Search clinical trials for: Pharmacodynamic profile

Total 5547 results

Chipscreen Biosciences, Ltd.

Not yet recruiting

A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic Profiles and Food Effect of CS32582 Capsules

Healthy

China
Mabscale, LLC

Recruiting

Study, Evaluating Pharmacokinetics, Pharmacodynamics, Immunogenicity and Safety Profiles of Rituximab Compared to MabThera® in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

Russian Federation
Shanghai Junshi Bioscience Co., Ltd.

Recruiting

A Clinical Trial Evaluated the Safety and Tolerability, Pharmacokinetic and Pharmacodynamics Profile, and Immunogenicity of a Single Dose of JS010 Injection in Healthy Subjects

Migraine

China
Zhuhai Trinomab Pharmaceutical Co., Ltd.

Not yet recruiting

A Trial to Evaluate the Safety, Pharmacokinetics and Pharmacodynamic Profile of TNM005 in Healthy Adult Subjectsy

Varicella

United States
Peking University First Hospital

Not yet recruiting

Imapct of bioMarkers on Pharmacodynamics and Bleeding Risk of Direct Oral AntiCoagulants and Ticagrelor Study II

Bleeding | Pharmacodynamics | Apixaban | Pharmacogenomics | Biomarker | Ticagrelor | Rivaroxaban | Novel Oral Anticoagulants | NOACs | Dabigatran | Edoxaban | RNA Profile

China
University of Oxford

Recruiting

A Phase 2 Trial Comparing Antiviral Treatments in Early Symptomatic Influenza (AD ASTRA)

Influenza | Influenza, Human

Thailand
The Hospital for Sick Children

Recruiting

Safety and PK-PD Study of Oral L-CIT in Preterm Infants With BPD±PH and NEC

Pulmonary Hypertension | NEC | BPD - Bronchopulmonary Dysplasia

Canada
LaSanta S A S

Not yet recruiting

Pharmacokinetic and Pharmacodynamic Evaluation of Formulations of Δ9-THC

Neoplasms | Vomiting | Cancer Pain | Nausea Post Chemotherapy | Cancer Related Pain

Colombia
Duke University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (POPS or POP02)

Heart Failure | Pain | Pneumonia | Hypertension | Edema | Hemophilia | Insomnia | Pulmonary Arterial Hypertension | Coagulation Disorder | Asthma in Children | Down Syndrome | Attention Deficit Hyperactivity Disorder | Bronchopulmonary Dysplasia | Hypokalemia | Hyperphosphatemia | Primary Hyperaldosteronism | Adrenal Insufficiency and other conditions

United States, Canada
St. Jude Children's Research Hospital
Baylor College of Medicine; Gateway for Cancer Research

Active, not recruiting

Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I

Acute Lymphoblastic Leukemia

United States, Canada
National Cancer Institute (NCI)

Active, not recruiting

Sunitinib or Cediranib for Alveolar Soft Part Sarcoma

Sarcoma, Alveolar Soft Part

United States
Response Pharmaceuticals

Completed

Safety, Tolerability, and Pharmacodynamic Profile of Oral 2101 in Secondary Raynaud's Disease

Raynaud's Disease

Germany
Fresenius Kabi SwissBioSim GmbH

Completed

A Study to Evaluate the Efficacy, Pharmacodynamics, Safety, and Immunogenicity of FKS518 in Postmenopausal Women With Osteoporosis

Postmenopausal Osteoporosis

Hungary, Poland, Georgia, Bulgaria, Czechia, Estonia
Ionis Pharmaceuticals, Inc.

Completed

Evaluate the Safety and Tolerability, as Well as the Pharmacokinetic and Pharmacodynamic Profiles of Single and Multiple Doses of Eplontersen Administered Subcutaneously to Healthy Volunteers and Patients With Hereditary Transthyretin-Mediated Amyloidosis (hATTR ).

