Neuroimaging Studies of Depression in Parkinson's Disease

Neuroimaging Studies of Depression in Parkinson's Disease

Patrocinadores

Patrocinador principal: Lee Blonder

Colaborador: National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)

Fuente University of Kentucky
Resumen breve

The purpose of this study is to investigate similarities and differences in the neural pathways of depressed Parkinson's patients, non-depressed Parkinson's patients, and healthy controls using magnetic resonance imaging (MRI) of the brain and neuropsychological assessment.

Descripción detallada

Depression is a common and potentially serious complication of Parkinson's disease (PD). Studies show that approximately 40 percent of PD patients are depressed. There is evidence that these patients have deficits in neuropsychological function relative to non-depressed PD patients. Despite the widespread toll on emotional health posed by PD, few studies have undertaken a comprehensive examination of the neural underpinnings of Parkinsonian depression. In this project, we will compare depressed versus non-depressed Parkinson patients to a sample of demographically-matched healthy controls using neuropsychological assessment and magnetic resonance imaging (MRI). To investigate possible effects of anti-Parkinsonian medication on mood, cognitive function, and neural response, PD patients will be tested both off and on Parkinsonian medications.

Estado general Completed
Fecha de inicio July 2006
Fecha de Terminación December 2011
Fecha de finalización primaria December 2011
Tipo de estudio Observational
Inscripción 120
Condición
Elegibilidad

Método de muestreo: Non-Probability Sample

Criterios:

Inclusion Criteria:

- right-handed

- willing/able to undergo magnetic resonance imaging (MRI)

Exclusion Criteria:

- history of neurological condition other than Parkinson's disease

- history of psychiatric condition other than depression

- history of substance abuse/dependence

Género: All

Edad mínima: 40 Years

Edad máxima: 85 Years

Voluntarios Saludables: Accepts Healthy Volunteers

Oficial general
Apellido Papel Afiliación
Lee X. Blonder, PhD Principal Investigator University of Kentucky
Ubicación
Instalaciones: University of Kentucky
Ubicacion Paises

United States

Fecha de verificación

April 2013

Fiesta responsable

Tipo: Sponsor-Investigator

Afiliación del investigador: University of Kentucky

Nombre completo del investigador: Lee Blonder

Título del investigador: PI

Palabras clave
Tiene acceso ampliado No
Condición Examinar
Grupo de brazo

Etiqueta: 1

Descripción: Patient Group

Etiqueta: 2

Descripción: Control Group

Información de diseño del estudio

Modelo de observación: Case Control

Perspectiva de tiempo: Prospective

Fuente: ClinicalTrials.gov