Search clinical trials for: germline variants

Total 398 results

IRCCS San Raffaele

Recruiting

Integrated PET/MRI and Germline Variants to Differentiate Brain Tumopr Recurrence From Iatrogenicchanges in Children

Pediatric Brain Tumor

Italy
Oscar Gerardo Arrieta Rodríguez

Recruiting

Pathogenic Variants in Genes Associated With Lung Adenocarcinoma

Lung Adenocarcinoma

Mexico
Second Affiliated Hospital, School of Medicine,...

Recruiting

Multicenter Study on the Pathogenic Germline Gene Variants of Colorectal Polyposis in China

Colorectal Polyposis

China
National Cancer Institute (NCI)

Recruiting

Precision-Based Genomics in Prostate Cancer

Prostate Cancer

United States, Spain
National Cancer Institute (NCI)

Recruiting

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Peripheral Neuropathy Receiving Paclitaxel for Breast Cancer

Breast Carcinoma | Neuropathy

United States
National Cancer Institute (NCI)

Recruiting

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Congestive Heart Failure Receiving Therapy for Breast Cancer

Breast Carcinoma

United States
National Cancer Institute (NCI)

Recruiting

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

Breast Carcinoma

United States
King Hussein Cancer Center

Active, not recruiting

Universal Genetic Testing Versus Guidelines-Directed Testing for Germline Pathogenic Variants Among Non-Western Patients With Breast Cancer

Breast Cancer

Jordan
King Hussein Cancer Center

Active, not recruiting

Universal- Versus Guidelines-Directed Genetic Testing for Germline Pathogenic Variants Utilizing a Multi-Gene Panel for Inherited Cancers in Non-Western Society.

Genetic Predisposition

Jordan
Aspira Women's Health

Terminated

A Multivariate Index Assay for Ovarian Cancer Risk Assessment in Women With Adnexal Mass and High-Risk Germline Variants (OVAnex)

Adnexal Mass

United States
National Cancer Institute (NCI)

Completed

Needs Assessment for Individuals and Families Affected by Dyskeratosis Congenita (DC) and Related Telomere Biology Disorders (TBD)

Dyskeratosis Congenita | Telomere Biology Disorders

United States
Hellenic Cooperative Oncology Group
Hellenic Society of Medical Oncology

Active, not recruiting

Detection of Germline and Somatic Pathogenic Variants in Patients With de Novo Metastatic Breast Cancer

Metastatic Breast Cancer

Greece
Alnylam Pharmaceuticals

Not yet recruiting

Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy

Hereditary Amyloidosis, Transthyretin-Related | Asymptomatic Carrier State

France
University Hospital, Lille
France Alzheimer

Not yet recruiting

Social & Affective Cognition in Alzheimer's Disease & Associated Disorders (SOCIALIZE)

Alzheimer's Disease | Frontotemporal Degeneration (Semantic & Behavioral Variants)
University Hospital Tuebingen

Recruiting

Non-Invasive Plasma Treatment for Cervical Infections: Targeting High- and Low-Risk HPV Variants

Cervical Cancer | HPV Infection

Germany
Medanta, The Medicity, India

Recruiting

Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes

Type2diabetes

India
Sohag University

Recruiting

Prevalence of Anatomical Variants of Dural Sinuses by Magnetic Resonance Venography Evaluation in Sohag

Anatomical Variants of Dural Sinuses by Magnetic Resonance Venography

Egypt
Nantes University Hospital
AXA Assurances VIE Mutuelle

Not yet recruiting

Identification of Genetic Variants Associated With Unexpected Infant Death Syndrome (BIOMINRISK)

Sudden Infant Death | Sudden Unexplained Infant Death

France
University of Copenhagen
Gentofte Hospital, Denmark

Recruiting

The Effect of GIP, GLP-1 and GLP-2 in Individuals With Genetically Altered Receptor Function (H-21044858)

