Clinical Trials Sponsored by Sparks

Total 5163 results

Spark Therapeutics

Completed

Safety and Dose-escalation Study of AAV2-hCHM in Participants With CHM (Choroideremia) Gene Mutations

Choroideremia | CHM (Choroideremia) Gene Mutations

United States
Spark Therapeutics

Active, not recruiting

A Gene Transfer Study for Late-Onset Pompe Disease (RESOLUTE)

Lysosomal Storage Diseases | Glycogen Storage Disease Type II | Glycogen Storage Disease Type 2 | Pompe Disease (Late-onset) | Pompe Disease | LOPD | Acid Maltase Deficiency

United States, Canada, Netherlands, France, Denmark, Germany, Italy, United Kingdom
Spark Therapeutics

Active, not recruiting

Phase 1 Follow-on Study of AAV2-hRPE65v2 Vector in Subjects With Leber Congenital Amaurosis (LCA) 2

Leber Congenital Amaurosis

United States
Spark Therapeutics

Completed

Neutralizing Antibody Seroprevalence Study With a Retrospective Component in Participants With Late-Onset Pompe Disease

Lysosomal Storage Diseases | Glycogen Storage Disease Type 2 | Pompe Disease (Late-onset) | Pompe Disease | LOPD | Acid Maltase Deficiency

United States, Italy, United Kingdom, Netherlands, France, Germany
Spark Therapeutics

Completed

Safety Study in Subjects With Leber Congenital Amaurosis

Leber Congenital Amaurosis

United States
SPARK Biopharma

Recruiting

SB17170 Phase 1 Clinical Trial in Solid Tumors

Solid Tumor

Korea, Republic of
SPARK Biopharma

Completed

SB17170 Phase1 Trial in Healthy Volunteer

Pharmacokinetics | Pharmacodynamics | Safety Issues | Tolerability

Korea, Republic of
Spark Therapeutics

Active, not recruiting

A Patient Registry Study for Patients Treated With Voretigene Neparvovec in US

Confirmed Biallelic RPE65 Mutation-associated Retinal Dystrophy

United States
Spark Therapeutics

Active, not recruiting

Long-Term Safety and Efficacy of Spark-Sponsored Gene Therapies in Males With Hemophilia A

Hemophilia A

United States, Canada, Australia
Spark Therapeutics

Completed

A Gene Transfer Study for Hemophilia A

Hemophilia A

United States, Australia, Canada, Israel, Thailand
Spark Therapeutics

Active, not recruiting

Long-term Follow-up Study in Subjects Who Received Voretigene Neparvovec-rzyl (AAV2-hRPE65v2)

Inherited Retinal Dystrophy Due to RPE65 Mutations
Spark Therapeutics

Completed

Dose-finding Study of SPK-8016 Gene Therapy in Patients With Hemophilia A to Support Evaluation in Individuals With FVIII Inhibitors

Hematologic Diseases | Blood Coagulation Disorders, Inherited | Coagulation Protein Disorders | Hemorrhagic Disorders | Genetic Diseases, Inborn | Genetic Diseases, X-Linked | Gene Therapy | Blood Coagulation Disorder | Gene Transfer | Adeno-Associated Virus (AAV) | Factor VIII (FVIII) | Factor VIII (FVIII)... and other conditions

United States
Spark Therapeutics

Completed

Lead-in Study to Collect Prospective Efficacy and Safety Data of Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Participants

Hematologic Diseases | Hemophilia A | Blood Coagulation Disorders, Inherited | Coagulation Protein Disorders | Hemorrhagic Disorders | Genetic Diseases, Inborn | Genetic Diseases, X-Linked | Blood Coagulation Disorder | Factor VIII Deficiency

United States, Australia, Thailand, Canada
Spark Therapeutics, Inc.

Recruiting

Study of a Gene Therapy Treatment for Hemophilia A (KEYSTONE 1)

Hemophilia A

United States
Spark Biomedical, Inc.

Completed

Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal

Opioid-use Disorder | Opioid Withdrawal

United States
Spark Neuro Inc.

Recruiting

SPARK Neuro REMIND Study

Cognitive Impairment | Alzheimer Disease

United States
Spark Biomedical, Inc.

Completed

Novel Earpiece for Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal

Opioid-use Disorder | Opioid Withdrawal

United States
Autism Speaks

Completed

Promoting Development in Toddlers With Communication Delays

Autism Spectrum Disorder

United States
Stanford University
SPARK (Stanford University)

Suspended

A Study of Esomeprazole in Children With Autism

Autism Spectrum Disorder | Autism

United States
Douglas Sears

Completed

A Study of Combination Therapy in Children With ADHD

ADHD | Attention Deficit and Disruptive Behavior Disorders | Attention Deficit Hyperactivity Disorder | Attention Deficit Disorder With Hyperactivity | Mental Disorders Diagnosed in Childhood

United States
Mayo Clinic
Spark Neuro Inc.

Enrolling by invitation

Development of an EEG Diagnostic for Alzheimer's Disease

Alzheimer Disease | Mild Cognitive Impairment | Dementia With Lewy Bodies | Normal Control APOE e4 Carriers and Noncarriers

United States
Mayo Clinic
Spark Neuro Inc.

