Roles of T Helper 1 Cytokines in Type 1 Diabetes

The study included 98 T1DPs and 30 healthy subjects (CG). All subjects

were matched on age and gender. β-cell function of 98 T1DPS was assesseed by measuring C-Peptide levels

after mixed-meal tolarence test (MMTT)s. T1DPs were divided into 3

groups according to the C-Peptide levels after MMTTs and the groups

were as follows: patients with undetectable ≤0.1 ng/mL(group 1a, n=30)

C-Peptide levels; minimal 0.1-0.8 ng/mL(group1b, n=30); and sustained

≥0.8ng/mL(group1c, n=38) C-peptide levels which increased at the 90th

minute after the meal ≥150% of fasting C-peptide level.

Inclusion Criteria:

• Patients giving consent to participate the study
• Patients with type 1 diabetes according to WHO definiton

Exclusion Criteria:

• Acute and chronic inflammatory diseases,
• significant concomitant diseases which may interfere with glucose metabolism
• cancers,
• hemoglobinopathies,
• recently received antibiotics,
• drugs influencing β-cell function and
• insulin sensitivity or anti-inflammatory drugs
• recent history of trauma