Search clinical trials for: PDE4 inhibitor

Total 67453 results

NMP Medical Research Institute

Completed

Homeopathy as an Adjuvant to Chemotherapy Improves Clinical Outcome in Relapsed Pulmonary Tuberculosis

Pulmonary Tuberculosis

India
Assiut University

Unknown

Assessment of Early Outcomes of Roflumilast in Patients With Non Cystic Fibrosis Bronchiectasis

Bronchiectasis
Tianjin Hemay Pharmaceutical Co., Ltd

Completed

Efficacy and Safety Study of Hemay005 in Subjects With Moderate to Severe Plaque Psoriasis

Psoriasis

China
Pfizer

Completed

A Study To Evaluate the Safety, Tolerability, And Pharmacokinetics Of PF-06266047 In Healthy Adult Subjects

Healthy Volunteers

Belgium
GlaxoSmithKline

Completed

A Repeat Dose Study in Healthy Volunteers Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK356278

Huntington Disease

Netherlands
Chiesi Farmaceutici S.p.A.

Completed

A Study to Evaluate the Efficacy After Allergen Challenge, Safety and Tolerability of Inhaled CHF6001 DPI in Asthmatics (CHF6001_POC2)

Asthma

United Kingdom
Chiesi Farmaceutici S.p.A.

Completed

A 24-wk Dose Ranging Study to Evaluate the Efficacy and Safety of 4 Doses of a New PDE4 Inhibitor in Patients With COPD (PIONEER)

Chronic Obstructive Pulmonary Disease
Amgen

Completed

Safety and Efficacy Study of Apremilast to Treat Psoriatic Arthritis

Psoriatic Arthritis

Spain, Canada, United States, Czechia, Russian Federation, Hungary, Australia, New Zealand, Estonia, Romania
GlaxoSmithKline

Completed

Topical GW842470X In Adults Patients With Moderate Atopic Dermatitis

Dermatitis, Atopic | Atopic Dermatitis

Germany, Netherlands
National Institute of Mental Health (NIMH)

Completed

Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients

Healthy | Major Depressive Disorder

United States
NHS Greater Glasgow and Clyde

Completed

Immune Metabolic Associations in Psoriatic Arthritis (IMAPA)

Psoriasis | Psoriatic Arthritis

United Kingdom
Icahn School of Medicine at Mount Sinai
Pfizer

Recruiting

PDE4 Inhibition in Seborrheic Dermatitis and Papulopustular Rosacea

Seborrheic Dermatitis | Papulopustular Rosacea

United States
Chiesi Farmaceutici S.p.A.

Recruiting

Efficacy and Safety of Tanimilast in Asthmatics uNcontrolled on ICS-containinG backgrOund Maintenance Therapy (TANGO)

Uncontrolled Asthma

Argentina, Bulgaria, Czechia, Georgia, Germany, Hungary, Italy, Korea, Republic of, Latvia, Lithuania, Poland, Romania, South Africa, Spain
Chiesi Farmaceutici S.p.A.

Recruiting

A 52-week, Placebo-controlled Study to Evaluate the Efficacy and Safety of 2 Doses of CHF6001 DPI (Tanimilast), as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis (PILASTER) (PILASTER)

Chronic Obstructive Pulmonary Disease

Bulgaria, United States, Albania, Argentina, Australia, Austria, Bosnia and Herzegovina, Chile, China, Czechia, Georgia, Germany, Greece, Hungary, Israel, Italy, Mexico, Netherlands, New Zealand, North Macedonia, Poland, Romania, Russian... and more
Duke University
Pfizer

Completed

Pilot Study Evaluating the Efficacy of a Topical PDE4 Inhibitor for Morphea

Morphea

United States
Chiesi Farmaceutici S.p.A.

Recruiting

A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR) (PILLAR)

Chronic Obstructive Pulmonary Disease

Bulgaria, United States, Argentina, Austria, Bosnia and Herzegovina, Chile, Croatia, Czechia, Estonia, Germany, Greece, Hungary, Israel, Latvia, Mexico, Netherlands, New Zealand, North Macedonia, Poland, Romania, Russian Federation and more
Tufts Medical Center
Celgene Corporation

Completed

Study of Apremilast in Atopic or Contact Dermatitis

Atopic Dermatitis | Allergic Contact Dermatitis

United States
Maastricht University
Netherlands Brain Foundation

Completed

Roflumilast to Treat Cognitive Sequela After Stroke (ROSTMEMA)

Cerebrovascular Disorders | Functional Recovery | Memory | Drug Intervention

Netherlands
Maastricht University Medical Center

Recruiting

Cognitive Effects of Roflumilast in (a)MCI and Mild Dementia Patients (ROMEMA)

Mild Cognitive Impairment | Mild Dementia | Amnestic Mild Cognitive Disorder

Netherlands
Maastricht University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Completed

Roflumilast and Cognition (EEGrofl)

Dementia

Netherlands
Ganzhou Hemay Pharmaceutical Co., Ltd

Recruiting

A Study of Efficacy and Safety of Hemay005 Tablets in Patients With Behçet's Disease

Behçet's Disease

China
Tianjin Hemay Pharmaceutical Co., Ltd

Terminated

A Study to Evaluate the Efficacy and Safety of Hemay005 in the Treatment of Behçet Disease

Behçet Disease

China
National Institute of Mental Health (NIMH)

Completed

PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome

Nervous System Disease

United States
Arcutis Biotherapeutics, Inc.

