Interval Training, Inflammation and Immune Function

November 7, 2017 updated by: Duke University

The Impact of High Intensity Interval Training on Inflammatory State and Immune Function in Elderly Individuals

PURPOSE: The purpose of this study is to investigate whether High Intensity Interval Training (HIIT)can improve the health and wellbeing of pre-diabetic elderly adults. In particular, there is specific interest in describing the effects of an interval exercise program on inflammatory state and immune function.

DESIGN: Subjects will be sedentary, 65 to 80 years old adults, with prediabetes as defined by fasting plasma glucose (100 to 125 mg/dl). Before and after a 10-12 week High Intensity Interval Exercise training program subjects will undergo several tests including: 1) a maximal treadmill test, 2) an Oral Glucose Tolerance Test, 3) muscle biopsy, 4) body composition, 5) several physical function tests and 6) other health related measures including lung function, arterial stiffness and several blood measures (e.g. liver enzymes, kidney function).

DATA ANALYSES & SAFETY ISSUES: As there are no comparison groups, data analyses will consist of performing paired t-tests on pre and post exercise training values for each of the measurement variables of interest. In addition, the data will be used to provide power calculations for future grant proposals. High Intensity Interval Training is a very safe exercise modality. The regular use of vigorous intensity exercise intervals have been used extensively in exercise training. In fact, the exercise intervals will start at levels lower and will be of shorter duration than were used during the maximal exercise test. They will then be carefully and slowly made to be more challenging as each subject is able to safely tolerate.

HYPOTHESIS: The investigators hypothesize that HIIT will result in significant improvements in markers of inflammation, immune system markers and other health-related risk factors.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • North Carolina
      • Durham, North Carolina, United States, 27705
        • Duke Center For Living

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

65 years to 80 years (Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Age 65-80 years
  • Prediabetic - Fasting plasma glucose is 100 - 125 on two separate days
  • Able to walk for 2 minutes or more without stopping
  • LDL Cholesterol ≤ 190; Triglycerides < 600;
  • Blood Pressure ≤ 160/90
  • Inactive: Exercise < 2 days per week
  • Medications: Stable use of all medications ≥ three months

Exclusion Criteria:

  • Smoker: tobacco use within the last 12 months
  • Dieting or intending to diet; not weight stable ≥ six months (weight change < 5 pounds)
  • Use of confounding inflammatory medications: aspirin, ibuprofen, naproxen (NSAIDS - nonsteriodal anti-inflammatory drugs)
  • History of diabetes, heart disease or taking medications for those conditions
  • History of hypertension (high blood pressure) not controlled with medication
  • Unwillingness to undergo muscle biopsies and all other study testing, or to continuously participate in exercise training for 12 weeks.
  • Inability to give blood continuously through a catheter (please notify the study nurse of any difficulties you have had in the past when having your blood drawn; the study nurse will determine whether you are excluded for this reason)
  • Unwillingness to conduct ALL exercise sessions at the fitness facility during research study staff supervised times.
  • Orthopedic limitations, musculoskeletal disease and/or injury Due to the nature of the study, persons with known joint, muscle or other orthopedic limitations that restrict physical activity may be excluded.
  • Able to decide if you want to take part in the study
  • Lack of transportation to the exercise and testing facilities

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: HIIT Aging
all subjects will undergo high intensity interval training 3 x per week for 10-12 weeks. the intervals of high-intensity (~85% of maximal capacity) will be 5 to 10 bouts of 30 seconds at this intensity with rest periods in between intervals that range from 30 seconds to 2 minutes
Behavioral: High Intensity Interval training
all subjects will undergo high intensity interval training 3 x per week for 10-12 weeks. the intervals of high-intensity (~85% of maximal capacity) will be 5 to 10 bouts of 30 seconds at this intensity with rest periods in between intervals that range from 30 seconds to 2 minutes

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Change in inflammatory markers in plasma
Time Frame: baseline and following exercise training, approximately 10-12 weeks
baseline and following exercise training, approximately 10-12 weeks
Change in inflammatory markers in muscle
Time Frame: baseline and following exercise training, approximately 10-12 weeks
baseline and following exercise training, approximately 10-12 weeks
Change in immune markers in peripheral blood
Time Frame: baseline and following exercise training, approximately 10-12 weeks
baseline and following exercise training, approximately 10-12 weeks
Change in immune markers in muscle
Time Frame: baseline and following exercise training, approximately 10-12 weeks
baseline and following exercise training, approximately 10-12 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Metabolic Syndrome risk factors composite score
Time Frame: baseline and following exercise training, approximately 10-12 weeks
Classic and additional Metabolic Syndrome measures include: blood pressure, waist circumference, triglycerides, HDL, fasting glucose; plus liver and kidney function, insulin sensitivity, glucose tolerance, etc...
baseline and following exercise training, approximately 10-12 weeks

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Physical Function outcome measures composite score
Time Frame: baseline and following exercise training, approximately 10-12 weeks
Peak VO2, 400 meter walk time, short physical performance battery (SPPB)
baseline and following exercise training, approximately 10-12 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Duke University

Investigators

  • Principal Investigator: William Kraus, MD, Duke University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 1, 2015

Primary Completion (Actual)

November 14, 2016

Study Completion (Actual)

November 14, 2016

Study Registration Dates

First Submitted

April 9, 2015

First Submitted That Met QC Criteria

May 7, 2015

First Posted (Estimate)

May 12, 2015

Study Record Updates

Last Update Posted (Actual)

November 9, 2017

Last Update Submitted That Met QC Criteria

November 7, 2017

Last Verified

February 1, 2017

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • Pro00055208

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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