Incretin Effect

Denmark
Sohag University

Recruiting

Prevalence of Anatomical Variants of Dural Sinuses by MRV Evaluation in Sohag

Anatomical Variants of Dural Sinuses by MRV

Egypt
Hospital do Rim e Hipertensão

Recruiting

Evaluation of APOL1 Gene Variants in Kidney Donors and Their Impact on Long-term Renal Function in Donors and Recipients

Kidney Diseases | Transplant Failure

Brazil
National Cancer Institute (NCI)

Recruiting

Imatinib to Increase RUNX1 Activity in Participants With Germline RUNX1 Deficiency

Inherited Bone Marrow Failure Syndrome | Familial Platelet Disorder With Predisposition to Myeloid Malignancies

United States
Nantes University Hospital
Institut National de la Santé Et de la Recherche Médicale, France; Centre National...

Recruiting

Building of a Diagnostic/Prognostic Database for Human ERG Variant Effects (CarDiag)

Long QT Syndrome

France
Central Hospital, Nancy, France

Recruiting

Olfactory Cleft Stenosis and Obstruction on Paranasal Sinus CT Scan in Pre Septo Rhinoplasty Patients Without Respiratory Mucosa Pathology : Normal Variants or Pathologic Findings ?

Olfactory Impairment

France
Örebro University, Sweden
NutriLeads B.V. (Wageningen, The Netherlands); ProDigest (Ghent, Belgium); Ambiotis...

Recruiting

Towards a Food Ingredient Clinically Proven to Benefit Gut Health: Novel RG-I Variants (NUTRIGUT)

Healthy

Sweden
Stanford University

Not yet recruiting

Sirolimus for Improving Social Abilities in People With PTEN Germline Mutations

PTEN Gene Mutation | PTEN Hamartoma Tumor Syndrome | PTEN Hamartoma Syndrome

United States
Institut Claudius Regaud

Recruiting

Study of Families With an Hemopathies Predisposition Related to the DDX41 Gene. (LUCID)

DDX41 Gene Mutation

France
Mario Negri Institute for Pharmacological Research

Recruiting

New Analytic Tools for aHUS and C3G Diagnosis (COMPRare)

Healthy | Hemolytic-Uremic Syndrome | Membranoproliferative Glomerulonephritis

Italy
Institut Claudius Regaud

Recruiting

Study for Characterisation of Predictive Parameters of Clonal Evolution in Subjects With GATA2 Germline Mutation (GATA-2)

GATA2 Gene Mutation

France
National Cancer Institute (NCI)

Recruiting

Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma

Mesothelioma | BRCA1-Associated Protein-1 (BAP1) Mutations | Malignant Mesothelioma (MM) | Early-stage Mesothelioma | Subclinical Mesothelioma | Early-stage BAP1-associated Malignancies

United States
Hospices Civils de Lyon

Recruiting

Protection Response to Cellular Stress in BPAN's Patient Study (REP-BPAN)

Children and Adults With BPAN Carrying Pathogenic Variants of WDR45

France
University Hospital, Montpellier

Recruiting

Search for Structural Variants in Patients With DSD and Inconclusive Molecular Diagnosis (GENEXPLOR)

Disorder of Sex Development, 46,XY

France
Institut Pasteur
Biogroup Laboratoire de biologie médicale

Not yet recruiting

Understanding the Determinants of Mucosal Immunity and Optimizing the Diagnosis of Infection With SARS-CoV-2 Variants (COVARIANT)

COVID-19
The First Affiliated Hospital with Nanjing Medical...
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

Neoadjuvant Fluzoparib in Germline BRCA-mutated Three-negative Breast Cancer Breast Cancer

TNBC - Triple-Negative Breast Cancer

China
Hospital Universitari Vall d'Hebron Research Institute
Hospital Universitario La Paz

Not yet recruiting

Identification and Characterization of Genetic Variants in Hereditary Angioedema (GENOMAEH_01)

Hereditary Angioedema With C1 Esterase Inhibitor Deficiency

Spain
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

PREDICTION OF GERMLINE BRCA 1/2 GENES FROM HEALTHY OVARIES

Ovarian Cancer | Ultrasound Therapy; Complications | BRCA Mutation

Italy
University of California, San Francisco
University of California Pancreatic Cancer Consortium (UCPCC)

Recruiting

Genetic Predisposition Testing Program for Pancreatic Neuroendocrine Neoplasms (PanNEN)

Pancreatic Neuroendocrine Neoplasm

United States
Children's Hospital of Philadelphia
National Institutes of Health (NIH); National Human Genome Research Institute...

