- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01366768
Gut Hormones After Oral Versus Intravenous Amino Acids
October 9, 2012 updated by: Bo Ahren, Lund University
Release of Gut Hormones After Oral Versus Intravenous Amino Acids
The study hypothesis is that gut hormones are released after oral but not intravenous amino acids which result in stimulation of insulin secretion.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Amino acid mixture is given orally or intravenously to match total concentrations of amino acids in healthy subjects.
Samples are taken regularly for 300 min after administrations.
Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and glucagon.
Study Type
Interventional
Enrollment (Actual)
12
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Lund, Sweden, 221 84
- Department of Clinical Sciences Lund, Lund University
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years to 30 years (Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- Healthy subjects
Exclusion Criteria:
- Diabetes
- Liver disease
- Kidney disease
- Thyroid disease
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Non-Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Oral amino acid mixture
Oral administration of amino acid mixture in healthy volunteers
|
Amino acid mixture 2,93 ml/kg
Other Names:
|
Experimental: Intravenous amino acid administration
Intravenous infusion of amino acid mixture in healthy volunteers
|
Amino acid mixture 2,93 ml/kg
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Gut hormone secretion
Time Frame: 300 min
|
300 min
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Insulin secretion
Time Frame: 300 min
|
300 min
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
May 1, 2011
Primary Completion (Actual)
September 1, 2012
Study Completion (Actual)
September 1, 2012
Study Registration Dates
First Submitted
May 31, 2011
First Submitted That Met QC Criteria
June 3, 2011
First Posted (Estimate)
June 6, 2011
Study Record Updates
Last Update Posted (Estimate)
October 10, 2012
Last Update Submitted That Met QC Criteria
October 9, 2012
Last Verified
October 1, 2012
More Information
Terms related to this study
Other Study ID Numbers
- 003 (NuSkin International)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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