The Jackson Heart Study of Cardiovascular Disease Among African Americans (JHS)

March 30, 2023 updated by: National Heart, Lung, and Blood Institute (NHLBI)
This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American men and women. The cohort is a collaboration among multiple institutions (Jackson State University, Mississippi State Department of Health, Tougaloo College, and the University of Mississippi Medical Center), the National Institute on Minority Health and Health Disparities (NIMHD), and the National Heart, Lung, and Blood Institute (NHLBI).

Study Overview

Status

Enrolling by invitation

Conditions

Detailed Description

The Jackson Heart Study (JHS) initiated in 1998, is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African Americans. In addition, the JHS conducts community education and outreach activities to promote healthy lifestyles and reduce disease risk burden, undergraduate- and graduate-level research training programs, and high school science and math enrichment programs to prepare and encourage students from underrepresented racial/ethnic groups to pursue biomedical careers. The study recruited 5306 African-American residents living in the Jackson, MS, metropolitan statistical area of Hinds, Madison, and Rankin Counties. Participants were enrolled from each of 4 recruitment pools: random, 17%; volunteer, 30%; currently enrolled in the Atherosclerosis Risk in Communities (ARIC) Study, 31% (shared JHS/ARIC cohort); and secondary family members, 22%. Recruitment was limited to non-institutionalized adult African Americans aged 35-84 years, except in a nested family cohort where those 21 to 34 years of age were also eligible. The final cohort included 6.59% of all African American residents in the Jackson MSA aged 35-84 during the baseline exam (N=76,426, US Census 2000). Among these, approximately 3,700 gave consent that allows genetic research and deposition of data into dbGaP. JHS participants have completed three clinical examinations (Exam 1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) that have generated extensive longitudinal data on traditional and putative CVD risk factors, socioeconomic and sociocultural factors, biochemical analytes, and measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and abdomen. Stored biological samples have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes cryopreserved for study of candidate genes, genome-wide scanning, expression, and other -omics investigations. Participants have been contacted annually to update information, confirm vital status, document interim medical events, hospitalizations, and functional status, and obtain additional sociocultural information. Ongoing cohort surveillance includes abstraction of medical records and death certificates for relevant International Classification of Diseases (ICD) codes and adjudication of nonfatal events and deaths. The JHS serves as a resource to the scientific community for novel research, promotes cardiovascular health in the local community, and encourages underrepresented minority students to pursue biomedical careers.

Exam 4 began in 2020 and is ongoing. Data collection for the current exam includes anthropometrics, blood pressure, urine and blood samples, echocardiogram, electrocardiogram, neurocognitive battery, physical function, interviews, and brain MRI.

Study Type

Observational

Enrollment (Anticipated)

3000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Mississippi
      • Jackson, Mississippi, United States, 39213
        • UMMC, JSU, Tougaloo College, MSDH

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

35 years to 84 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

African-American men and women residents of metropolitan Jackson, Mississippi

Description

Inclusion Criteria:

  • African American
  • Residents of Jackson, Mississippi

Exclusion Criteria:

  • Institutionalization

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cardiovascular Disease
Time Frame: 2000-2016
Coronary Heart Disease, Stroke, Heart Failure
2000-2016

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mortality
Time Frame: 2000-2018
All Cause
2000-2018

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Collaborators

National Institute on Minority Health and Health Disparities (NIMHD)

Investigators

  • Principal Investigator: Wendy White, PhD, Tougaloo College JHS UTEC
  • Principal Investigator: Marinelle Payton, MD, PhD, Jackson State University JHS GTEC
  • Principal Investigator: April P Carson, PhD, UMMC JHS CC and FC
  • Principal Investigator: Victor Sutton, PhD, Mississippi State Department of Health JHS CEC
  • Principal Investigator: Jennifer Reneker, PhD, UMMC JHS GTEC

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 19, 2000

Primary Completion (Anticipated)

April 12, 2025

Study Completion (Anticipated)

April 12, 2025

Study Registration Dates

First Submitted

May 25, 2000

First Submitted That Met QC Criteria

May 25, 2000

First Posted (Estimate)

May 26, 2000

Study Record Updates

Last Update Posted (Actual)

April 3, 2023

Last Update Submitted That Met QC Criteria

March 30, 2023

Last Verified

March 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 5001
  • HHSN268201800010I (Other Grant/Funding Number: NHLBI and NIMHD)
  • HHSN268201800011I (Other Grant/Funding Number: NHLBI and NIMHD)
  • HHSN268201800012I (Other Grant/Funding Number: NHLBI and NIMHD)
  • HHSN268201800013I (Other Grant/Funding Number: NHLBI and NIMHD)
  • HHSN268201800014I (Other Grant/Funding Number: NHLBI and NIMHD)
  • HHSN268201800015I (NHLBI and NIMHD)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

The JHS adheres to NIH and NHLBI policies for data sharing of epidemiologic studies. Data from each cycle of an examination or follow-up component are prepared by the JHS Coordinating Center and sent to the NHLBI PO for distribution as a data set after the completion of each examination or two years after the baseline, follow-up, genetic, ancillary study, or other data set is finalized within the study for analysis for use in publication. De-identified data from Exams 1, 2 and 3 of the JHS are available and shared commonly through the JHS processes for presentation and publication, ancillary studies, and Vanguard Centers. Public datasets for Exam 1, Exam 2, and Exam 3 have been provided to BioLINCC and dbGaP.

IPD Sharing Time Frame

Data are currently available for exams 1, 2 and 3 and for hospitalizations for cardiovascular events (2000-2015+ for coronary heart disease and stroke; 2005-2015+ for heart failure) and mortality (2000-2017+). Data will be available indefinitely.

IPD Sharing Access Criteria

Data can accessed from JHS with approved manuscript proposals and from dbGaP and BIOLINCC.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • ICF

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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