Search clinical trials for: mechanism

Total 95912 results

University of Florida

Not yet recruiting

Examining the Impact of High-protein Oral Supplement With Liposomal Curcumin on Inflammation Markers and Oxidative Stress in Adults Undergoing Hemodialysis.

Chronic Kidney Disease 5D
Primus Pharmaceuticals
Sun Valley Arthritis Center

Recruiting

Effect of Metaxalone 640 mg (M640) on Truck Driving Ability and Cognition Compared to Other Skeletal Muscle Relaxants

Cognitive Impairment

United States
University of Redlands

Not yet recruiting

Pharmacokinetics of Melatonin Administered in Oral, Lotion, and Bubble Bath Formulations

Sleep

United States
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Recruiting

The Clinical Efficacy and Safety of Finerenone in the Treatment of Primary Aldosteronism

Primary Aldosteronism | Mineralocorticoid Receptor Antagonist | Finerenone

China
Centre Hospitalier Universitaire, Amiens
University Hospital, Rouen; University Hospital, Lille

Recruiting

Non-steroidal Anti-inflammatory in Cardiac Surgery (KETOPAIN)

Cardiac Surgery | Acute Postoperative Pain | Pain Intensity | Multimodal Pain Management | Non-steroidal Anti-inflammatory Drugs

France
MedSIR
Stemline Therapeutics, Inc.

Not yet recruiting

Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i. (ADELA)

Advanced Breast Cancer | ER-positive Breast Cancer | HER2-negative Breast Cancer | ESR1 Gene Mutation
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Not yet recruiting

A Study Comparing BL-B01D1 With Platinum Based Chemotherapy in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
Washington University School of Medicine
American Academy of Clinical Toxicology

Not yet recruiting

Rivastigmine for Antimuscarinic Delirium: a Randomized, Placebo-controlled Trial (RIVA-AM)

Anticholinergic Toxicity

United States
Nordsjaellands Hospital

Recruiting

Combining Lidocaine and Ropivacaine for an Infraclavicular Brachial Plexus Nerve Block

Anesthesia, Local | Surgery | Brachial Plexus Block | Nerve Block | Forearm Fracture

Denmark
Shanghai Zhongshan Hospital

Not yet recruiting

Biomarkers and Molecular Mechanism Study of Hepatocellular Carcinoma After Radical Resection and Conversion Therapy

Hepatocellular Carcinoma

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Bayesian Basket Trial (PALETTE)

Sepsis
Instituto Nacional de Ciencias Medicas y Nutricion...
Emory University; Universidad Nacional Autonoma de Mexico

Recruiting

Melatonin's Effect on Nighttime Blood Pressure and Sleep in OSA Patients (MEBP-OSA) (MEBP-OSA)

Obstructive Sleep Apnea of Adult

Mexico
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Not yet recruiting

A Study Comparing BL-B01D1 With Docetaxel in Patients With Unresectable Locally Advanced or Metastatic EGFR Wild-type Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
Montefiore Medical Center

Not yet recruiting

Antiemetic Fosaprepitant To Remedy Nausea and Vomiting: A Randomized Control Trial (AFTR NV RCT)

Nausea | Vomiting | Nausea and Vomiting

United States
Wayne State University

Not yet recruiting

Warrior CARE: Cannabis Behavioral Health (CBH)

Suicide | Post Traumatic Stress Disorder | Cannabis Use | Veterans | Marijuana

United States
Indonesia University

Not yet recruiting

Opioid Free Versus Opioid Balanced Anesthesia in Ophthalmic Surgery

Anesthesia and Analgesia | Anesthesia, Endotracheal
Daniel Morgenstern
The Hospital for Sick Children

Recruiting

Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas (VICTORY)

Low-grade Glioma

Canada
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Not yet recruiting

A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced or Metastatic Triple-Negative Breast Cancer

Triple-Negative Breast Cancer

China
Air Force Military Medical University, China

Not yet recruiting

Diagnosis of Depressive Disorder Malinger Using the Niacin Skin Response Test (NSRT)

Depressive Disorder | Malingering

China
Mayo Clinic
National Cancer Institute (NCI)

Not yet recruiting

Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advance or Metastatic Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma | Locally Advanced Pancreatic Adenocarcinoma | Unresectable Pancreatic Adenocarcinoma

United States
AstraZeneca

Not yet recruiting

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer (EvoPAR-BR01)

Advanced Breast Cancer

Canada
University of Salerno

Not yet recruiting

Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients (BESAFE)

Cardiovascular Diseases | Dyslipidemias | Lipid Metabolism Disorders | Statin Adverse Reaction
Nordsjaellands Hospital

Recruiting

Ultrasound-guided Infraclavicular Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures

Colles' Fracture | Fracture Dislocation | Distal Radius Fractures | Lidocaine | Ropivacaine | Closed Reduction of Fracture and Application of Plaster Cast

Denmark
Northwell Health

Recruiting

Impact of Preoperative Opioid-free Multimodal Analgesia on Time to Trial of Void in Ambulatory Urogynecologic Surgeries

Pain, Postoperative | Postoperative Pain, Acute

United States
The First Affiliated Hospital of Zhejiang Chinese...

