Search clinical trials for: Polymyxin B

Total 486065 results

Southeast University, China

Recruiting

Comparison of Epithelial Lining Fluid and Blood Pharmacokinetics and Pharmacodynamics of Intravenous and Intravenous Plus Nebulized Polymyxin B in Multidrug Resistant Bacteria Ventilator-associated Pneumonia Patients

Ventilator-associated Pneumonia | Multidrug Resistant Bacterial Infection | Polymyxin B | Pharmacogenomic Drug Interaction

China
BioVersys AG

Recruiting

PK of BV100 in Patients VABP Suspected or Confirmed to be Due to CRAB

Ventilator Associated Pneumonia

Greece, Georgia, Hungary
Massachusetts Eye and Ear Infirmary

Recruiting

Dropless Pars Plana Vitrectomy Study (DVS)

Rhegmatogenous Retinal Detachment

United States
Petrovsky National Research Centre of Surgery

Recruiting

Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surgery Patients (РМХ vs SS) (РМХ vs SS)

Multiple Organ Dysfunction With Severe Endotoxemia

Russian Federation
MEDSI Clinical Hospital 1, ICU

Recruiting

Efficacy and Safety of Selective Digestive Decontamination in the ICU With High Rates of Antibiotic-resistant Bacteria

Respiratory Tract Infections | Pneumonia | Sepsis | Critical Illness | Respiratory Distress Syndrome | Pneumonia, Ventilator-Associated | Bloodstream Infection

Russian Federation
Spectral Diagnostics (US) Inc.

Recruiting

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study (TIGRIS)

Septic Shock | Endotoxemia

United States
Altamash Institute of Dental Medicine

Completed

Retentive Strength of Denture Adhesives on Various RR Ridges

Retentive Strength of Denture Adhesives

Pakistan
Atsena Therapeutics Inc.

Active, not recruiting

Study of Subretinally Injected ATSN-101 Administered in Patients With Leber Congenital Amaurosis Caused by Biallelic Mutations in GUCY2D

Leber Congenital Amaurosis | LCA | LCA1

United States
Rutgers, The State University of New Jersey

Completed

Optimizing Clinical Use of Polymyxin B

Pneumonia | Sepsis | Urinary Tract Infections | Blood Stream Infection | Respiratory Tract Infection (Including Tracheobronchitis)

United States, Brazil, Singapore
Yale University
Bill and Melinda Gates Foundation

Completed

Topical Antibacterial Agents for Prevention of COVID-19

COVID-19 | SARS-CoV2 Infection

United States
Dana-Farber Cancer Institute

Completed

Gut Decontamination In Pediatric Allogeneic Hematopoietic

Hematopoietic Stem Cell Transplantation (HSCT) | Acute GVH Disease

United States
University of Michigan
Cystic Fibrosis Foundation

Completed

Pharmacokinetics of Polymyxin B in Adult Patients With Cystic Fibrosis

Cystic Fibrosis | Polymyxin B

United States
TTY Biopharm

Completed

A Pharmacokinetic Study of Polymyxin B in Healthy Subjects and Subjects With Renal Insufficiency

Antibiotic Toxicity

Taiwan
Qpex Biopharma, Inc.
Biomedical Advanced Research and Development Authority

Completed

SAD/MAD Safety and PK Study of QPX9003 (Novel Polymyxin) in Normal Healthy Volunteers (QPX9003)

Bacterial Infections

United States
Hospital de Clinicas de Porto Alegre
Conselho Nacional de Desenvolvimento Científico e Tecnológico

Terminated

Best Available Therapy With or Without Meropenem for Bloodstream Infections by Enterobacterales With High Level of Resistance to Carbapenems (ABOVE)

Bloodstream Infection | Carbapenem-Resistant Enterobacteriaceae Infection

Brazil
Vanderbilt University Medical Center
Thomas Jefferson University; Medtronic; The Cooper Health System; Valley Health...

