Search clinical trials for: prostacyclin synthase

Total 135 results

Albert Einstein College of Medicine
Juvenile Diabetes Research Foundation; National Institutes of Health (NIH)

Completed

Reactive Oxygen Species in the Pathogenesis of Diabetic Complications

Type 1 Diabetes

United States
AstraZeneca

Not yet recruiting

A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Asian Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension (BaxAsia)

Resistant Hypertension | Uncontrolled Hypertension

Vietnam, Korea, Republic of, Philippines, China, Hong Kong, Turkey, Japan, India, Russian Federation, Argentina
Pär Johansson

Not yet recruiting

Infusion of Prostacyclin vs Placebo for 72-hours in Mechanically Ventilated Patients With Acute Respiratory Failure (COMBAT-ARF)

Endothelial Dysfunction | Acute Respiratory Failure | Pulmonary Infection

Denmark
Travere Therapeutics, Inc.

Recruiting

A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment (HARMONY)

Homocystinuria

United States
Hamilton Health Sciences Corporation
Canadian Institutes of Health Research (CIHR); Population Health Research Institute and other collaborators

Not yet recruiting

Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy (TaRGET)

Arrhythmogenic Right Ventricular Cardiomyopathy | Arrhythmogenic Cardiomyopathy

Canada
AstraZeneca

Recruiting

A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension (Bax24)

Resistant Hypertension

Spain, Argentina, United States, Belgium, Czechia, Vietnam, Thailand, Australia, Turkey, Philippines, Greece, Taiwan, United Kingdom, Poland, South Africa, Canada, Germany, Hungary, Malaysia, Bulgaria, Saudi Arabia, Slovakia
Anna Stanhewicz, PhD

Recruiting

Sex Differences in the Vascular Effects of E-cigarette Use

E-cigarette Use

United States
Mineralys Therapeutics Inc.

Recruiting

Efficacy and Safety of Lorundrostat Alone, and in Combination With Dapagliflozin in Subjects With Hypertension and Chronic Kidney Disease (CKD) With Albuminuria

Chronic Kidney Disease

United States
AstraZeneca

Recruiting

A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension (BaxHTN)

Resistant Hypertension | Uncontrolled Hypertension

United States, Canada, Italy, South Africa, Korea, Republic of, Australia, Belgium, France, Germany, Poland, Japan, Spain, Vietnam, Argentina, Bulgaria, Turkey, India, Malaysia, Taiwan, Thailand, Austria, Israel, Netherlands, Sweden, United... and more
Centre Hospitalier Régional d'Orléans

Recruiting

Exploration of the Activity of DNA Located Outside of Cellular Nucleus to Amplify Inflammation in Inflammatory Bowel Disease in Children Through Biological Pathway Cyclic GMP-AMP Synthase (cGAS) - Stimulator of Interferon Genes (STING) (ROXANE)

Inflammatory Bowel Diseases | Crohn Disease | Ulcerative Colitis

France
West Kazakhstan Medical University

Recruiting

Selective Screening of Children for Hereditary Metabolic Diseases by Tandem Mass Spectrometry in Kazakhstan

Ornithine Transcarbamylase Deficiency | Biotinidase Deficiency | Citrullinemia | Glutaric Acidemia Type II | Argininosuccinic Aciduria | Maple Syrup Urine Disease | Primary Carnitine Deficiency | Homocystinuria | Carnitine Palmitoyltransferase II Deficiency | Arginase Deficiency | Very Long-chain Acyl-CoA... and other conditions

Kazakhstan
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield; University of Cambridge; University of Newcastle Upon-Tyne and other collaborators

Recruiting

Pulmonary Hypertension: Intensification and Personalisation of Combination Rx (PHoenix)

Pulmonary Arterial Hypertension

United Kingdom
Centre Hospitalier Régional de la Citadelle
Sanofi; Takeda; University of Liege; Orchard Therapeutics; Centre Hospitalier Universitaire... and other collaborators

Recruiting

Baby Detect : Genomic Newborn Screening

Congenital Adrenal Hyperplasia | Hemophilia A | Hemophilia B | Mucopolysaccharidosis I | Mucopolysaccharidosis II | Cystic Fibrosis | Alpha 1-Antitrypsin Deficiency | Sickle Cell Disease | Fanconi Anemia | Chronic Granulomatous Disease | Wilson Disease | Severe Congenital Neutropenia | Ornithine Transcarbamylase... and other conditions

Belgium
Hospital Costa del Sol
Hospital Universitario Virgen Macarena; Hospital San Juan de la Cruz; Hospitales... and other collaborators

Recruiting

RWD Patients With Pulmonary Arterial Hypertension Treated With IP Prostacyclin Receptor Agonists (RAMPHA)

Pulmonary Arterial Hypertension

Spain
University Hospital, Grenoble
National Research Agency, France

Recruiting

Prostacyclin (PGI2) Pathway to Enhance Wound Healing in Diabetic Foot Ulcers (PGI2HEAL)

