- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00707525
Embryo Aneuploidies and Ovarian Stimulation
Incidence of EmbyoO Aneuploidies in Natural Versus Stimulated Cycles in the Same Women.
There is a considerable concern about the effects of controlled ovarian hyperstimulation (COH) for In Vitro Fertilization- Embryo Transfer (IVF-ET) on embryo quality and on the incidence of chromosomal abnormalities in oocytes and embryos.
The main question remaining is if COH may increase the aneuploidies rate in young and healthy women. Therefore, the primary endpoint of the present study is to analyse the incidence of chromosomal abnormalities in this group of patients (oocyte donors), either in oocytes obtained after a natural cycle or in those retrieved after a COH cycle. To get rid of the male factor influence, donated sperm will be used.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Phase
- Phase 4
Contacts and Locations
Study Locations
-
-
-
Valencia, Spain, 46015
- Instituto Valenciano de Infertilidad
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Donor Inclusion Criteria:
- 18 to 35 years old.
- BMI: 18-25Kg/m2
- Regular menstrual cycles
- Normal kariotype
- No previous controlled ovarian hyperstimulation (COH) treatments.
Donor Exclusion Criteria:
- Endometriosis
- Policystic ovarian syndrome
- Recurrent miscarriages.
Recipient Inclusion Criteria
- Aged until 45 years old
- No systemic diseases
- Following egg and sperm donation treatment.
Recipient exclusion criteria:
- Uterine disease (polyps, myomas, mullerian defects)
- Recurrent miscarriages.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
No Intervention: 1
Natural cycle oocyte donation
|
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Active Comparator: 2
Stimulated cycle oocyte donation.
|
Preimplantation Genetic Diagnosis (PGD) is performed on the embryos resulting from these natural and stimulated cycles.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Embryo aneuploidies
Time Frame: 2 cycles
|
2 cycles
|
Collaborators and Investigators
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 0607-C-M09-EL
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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