Search clinical trials for: enzyme replacement therapy

Total 94444 results

Shen Lei

Not yet recruiting

Comparison of Nafamostat and Unfractionated Heparin in RRT for Sepsis Associated AKI

Sepsis

China
Mỹ Đức Hospital

Not yet recruiting

Letrozole-stimulated Cycle Strategy Versus Artificial Cycle Strategy (LETSACT)

Hormone Replacement Therapy | Embryo Transfer | Letrozole | Irregular Menstruation
Rohan Garje
Janssen Scientific Affairs, LLC

Not yet recruiting

177Lu-PSMA, Niraparib/AA Plus Prednisone for Prostate Cancer (LUNAAR)

Castration-resistant Prostate Cancer | Metastatic Prostate Cancer | Metastatic Castration-resistant Prostate Cancer

United States
University of Washington
Washington State University

Not yet recruiting

Single-Dose Pharmacokinetics of Oral Testosterone Undecanoate With and Without Concomitant Inhibition of UGT2B17 (OralT12)

Hypogonadism, Male
National Institute of Respiratory Diseases, Mexico

Recruiting

Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects

Tobacco Smoking | Nicotine Addiction | Nicotine Withdrawal | Nicotine Replacement Therapy | Tobacco Withdrawal

Mexico
Carol Davila University of Medicine and Pharmacy

Not yet recruiting

The Role of oAncreatic Enzyme ReplAcement Therapy (PERT) on Mucosal Visibility Before Upper GI Endoscopy (AERATE)

Upper Gastrointestinal Endoscopy
Grace Science, LLC

Recruiting

Safety and Efficacy of GS-100 Gene Therapy in Patients With NGLY1 Deficiency

NGLY1 Deficiency

United States
Talphera, Inc

Not yet recruiting

Nafamostat Efficacy in Phase 3 Registrational CRRT Study (NEPHRO)

Acute Kidney Injury
Ruijin Hospital

Recruiting

The Effect of PERT on Patients Undergoing Pancreaticoduodenectomy

Pancreatic Exocrine Insufficiency | Pancreaticoduodenectomy | Pancreatic Enzyme Replacement Therapy

China
Westfälische Wilhelms-Universität Münster
Chiesi GmbH

Recruiting

German Observational Multicenter Study of Patients With Fabry Disease Under Enzyme Replacement Therapy With Pegunigalsidase-alfa (GoPEG)

Fabry Disease

Germany
Astellas Pharma Global Development, Inc.

Recruiting

A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats (OPTION-VMS)

Hot Flashes

United States
Implantology Institute

Recruiting

3D Evaluation of Postoperative Edema After Third Molar Surgery

Quality of Life | Pain, Postoperative | Molar, Third | Third Molar Surgery | Soft Tissue Swelling

Portugal
Duk-Woo Park, MD
CardioVascular Research Foundation, Korea; Daewoong Pharmaceutical Co. LTD.

Not yet recruiting

ENAVOgliflozin Outcome Trial in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement (ENAVO-TAVR)

Aortic Valve Stenosis

Korea, Republic of
Follicle Pharma Ltd

Recruiting

Study to Evaluate Safety & Usability of a New Formulation for Male Androgenetic Alopecia

Androgenic Alopecia

Israel
Tanta University

Recruiting

Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis

Hepatic Encephalopathy | Cirrhosis | Ascites | Varices | SBP - Spontaneous Bacterial Peritonitis

Egypt
Centro Hospitalar e Universitário de Coimbra, E...
University of Coimbra

Recruiting

Exocrine Pancreatic Insufficiency After Acute Pancreatitis and Pancreatic Enzyme Replacement Therapy

Immunology | Acute Pancreatitis | Exocrine Pancreatic Insufficiency | Gut Microbiota

Portugal
Sunnybrook Health Sciences Centre

Recruiting

PERT to Improve Quality of Life in Patients Undergoing Pancreaticoduodenectomy: A Pilot Randomized Controlled Trial (PERQ-UP)

Pancreatic Insufficiency

Canada
University of Calgary
Dr. Sandra Dumanski

Recruiting

Hormone Therapy and Angiotensin-Dependent Arterial and Renal Vasoconstriction in Humans