Completed

Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (INTEGUMENT-I)

Atopic Dermatitis Eczema

United States, Canada
Arcutis Biotherapeutics, Inc.

Completed

Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (Integument-PED)

Atopic Dermatitis Eczema

United States, Canada
GlaxoSmithKline

Completed

Healthy Volunteer Positron Emission Tomography (PET) Brain Occupancy Study of a Phosphodiesterase 4 (PDE4) Inhibitor in Huntington's Disease

Huntington Disease

United Kingdom
Arcutis Biotherapeutics, Inc.

Completed

Trial of PDE4 Inhibition With Roflumilast for the Management of Plaque Psoriasis (DERMIS-1)

Chronic Plaque Psoriasis

United States, Canada
Assistance Publique - Hôpitaux de Paris
Société de Dermatologie Française

Completed

Assessing the Long Term Effectiveness and Safety of Systemic Treatments in Cutaneous Psoriasis (PSOBIOTEQ)

Psoriasis

France
Arcutis Biotherapeutics, Inc.

Completed

Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (INTEGUMENT-II)

Atopic Dermatitis Eczema

United States, Canada
Astellas Pharma Inc

Completed

A Proof-of-principle Study of Oral Treatment of Non-alcoholic Steatohepatitis With a Novel PDE4 Inhibitor ASP9831 (ASTER)

Non-Alcoholic Steatohepatitis

United Kingdom, Belgium, Switzerland, Germany, France, Romania, Czech Republic
Arcutis Biotherapeutics, Inc.

Completed

Twin Trial of PDE4 Inhibition With Roflumilast for the Management of Plaque Psoriasis (DERMIS-2)

Chronic Plaque Psoriasis

United States, Canada
Arcutis Biotherapeutics, Inc.

Completed

Trial of PDE4 Inhibition With Roflumilast (ARQ-154) Foam 0.3% for the Management of Seborrheic Dermatitis (STRATUM)

Seborrheic Dermatitis

United States, Canada
Arcutis Biotherapeutics, Inc.

Completed

Open-Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Plaque Psoriasis (DERMIS-OLE)

Chronic Plaque Psoriasis

United States, Canada, Dominican Republic
Arcutis Biotherapeutics, Inc.

Active, not recruiting

Open Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (INTEGUMENT-OLE)

Atopic Dermatitis Eczema

United States, Canada
MedSIR
Stemline Therapeutics, Inc.

Not yet recruiting

Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i. (ADELA)

Advanced Breast Cancer | ER-positive Breast Cancer | HER2-negative Breast Cancer | ESR1 Gene Mutation
Centre Hospitalier Universitaire, Amiens
University Hospital, Rouen; University Hospital, Lille

Recruiting

Non-steroidal Anti-inflammatory in Cardiac Surgery (KETOPAIN)

Cardiac Surgery | Acute Postoperative Pain | Pain Intensity | Multimodal Pain Management | Non-steroidal Anti-inflammatory Drugs

France
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Not yet recruiting

A Study Comparing BL-B01D1 With Platinum Based Chemotherapy in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
University of Florida

Not yet recruiting

Examining the Impact of High-protein Oral Supplement With Liposomal Curcumin on Inflammation Markers and Oxidative Stress in Adults Undergoing Hemodialysis.

Chronic Kidney Disease 5D
Primus Pharmaceuticals
Sun Valley Arthritis Center

Recruiting

Effect of Metaxalone 640 mg (M640) on Truck Driving Ability and Cognition Compared to Other Skeletal Muscle Relaxants

Cognitive Impairment

United States
Washington University School of Medicine
American Academy of Clinical Toxicology

Not yet recruiting

Rivastigmine for Antimuscarinic Delirium: a Randomized, Placebo-controlled Trial (RIVA-AM)

Anticholinergic Toxicity

United States
Children's Hospital of Fudan University

Not yet recruiting

Thalidomide Therapy for VEOIBD

Inflammatory Bowel Diseases
Acerand Therapeutics (Shanghai) Limited

Recruiting

Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors

Breast Cancer | Ovarian Cancer | Prostate Cancer | BRCA1 Mutation | BRCA2 Mutation | Solid Tumor, Adult

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Bayesian Basket Trial (PALETTE)

Sepsis
Mayo Clinic
National Cancer Institute (NCI)

Not yet recruiting

Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advance or Metastatic Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma | Locally Advanced Pancreatic Adenocarcinoma | Unresectable Pancreatic Adenocarcinoma

United States
AstraZeneca

Not yet recruiting

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer (EvoPAR-BR01)

Advanced Breast Cancer

Canada
University of Salerno

Not yet recruiting

Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients (BESAFE)

Cardiovascular Diseases | Dyslipidemias | Lipid Metabolism Disorders | Statin Adverse Reaction
Northwell Health

Recruiting

Impact of Preoperative Opioid-free Multimodal Analgesia on Time to Trial of Void in Ambulatory Urogynecologic Surgeries

Pain, Postoperative | Postoperative Pain, Acute

United States
Infectopharm Arzneimittel GmbH
Winicker Norimed GmbH

Not yet recruiting

Therapy for Scabies With Two Differently Concentrated Permethrin Creams (SKABUP)

Scabies
Ganzhou Hemay Pharmaceutical Co., Ltd

Not yet recruiting

To Evaluate the Pharmacokinetics of Hemay005 Tablets in Patients With Renal Impairment

Psoriasis
KU Leuven
Utrecht University

Recruiting

Virtual Reality Exposure for Socially Anxious Adolescents (VIRTUS)

Social Anxiety

Belgium

Search clinical trials for: PDE4 inhibitor

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