Clinical Trials Sponsored by Simbec-Orion Research

Total 63 results

Minervax ApS
Simbec-Orion Group

Enrolling by invitation

A Follow up Study of Group B Streptococcus Vaccine (GBS-NN/NN2 Vaccine) in Healthy Volunteers

Group B Streptococcus Infection

United Kingdom
Artax Biopharma Inc
Simbec-Orion Group

Completed

A Study of the Safety, Tolerability, Pharmacokinetics and Food Effect After Single and Multiple Ascending Oral Doses

Autoimmune Diseases

United Kingdom
F2G Biotech GmbH
Simbec-Orion Group

Completed

Single Ascending Oral Dose Study of F901318

Invasive Aspergillosis

United Kingdom
Zionexa
GE Healthcare; Simbec-Orion Group; Keosys

Recruiting

Impact of 18F-FES PET on the Therapeutic Treatment of Patients With Metastatic Breast Cancer (ESTROTIMP)

Metastatic Breast Cancer

France
Simbec Research

Completed

A Study Comparing Three Formulations of Ibuprofen in Healthy Subjects

Healthy Volunteer Study

United Kingdom
ImmunoBiology Limited
Simbec Research; ORION Clinical Services; Oxford Therapeutics Consulting Limited

Completed

A Phase I Study to Evaluate the Safety and Immunogenicity of PnuBioVax

Pneumococcal Infection

United Kingdom
Zionexa
GE Healthcare; Medpace, Inc.; Simbec-Orion Group

Recruiting

Clinical Utility of FES F18 PET/CT in Metastatic Breast Cancer Patients

Metastatic Breast Cancer

United States
AstraZeneca
Simbec Research

Completed

A Scintigraphy Study of PT010 in COPD Patients (RD708/34000)

Chronic Obstructive Pulmonary Disease

United Kingdom
Onxeo
Simbec Research

Completed

Phase 1 PK, Bioavailability, Safety Study of Clonidine MBT w Catapres in Healthy Volunteers

Healthy

United Kingdom
Paion UK Ltd.
Simbec Research; ORION Clinical Services; Creative Clinical Research GmbH

Completed

Efficacy and Safety of Remimazolam (CNS7056) Compared to Propofol for Intravenous Anesthesia During Elective Surgery

Anesthesia, Intravenous

Germany
3M
Simbec Research

Completed

Two-period 21 Day Cross-over Study to Compare the Pharmacokinetics of Tiotropium From Two Inhalers

Healthy

United Kingdom
ADDMEDICA SASA
Simbec-Orion Group; PhinC Development; Oncodesign SA

Completed

A Bioequivalence Study to Compare the Pharmacokinetics of Two Formulations of Siklos® in Healthy Volunteers

Healthy Volunteers

United Kingdom
Simbec Research
Sensorion

Completed

A Study of SENS 401 in Healthy Subjects

Inner Ear Disease

United Kingdom
Diurnal Limited
Simbec Research

Completed

An Investigational Study of Hydrocortisone

Adrenal Insufficiency

United Kingdom
Prokarium Ltd
Simbec Research

Completed

Study to Evaluate the Safety, Tolerability and Immunogenicity of a Potential Enteric Fever Vaccine

Enteric Fever

United Kingdom
Viramal Limited
Simbec Research

Recruiting

Study to Investigate the Pharmacokinetics & Safety Following One Application of 3 Different Doses 0.5,0.75,& 1.25 gm,a Transdermal Estradiol Cream (VML-0203), in Comparison to a Single Dose of EstroGel 1.25 gm to Healthy Post-menopausal Women.

Menopause

United Kingdom
Minervax ApS
Simbec Research

Completed

Group B Streptococcus Vaccine in Healthy Females (MVX0002)

Group B Strep Infection

United Kingdom
Spero Therapeutics
Simbec Research

Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of SPR720 in Healthy Volunteers

Healthy Volunteers

United Kingdom
Diurnal Limited
Simbec Research

Completed

Comparison of Pharmacokinetics of Infacort® Versus Immediate-release Hydrocortisone

Healthy Subjects
Diurnal Limited
Simbec Research

Completed

An Open Label Study in Healthy Volunteers to Compare Chronocort® to Hydrocortisone

Congenital Adrenal Hyperplasia | Adrenal Insufficiency
Simbec Research
CN creative

Completed

A Study of Blood Levels of Nicotine Following an Electronic Cigarette

Nicotine Replacement Therapy
Diurnal Limited
Simbec Research

Completed

Effect of Slow Release Hydrocortisone on Fed & Fasting Volunteers; Immediate Release on Fasting Only

Healthy
Accure Therapeutics
Simbec Research

Completed

BN201 SAD MAD Study in Healthy Subjects

Optic Neuritis | Optic; Neuritis, With Demyelination

United Kingdom
Diurnal Limited
Simbec Research

Completed

A Two-part, Study to Compare the Pharmacokinetics and Dose Proportionality of up to 6 Chronocort Formulations

Congenital Adrenal Hyperplasia | Adrenal Insufficiency
Simbec Research
Sensorion SA

Completed

A Single Dose PK Study of SENS-218 in Healthy Volunteers

Inner Ear Diseases
Menarini Group
Simbec Research

Completed

Comparative Bioavailability of Dexketoprofen Trometamol Oral Solution vs Tablet Formulations

Acute Pain

United Kingdom
Genmedica Therapeutics S.L.
Simbec Research

Terminated

Multiple Ascending Dose Study of GMC-252-L-Lys Salt in Healthy Subjects and Type 2 Diabetics