Healthy Volunteers | hATTR Amyloidosis

Canada
Chong Kun Dang Pharmaceutical

Completed

A Clinical Traial to Assess Pharmacokinetic/Pharmacodynamic Profiles and Safety of CKD-843

Alopecia

Korea, Republic of
Inventage Lab., Inc.

Completed

A Clinical Trial to Assess Pharmacokinetic/Pharmacodynamic Profiles and Safety of IVL3001

Androgenetic Alopecia

Australia
Enteris BioPharma Inc.
Syneos Health

Completed

A Study of Pharmacokinetic/Pharmacodynamic Profile of Orally Administered Leuprolide in Healthy Female Volunteers

Endometriosis

Canada
Bial - Portela C S.A.

Terminated

Effect of Age-gender on the Pharmacokinetic and Pharmacodynamic Profiles of BIA 5 1058

Pulmonary Arterial Hypertension
Medicines for Malaria Venture
Nucleus Network Ltd; Southern Star Research Pty Ltd.

Completed

Assess Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of Ruxolitinib With Artemether-lumefantrine

Malaria

Australia
Shire

Completed

Pharmacodynamic Profile of SPD489 in Healthy Adult Males Undergoing a Nocturnal Period of Acute Sleep Loss

Sleep Deprivation

United States
Guerbet

Completed

Pharmacokinetics, Pharmacodynamics Profile and Tolerance of P03277 in Healthy Subjects and Patients With Brain Lesions

Healthy Volunteers | Brain Lesion

Belgium
Fruithy Medical Pty Ltd

Completed

Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of HYR-PB21 in Healthy Volunteers

Acute Postoperative Pain

Australia
Novartis

Completed

Pharmacokinetic and Pharmacodynamic Profiles of Aliskiren in Japanese Patients With Mild to Moderate Essential Hypertension

Hypertension

Japan
Philip Morris Products S.A.

Completed

Nicotine Pharmacokinetic and Pharmacodynamics Profile, Safety and Tolerability of P3L

Smoking

New Zealand
Philip Morris Products S.A.

Completed

Study to Investigate the Nicotine Pharmacokinetic Profiles and Pharmacodynamic Effects of P4M3 Variants

Vaping | Nicotine Absorption

United States
Lee's Pharmaceutical Limited

Completed

A Study to Evaluate the Safety and Tolerability of Tecarfarin in Healthy Chinese Volunteers

Pharmacokinetic and Pharmacodynamic Profile of Tecarfarin

Hong Kong
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

First-in-Human Study of the Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Profile of VX-984 in Combination With Chemotherapy

Advanced Solid Tumor

United States
Ipsen

Completed

BN83495 in Prostate Cancer (STX64PC)

Prostate Cancer

United States
Laboratorios Silanes S.A. de C.V.

Completed

Clinical Trial to Evaluate Safety and pK Profile of Metformin Glycinate in Healthy Volunteers (NTC00940472)

Healthy

Spain
GlaxoSmithKline

Completed

A Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic (PD) Profiles of 3 Doses of Fluticasone Furoate (FF)/GW642444 Inhalation Powder at the End of a 28-day Treatment Period in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Compared to Placebo

Pulmonary Disease, Chronic Obstructive

United States
Stanford University

Completed

Effects of Epidural Lidocaine on the Pharmacokinetic and Pharmacodynamic Profiles of DepoDur® After Cesarean Delivery

Epidural Analgesia, Obstetric

United States
Merck Sharp & Dohme LLC

Completed

A Study Comparing the Pharmacokinetic and Pharmacodynamic Profiles for Sitagliptin, Saxagliptin and Vildagliptin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-142)

Type 2 Diabetes Mellitus
Centre Hospitalier Universitaire, Amiens

Withdrawn

Evaluation of the Pharmacokinetic Profile, Pharmacodynamic Effects, Acceptability and Tolerability of an Oral Amiodarone Solution of 15 mg / mL in Children With Supra Ventricular Tachycardia (Enteramio)

