- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04175977
The Hospice Advanced Dementia Symptom Management and Quality of Life Trial (HAS-QOL)
November 13, 2023 updated by: NYU Langone Health
The Hospice Advanced Dementia Symptom Management and Quality of Life Trial (HAS-QOL) Stepped Wedge Trial
The Aliviado Dementia Care Program (formerly known as the Dementia Symptom Management at Home Program, or DSM-H) was developed to implement dementia friendly care for persons with Dementia and their caregivers living in the community.
Aliviado Dementia Care-Hospice Edition is a systems level quality assurance performance improvement program that includes interdisciplinary team training, validated assessment instruments, patient-centered care plans, treatment algorithms for behavioral and psychological symptoms of dementia and terminal delirium, and caregiver education pamphlets.
Utilizing the R61/R33 mechanism, the Aliviado Dementia Care-Hospice Edition was successfully implemented in 2 sequential pilot trials in the hospice setting in 2019 (R61 phase).
Following the successful pilot trials and the attainment of the R61 milestones, the investigators now seek to test the effectiveness of Aliviado Dementia Care-Hospice Edition in a pragmatic RCT in 25 hospice agencies across the nation (R33 phase) on its ability to reduce antipsychotic use (primary outcome) and effect quality (secondary and exploratory outcomes).
Study Overview
Status
Active, not recruiting
Conditions
Intervention / Treatment
Detailed Description
As the population ages, the incidence rate of Alzheimer's Disease and Related Disorders (dementia) is expected to triple.
The National Alzheimer's Plan recognizes that while the number of persons with dementia (PWD) is increasing substantially, the healthcare and long term care systems are unprepared to provide high quality, effective and efficient care to the PWD and their caregivers.
PWD often have many behavioral and psychological symptoms of dementia (BPSD) including agitation, depression and sleep disturbances that affect both the quality of life (QOL) of the PWD and the caregiver.
Unfortunately, due to a lack of programs to insert evidence-based care into the community, and hospice system specifically, PWD receive inappropriate and even harmful care.
The investigators have developed the Aliviado Dementia Care Program (formerly known as the Dementia Symptom Management at Home Program, or DSM-H) to implement dementia friendly care for PWD and their caregivers in the community.
Initially developed for use in home healthcare (HHC), the investigators have modified the program for use in hospice.
The Aliviado Dementia Care-Hospice Edition is a systems level quality assurance performance improvement (QAPI) program that includes workforce training, and agency level workflow changes.
Study Type
Interventional
Enrollment (Actual)
44143
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
New York
-
New York, New York, United States, 10016
- NYU Langone Health
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
Interdisciplinary Team (IDT) MEMBERS:
- All English speaking IDT members
- Employed or contracted by the participating agency who are receiving Aliviado Dementia Care-Hospice Edition online or champion training
- All PWD (Persons with dementia) who are newly admitted to a participating hospice during the timeframe following implementation of the intervention who are over the age of 50 and have an ICD-10 code corresponding to a dementia diagnosis in their chart will be eligible.
- Greater than 18 years of age
Exclusion Criteria:
IDT MEMBERS:
• IDT members who are per diem
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Sequential Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Wave 1: Usual Care for Months 1-7, Transition for Months 8-9, Intervention for Months 10-26
PWD at the hospice sites randomized to Wave 1 will receive usual care for 7 months, followed by the 2-month-long transition to the intervention over months 8 and 9, followed by the QAPI intervention for 16 Months from Month 10-26.
|
Multi-modal QAPI program for improving the quality of care provided to PWD and support to their informal caregivers through hospice.
It has been culturally tailored for use in diverse settings and tested with multiple minority communities in New York, including multiple Hispanic groups and African-Americans and Caribbean blacks.
The intervention includes mentorship, training, a toolkit, and mobile app to assist clinicians in providing evidence-based symptom management to persons with dementia.
Usual care as provided by the hospice agency
|
Experimental: Wave 2: Usual Care for Months 1-8, Transition for Months 9-10, Intervention for Months 11-26
PWD at the hospice sites randomized to Wave 2 will receive usual care for 8 months, followed by the 2-month-long transition to the intervention over months 9 and 10, followed by the QAPI intervention for 15 months from Month 11-26.
|
Multi-modal QAPI program for improving the quality of care provided to PWD and support to their informal caregivers through hospice.
It has been culturally tailored for use in diverse settings and tested with multiple minority communities in New York, including multiple Hispanic groups and African-Americans and Caribbean blacks.
The intervention includes mentorship, training, a toolkit, and mobile app to assist clinicians in providing evidence-based symptom management to persons with dementia.
Usual care as provided by the hospice agency
|
Experimental: Wave 3: Usual Care for Months 1-9, Transition for Months 10-11, Intervention for Months 12-26
PWD at the hospice sites randomized to Wave 3 will receive usual care for 9 months, followed by the 2-month-long transition to the intervention during months 10 and 11, followed by the QAPI intervention for 14 months from Months 12-26.
|
Multi-modal QAPI program for improving the quality of care provided to PWD and support to their informal caregivers through hospice.
It has been culturally tailored for use in diverse settings and tested with multiple minority communities in New York, including multiple Hispanic groups and African-Americans and Caribbean blacks.
The intervention includes mentorship, training, a toolkit, and mobile app to assist clinicians in providing evidence-based symptom management to persons with dementia.
Usual care as provided by the hospice agency
|
Experimental: Wave 4: Usual Care for Months 1-10, Transition for Months 11-12, Intervention for Months 13-26
PWD at the hospice sites randomized to Wave 4 will receive usual care for 10 months, followed by the 2-month-long transition to the intervention during months 11 and 12, followed by the QAPI intervention for 13 months from Months 13-26.
|
Multi-modal QAPI program for improving the quality of care provided to PWD and support to their informal caregivers through hospice.
