- ICH GCP
- US-Register für klinische Studien
- Klinische Studie NCT01867372
Early Markers of Alzheimer's Disease: Structural and Functional Brain Changes
Early Markers of Alzheimer's Disease in BLSA Participants: Structural and Functional Brain Changes
Background:
- Participants in the Baltimore Longitudinal Study of Aging are being studied to examine changes in brain structure and function over time, and to determine if these changes can predict the likelihood that an individual will develop thinking and memory impairments such as Alzheimer s disease later in life. Imaging studies and neuropsychological testing have been conducted on current participants, and new participants are being recruited to the study. To develop better treatments and therapies for aging-related memory loss and other disorders, researchers are interested in determining whether early prediction of thinking and memory impairments are accurate and in evaluating factors that affect these predictions.
Objectives:
- To use imaging studies and tests of thinking and memory to determine early markers of Alzheimer s disease and other cognitive impairments.
Eligibility:
- Current participants and new recruits to the Baltimore Longitudinal Study of Aging.
Design:
- Participants will be screened with a full medical history and physical examination, as well as blood and urine tests.
- Participants will have testing visits as directed by the study researchers. All participants will have tests as part of their an initial enrollment in the study, and may be asked to return yearly, 2 years later, or 4 years later for repeated tests.
- At each visit, participants will have brain imaging scans (including magnetic resonance imaging and/or magnetic resonance spectroscopy to measure brain structure and function, and positron emission tomography to study blood flow in the brain) to evaluate brain structure and function. Participants will also take tests of memory and problem-solving skills.
- Treatment will not be provided as part of this protocol.
Studienübersicht
Status
Bedingungen
Detaillierte Beschreibung
Studientyp
Einschreibung (Tatsächlich)
Kontakte und Standorte
Studienorte
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Maryland
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Baltimore, Maryland, Vereinigte Staaten, 21205
- Johns Hopkins University
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Baltimore, Maryland, Vereinigte Staaten, 21205
- Kennedy Krieger Institute
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Baltimore, Maryland, Vereinigte Staaten, 21224
- National Institute of Aging, Clinical Research Unit
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Teilnahmekriterien
Zulassungskriterien
Studienberechtigtes Alter
Akzeptiert gesunde Freiwillige
Studienberechtigte Geschlechter
Beschreibung
- INCLUSION CRITERIA:
BLSA participants who do not meet exclusion criteria
EXCLUSION CRITERIA:
- Miscellaneous: Body weight > 300 pounds, history of significant radiation exposure.
- Participants with pacemakers, implanted electronic hearing devices, aneurysm clips, shrapnel, unallowed prosthetic or any other metallic device in their bodies.
- Pre-existing CNS disease or severe cardiovascular disease (MI, CABG, angioplasty).
Studienplan
Wie ist die Studie aufgebaut?
Designdetails
Was misst die Studie?
Primäre Ergebnismessungen
Ergebnis Maßnahme |
Zeitfenster |
---|---|
Accelerated preclinical changes in brain structure and function in specific regions will predict which individuals develop cognitive impairment and Alzheimer s disease
Zeitfenster: Ongoing
|
Ongoing
|
Changes in brain structure are predictors of cognitive decline and impairment though neuroimaging assessments
Zeitfenster: Ongoing
|
Ongoing
|
Mitarbeiter und Ermittler
Mitarbeiter
Ermittler
- Hauptermittler: Susan M Resnick, Ph.D., National Institute on Aging (NIA)
Studienaufzeichnungsdaten
Haupttermine studieren
Studienbeginn
Primärer Abschluss (Tatsächlich)
Studienabschluss
Studienanmeldedaten
Zuerst eingereicht
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
Zuerst gepostet (Schätzen)
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Tatsächlich)
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
Zuletzt verifiziert
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Schlüsselwörter
Zusätzliche relevante MeSH-Bedingungen
Andere Studien-ID-Nummern
- 999903328
- 03-AG-N328
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