Clinical Trials Sponsored by UNC Lineberger Comprehensive Cancer Center

Total 5612 results

UNC Lineberger Comprehensive Cancer Center

Completed

Feasibility of an Evidence-based Walking Program in Cancer Pts 60+ During Chemotherapy (WWE)

Breast Cancer | Lung Cancer | Colon Cancer

United States
UNC Lineberger Comprehensive Cancer Center

Active, not recruiting

De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study

Head and Neck Neoplasms | Carcinoma, Squamous Cell | Oropharyngeal Neoplasms

United States
UNC Lineberger Comprehensive Cancer Center

Active, not recruiting

Development and Application of a Novel Digital Array PCR for Acute Myeloid Leukemia (AML)

Leukemia, Myeloid, Acute | Minimal Residual Disease

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Contrast-Enhanced Ultrasound for Kidney Cancer Subtyping and Staging

Kidney Cancer

United States
UNC Lineberger Comprehensive Cancer Center

Terminated

Intervention to Address Psychosocial Needs Among Socially Disadvantaged Older Adults With Cancer

Hematological Disorder

United States
UNC Lineberger Comprehensive Cancer Center

Active, not recruiting

Genotype-Directed Study Of Irinotecan Dosing In FOLFIRI + BevacizumabTreated Metastatic Colorectal Cancer

Colon Cancer

United States
UNC Lineberger Comprehensive Cancer Center

Active, not recruiting

P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC

Head and Neck Neoplasms | Carcinoma, Squamous Cell | Oropharyngeal Neoplasms

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Functional Sparing of Salivary Glands Using MRI Sialography for Patients Undergoing Definitive Radiation Therapy for Head and Neck Cancers of the Oropharynx

Head and Neck Cancer | Oropharynx Cancer | Xerostomia Due to Radiotherapy

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients

Chronic Myeloid Leukemia | Chronic Myeloid Leukemia, Chronic Phase | CML, Chronic Phase | CML - Philadelphia Chromosome | CML (Chronic Myelogenous Leukemia

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Selective Image Guided Resection of Pathologically Documented Axillary Lymph Node Metastases (TAD)

Breast Cancer

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Evaluation of the Lung Nodule Sensitivity of Stationary Chest Tomosynthesis in Patients With Known Lung Nodules

Signs and Symptoms

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Hybrid PET/MR in the Therapy of Cervical Cancer

Cervical Adenosquamous Carcinoma | Cervical Squamous Cell Carcinoma | Cervix Carcinoma

United States
UNC Lineberger Comprehensive Cancer Center

Withdrawn

Neoadjuvant Therapy for Localized Rectal Adenocarcinoma

Rectal Adenocarcinoma

United States
UNC Lineberger Comprehensive Cancer Center

Completed

An Evaluation of the Fathers and Mothers With Cancer Communication Tool (Fam-CT)

Neoplasms | Cancer | Communication | Parent-Child Relations | Parenting | Parents

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Get REAL and HEEL Research Program

Breast Cancer

United States
UNC Lineberger Comprehensive Cancer Center

Completed

ARFI, VisR and DDAI Ultrasound for Improving Discrimination of Malignant and Unresponsive Breast Cancer

Breast Cancer

United States
UNC Lineberger Comprehensive Cancer Center

Withdrawn

Plasma Circulating Tumor DNA Analyses in ER+ Metastatic Breast Cancer

Metastatic Breast Cancer

United States
UNC Lineberger Comprehensive Cancer Center

Completed

PET/MR in Assessing Response to Neoadjuvant Radiation Therapy in the Tx of High Grade Sarcomas

Sarcoma

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Weekly Carboplatin, Paclitaxel and Cetuximab Treatment for Patients With Recurrent or Metastatic SCCHN

Head and Neck Cancer | Squamous Cell Carcinoma of the Head and Neck

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Multimedia Aid Gynecologic Counseling and Consent