Recruiting

Care Plans for Cancer Predisposition

Genetic Predisposition

United States
University Hospital, Basel, Switzerland

Recruiting

Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases (NEUTROSKIN)

Inflammatory Dermatoses | Neutrophil-mediated Inflammatory Dermatoses

Switzerland
Rigshospitalet, Denmark

Not yet recruiting

Follow-up Study on Female Carriers With DMD Gene Variants

Muscular Dystrophy | Duchenne Muscular Dystrophy | Becker Muscular Dystrophy

Denmark
University Hospital Muenster

Recruiting

Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.

Sepsis | Pre-Eclampsia | Adiposity | Microscopic Polyangiitis | Granulomatosis With Polyangiitis | SIRS | Procalcitonin

Germany
The Christie NHS Foundation Trust
Prostate Cancer UK

Recruiting

Hypoxia-driven Prostate Cancer Genomics (HYPROGEN) (HYPROGEN)

Hypoxia | Prostate Cancer

United Kingdom
St. Louis University
Mid-America Transplant

Recruiting

APOL1 Genetic Testing in African Americans

Chronic Kidney Diseases | Genetic Predisposition | Nephropathy

United States
Fudan University
Amoy Diagnostics Co., LTD

Recruiting

Assessment of Prognosis Using Peripheral Blood Circulating Tumor DNA in Patients With Cervical Cancer

Locally Advanced Cervical Cancer

China
Jaeb Center for Health Research
Foundation Fighting Blindness

Recruiting

Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants (Uni-Rare)

Retinitis Pigmentosa | Inherited Retinal Degeneration

United States, United Kingdom, France, Brazil, Canada, Finland, Israel, Mexico, Netherlands, Switzerland, Australia
University of Michigan Rogel Cancer Center

Recruiting

Evaluating a Pharmacogenetic Testing Panel in Patients Suspected to be at Increased Risk for Pharmacogenetics-related AEs While Receiving Fluoropyrimidine or Irinotecan Therapy

Cancer

United States
Children's Oncology Group

Recruiting

Molecular Epidemiology of Pediatric Germ Cell Tumors

Teratoma | Choriocarcinoma | Germinoma | Germ Cell Tumor | Yolk Sac Tumor | Embryonal Carcinoma | Mixed Germ Cell Tumor | Late Effects | Pediatric Germ Cell Tumor

United States
Hospital Garcia de Orta
Instituto de Medicina Molecular João Lobo Antunes

Recruiting

Diastolic Dysfunction in Septic Shock and Cardiomyopathy Genetic Variants (SepticHeartG)

Septic Shock | Cardiomyopathies | Diastolic Dysfunction

Portugal
University of Geneva, Switzerland
All India Institute of Medical Sciences, New Delhi; Swiss National Science... and other collaborators

Recruiting

Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia (MPGx-INDALL)

Drug Effect | Pediatric Cancer | Adverse Drug Event | Drug Interaction | ALL, Childhood | Drug Toxicity | Toxicity, Drug | Relapse Leukemia

India
Okayama University
Merck Sharp & Dohme LLC

Recruiting

Novel Neoadjuvant and Adjuvant Strategy for Germline BRCA 1/2 Mutated Triple Negative Breast Cancer

Breast Cancer | Breast Neoplasms | Triple Negative Breast Cancer | Triple Negative Breast Neoplasms | BRCA1 Mutation | BRCA2 Mutation | BRCA Mutation | BRCA-Associated Breast Carcinoma

Japan

Search clinical trials for: germline variants

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