Recruiting

Peripheral Mechanisms of Humoral Immune Effector-mediated Tourette's Syndrome and the Role of Tuina Intervention

Inflammatory Response | Tourette Syndrome in Children | Food Intolerance

China
Infectopharm Arzneimittel GmbH
Winicker Norimed GmbH

Not yet recruiting

Therapy for Scabies With Two Differently Concentrated Permethrin Creams (SKABUP)

Scabies
KU Leuven
Utrecht University

Recruiting

Virtual Reality Exposure for Socially Anxious Adolescents (VIRTUS)

Social Anxiety

Belgium
Ganzhou Hemay Pharmaceutical Co., Ltd

Not yet recruiting

To Evaluate the Pharmacokinetics of Hemay005 Tablets in Patients With Renal Impairment

Psoriasis
Haisco Pharmaceutical Group Co., Ltd.

Recruiting

A Study to Evaluate the Effects of HSK3486 Administration on Cardiac Repolarization in Healthy Subjects

Thorough QT Study

China
The First Affiliated Hospital of Soochow University

Recruiting

Maintenance Therapy of Hypomethylating Agent (HMA) in Favorable Risk Acute Myeloid Leukemia (AML) Patients

Acute Myeloid Leukemia

China
Johns Hopkins University
National Institutes of Health (NIH)

Not yet recruiting

Behavioral Pharmacology of Orally Administered THC and D-limonene

THC | Subjective Drug Effects | D-limonene

United States
The First Hospital of Jilin University

Not yet recruiting

The Diagnostic and Prognostic Value of TAT, PIC, tPAI·C and TM in Sepsis-induced Coagulopathy

Sepsis-induced Coagulopathy
Modern Biosciences Ltd

Not yet recruiting

Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects

Pharmacokinetics

United Kingdom
Xiaojun Chen

Recruiting

GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer Patients

Obesity | Atypical Endometrial Hyperplasia | Endometrial Neoplasms | Progesterone Resistance

China
University of Kansas Medical Center

Not yet recruiting

Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft

Burns | Skin Graft Complications
HALEON

Not yet recruiting

A Real-World Evidence Study to Evaluate the Effects of Voltaren Use on Mobility and Quality of Life in Participants With Knee Osteoarthritis Pain

Pain
University of Colorado, Denver

Not yet recruiting

Maternal Choline Supplementation and Cannabis Use During Pregnancy: Impact on Early Brain Development

Child Development | Cannabis Use

United States
RenJi Hospital

Recruiting

the Predictive Value of Immune Cell in Locally Advanced Cervical Cancer

Immunotherapy | Locally Advanced Cervical Carcinoma | Concurrent Chemoradiotherapy

China
Shanghai JMT-Bio Inc.

Not yet recruiting

JMT101 in Combination With Osimertinib, Versus Cisplatin-pemetrexed in Participants With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Characterized by Epithermal Growth Factor Receptor (EGFR) Exon 20ins Mutations

Local Advanced or Metastatic NSCLC
University of Novi Sad

Recruiting

Intraoperative Dexmedetomidine and Coronary Artery Bypass Graft Surgery

Acute Kidney Injury

Serbia
Wangxia LV

Recruiting

Trifluridine/Tipiracil Combined With Cetuximab in the Treatment of Third-line and Above RAS/BRAF Wild-type mCRC

Colorectal Cancer Metastatic

China
Novartis Pharmaceuticals

Not yet recruiting

NEPC Study: An Exploratory Safety and Efficacy Study With PSMA, SSTR2 and GRPR Targeted Radioligand Therapy in Metastatic Neuroendocrine Prostate Cancer.

Metastatic Neuroendocrine Prostate Cancer
Bayer

Recruiting

A Study to Learn About How Food and Esomeprazole Affect the Level of BAY2927088 in the Blood When Taken Together in Healthy Participants

Healthy Volunteers | Advanced Non-small Cell Lung Cancer | EGFR Mutation | HER2 Mutation

United States
National University of Malaysia

Not yet recruiting

Efficacy & Safety of Dry Powder Ivy Extract (Syrup Prospan) Versus NAC Among COPD Patients (SyProNAC)

Chronic Obstructive Pulmonary Disease

Malaysia
Masonic Cancer Center, University of Minnesota

Not yet recruiting

MT2022-60: Ph 2 Study of Pembro+ BEAM With ASCT for Relapsed Hodgkin Lymphoma

Classic Hodgkin Lymphoma | Autologous Stem Cell Transplant
University of Wisconsin, Madison

Not yet recruiting

Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)

Posttraumatic Stress Disorder

United States
University of Michigan Rogel Cancer Center
National Cancer Institute (NCI)

Not yet recruiting

A Trial of Omeprazole and Low Dose Aspirin to Identify Colorectal Biomarkers of Preventive Efficacy

Colorectal Neoplasia

United States
H. Lee Moffitt Cancer Center and Research Institute
Angiodynamics, Inc.

Recruiting

Irreversible Electroporation & Pembro Immunotherapy in Locally Advanced Pancreatic Cancer

Pancreatic Cancer | Locally Advanced Pancreatic Cancer

United States
Teoxane SA

Not yet recruiting

RHA® Redensity With New Anesthetic Agent Perioral Rhytids (PAS)

Pain | Aging

United States
University Hospital Schleswig-Holstein

Recruiting

Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes

Safety Issues | Pharmacokinetic

Germany

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