A Study to Investigate the Effect of Rosuvastatin (CRESTOR®) on High Density Lipoprotein Kinetics in Patients With the Metabolic Syndrome

Inclusion Criteria:

• Signed informed consent
• male aged 30 to 70 years of age
• LDL-C <6 mmol/L
• HDL-C ≤1.2 mmol/L
• at least 2 of the following:
• insulin resistance (fasting glucose >6 mmol/L or insulin >10 mU/L or HOMA score >2.5)
• central obesity (waist circumference >=94 cm).
• plasma triglycerides >=1.7 and <4.5 mmol/L.
• blood pressure >=130/ >=85 mm Hg or on drug treatment for hypertension

Exclusion Criteria:

• LDL cholesterol >=6 mmol/L
• pre-existing or history of cardiovascular disease, diabetes, renal dysfunction, anaemia, history of significant dyspepsia or gastrointestinal disease
• apolipoprotein genotype E2/E2