Hormone Therapy

Canada
University of California, San Francisco
National Cancer Institute (NCI); Kenya Medical Research Institute

Recruiting

Integrating Tobacco Use Cessation Into HIV Care and Treatment in Kisumu County, Kenya

Tobacco Use | Tobacco Use Cessation

Kenya
Odense University Hospital
Odense Patient Data Explorative Network; GCP-unit at Odense University Hospital

Recruiting

Statin Therapy With Atorvastatin in Surgical Aortic Valve Replacement (STARC)

Postoperative Atrial Fibrillation

Denmark
University of Oxford

Recruiting

Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV) (PLATCOV)

COVID-19

Lao People's Democratic Republic, Thailand, Brazil, Pakistan
Oslo University Hospital
University of Oslo

Recruiting

AntiCoagulation Versus AcetylSalicylic Acid After Transcatheter Aortic Valve Implantation (ACASA-TAVI)

Aortic Stenosis

Norway
Chinese Academy of Medical Sciences, Fuwai Hospital

Recruiting

Comparison of Atorvastatin and Pitavastatin on the Effect of HbA1c in AMI Patients With Abnormal Glucose Metabolism (CAPE-AMI)

Glucose Metabolism Disorders | Acute Myocardial Infarction

China
Central Hospital, Nancy, France

Recruiting

Effect of Enzyme Replacement Therapy in Patients With Juvenile-onset Pompe Disease

Pompe's Disease Juvenile Onset

France
Rambam Health Care Campus

Recruiting

Exercise Capacity in Response to Enzyme Replacement Therapy in Pediatric Pompe Disease.

Pompe Disease Infantile-Onset

Israel
Joseph Valentino, MD

Recruiting

Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment (TTOP)

Smoking Cessation | Cancer, Treatment-Related

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial

Cigarette Smoking-Related Carcinoma

United States
University of California, San Francisco
Duke University

Recruiting

In Utero Enzyme Replacement Therapy for Lysosomal Storage Diseases (IUERT)

Wolman Disease | MPS IVA | Pompe Disease Infantile-Onset | Gaucher Disease, Type 2 | MPS VI | MPS I | Gaucher Disease, Type 3 | MPS II | Mps VII

United States
Gustave Roussy, Cancer Campus, Grand Paris

Recruiting

High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN) (HR-NBL2)

High-Risk Neuroblastoma

France, Spain, United Kingdom, Norway, Sweden, Finland, Australia, Czechia, Italy, Netherlands, Slovenia, Switzerland, Belgium, Denmark, Greece, Lithuania
Yonsei University

Recruiting

Impact of Agalsidase Alfa Therapy on Cardiac funcTION in Patients With Fabry's Cardiomyopathy

Fabry Disease

Korea, Republic of
Yonsei University

Recruiting

Impact of Enzyme Replacement Therapy on Cardiac Function in Patients With Fabry's Cardiomyopathy (RECAFTURE Trial)

Fabry's Disease

Korea, Republic of
National Health Research Institutes, Taiwan
National Taiwan University Hospital; Mackay Memorial Hospital; China Medical... and other collaborators

Recruiting

First-line Antibiotic Therapy for Early-stage HP(+) Gastric Pure DLBCL

Gastric Diffuse Large B-cell Lymphoma

Taiwan
Duke University
Genzyme, a Sanofi Company

Recruiting

Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease

Pompe Disease

United States
Shire

Active, not recruiting

An Extension Study of HGT-HIT-045 Evaluating Long-Term Safety and Clinical Outcomes of Idursulfase-IT in Conjunction With Elaprase in Pediatric Participants With Hunter Syndrome and Cognitive Impairment

Hunter Syndrome

United States, United Kingdom, Canada
Genzyme, a Sanofi Company

Terminated

Study of the Effects of Fabrazyme Treatment on Lactation and Infants

Fabry Disease | Alpha Galactosidase A Deficiency

United States, Austria, United Kingdom
Janssen Research & Development, LLC

Active, not recruiting

A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer

Prostatic Neoplasms

Belgium, Netherlands, Spain, Sweden, Poland, United States, France, Georgia, Moldova, Republic of, United Kingdom, Ukraine
Janssen Research & Development, LLC

