Search clinical trials for: Phase+1

Total 59732 results

Imperial College London
Medical Research Council

Completed

Safety and Pharmacokinetic Study of Y242 in Adult Subjects (Y242-01)

Obesity

United Kingdom
The Affiliated Hospital of Qingdao University

Unknown

Bioequivalence of Oral Formulations of Anastrozole in Healthy Chinese Volunteers Under Fasted Condition

Healthy Volunteers

China
The Affiliated Hospital of Qingdao University

Completed

Pharmacokinetics and Bioequivalence of Rivaroxaban Tablet in Healthy Chinese Volunteers

Healthy Subjects

China
The Affiliated Hospital of Qingdao University

Completed

Bioequivalence of Levamlodipine Besylate Tablets in Healthy Chinese Subjects

Healthy Subjects

China
Ology Bioservices
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Study to Evaluate Safety and PK of NTM-1634 vs Placebo Administered Intravenously in Healthy Adults

Healthy

United States
MassBiologics

Completed

Evaluate the Safety Pharmacokinetics of a Human Monoclonal Antibody S315 Against Diphtheria Toxin in Healthy Subjects (S315)

Diphtheria

United States
Neuraly, Inc.

Completed

A Phase 1 Study to Assess the Safety of NLY01 in Healthy Subjects (NLY01-H1)

Safety and Tolerability in Healthy Volunteers

United States
Suven Life Sciences Limited

Completed

Effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-911 in Healthy Subjects (SUVN-911)

Major Depressive Disorder

United States
Exvastat Ltd.
Parexel

Completed

A Study to Investigate the Effects of Imatinib on Pulmonary Vascular Dysfunction in a Human Model of Lung Injury

Acute Lung Injury

United Kingdom
Heptares Therapeutics Limited

Completed

Phase I, Healthy Subject, Safety, Tolerability and Pharmacokinetic Study of an M1 Agonist to Treat Cognitive Impairment

Alzheimer's Disease

United Kingdom
Astellas Pharma Europe B.V.

Completed

A Study to Evaluate How Tamsulosin (at 1 Dose) and Solifenacin (at 2 Different Doses) Are Taken up From the Intestine, Distributed Through the Body and Eliminated From the Body When Administered in Combination as a Single Tablet (Called EC905)

Healthy Subjects | Pharmacokinetics | EC905 | Multiple Dose

United Kingdom
Astellas Pharma Europe B.V.

Completed

A Study to Evaluate Whether Food Has an Effect on the Uptake of Solifenacin and Tamsulosin When Administered in a Combination Tablet

Healthy Subjects | Pharmacokinetics | EC905

United Kingdom
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study to Evaluate the Effect of Multiple Doses of Esomeprazole on the Pharmacokinetics of Isavuconazole

Healthy Subjects | Pharmacokinetics of Isavuconazole

United States
Astellas Pharma Europe B.V.

Completed

A Study to Investigate the Appearance and Disappearance of ASP3652 in Blood and Spinal Fluid in Healthy Male Subjects

Healthy Subjects | Pharmacokinetics of ASP3652 | Pharmacodynamics of ASP3652

United Kingdom
Astellas Pharma Europe B.V.

Completed

A Study to Assess the Effect of Multiple Doses of Gemfribozil on a Single Dose of ASP3652, and to Assess the Effects of Multiple Doses of ASP3652 on a Single Dose of Repaglinide in the Body of Healthy Subjects

Healthy Subjects | Drug-Drug Interaction (DDI)

United Kingdom
Moberg Pharma AB

Completed

A Double-blind, Randomized, Single Centre, Vehicle-controlled Study to Evaluate the Safety and Tolerability of a New Topical Formulation Containing 0,09% Imiquimod (Limtop) in Healthy Subjects (Limsafe)

Healthy

Germany
Orion Corporation, Orion Pharma

Completed

Bioequivalence Study Comparing Two Alprazolam 1 mg Tablets Under Fed Conditions

Healthy

Finland
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Pilot Study on Budesonide/Formoterol Device-metered Dry Powder Inhaler

Healthy

Finland
Pfizer

Completed

Phase I Study of the Clinical Pharmacology of Azithromycin in Buffy Coat of HIV-Infected Subjects.

HIV Infections | Bacterial Infections

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Eltrombopag Olamine in Treating Thrombocytopenia in Patients With Chronic Myeloid Leukemia or Myelofibrosis Receiving Tyrosine Kinase Therapy

Primary Myelofibrosis | Thrombocytopenia | Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive

United States
The Affiliated Hospital of Qingdao University
Chenland Nutritionals Inc.

Recruiting

Pharmacokinetics and Bioavailability of Curcumin UP 30 Capsules in Healthy Adult Subjects (CuminUP30)

Healthy Adult Subjects

China
Xencor, Inc.
ICON Clinical Research

Completed

Safety, Tolerability and PK of a Single Subcutaneous Injection of XmAb27564 in Healthy Volunteers

Safety in Healthy Volunteers

United States
Eleusis Therapeutics

Completed

A Dose-Ranging Study of 50 µg to 100 µg LSD in Healthy Volunteers

Healthy

United Kingdom
Astellas Pharma Global Development, Inc.

Completed

A Study to Assess Bioequivalence of Fezolinetant Formulations in Healthy Female Participants

Healthy Volunteers

United States
The Affiliated Hospital of Qingdao University

Completed

Pharmacokinetic and Safety Comparison of Two Capecitabine Tablets in Patients With Colorectal or Breast Cancer

Patient Participation

China
Perosphere Pharmaceuticals Inc, a wholly owned...
Quintiles, Inc.