Sentinel Lymph Node | Perioperative/Postoperative Complications | Endometrium Cancer

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Prospective Evaluation of Patient Reported Xerostomia After Whole Brain Radiation (NRR)

Xerostomia

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Assessing the Feasibility of Screening and Treating Anxiety and Depression in the Bone Marrow Transplant Population

Depression | Anxiety

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Geriatric Assessment Reporting in Real Time (GARRT) in Non-electively Hospitalized Older Cancer Patients

Oncology

United States
UNC Lineberger Comprehensive Cancer Center

Withdrawn

FLT PET/MR for Evaluation of Pseudoprogression in Patients With Brain Lesions

Brain Metastasis | Brain Metastases | Brain Lesions

United States
UNC Lineberger Comprehensive Cancer Center

Completed

Safety, Efficacy, and Dosing of Stereotactic Radiosurgery for Hepato-cellular Carc/Colo-rectal Liver Metastases

Liver Neoplasms | Colonic Neoplasms | Metastatic Cancer to Liver

United States
UNC Lineberger Comprehensive Cancer Center

Completed

The Ability of Electronic Patient Symptom Reporting to Reduce Symptom Burden During Hospitalization for Chemotherapy

Stem Cell Transplantation, Hematopoietic

United States
UNC Lineberger Comprehensive Cancer Center

Completed

BKM120 + mFOLFOX6 in Advanced Solid Tumors With Expansion Cohort Pancreatic Cancer

Metastatic Colorectal Cancer | Advanced Solid Tumors | Metastatic Pancreatic Cancer

United States
UNC Lineberger Comprehensive Cancer Center

Terminated

Pilot Study: Utilizing Manometry to Assess Radiation-Induced Changes in Esophageal Function

Lung Cancer

United States
UNC Lineberger Comprehensive Cancer Center

Withdrawn

Crossover Evaluation of Effect of Atorvastatin on PK of Irinotecan in CRC Patients Receiving FOLFIRI

Advanced Adenocarcinoma of the Colon or Rectum

United States
UNC Lineberger Comprehensive Cancer Center
Seagen Inc.

Completed

Induction Chemo w/ABVD Followed by Brentuximab Vedotin Consolidation in Newly Diagnosed, Non-Bulky Stage I/II Hodgkin Lymphoma

Hodgkin Lymphoma, Adult

United States
UNC Lineberger Comprehensive Cancer Center
Genentech, Inc.

Terminated

Efalizumab in Treating Patients With Graft-Versus-Host Disease of the Skin That Did Not Respond to Previous Steroids (NRR)

Graft Versus Host Disease

United States
UNC Lineberger Comprehensive Cancer Center
GlaxoSmithKline

Completed

LCCC 1128: Open Label Phase II Trial of the BRAF Inhibitor (Dabrafenib) and the MEK Inhibitor (Trametinib) in Unresectable Stage III and Stage IV BRAF Mutant Melanoma; Correlation of Resistance With the Kinome and Functional Mutations

Unresectable Melanoma | Stage IV Melanoma | Stage III Melanoma | BRAF Mutant Melanoma

United States
UNC Lineberger Comprehensive Cancer Center
Pfizer

Terminated

Phase II Trial of Palbociclib in Patients With Metastatic Urothelial Cancer After Failure of First-Line Chemotherapy

Metastatic Urothelial Carcinoma (UC)

United States
UNC Lineberger Comprehensive Cancer Center
GlaxoSmithKline

Completed

Neoadjuvant Pazopanib in Renal Cell Carcinoma

Renal Cell Carcinoma

United States
UNC Lineberger Comprehensive Cancer Center
Veracyte, Inc.

Recruiting

Harnessing Analysis RNA Expression and Molecular Subtype to Optimize Novel TherapY MBCA (HARMONY)

Breast Cancer

United States
UNC Lineberger Comprehensive Cancer Center
Seagen Inc.