It has been culturally tailored for use in diverse settings and tested with multiple minority communities in New York, including multiple Hispanic groups and African-Americans and Caribbean blacks.
The intervention includes mentorship, training, a toolkit, and mobile app to assist clinicians in providing evidence-based symptom management to persons with dementia.
Usual care as provided by the hospice agency
|
Experimental: Wave 5: Usual Care for Months 1-11, Transition for Months 12-13, Intervention for Months 14-26
PWD at the hospice sites randomized to Wave 5 will receive usual care for 11 months, followed by the 2-month-long transition to the intervention during months 12 and 13, followed by the QAPI intervention for 12 months from Months 14-26.
|
Multi-modal QAPI program for improving the quality of care provided to PWD and support to their informal caregivers through hospice.
It has been culturally tailored for use in diverse settings and tested with multiple minority communities in New York, including multiple Hispanic groups and African-Americans and Caribbean blacks.
The intervention includes mentorship, training, a toolkit, and mobile app to assist clinicians in providing evidence-based symptom management to persons with dementia.
Usual care as provided by the hospice agency
|
Experimental: Wave 6: Usual Care for Months 1-12, Transition for Months 13-14, Intervention for Months 15-26
PWD at the hospice sites randomized to Wave 6 will receive usual care for 12 months, followed by the 2-month-long transition to the intervention during months 13 and 14, followed by the QAPI intervention for 11 months from Months 15-26.
|
Multi-modal QAPI program for improving the quality of care provided to PWD and support to their informal caregivers through hospice.
It has been culturally tailored for use in diverse settings and tested with multiple minority communities in New York, including multiple Hispanic groups and African-Americans and Caribbean blacks.
The intervention includes mentorship, training, a toolkit, and mobile app to assist clinicians in providing evidence-based symptom management to persons with dementia.
Usual care as provided by the hospice agency
|
Experimental: Wave 7: Usual Care for Months 1-13, Transition for Months 14-15, Intervention for Months 16-26
PWD at the hospice sites randomized to Wave 7 will receive usual care for 13 months, followed by the 2-month-long transition to the intervention during months 14 and 15, followed by the QAPI intervention for 10 months from Months 16-26.
|
Multi-modal QAPI program for improving the quality of care provided to PWD and support to their informal caregivers through hospice.
It has been culturally tailored for use in diverse settings and tested with multiple minority communities in New York, including multiple Hispanic groups and African-Americans and Caribbean blacks.
The intervention includes mentorship, training, a toolkit, and mobile app to assist clinicians in providing evidence-based symptom management to persons with dementia.
Usual care as provided by the hospice agency
|
Experimental: Wave 8: Usual Care for Months 1-14, Transition for Months 15-16, Intervention for Months 17-26
PWD at the hospice sites randomized to Wave 7 will receive usual care for 14 months, followed by the 2-month-long transition to the intervention during months 15 and 16, followed by the QAPI intervention for 9 months from Months 17-26.
|
Multi-modal QAPI program for improving the quality of care provided to PWD and support to their informal caregivers through hospice.
It has been culturally tailored for use in diverse settings and tested with multiple minority communities in New York, including multiple Hispanic groups and African-Americans and Caribbean blacks.
The intervention includes mentorship, training, a toolkit, and mobile app to assist clinicians in providing evidence-based symptom management to persons with dementia.
Usual care as provided by the hospice agency
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change from Baseline in Monthly Percentage of Home Hospice Patients who are Prescribed Antipsychotic Medication
Time Frame: Baseline, Month 26
|
Antipsychotic use measured using medical records.
|
Baseline, Month 26
|
Change from Baseline in Monthly Percentage of Home Hospice Patients who are Prescribed Non-Opioid Analgesic Medication
Time Frame: Baseline, Month 26
|
Non-opioid analgesic use measured using medical records.
|
Baseline, Month 26
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change from Baseline in Monthly Hours of Continuous Hospice Use
Time Frame: Baseline, Month 26
|
Measured using hospice administrative data.
|
Baseline, Month 26
|
Change from Baseline in Monthly Days of Inpatient Hospice Use
Time Frame: Baseline, Month 26
|
Measured using hospice administrative data.
|
Baseline, Month 26
|
Change from Baseline in Monthly Days of Respite Care
Time Frame: Baseline, Month 26
|
Measured using hospice administrative data.
|
Baseline, Month 26
|
Change from Baseline in Monthly Percentage of Participants who are Permanently Institutionalized in a Nursing Home
Time Frame: Baseline, Month 26
|
Measured using hospice administrative data.
|
Baseline, Month 26
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Abraham Brody, Ph.D., NYU Langone
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 2020
Primary Completion (Actual)
August 31, 2022
Study Completion (Estimated)
January 15, 2024
Study Registration Dates
First Submitted
November 12, 2019
First Submitted That Met QC Criteria
November 21, 2019
First Posted (Actual)
November 25, 2019
Study Record Updates
Last Update Posted (Actual)
November 15, 2023
Last Update Submitted That Met QC Criteria
November 13, 2023
Last Verified
November 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 19-01186
- 5R33AG061904-05 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
YES
IPD Plan Description
Individual participant data that underlie the results reported in this article, after deidentification (text, tables, figures, and appendices).Upon reasonable request.
Requests should be directed to Abraham.Brody@nyulangone.org.
To gain access, data requestors will need to sign a data access agreement.
IPD Sharing Time Frame
Immediately following publication.
No end date.
IPD Sharing Access Criteria
Investigators whose proposed use of the data has been approved by an independent review committee ("learned intermediary") identified for this purpose.
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
- ANALYTIC_CODE
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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