Supraventricular Tachycardia

France
GlaxoSmithKline

Completed

Pharmacokinetics and PharmacoDynamics of GW685698 in Paedeatric Asthmatic Patients

Asthma

United States
Northumbria University
Plant & food Research Ltd

Completed

Pharmacodynamic Profile of 'Blackadder' Blackcurrant Juice Effects Upon the Monoamine Axis in Humans

Monoamine Oxidase Inhibitor Activity | Prolactin Levels | Postprandial Blood Glucose
Bial - Portela C S.A.

Completed

Study to Investigate the Safety, Tolerability, Steady State Pharmacokinetic and Pharmacodynamic Profile of BIA 3-202

Parkinson's Disease

United Kingdom
Bial - Portela C S.A.

Completed

Safety, Tolerability, Pharmacokinetic, Including Food Interaction, and Pharmacodynamic Profile of BIA 5-1058.

Hypertension and Chronic Heart Failure

Netherlands
Chongqing Medical University

Completed

Pharmacokinetic and Pharmacodynamic Profile of Insulin Lispro Using Needle-Free Jet Injection Technology

Healthy

China
University of Florida
AstraZeneca

Completed

Impact of Ticagrelor Re-load on Pharmacodynamic Profiles

Coronary Artery Disease

United States
UCB Celltech
Parexel

Completed

Study to Assess the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profiles of UCB5857 in Healthy Subjects

Healthy Volunteers

United Kingdom
Bial - Portela C S.A.

Completed

The Effect of BIA 2-093 on the Steady-state Pharmacodynamic and Pharmacokinetic Profiles of Warfarin

Epilepsy
Neurovance, Inc.

Completed

A Study to Evaluate the Safety, Tolerance, and Pharmacokinetic and Pharmacodynamic Profile Of 1 SR Formulation of EB-1020

Normal, Healthy Volunteers

Australia
Teva Branded Pharmaceutical Products R&D, Inc.

Completed

Pharmacokinetic and Pharmacodynamic Profiles of Albuterol Spiromax® and ProAir® Hydrofluoroalkane (HFA) in Pediatric Patients With Asthma

Asthma

United States
Dey

Completed

A Study Characterizing Pharmacodynamic Profiles in Subjects With Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD)

United States
Ferrer Internacional S.A.

Terminated

Single Dose Study to Compare the Pharmacodynamics of Torasemide-PR 10 mg,Torasemide-IR 10 mg and Furosemide-IR 40 mg in Patients With Compensated Heart Failure

Compensated Heart Failure

Spain
Asan Medical Center
Institut de Recherches Internationales Servier

Completed

Pharmacokinetic, Pharmacodynamic Profiles and Safety After Oral Administration of Ivabradine in Male Healthy Korean Volunteers

Healthy Individual

Korea, Republic of
Sanofi

Completed

Pharmacokinetic Profile and Pharmacodynamic Characteristics of a Furosemide High Dosage Formulation in Patients With Chronic Renal Failure Undergoing Peritoneal Dialysis

Renal Failure

Canada
CrystalGenomics, Inc.

Unknown

Examine Maximum Tolerated Dose and Pharmacokinetic and Pharmacodynamic Profile

Solid Tumour

Korea, Republic of
Norgine

Completed

A Three-Period Study to Investigate the Relative Bioavailability and Pharmacodynamic Profiles of a Zegerid 20mg Capsule, Zegerid 20mg Powder for Oral Suspension and Losec 20mg Capsule in Healthy Adult Volunteers Under Fasting Conditions

Acid Reflux | Gastro Oesophageal Reflux Disease

United Kingdom
Universidad del Desarrollo

Completed

Propofol Effect-Site Target Controlled Infusion in the Obese: Characterization of the Time Profile of Bispectral Index Response

Obesity

Chile

3

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