Completed

Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. (ENVELOPE)

Syncope | Sick Sinus Syndrome | Complete Heart Block | Chronic Systolic Heart Failure

United States
University Hospital, Bordeaux

Completed

Detection of Colistin-resistant Isolates From Patients of Intensive Care Units and Oncohaematology Wards. (RESCO)

Colistin Resistance in Bacteria

France
Indiana University

Completed

Antibiotic Irrigation for Pancreatoduodenectomy

Surgery | Infection

United States
MetroHealth Medical Center

Completed

Cytoscopic Antibiotic Irrigant to Reduce Postoperative Urinary Tract Infection

Urinary Tract Infections

United States
National Institute of Allergy and Infectious Diseases...
Glaxo Wellcome

Completed

Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical Trifluridine

HIV Infections | Herpes Simplex

United States
Spectral Diagnostics (US) Inc.

No longer available

Evaluating the Use of Polymyxin B Cartridge Hemoperfusion for Patients With Septic Shock and COVID 19

Septic Shock | Endotoxemia | COVID | Corona Virus Infection | Sepsis, Severe

United States
Spectral Diagnostics (US) Inc.

Temporarily not available

Open-label Evaluation of Polymyxin B Hemoperfusion for Septic Shock (EUPHORIA)

Septic Shock | Endotoxemia
Hospital de Clinicas de Porto Alegre
Conselho Nacional de Desenvolvimento Científico e Tecnológico; Pontificia Universidade...

Terminated

Melatonin for Renal Protection in Patients Receiving Polymyxin B

Acute Kidney Injury | Melatonin | Polymyxin B Adverse Reaction

Brazil
Xiangya Hospital of Central South University

Unknown

Efficacy Analysis of Tigecycline-based Therapy and Polymyxin B-based Therapy in ICU Infection

Intensive Care Unit | Polymyxin B | Tigecycline

China
Julio Ramirez
University of Louisville

Terminated

Patients Response to Early Switch To Oral:Osteomyelitis Study (PRESTO:Osteo)

Osteomyelitis

United States
Chulalongkorn University

Completed

The Pilot Study of the Efficacy of Polymyxin-B Hemoperfusion in Critically Ill Patients With Severe Sepsis

Severe Sepsis

Thailand
EMS

Completed

Effectiveness of Polymyxin B Sulphate + Prednisolone + Benzocaine + Clioquinol in Acute and Sub-acute Dermatitis Eczematous

Eczema
National Cancer Institute, Egypt

Completed

Effect of Different Colistin Doses on Clinical Outcome of Pediatric Cancer Patients With Gram Negative Infections

Gram-Negative Bacterial Infections | Pediatric Cancer | Colistin | Colistin Adverse Reaction | MIC

Egypt
Al-Azhar University

Unknown

Comparative Clinical Study Between Colistin-Tigecycline Combined Therapy Versus Colistin-Meropenem Combined Therapy in Treatment of Blood Stream Infections With Multidrug-Resistant Klebsiella Pneumoniae

Treatment of Blood Stream Infections Due to Multidrug-Resistant Klebsiella Pneumoniae

Egypt
Tan Tock Seng Hospital
National University Hospital, Singapore; Singapore General Hospital; Changi General...

Withdrawn

Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria (XDR-GNB)

Bacteremia | Ventilator-associated Pneumonia | Healthcare-associated Pneumonia

Singapore
University of Zurich

Completed

The Effects of a Polyethyleneimine-coated Membrane (oXiris™) for Hemofiltration Versus Polymyxin B- Immobilized Fibre Column (Toraymyxin™) for Hemoperfusion on Endotoxin Activity and Inflammatory Conditions in Septic Shock- A Randomized Controlled Pilot Study (ENDoX-study)

Patients in Septic Shock

Switzerland
Shanghai 10th People's Hospital

Unknown

The Combined Antibiotic Therapy for Carbapenem Resistant Klebsiella Pneumoniae

Antibiotic Resistant Infection

China
University Hospital, Geneva

Completed

Impact of Early Peri-operative Use of Polymyxin-B Hemoperfusion in Septic Patients Undergoing Emergent Abdominal Surgery

Peritonitis | Abdominal Sepsis | Colon Perforation

Switzerland
National Taiwan University Hospital

Terminated

Efficacy of Polymyxin B Hemoperfusion on Severe Sepsis Secondary to Pneumonia or Urinary Tract Infection

Sepsis

Taiwan
Spectral Diagnostics (US) Inc.

