-La Roche; Swiss National Science Foundation

Completed

Immunopharmacological Effects of Rituximab in Atopic Dermatitis

Dermatitis, Atopic

Switzerland
Hoffmann-La Roche
Roche Molecular Systems, Inc

Not yet recruiting

A Study of the Cobas® Liat CT/NG/MG Test Versus Current Standard Practice for Managing Participants at Increased Risk of Sexually Transmitted Infections

Chlamydia Trachomatis Infection | Mycoplasma Genitalium Infection | Neisseria Gonorrhoeae Infection
Hoffmann-La Roche
Roche Diabetes Care GmbH

Completed

Comparing Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections to Reach HbA1c Targets in Children and Adolescents With Type 1 Diabetes (Insight Kids)

Diabetes Mellitus Type 1

Germany, Austria, United Kingdom
Hoffmann-La Roche
Roche Diabetes Care GmbH

Completed

ACCU-CHEK Connect Personal Diabetes Management Study (PDM CONNECT)

Diabetes Mellitus, Type 1

United States
Fundacion SEIMC-GESIDA
Roche Pharma AG; Dynamic Science S.L.

Completed

Clinical Trial to Evaluate the Effectiveness and Safety of Tocilizumab for Treating Patients With COVID-19 Pneumonia

COVID-19

Spain
UNICANCER
Hoffmann-La Roche; National Cancer Institute, France; Fondation ARC

Active, not recruiting

Phase 2 Study Assessing Secured Access to Vemurafenib for Patients With Tumors Harboring BRAF Genomic Alterations (AcSé)

Solid Tumors | Hematologic Cancers | Metastatic Cancers

France
The Christie NHS Foundation Trust
Hoffmann-La Roche; ConcR; Durham University

Active, not recruiting

Carcinoma of Unknown Primary (CUP): A Comparison Across Tissue and Liquid Biomarkers (CUP-COMP)

Cancer of Unknown Primary Site

United Kingdom
University of Edinburgh
Roche Educational Grant; Edinburgh Sick Kids Friends Foundation

Completed

Effect of an Integrated Care Pathway on Asthma Care in Hospital

Asthma

United Kingdom
Hoffmann-La Roche
Roche Diabetes Care Deutschland GmbH

Completed

A German Study Evaluating the Efficacy and the Benefit of Integrated Personalized Diabetes Management (PDM) for Type 2 Diabetes Patients. (PDM-ProValueGP)

Diabetes Mellitus, Type 2

Germany
Hoffmann-La Roche
Roche Diabetes Care Deutschland GmbH

Completed

A Study Evaluating the Efficacy and the Benefit of Integrated Personalized Diabetes Management (PDM) for Diabetic Patients. (PDMProValueDSP)

Type II Diabetes Mellitus

Germany
Hoffmann-La Roche

Recruiting

A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamics Of Satralizumab In Participants With Thyroid Eye Disease (SatraGO-2) (SatraGO-2)

Thyroid Eye Disease

Korea, Republic of, United States, United Kingdom, China, Canada, France, Spain
Hoffmann-La Roche

Recruiting

A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma (GLOBRYTE)

Lymphoma

Korea, Republic of, United States, France, Brazil, China, Spain, Australia, Sweden, Taiwan, Italy, United Kingdom

Clinical Trials Sponsored by Roche Foundation

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