Diabetes Mellitus, Type 2 | Diabetic Foot

France
Southeast University, China

Not yet recruiting

The Role and Mechanism of O-GlcNAc Glycosylation Modified HAS2 in the Hyaluronic Acid Synthesis in ARDS

Hyaluronic Acid
Baylor College of Medicine
Children's National Research Institute

Recruiting

Hepatic Histopathology in Urea Cycle Disorders

Ornithine Transcarbamylase Deficiency | Urea Cycle Disorder | Carbamyl Phosphate Synthetase Deficiency | Argininosuccinic Aciduria | Hyperargininemia | Citrullinemia 1 | ARGI Deficiency | ASL Deficiency | ASS Deficiency | NAGS Deficiency

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Recruiting

Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer (FASN)

Prostate Cancer | Refractory Cancer | Castration Resistant Prostatic Cancer

United States
Rhode Island Hospital
United Therapeutics; University of Rhode Island

Recruiting

Safety and Efficacy of Treprostinil (Remodulin®) In Reducing Ischemia-Reperfusion Injury During Kidney Transplantation

Ischemia Reperfusion Injury | Delayed Graft Function

United States
United Therapeutics

Recruiting

A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Cardiovascular Diseases | Vascular Diseases | Lung Diseases | Hypertension | Connective Tissue Diseases | Pulmonary Arterial Hypertension | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary | Pulmonary Hypertension | PAH | Respiratory Tract Disease

United States, Australia, Austria, Italy, Taiwan, Spain, Korea, Republic of, Canada, United Kingdom, Singapore, Argentina, Germany, France, Belgium, Mexico, Brazil, Hungary, Bulgaria, Chile, Czechia, Denmark, Greece, Israel, Netherlands, Pola... and more
Nicholas Ah Mew
Icahn School of Medicine at Mount Sinai; Boston Children's Hospital

Recruiting

Orphan Europe Carbaglu® Surveillance Protocol

N-acetylglutamate Synthase (NAGS) Deficiency

United States
Travere Therapeutics, Inc.

Recruiting

Natural History Study of Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (ACAPPELLA)

Homocystinuria Due to CBS Deficiency

Ireland, Qatar, United States, United Kingdom
AstraZeneca

Active, not recruiting

A Study to Investigate the Effect on QTcF of Baxdrostat Compared With Placebo, Using Moxifloxacin as a Positive Control, in Healthy Participants

Healthy Participants

Germany
National Institute of Environmental Health Sciences...

Completed

The COX-2 Gene and the Immune System

Asthma | Allergic Inflammation

United States
Helsinki University Central Hospital
University of Helsinki; Tampere University; Tampere University Hospital; Finnish...

Active, not recruiting

Postmortem Evaluation of Adrenal and Other Endocrine Tumors in Patients With Sudden Death (SuddenDeath)

Primary Aldosteronism | Pheochromocytoma | Adrenal Cushing Syndrome | Endocrine Neoplasia

Finland
United Therapeutics

Enrolling by invitation

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Cardiovascular Diseases | Vascular Diseases | Lung Diseases | Hypertension | Connective Tissue Diseases | Pulmonary Arterial Hypertension | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary | Pulmonary Hypertension | PAH | Respiratory Tract Disease

United States, Spain, Australia, Taiwan, Canada, Singapore, United Kingdom, Italy, Germany, China, Mexico, Argentina, Korea, Republic of, Austria, Greece, Sweden, Portugal, Belgium, Brazil, Bulgaria, Chile, Croatia, Czechia, Denmark, Fr... and more
RTI International
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Enrolling by invitation

Early Check: Expanded Screening in Newborns

Primary Hyperoxaluria Type 3 | Diabetes Mellitus | Hemophilia A | Hemophilia B | Hereditary Fructose Intolerance | Cystic Fibrosis | Factor VII Deficiency | Phenylketonurias | Sickle Cell Disease | Dravet Syndrome | Duchenne Muscular Dystrophy | Prader-Willi Syndrome | Fragile X Syndrome | Chronic Granulomatous Disease and other conditions

United States
Actuate Therapeutics Inc.

Active, not recruiting

9-ING-41 in Patients With Advanced Cancers

Sarcoma | Cancer | Breast Neoplasms | Neoplasm Metastasis | Pancreatic Neoplasms | Pancreatic Cancer | Pancreatic Adenocarcinoma | Bone Cancer | Malignant Glioma | Bone Metastases | Pancreas Cancer | Renal Cancer | Refractory Non-Hodgkin Lymphoma | Bone Neoplasm | Neoplasm, Breast | Refractory Cancer | Refractory Neoplasm | Resistant... and other conditions

United States, Belgium, Canada, Spain, France, Netherlands, Portugal
Actelion

Completed

A Study of Single and Multiple Doses of Different Formulations of a Prostacyclin Receptor Agonist

Pulmonary Arterial Hypertension

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Ribociclib and Aromatase Inhibitor in Treating Older Participants With Hormone Receptor Positive Metastatic Breast Cancer

HER2/Neu Negative | Stage IV Breast Cancer AJCC v6 and v7 | Estrogen Receptor and/or Progesterone Receptor Positive

United States
University of Copenhagen
Deakin University

Completed

Maximal Fat Oxidation and Fuel Use During Exercise

Obesity

Denmark
Actuate Therapeutics Inc.

