- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03132051
Sonographic Evaluation of Patients With Carpal Tunnel Syndrome Following Steroid Injection
April 24, 2017 updated by: Taipei Veterans General Hospital, Taiwan
The objective of this study was to assess sonographic changes of the median nerve after steroid injection for carpal tunnel syndrome.
Study Overview
Detailed Description
Patients with CTS were recruited.
The Boston Questionnaire (BQ) was administered and ultrasonographic and electrophysiological examinations were performed before and at two, six, and 12 weeks after steroid injection.
Cross sectional area (CSA) was measured at 2 levels: at the tunnel inlet and in the mid-carpal tunnel.
Flattening ratio (FR) was measured only in the mid-carpal tunnel.
Correlation analyses between baseline ultrasonography, BQ, and electrophysiological measures were performed.
Study Type
Interventional
Enrollment (Anticipated)
54
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Jia chi Wang, MD
- Phone Number: 886-2-28757361
- Email: jcwang0726@gmail.com
Study Locations
-
-
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Taipei, Taiwan
- Recruiting
- Teipei Veterans General Hospital
-
Contact:
- Jia chi Wang, MD
- Phone Number: 886-2-28757361
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- clinical diagnosis of CTS
- The diagnosis of CTS was confirmed by electrophysiological tests.
Exclusion Criteria:
- neurologic disorders that could mimic CTS such as cervical radiculopathy, polyneuropathy, proximal median nerve entrapment, or thoracic outlet syndrome
- history of distal radius fracture
- pregnancy or lactation
- regular use of systemic NSAIDs or corticosteroids
- known allergy to corticosteroids and local anesthetics.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: steroid injection
ultrasound-guided steroid injection using 1ml of 10 mg (10mg/ml) triamcinolone acetonide
|
ultrasound-guided steroid injection using 1ml of 10 mg (10mg/ml) triamcinolone acetonide
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cross sectional area
Time Frame: 12 weeks
|
The CSA of the median nerve was measured at 2 levels: at the carpal tunnel inlet (CSA-I; immediately prior to the proximal margin of the flexor retinaculum) and in the mid-carpal tunnel (CSA-M; at the level of the pisiform bone and scaphoid tubercle)
|
12 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
flattening ratio
Time Frame: 2, 6, 12 weeks
|
The flattening ratio was measured only at the mid-tunnel (FR-M).
FR was calculated by dividing the horizontal diameter of the nerve by the vertical diameter.
|
2, 6, 12 weeks
|
Boston Carpal Tunnel Questionnaire (BQ)
Time Frame: 2, 6, 12 weeks
|
The BQ was interviewed-administered to assess the severity of symptoms and functional status.
|
2, 6, 12 weeks
|
Median nerve distal motor latency
Time Frame: 2, 6, 12 weeks
|
the CMAPs were obtained via surface electrodes placed on the abductor pollicis brevis muscle.
The active recording electrode was placed on the muscle belly, and the reference electrode was placed on the tendon insertion.
The median nerve was stimulated 8 cm proximal to the active recording electrode.
Distal motor latencies were measured from the onset of stimulus artifact to the onset of the CMAP
|
2, 6, 12 weeks
|
sensory nerve conduction velocity
Time Frame: 2, 6, 12 weeks
|
SNAPs were obtained using an antidromic method and recorded by surface electrodes placed at the proximal and distal interphalangeal joints of the index finger for the median nerve and the same joints of the little finger for the ulnar nerve.
The median nerves were stimulated at the wrist at a distance of 14 cm from the wrist to the active electrode.
Distal sensory latencies were measured from the onset of the stimulus artifact to the onset of the SNAP.
SNCV was calculated dividing the distance of 14 cm by the distal sensory latency.
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2, 6, 12 weeks
|
compound muscle action potential amplitude (CMAP)
Time Frame: 2, 6, 12 weeks
|
the CMAPs were obtained via surface electrodes placed on the abductor pollicis brevis muscle.
The active recording electrode was placed on the muscle belly, and the reference electrode was placed on the tendon insertion.
The median nerve was stimulated 8 cm proximal to the active recording electrode.
The amplitude of CMAP were measured from baseline to negative peak.
|
2, 6, 12 weeks
|
sensory nerve action potential amplitudes.
Time Frame: 2, 6, 12 weeks
|
SNAPs were obtained using an antidromic method and recorded by surface electrodes placed at the proximal and distal interphalangeal joints of the index finger for the median nerve and the same joints of the little finger for the ulnar nerve.
The median nerves were stimulated at the wrist at a distance of 14 cm from the wrist to the active electrode.
The amplitude of SNAP were measured from baseline to negative peak.
|
2, 6, 12 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Jia chi Wang, Taipei Veteran General Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
April 1, 2013
Primary Completion (Anticipated)
February 1, 2018
Study Completion (Anticipated)
February 1, 2018
Study Registration Dates
First Submitted
February 16, 2017
First Submitted That Met QC Criteria
April 24, 2017
First Posted (Actual)
April 27, 2017
Study Record Updates
Last Update Posted (Actual)
April 27, 2017
Last Update Submitted That Met QC Criteria
April 24, 2017
Last Verified
February 1, 2017
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Pathologic Processes
- Nervous System Diseases
- Wounds and Injuries
- Disease
- Neuromuscular Diseases
- Mononeuropathies
- Peripheral Nervous System Diseases
- Median Neuropathy
- Nerve Compression Syndromes
- Cumulative Trauma Disorders
- Sprains and Strains
- Syndrome
- Carpal Tunnel Syndrome
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Enzyme Inhibitors
- Anti-Inflammatory Agents
- Immunosuppressive Agents
- Immunologic Factors
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Triamcinolone
- Triamcinolone Acetonide
- Triamcinolone hexacetonide
- Triamcinolone diacetate
Other Study ID Numbers
- 2016-07-006A; 2012-05-021A
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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