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Immune Response to Influenza Vaccine in HIV-Infected Individuals

3. März 2008 aktualisiert von: National Institute of Allergy and Infectious Diseases (NIAID)

Immune Response to Influenza Vaccination in HIV-Infected Individuals

This study will evaluate how HIV infection, including CD4 cell count and viral load, affects the patient's ability to produce antibodies in response to vaccination with the influenza (flu) vaccine. Earlier studies have shown that people with HIV infection do not respond as well as healthy subjects to flu vaccine; that is, they don't make as many antibodies in response to the vaccine. Before the use of current anti-HIV medications, antibodies made to flu vaccination in HIV-positive individuals was related to their CD4 cell count. This trial will examine how CD4 counts and the amount of virus in the blood affect how much and what kind of antibodies the body makes to the flu vaccine.

HIV-infected patients and healthy normal volunteers between 18 and 60 years of age may be eligible for this study. Healthy subjects will serve as controls to make sure the flu vaccine works (i.e., stimulates production of enough antibody to protect against the flu), and to compare the amount of antibodies made by HIV-positive and HIV-negative people. Candidates will be screened with a medical history and blood tests (see below). Women who are able to have children will have a pregnancy test. Pregnant women are excluded from the study.

Participants will undergo the following procedures:

  1. Blood drawing for the following tests:

    • Routine tests (complete blood count, kidney and liver functions, electrolyte levels).
    • CD4 cell count.
    • HLA typing (a genetic marker of the immune system) if it has not already been done at the NIH. This test may be used to try to identify factors associated with the rate of progression of HIV disease or related conditions. Determining HLA type is necessary to be able to perform certain research studies. Some HLA types have been associated with an increased risk of certain diseases like arthritis and other rheumatologic problems.
    • Viral load (HIV-infected patients only).
    • Influenza antibody levels.
    • B cell levels.
  2. Flu vaccination

  3. Follow-up visits on days, 7, 28, and 54 after vaccination for the following:

    • Review of any illnesses or fever.
    • Review of medications, if any changes were made.
    • Repeat blood tests.

Studienübersicht

Status

Abgeschlossen

Bedingungen

Detaillierte Beschreibung

The purpose of this protocol is to evaluate the effect of HIV viral load and CD4 counts on the generation of influenza-specific antibodies and influenza-specific B cell responses in HIV-infected adults. HIV-infected subjects will be enrolled to receive the influenza vaccine appropriate to the on-going USA influenza season (Oct-March). Laboratory studies (including influenza titers, influenza-specific B cell frequencies, CD4 counts, and HIV viral loads) will be obtained at baseline (day of vaccination), day 7, 28, and 54 post-vaccination. HIV-negative healthy volunteers will serve as controls. Although there are some risks to influenza vaccine, the CDC Advisory Committee on Immunizations recommends influenza vaccination for HIV-infected patients. The primary study risks are those of phlebotomy and the inconvenience of multiple visits. Subjects will be compensated for participation in the study. Total enrollment of the study is a maximum of 165 subjects (132 HIV-infected individuals and 33 HIV-negative controls).

Studientyp

Beobachtungs

Einschreibung

165

Kontakte und Standorte

Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.

Studienorte

  • Vereinigte Staaten
    • Maryland
      • Bethesda, Maryland, Vereinigte Staaten, 20892
        • National Institute of Allergy and Infectious Diseases (NIAID)

Teilnahmekriterien

Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.

Zulassungskriterien

Studienberechtigtes Alter

  • Kind
  • Erwachsene
  • Älterer Erwachsener

Akzeptiert gesunde Freiwillige

Ja

Studienberechtigte Geschlechter

Alle

Beschreibung

INCLUSION CRITERIA:

HIV Positive:

  1. Age greater than or equal 18 but less than or equal to 60 years old and willing and able to give informed consent
  2. Enrollment during the USA influenza season (October-March)
  3. Self-reported history of HIV infection at enrollment (If NIH HIV testing does not confirm that the subject is HIV-positive, the subject will be discontinued from the study and not included in the analysis.)

HIV Negative:

  1. Age greater than or equal to 18 but less than or equal to 60 years old and willing and able to give informed consent
  2. Enrollment during USA influenza season (October-March)
  3. Self-reported healthy HIV-negative (If NIH HIV testing does not confirm that the subject is HIV-negative, the subject will be discontinued from the study and not included in the analysis.)

EXCLUSION CRITERIA:

HIV Positive:

  1. Self-reported history of vaccination with the trivalent influenza preparation used for the current influenza season
  2. Self-reported vaccination with any vaccine within the one month period prior to study enrollment
  3. Acute febrile illness (may defer vaccine until resolved)
  4. History of hypersensitivity to any influenza vaccine components including thimerosal or egg
  5. History of Guillain-Barre syndrome
  6. Intention to receive any other vaccine during the study period
  7. Pregnancy
  8. Self-reported treatment with immunomodulator/immunosuppressive drugs (interleukins, corticosteroids, or G(M)-CSF in the 4 weeks prior to enrollment
  9. Self-reported history of IL-2 administration within the past 5 years
  10. Use of theophylline preparations or warfarin because of the theoretical possibilities, of enhanced drug effects and toxicities post influenza vaccination
  11. Active infection or other serious illness other than HIV that might affect the immune response to a vaccine
  12. Current alcohol, substance abuse, or systemic/psychiatric illness that potentially could interfere with patient compliance and ability to make study visits

HIV Negative:

  1. Self-reported history of vaccination with the trivalent influenza preparation used for the current influenza season
  2. Self-reported vaccination with any vaccine within the one month period prior to study enrollment
  3. Acute febrile illness (may defer vaccine until resolved)
  4. History of hypersensitivity to any influenza vaccine components including thimerosal or egg
  5. History of Guillain-Barre syndrome
  6. Intention to receive any other vaccine during the study period
  7. Pregnancy
  8. Self-reported treatment with immunomodulator/immunosuppressive drugs (interleukins, corticosteroids, or G(M)-CSF in the 4 weeks prior to enrollment
  9. Use of theophylline preparations or warfarin because of the theoretical possibilities, of enhanced drug effects and toxicities post influenza vaccination
  10. Any medical conditions, or medication use might affect the immune response to a vaccine
  11. Current alcohol, substance abuse, or systemic/psychiatric illness that potentially could interfere with patient compliance and ability to make study visit

Studienplan

Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.

Wie ist die Studie aufgebaut?

Mitarbeiter und Ermittler

Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Publikationen und hilfreiche Links

Die Bereitstellung dieser Publikationen erfolgt freiwillig durch die für die Eingabe von Informationen über die Studie verantwortliche Person. Diese können sich auf alles beziehen, was mit dem Studium zu tun hat.

Allgemeine Veröffentlichungen

Studienaufzeichnungsdaten

Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.

Haupttermine studieren

Studienbeginn

1. September 2003

Studienabschluss

1. September 2005

Studienanmeldedaten

Zuerst eingereicht

2. Oktober 2003

Zuerst eingereicht, das die QC-Kriterien erfüllt hat

2. Oktober 2003

Zuerst gepostet (Schätzen)

3. Oktober 2003

Studienaufzeichnungsaktualisierungen

Letztes Update gepostet (Schätzen)

4. März 2008

Letztes eingereichtes Update, das die QC-Kriterien erfüllt

3. März 2008

Zuletzt verifiziert

1. September 2005

Mehr Informationen

Begriffe im Zusammenhang mit dieser Studie

Schlüsselwörter

Zusätzliche relevante MeSH-Bedingungen

Andere Studien-ID-Nummern

  • 030310
  • 03-I-0310

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