Active, not recruiting

BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma

Lymphoma | Lymphatic Diseases | Adult T-Cell Leukemia/Lymphoma

United States
UNC Lineberger Comprehensive Cancer Center
Genentech, Inc.

Completed

Cancer Patients' Performance Status Assessed Using Cardiopulmonary Exercise Testing and Wearable Data Generation

Hematologic Malignancies | Malignant Solid Tumor

United States
UNC Lineberger Comprehensive Cancer Center
Genentech, Inc.

Recruiting

Polatuzumab Vedotin With R-GDP in Relapsed/Refractory Diffuse Large B-cell Lymphoma

Diffuse Large B-cell Lymphoma

United States
UNC Lineberger Comprehensive Cancer Center
AstraZeneca

Recruiting

A Pilot Study of Acalabrutinib in Relapsed/Refractory Primary and Secondary CNS Lymphomas

Central Nervous System Lymphoma

United States
UNC Lineberger Comprehensive Cancer Center
Amgen

Completed

Denosumab + PD-1 in Subjects With Stage III/ IV Melanoma

Melanoma | Melanoma (Skin) | Melanoma Stage Iv | Melanoma Stage Iii | Cutaneous Melanoma

United States
UNC Lineberger Comprehensive Cancer Center
GlaxoSmithKline

Active, not recruiting

Multimodality Risk Adapted Tx Including Induction Chemo for SCCHN Amenable to Transoral Surgery

Head and Neck Cancer | Squamous Cell Carcinoma of the Head and Neck

United States
UNC Lineberger Comprehensive Cancer Center
Pfizer

Completed

The STEPP Study: Sensors To Evaluate Physical Performance (STEPP)

Oncology

United States
UNC Lineberger Comprehensive Cancer Center
Cephalon

Terminated

Trisenox® in Women With Metastatic Endometrial Cancer (NRR)

Endometrial Carcinoma

United States
UNC Lineberger Comprehensive Cancer Center
Sanofi

Completed

Docetaxel, Androgen Ablation, and External-Beam Radiation Therapy in Patients With High-Risk Localized Prostate Cancer (NRR)

Prostate Cancer

United States
UNC Lineberger Comprehensive Cancer Center
Cephalon

Completed

Bendamustine + Rituximab in Older Patients With Previously Untreated Diffuse Large B-cell Lymphoma

Lymphoma | Diffuse Large B-Cell Lymphoma | Lymphoma, Diffuse Large-Cell | Diffuse Large-Cell Lymphoma

United States
UNC Lineberger Comprehensive Cancer Center
GlaxoSmithKline

Withdrawn

Ofatumumab In Older Patients With Untreated Low Or Intermediate Risk Indolent B-Cell Lymphomas

Lymphoma, Follicular | Lymphoma, Non-Hodgkin | Lymphoma, B-Cell, Marginal Zone | Lymphoma, Low-Grade | Lymphoma, Intermediate-Grade
UNC Lineberger Comprehensive Cancer Center
Amgen

Withdrawn

Selective IMRT for Locally Advanced Head and Neck Carcinoma With Concurrent Panitumumab

Head and Neck Cancer
UNC Lineberger Comprehensive Cancer Center
University Cancer Research Fund at Lineberger Comprehensive Cancer Center

Recruiting

CD30 CAR for CD30+ NSGCT

Nonseminomatous Germ Cell Tumor | Germ Cell Tumor

United States
UNC Lineberger Comprehensive Cancer Center
AstraZeneca

Active, not recruiting

Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN

Oral Cancer | Larynx | Lip | Digestive Organs--Diseases

United States
UNC Lineberger Comprehensive Cancer Center
Celgene

Completed

Lenalidomide as Consolidation and Maintenance in Adults >/= 60 Years of Age With AML Following Standard Induction

Acute Myeloid Leukemia

United States

Clinical Trials Sponsored by UNC Lineberger Comprehensive Cancer Center

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