Completed

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock (EUPHRATES)

Septic Shock | Endotoxemia

United States, Canada
University of Puerto Rico

Unknown

Polymyxin B Monotherapy vs Combination Therapy in Critically Ill Patients With Multi-drug Resistant Pathogens (MUSEUM)

Critical Illness | Trauma | Resistant Infection

Puerto Rico
University of British Columbia

Unknown

Tacrolimus for Malar Edema

Edema Face

Canada
Jason Hsu, MD

Completed

The Effect of Glaucoma Drops on of the Duration of a Pure Intraocular Gas Bubble

Scleral Buckling

United States
Hospital Barros Luco Trudeau
Fondo Nacional de Desarrollo Científico y Tecnológico, Chile

Unknown

Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patients

Gram Negative Bacterial Infections

Chile
Stephen Harbarth
European Commission

Unknown

Eradication of Antibiotic-resistant Bacteria Through Antibiotics and Fecal Bacteriotherapy (R-GNOSIS WP3)

Intestinal Colonization With Multidrug-resistant Bacteria

Israel, Switzerland, France, Netherlands
National Taiwan University Hospital

Unknown

Safety and Efficacy of Heparin Dosing Score Protocol for Polymyxin-B Hemoperfusion

Septic Shock | Polymyxin B Hemoperfusion

Taiwan
Rambam Health Care Campus

Completed

A Study Evaluating the Role of Oral Antibiotics in an Aim to Eradicate Carrier State of Carbapenem- Resistant Klebsiella Pneumonia (KPC).

Klebsiella Pneumoniae Carbapenemase Resistant Associated Bacteremia or Pneumonia

Israel
Parc de Salut Mar

Completed

Multicentric Study About the Usefulness of Monitoring Plasma Levels of Colistin and Sodium Colistimethate in Patients With Infections Due to Multi-drug Resistant Gram Negative Bacilli, Treated With Colistin

Multidrug Resistant Gram Negative Bacterial Infections

Spain
Next Science TM
Mayo Clinic; Jacksonville Center For Clinical Research

Completed

Next Science Wound Gel Efficacy in Chronic Wound Versus Standard of Care

Wound Chronic Draining

United States
Rutgers, The State University of New Jersey
Bausch & Lomb Incorporated

Completed

Safety and Efficacy Study of Besivance™ for Treatment of Congenital Nasolacrimal Duct Obstruction in Children

Congenital Nasolacrimal Duct Obstruction

United States
Johnson & Johnson Consumer and Personal Products...

Completed

Trial to Test if Antibiotic Ointments & Cream Will Sting After Application on a Minor Wound After Tape Stripping Injury

Sting
Mahidol University

Unknown

Efficacy of Polymyxin B Against Infections Caused by Extensively Drug-resistant (XDR) Gram-Negative Bacteria (XDR)

Hospital Infection

Thailand
Fraser Health

Withdrawn

Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections (ToPICL)

Skin Diseases, Infectious | Blood Stream Infections

Canada
Laboratoire Innotech International

Completed

Open Study of the Efficacy of the Local Treatment With Polygynax of Bacterial and/or Mycotic Vaginitis

Vaginitis
Universiti Sains Malaysia

Completed

Effect of Systemic Oxygen on Corneal Epithelial Wound Healing in Diabetic Patients Undergoing Pars Plana Vitrectomy

Corneal Diseases

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