- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01993628
Construction-LBD (Constructional Apraxia in Alzheimer's Disease (AD) and Lewy Body's Dementia (LBD))
Constructional Apraxia in Alzheimer's Disease (AD) and Lewy Body's Dementia (LBD)
Alzheimer's disease (AD) and Lewy body's dementia (LBD) are two frequent neurodegenerative pathologies. They differ in their expression, their evolution but share same features which make their diagnosis uneasy.
Constructional apraxia has been described in both disease.The underlying mechanisms have been less studied and could be different in AD and LBD.
The definition of the constructional apraxia is purely descriptive and few models are inconclusive.
It is admitted that drawing tasks involve visuo-perceptive and visuo-spatial abilities, executive functions and working memory as well as purely "constructive" skills.
Regarding to different studies, visuo-perceptive abilities are more severely impaired in LBD than in AD and are considered as an early onset sign of the disease.
Executive functions deficits are documented in AD and LDB and could contribute to the drawing impairment.
It is possible to compensate the planning disorders in giving patient the best strategy to use.
If drawing impairment persists, they should result of others mechanisms like visuo-perception, visuo-spatial or constructive deficits.
The investigators suggest that giving the best planning strategy will help more AD patients who are supposed to fail in raison of an executive impairment, than the LDB group who is supposed to present visuo-perceptive deficits. An MRI will be proposed to study the cerebral areas involved in constructional apraxia.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Xavier DE PETIGNY, Docteur
- Phone Number: 0033 3 88 11 56 24
- Email: xavier.depetigny@chru-strasbourg.fr
Study Contact Backup
- Name: PHILLIPPS Clelie, Ingenior
- Phone Number: 0033 3 88 12 79 25
- Email: clelie.phillipps@chru-strasbourg.fr
Study Locations
-
-
-
Strasbourg, France
- Recruiting
- Hopitaux Universitaires de Strasbourg
-
Contact:
- Xavier De Pétigny, Docteur
- Phone Number: 0033 3 88 12 79 25
- Email: xavier.depetigny@chru-strasbourg.fr
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Alzheimer's disease or Lewy bodies dementia
- ≥ 45 years
- the cognitive impairment is mild to moderate
- French speaker
- a caregiver is present
- An informed consent is signed by the patient and the p.i.
Exclusion Criteria:
- MRI contraindication
- Other neurological disease (FTD, brain tumor, vascular disease…)
- Psychiatric disease (Schizophrenia, major depression, psychotic disorders, melancholia…)
- Patient who doesn't want to be informed in case of the discovery of an abnormality
- View or audition deficits, or motor disability which can interfere with the cognitive testing
- Patient participating to an exclusive protocol or in the period of exclusion
- Pregnant woman
- Person under an administrative or legal measure of liberty privation
- Person under a legal measure of protection or under administrative supervision
- Person unable to give his consent
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Alzheimer's disease (AD)
Rey figure test and MRI
|
|
Experimental: Lewy body's dementia (LBD)
Rey figure test and MRI
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Score obtained at the Rey figure test with a planning strategy help by LBD patients compared to the score obtained by AD patients.
Time Frame: At inclusion
|
At inclusion
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Mental Disorders
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Neurologic Manifestations
- Neurobehavioral Manifestations
- Neurocognitive Disorders
- Parkinsonian Disorders
- Basal Ganglia Diseases
- Movement Disorders
- Synucleinopathies
- Neurodegenerative Diseases
- Psychomotor Disorders
- Tauopathies
- Dementia
- Alzheimer Disease
- Lewy Body Disease
- Apraxias
Other Study ID Numbers
- 5565
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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