Active, not recruiting

9-ING-41 in Pediatric Patients With Refractory Malignancies.

Neuroblastoma | Pediatric Cancer | Diffuse Intrinsic Pontine Glioma | Pediatric Brain Tumor | Refractory Cancer | Refractory Neoplasm | Refractory Tumor | Cancer Pediatric | Neuroblastoma Recurrent | Pediatric Lymphoma | Pediatric Meningioma

United States
Actuate Therapeutics Inc.

Completed

Actuate 1901: 9-ING-41 in Myelofibrosis

Myelofibrosis

United States
Cairo University

Completed

Endothelial NO Synthase Polymorphic Gene in Coronary Artery Dilation Disease

Coronary Artery Ectasia

Egypt
United Therapeutics

Completed

Open-label, Clinical Study to Evaluate the Safety and Tolerability of TreT in Subjects With PAH Currently Using Tyvaso (BREEZE)

Pulmonary Arterial Hypertension

United States
Egymedicalpedia

Completed

Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction

Diabetes Mellitus | Erectile Dysfunction

Egypt
Travere Therapeutics, Inc.

Active, not recruiting

Pegtibatinase as an Enzyme Therapy for Patients With Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (COMPOSE)

Homocystinuria

United States
United Therapeutics

Completed

Digital Ischemic Lesions in Scleroderma Treated With Oral Treprostinil Diethanolamine (DISTOL-1)

Systemic Sclerosis | Scleroderma

United States, Canada, United Kingdom
Brendon Gurd, PhD

Completed

Examining The Effect of Blood Flow Restricted Aerobic Training on Mitochondrial Adaptations in Young Healthy Adults

Mitochondrial Biogenesis

Canada
United Therapeutics
University of Pittsburgh Medical Center

Withdrawn

Safety and Efficacy of Perioperative Remodulin® in Orthotopic Liver Transplant Recipients

Liver Transplant

United States
The Methodist Hospital Research Institute

Completed

L-NMMA Plus Taxane Chemotherapy in Refractory Locally Advanced or Metastatic Triple Negative Breast Cancer Patients

Metastatic Triple Negative Breast Cancer

United States
Research & Diagnostic Antibodies
National Institute of General Medical Sciences (NIGMS)

Terminated

Plasma Inducible Nitric Oxide Synthase (iNOS) Assay and Sepsis Study (PliNOSa® Test)

Sepsis | Septic Shock | Severe Sepsis
Bayer

Completed

Non-interventional, Postauthorization Safety Study of Ventavis for Pulmonary Arterial Hypertension (PAH)

Hypertension, Pulmonary

Japan
United Therapeutics

Terminated

A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH (CAPACITY)

Cardiovascular Diseases | Vascular Diseases | Lung Diseases | Hypertension | Pulmonary Arterial Hypertension | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary | Pulmonary Hypertension | PAH | Respiratory Tract Disease | Connective Tissue Disease

Spain, United States, Australia, Canada, United Kingdom, Italy, Argentina, Austria, Belgium, Brazil, Germany, Poland
Anwaar Saeed
Actuate Therapeutics Inc.; Incyte Corporation

Active, not recruiting

9-ING-41 Plus Retifanlimab and Gemcitabine/Nab-Paclitaxel in Patients With Advanced Pancreatic Adenocarcinoma (RiLEY)

Pancreatic Adenocarcinoma

United States
Bastiaan Driehuys
United Therapeutics

Completed

Assessing Response to Inhaled Prostacyclin With Hyperpolarized Xe MRI

Pulmonary Vascular Disease

United States
Aeglea Biotherapeutics

Terminated

A Multiple Ascending Dose Study of ACN00177 (Pegtarviliase) in Subjects With CBS Deficiency

Homocystinuria Due to Cystathionine Beta-Synthase Deficiency

United States, United Kingdom, Australia
Biozeus Biopharmaceutical S.A.
InCor Heart Institute

Terminated

Efficacy and Safety Evaluation of BZ371B in ARDS Patients

Pulmonary Disease | ARDS | ARDS, Human

Brazil
Wanpen Vongpatanasin

Withdrawn

Neural Mechanism of Aldosterone-induced Insulin Resistance

Hypertension

United States
Jakob Stensballe, MD, PhD
Innovation Fund Denmark; Independent Research Fund Denmark

Completed

Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in Patients With Septic Shock Suffering From Organ Failure (COMBAT-SHINE)

Septic Shock

Denmark

Search clinical trials for: prostacyclin synthase

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