Completed

EEG Diagnostic for Repetitive Sub-concussive Head Impacts

Concussion

United States
Lithuanian Sports University

Recruiting

Effect of a 16-day Hot and Cold Acclimation on Adaptive Responses and Health-related Indicators

Healthy

Lithuania
Lithuanian Sports University

Completed

Effects of Head and Neck Cooling and Heating on Fatigue in Multiple Sclerosis and Healthy Men

Multiple Sclerosis

Lithuania
Lithuanian Sports University

Completed

The Effect of Manual Therapy and Therapeutic Exercises on Pain and Functional Status in Persons With Low Back Pain

Low Back Pain

Lithuania
Lithuanian Sports University

Completed

Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions

Fasting | Cold Exposure | Calorie Deficiency

Lithuania
Lithuanian Sports University

Completed

Effect of Kinesio Taping and Sham Taping in Knee Osteoarthritis (OA)

Osteoarthritis

Lithuania
Lithuanian Sports University

Completed

The Effect of Tai Chi Chuan in Older Adults

Healthy Aging | Cognitive Function | Motor Learning

Lithuania
Lithuanian Sports University

Completed

Physiotherapy for Non-specific Neck Pain in Working Age Persons

Neck Pain | Non-specific Neck Pain

Lithuania
Lithuanian Sports University

Completed

Effect of Passive Heat Therapy on Metabolism

Healthy

Lithuania
Lithuanian Sports University

Completed

Young Age Soccer Player's Lower Limb Muscle Imbalance and Functional Status

Healthy

Lithuania
Lithuanian Sports University

Completed

Effect of Kinesio Tape on Motor Function in Subjects With ACL Rupture

Rehabilitation | ACL Rupture

Lithuania
Lithuanian Sports University

Completed

The Effect of Aerobic Exercise in Overweight and Obese Women

Obesity | Overweight

Lithuania
Lithuanian Sports University

Completed

The Effect of Combined Aerobic Exercise and Calorie Restriction on Mood, Cognition, and Motor Behavior in Overweight and Obese Women

Obesity | Metabolic Syndrome

Lithuania
Neuropharm
Autism Speaks

Terminated

Extended Management and Measurement of Autism (EMMA)

Autistic Disorder

United States
Lithuanian Sports University

Completed

Electrostimulation and PFMT for Stress Urinary Incontinence

Urinary Incontinence, Stress

Lithuania
Lithuanian Sports University

Completed

Physiotherapy in Knee Osteoarthritis

Knee Osteoarthritis

Lithuania
Lithuanian Sports University

Completed

Physiotherapy in Stress Urinary Incontinence

Urinary Incontinence,Stress

Lithuania
Lithuanian Sports University

Completed

Balance and Leg Function After Hip Replacement

Hip Injuries | Hip Replacement | Coxarthrosis

Lithuania
Lithuanian Sports University

Completed

10-week Yoga Practice Effect on Cognitive and Motor Function in Older Adults (BDNF)

Aging | Healthy Aging

Lithuania
Neuropharm
Autism Speaks

Completed

Study of Fluoxetine in Autism (SOFIA)

Autistic Disorder

United States
Five Liters, Inc.

Recruiting

Delivering Transcutaneous Auricular Neurostimulation to Reduce Heavy Menstrual Bleeding in Von Willebrand Disease Patients (HMB/VWD)

Heavy Menstrual Bleeding | Von Willebrand Disease, Type 1

United States
AURA Paris

Completed

Immune Response Following COVID-19 in Hemodialysis Patients (IMMUNOVIDIAL)

COVID-19 | Cytokine Storm | Dialysis; Complications

France
Duke University
Miami-Dade County Parks and Recreation; Durham Parks and Recreation (Durham...

Recruiting

You & Me Healthy: Youth Empowered Self-Care Substudy (YES) (YES)

Anxiety | Wellness, Psychological

United States
University of Cincinnati
Spark Biomedical, Inc.

Not yet recruiting

tAN for PTSD and OUD in Buprenorphine Therapy

Opioid Use Disorder | Posttraumatic Stress Disorder

United States
The Cleveland Clinic
Blue Spark Technologies

Unknown

Accuracy and Precision Comparison of Temptraq

Temperature
Assistance Publique - Hôpitaux de Paris
ESPCI Paris

Completed

Sublingual Milk Immunotherapy in Children (Lactaide)

Cow Milk Allergy

France
Emory University
Autism Speaks

Completed

Structured Function-Based Elopement Treatment Program (FBET)

Autism Spectrum Disorder

United States
Yale University
Autism Speaks

Completed

Nicotinic Cholinergic Modulation as a Novel Treatment Strategy for Aggression Associated With Autism

Aggression | Autism Spectrum Disorder | Irritability

United States
Rocky Mountain Sports Medicine

Completed

Improvement of Body Image Flexibility in High School Female Athletes Doing Educational About Nutrition and Body Image

Body Image | Nutrition, Healthy

United States

Clinical Trials Sponsored by Sparks

Sponsors and Collaborators

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