- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01623934
Role of Adipokines in Glucose Regulation During Pregnancy and in Fetal Development (GEN3G)
May 1, 2017 updated by: Marie-France Hivert, Université de Sherbrooke
This study includes 2 phases. During phase 1, pregnant women are followed over the course of pregnancy. The phase 2 is a follow-up of the mother-child dyad at 3 and 5 year after delivery.
The purpose of this phase 1 is to :
- assess the contribution and interactions of adipokines in the development of insulin resistance during pregnancy and gestational diabetes;
- assess levels of maternal adipokines as determinants of development and fetal growth;
- determine the genetic variations that influence levels of adipokines and glucose regulation during pregnancy and in newborns.
The purpose of this phase 2 is to:
- identify DNA methylation variations at birth that are predictive of childhood overweight/obesity.
- identify maternal characteristics associated with DNA methylation variations predictive of childhood overweight/obesity.
- establish whether the loci predictive of childhood overweight/obesity at birth are still differentially methylated at 5 years of age (samples collected at 5 years of age).
- identify DNA methylation variations at birth that are predictive of childhood neurodevelopment problems at 3 and 5 years of age.
Study Overview
Status
Unknown
Conditions
Study Type
Observational
Enrollment (Actual)
1086
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Quebec
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Sherbrooke, Quebec, Canada, J1H5N4
- Centre de recherche Étienne-Le Bel, Centre hospitalier universitaire de Sherbrooke
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Female
Sampling Method
Non-Probability Sample
Study Population
Pregnant women when they come for their first prenatal visit at the Clinique de Prélèvements et de Recherche en Grossesse.
Description
Inclusion Criteria:
- age ≥ 18 yrs
- gestational age between 6 and 13 weeks from last menstrual period
- no recognized diabetes or drugs interfering with glucose metabolism
- alcohol < 2 drinks/day
- not involved in regular high intensity physical activity
- otherwise good health status
Exclusion Criteria:
- twin pregnancy
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
---|
Phase 1: Pregnant women
|
Phase 2: Mother-offspring dyad
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Diagnosis of gestational diabetes mellitus
Time Frame: 24-28 weeks of gestation
|
75g oral glucose tolerance test
|
24-28 weeks of gestation
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Marie-France Hivert, MD, MSc, Université de Sherbrooke
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2010
Primary Completion (Anticipated)
May 1, 2019
Study Completion (Anticipated)
May 1, 2019
Study Registration Dates
First Submitted
June 18, 2012
First Submitted That Met QC Criteria
June 18, 2012
First Posted (Estimate)
June 20, 2012
Study Record Updates
Last Update Posted (Actual)
May 4, 2017
Last Update Submitted That Met QC Criteria
May 1, 2017
Last Verified
May 1, 2017
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- GEN3G
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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