Safety Pharmacology In Vivo Technician

Safety Pharmacology In Vivo Technician Req ID #:  197332 Location: 

Beerse, BE, 2340 For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about. Job Summary The primary responsibility of the in vivo technician is to provide research support for the Safety Pharmacology team in Janssen R&D Beerse, in particular to the integrated behavioral, EEG and cardiovascular assessment in rats. The technician is expected to strive for excellence in all aspects of the profession of laboratory animal science and maintain the highest standard of personal conduct. The technician is stakeholder-focused, strong at collaborating with internal and external partners and delivers results through both individual contributions and teamwork. The technician will ensure compliance with all applicable animal welfare regulations and guidelines, the Guide for the Use and Care of Laboratory Animals and internal compliance standards.

ESSENTIAL RESPOSNABILITIS  Provide quality animal care to animals, including providing food and water, cleaning animal cages and rooms and provides support with enrichment and socialization activities Execute safety pharmacology in vivo studies to assess the tolerability and efficacy of novel test articles Organization of internal studies, including preparation and identification of study animals, preparation of test articles) for administration, use automated data collection systems for analysis and interpretation  Perform standard rodent procedures including dosing and blood collection via multiple routes. Deliver rodent anesthesia and monitoring Perform routine observations and submit health concerns Collect tissue for necropsy for downstream processing following euthanasia Work independently and as a team member to conduct in vivo laboratory studies Understand the 3Rs and follow ethical protocol and amendments; perform in vivo studies to ethical guidelines and policies.  Create study reports, assist with preparing regulatory submission documents  Implement and maintain good documentation practices Stay current with the literature and technological advances in relevant fields Perform all other related duties as assigned Educational Requirements

B.S. or M.S. in a biological science with hands-on in vivo experience

Solid background in cardiovascular pharmacology, with knowledge or experience in safety pharmacology core battery a plus

Telemetry experience and/or experience with Ponemah™ or EMKA™ software and/or experience in small-animal surgery with anesthesia and wound closure using aseptic techniques would be at a distinct advantage

Proficiency in handling instrumented and anesthetized rodents, as well as laboratory techniques: PO, IP, SQ, IM, IV injection dosing; blood collection via tail and/or submandibular vein, vena cava, retroorbital venous plexus, cardiac puncture

Executing detailed in vivo work plans/experimental protocols through strong organizational skills and attention to detail

Familiarity with entering data, analysis, and interpretation into appropriate notebooks and/or databases

Knowledge of standard computer software applications for general office work (i.e., Microsoft Word, Excel, PowerPoint, Teams, SharePoint, etc.)

About Insourcing Solutions

Charles River Insourcing Solutions℠ can streamline research by delivering operational and cost efficiencies through the strategic insourcing of GMP, GLP and non-GLP research services from discovery through safety assessment. Insourcing Solutions℠ provides you with the ability to maintain control of your facility and expertise while leveraging available space.

About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.

Equal Employment Opportunity

Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

For more information, please visit www.criver.com.

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