Healthy | Type 2 Diabetes Mellitus

United Kingdom
Genmedica Therapeutics S.L.
Simbec Research

Terminated

Safety and Pharmacokinetics Study of a New Drug for Type 2 Diabetes

Healthy

United Kingdom
F2G Biotech GmbH
Simbec Research

Completed

F901318 Single Ascending Dose Study in Healthy Male Volunteers

Invasive Aspergillosis

United Kingdom
Atopix Therapeutics, Ltd.
Simbec Research

Completed

Evaluation of Metabolic Profile of OC000459

Asthma

United Kingdom
Redx Pharma Plc
Simbec Research

Completed

A 3-part Study to Evaluate Safety, Tolerability, Food Effect and Drug-drug Interactions of RXC007 in Healthy Volunteers

Liver Diseases | Fibrosis | Kidney Diseases | Inflammation | Idiopathic Pulmonary Fibrosis | Non-alcoholic Steatohepatitis

United Kingdom
Atopix Therapeutics, Ltd.
Simbec Research

Completed

First in Man Evaluation of Single and Multiple Doses of Oral ATX2417

Allergy

United Kingdom
Redx Pharma Plc
Simbec Research

Recruiting

Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of RXC007 in Idiopathic Pulmonary Fibrosis

Fibrosis | IPF

Italy, Spain, United States, Belgium, United Kingdom, Austria, Czechia, Poland, Switzerland
Artax Biopharma Inc
Simbec Research

Completed

Potential Food Effect And Repeated Dosing of AX-024.HCl In Healthy Subjects

Healthy

United Kingdom
Research in Real-Life Ltd
Orion Corporation, Orion Pharma

Completed

Real Life Effectiveness of Easyhaler (Orion)

Asthma
Simbec Research

Unknown

Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma

Testicular Germ Cell Tumor | Nausea and Vomiting
Reckitt Benckiser Healthcare (UK) Limited
Simbec Research

Completed

Naproxen Sodium (2 x 220 mg) Fasted Comparative Bioavailability Study

Healthy
Dr. Jurjan Aman
Exvastat Ltd.; Simbec-Orion Group; KABS laboratories

Terminated

Intravenous Imatinib in Mechanically Ventilated COVID-19 Patients (INVENT COVID)

Covid19 | Endothelial Dysfunction | Acute Respiratory Distress Syndrome | ARDS | Pulmonary Edema

Netherlands
Reckitt Benckiser Healthcare (UK) Limited
Simbec Research

Completed

Ibuprofen Bioavailability Study

Healthy

United Kingdom
Reckitt Benckiser Healthcare (UK) Limited
Simbec Research

Completed

Ibuprofen and Paracetamol Pharmacokinetic Study

Healthy Volunteer Study
University of Edinburgh
Wellcome Trust; Simbec Research

Completed

A Phase I Study of Oral UE2343 in Healthy Subjects (UE2343)

Healthy

United Kingdom
Reckitt Benckiser Healthcare (UK) Limited
Simbec Research

Terminated

Nurofen Ibuprofen Orodispersible Tablet Disintegration Study

Healthy

United Kingdom
Spero Therapeutics
Simbec Research; QPS Holdings LLC

Completed

Phase 1 Study to Evaluate DDI, PK, Safety, Tolerability of SPR741

Healthy Volunteers

United Kingdom
Reckitt Benckiser Healthcare (UK) Limited
Simbec Research

Completed

Ibuprofen and Pseudoephedrine Comparative Pharmacokinetic Study

Healthy
Artax Biopharma Inc
Simbec Research; ORION Clinical Services; Packaging Coordinators Inc; Centro de...

Completed

Safety Study of Immune System Modulator for Autoimmune Diseases

Healthy Volunteers

United Kingdom
Helsinki University Central Hospital
Finnish Cultural Foundation; Orion Corporation, Orion Pharma; Finnish Foundation... and other collaborators

Completed

Hydroxychloroquine for the Prevention of Cardiovascular Events in Myocardial Infarction Patients - a Safety Pilot Trial (OXI)

Myocardial Infarction | Cardiovascular Diseases | Inflammation | Acute Coronary Syndrome | Hydroxychloroquine | Antirheumatic Agents

Finland
Oxford BioMedica
The Methodist Hospital Research Institute; ORION Clinical Services

Completed

Safety and Biological Activity of TroVax® Vaccine Given With IL-2 in Renal Cell Carcinoma

Carcinoma, Renal Cell

United States
Rion Inc.
Professional Education and Research Institute

Recruiting

A Phase 2a Multi-Center, Prospective, Randomized Controlled Study to Evaluate the Safety and Efficacy of Topically Applied PEP-TISSEEL in Subjects With Diabetic Foot Ulcers (DFU)

Diabetic Foot Ulcer

United States
Diurnal Limited
Simbec Research; EMAS Pharma; Brush Clinical Research Ltd.; Voet Consulting; Medical...

Completed

Bioavailability of Infacort When Administered Onto Food Compared to Direct Oral Administration

Adrenal Insufficiency

United Kingdom
Diurnal Limited
Simbec Research; Brush Clinical Research Ltd.; Voet Consulting; Bionical Emas Ltd. and other collaborators

Completed

A Study of Chronocort® Versus Cortef ® in Healthy Adult Male Subjects

Adrenal Insufficiency

United Kingdom

Clinical Trials Sponsored by Simbec-Orion Research

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