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DMPK Biotransformation Specialist (Research Leader)
Charles River Laboratories International Inc (CRL)
Saffron Walden, GB, CB10 1XL
For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.
Business Area
Small Molecule - Discovery
We offer the industry's most comprehensive drug discovery service portfolio and a multidisciplinary staff of hundreds of scientists. We have the scientific excellence and technological capabilities to support our clients throughout the drug development life cycle, from target identification to IND programs. Our team takes a true collaborative approach working in partnership with clients to find and follow the optimum path to market while moving forward together to bring novel therapies to the patients who need them.
What You'll Do
We are looking for an experienced biotransformation specialist to grow our DMPK / ADME team, to support both multidisciplinary and stand-alone ADME programs at our Cambridge site in the UK.
As there is a practical element to this role some on site presence is required, therefore it is anticipated that that you could effectively utilise a hybrid working pattern in this role, however if you prefer, we would be happy for you to work on site all the time.
In this client facing role your main responsibility will be to provide expert DMPK support for metabolite identification studies for integrated small molecule Drug Discovery projects, typically using non-labeled compound, to expedite project progression through to candidate selection and early pre-clinical testing.
You will be lead and grow this area and define our strategy to ensure that the needs for integrated drug discovery projects are met.
You will build relationships with DMPK and Chemistry Project/Discipline Leaders and other subject matter experts in the Charles River family.
Essential Skills and Experience
• Demonstrated expertise of metabolite identification and structural elucidation studies using non-labeled compounds (ex vivo and in vitro samples), from analytical method development, data processing to the final reporting • Experience of cross-species metabolite profiling using non-labelled compounds to aid species selection for preliminary toxicology studies • Knowledge of modern high resolution mass spectrometers and software for identifying metabolites to understand the metabolic fate of small molecules • Strong strategic and influencing skills together as you will be responsible for the growth of this area within our business unit. • Comprehensive troubleshooting and problem-solving skills both technical and scientific • Strong organisation and time management skills alongside an inbuilt flexibility to adapt to change • Excellent communication skills and be an effective team player; these will be essential to successful execution of projects whilst working in a matrix and multi-skilled environment. • To be a positive role model and value the importance of coaching and mentoring colleagues.
Desirable
• An interest in analysis of large molecules using mass spectrometry • Prior experience in the training, supervision and development of others • Experience in the bioanalytical method development of challenging analytes
So, what’s next?
If you are inspired by the possibilities of science to make a difference and ready to discover what you can do by joining us on this exciting journey and believe you can contribute to this bold ambition – join us! One of our Recruiters will review your application and if it’s a good fit we will set up a call to find out more about you and your journey so far.
About Discovery Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.
About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.
With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.
At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.
At Charles River Laboratories, we recognize and recruit all talent. We are a company committed to the principle of diversity and inclusion and work daily in this direction.
Job posted: 2023-02-17