Active, not recruiting

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) (AMPLITUDE)

Metastatic Castration-sensitive Prostate Cancer

United States, Italy, China, Korea, Republic of, Canada, Australia, United Kingdom, Hungary, France, Taiwan, Thailand, Germany, Malaysia, Denmark, Russian Federation, New Zealand, Ukraine, Bulgaria, Israel, Spain, Turkey, Sweden, Cz... and more
National Cancer Institute (NCI)

Active, not recruiting

Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma

Adult T Acute Lymphoblastic Leukemia | Childhood T Acute Lymphoblastic Leukemia | Ann Arbor Stage II Adult Lymphoblastic Lymphoma | Ann Arbor Stage II Childhood Lymphoblastic Lymphoma | Ann Arbor Stage III Adult Lymphoblastic Lymphoma | Ann Arbor Stage III Childhood Lymphoblastic Lymphoma | Ann... and other conditions

United States, Canada, Australia, New Zealand
Dubai Fertility Center

Withdrawn

Letrozole Versus Hormonal Preparation in Frozen Cycles of PCOS Patients.

Miscarriage | Frozen Embryo Transfer | Hormone Replacement Therapy | Letrozole | Live Birth | Polycystic Ovarian Disease
Shire

Completed

Hunter Outcome Survey (HOS) (HOS)

Hunter Syndrome

United States
GlaxoSmithKline

Active, not recruiting

Placebo-controlled Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants With Advanced/Metastatic Non-small Cell Lung Cancer (ZEAL-1L)

Lung Cancer, Non-Small Cell

Argentina, France, Spain, Italy, Belgium, Korea, Republic of, United States, Mexico, Hungary, Sweden, Turkey, Ireland, Greece, Russian Federation, Germany, Netherlands, Bulgaria, Romania, Brazil, United Kingdom, Poland, Australia, C... and more
Takeda

Completed

A Study of Enzyme Replacement Therapy (VPRIV) in People With Type 1 Gaucher Disease Who Were Previously Treated With Substrate Reduction Therapy (SWITCH)

Gaucher Disease

United States
Alexion Pharmaceuticals, Inc.

Completed

Study of ALXN1850 in Participants With Hypophosphatasia (HPP)

Hypophosphatasia

United States
AM-Pharma

Completed

Pilot Trial of Single Dose Ilofotase Alfa in Hypophosphatasia

Hypophosphatasia

Germany
Hospital Universitari de Bellvitge
Baxter Healthcare Corporation

Completed

Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris®)

Sepsis | Acute Kidney Injury | Hemodiafiltration

Spain
VA Office of Research and Development
University of Florida

Terminated

Testosterone Plus Finasteride Treatment After Spinal Cord Injury

Central Nervous System Diseases | Nervous System Diseases | Wounds and Injuries | Endocrine System Diseases | Gonadal Disorders | Trauma, Nervous System | Spinal Cord Diseases | Hypogonadism | Spinal Cord Injuries | Spinal Cord Injury | Genital Diseases, Male

United States
Genzyme, a Sanofi Company

Completed

China Post-marketing Surveillance (PMS) Study of Aldurazyme®

Mucopolysaccharidosis I

China
Hadassah Medical Organization

Completed

A Second-generation AI Based Therapeutic Regimen in Patients With Gaucher Disease Treated With Enzyme Replacement Therapy.

Gaucher Disease Type 1

Israel
Protalix
Chiesi Farmaceutici S.p.A.

Completed

Safety and Efficacy of PRX-102 in Patients With Fabry Disease Currently Treated With REPLAGAL® (Agalsidase Alfa)

Fabry Disease

Australia, Netherlands, United Kingdom, Canada, Czechia, Norway, Slovenia
Protalix
Chiesi Farmaceutici S.p.A.

Completed

Safety, Efficacy, & PK of PRX-102 in Patients With Fabry Disease Administered Intravenously Every 4 Weeks (BRIGHT)

Fabry Disease

United States, Denmark, Belgium, United Kingdom, Norway, Italy, Czechia

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