Completed

A Study to Determine the Inter/Intra Observer and Intra-subject Variability of Whole Blood Clotting Time Measurements

Healthy

United States
Takeda

Completed

A Study to Evaluate the Pharmacokinetics of Dexlansoprazole 30 Milligram (mg) and 60 mg Delayed-release Capsules in Healthy Chinese Participants

Healthy Volunteers

China
H. Lundbeck A/S

Completed

Single Ascending Dose Study of Lu AF76432 in Healthy Young Men

Healthy

United Kingdom
Topivert Pharma Ltd

Completed

Study for Safety and Tolerability of TOP1288 Administered Orally in Healthy Subjects

Ulcerative Colitis

United Kingdom
Enzychem Lifesciences Corporation

Completed

A Safety and PK Study of EC-18 in Healthy Subjects

Chemotherapy-induced Neutropenia

United States
Dr. August Wolff GmbH & Co. KG Arzneimittel
Parexel

Completed

Safety, Tolerability, Pharmacokinetics and Efficacy of WOL071-007 in Atopic Dermatitis Patients

Dermatitis, Atopic

Germany
Astellas Pharma Europe B.V.

Terminated

A Study to Assess the Safety and Tolerability, Including Gastrointestinal Safety, Pharmacokinetics and Pharmacodynamics of ASP7657 in Caucasian Healthy Male and Female Subjects

Healthy Subjects | Pharmacokinetics of ASP7657 | Pharmacodynamics of ASP7657

United Kingdom
Astellas Pharma Europe B.V.

Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP3700 in Healthy Male Subjects

Healthy Volunteers | Pharmacokinetics of ASP3700

United Kingdom
Astellas Pharma Europe B.V.

Completed

A Study to Assess the Effect of Race on How a Single Dose of ASP3652 is Taken up, Metabolized and Distributed Through the Bodies of Young, Healthy Male and Female Subjects, and Its Safety and Tolerability

Healthy Subjects | Pharmacokinetics | Pharmacodynamics | Effect of Race

United Kingdom
Astellas Pharma Global Development, Inc.
Janssen Biotech, Inc.

Completed

A Study to Assess the Relative Bioavailability Between Two ASP015K Tablets and the Food Effect of a New Tablet in Healthy Adult Subjects

Healthy Subjects | Bioavailability of ASP015K | Pharmacokinetics of ASP015K | Food Effect of ASP015K

United States
B. Braun Medical Inc.
Parexel

Completed

Pharmacokinetics and Safety of Cefazolin 2g in DUPLEX (2 Cef)

Infection

United States
Orion Corporation, Orion Pharma

Completed

Comparison of Budesonide and Formoterol Absorption From Budesonide/Formoterol Easyhaler and Symbicort Turbuhaler

Asthma

Finland
Laboratoire français de Fractionnement et de Biotechnologies
Parexel

Completed

Dose-finding Study of LFB-R593, A Monoclonal Anti-RhD Antibody, in Healthy RhD Negative Volunteers

Healthy

Germany
TargeGen

Completed

A Phase 1 Safety Study of TG100801 Eye Drops in Healthy Volunteers

Macular Degeneration | Diabetic Retinopathy

United States
Institute of HIV Research and Innovation Foundation...
National Institutes of Health (NIH); amfAR, The Foundation for AIDS Research

Recruiting

Anal HSIL Screening Algorithm (0007/65)

Anal High-grade Squamous Intraepithelial Lesion

Thailand
University of Pittsburgh
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Multi-Tracer PET Quantitation of Insulin Action in Muscle (Phase 1, Phase 2, Phase 3, Phase 4)

Obesity | Diabetes

United States
University of Parma

Unknown

BNP and Vascular Surgery (BNPinVasc)

General Anesthesia | Abdominal Aortic Aneurysm | Vascular Surgery | Mets | Preoperative Period | Postoperative Period | Natriuretic Peptide, Brain

Italy
University of California, San Francisco

Recruiting

The Reducing Risk Study

Insomnia | Delayed Sleep Phase

United States
Novartis Pharmaceuticals
Medicine for Malaria Venture

Terminated

Effectiveness of KAE609 in Reducing Asexual & Sexual Blood-stage P.Falciparum Infection & Infectivity to Mosquitos

Plasmodium Falciparum Malaria

Australia
GlaxoSmithKline

Completed

A First Time In Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GSK1399686

Inflammatory Bowel Diseases

United Kingdom
AstraZeneca

Completed

To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of Inhaled AZD8683

Healthy

United Kingdom
AstraZeneca
Merck Sharp & Dohme LLC

Completed

A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

Neurofibromatosis 1 | Neurofibroma Plexiform

China
Hoffmann-La Roche

Terminated

Double-Blinded, Placebo-Controlled Phase 1b Study for Safety, PK, Efficacy, PD of RO7049665 in Participants With Ulcerative Colitis (UC)

Ulcerative Colitis

United States, Hungary, Georgia, Moldova, Republic of, Ukraine
East Carolina University

Terminated

Degenerative Consequences of Congenital Deafness

Congenital Deafness

United States
Ology Bioservices

Completed

Study to Assess Safety of an Inactivated H5N1 Influenza Vaccine Administered in GelVac Nasal Powder to Healthy Young Adults

Phase 1 Safety Study of GelVac Nasal Powder H5N1 Influenza Vaccine

United States

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