ICH GCP | Clinical Trials Registry

Clinical Trials



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#
NCTID/Status
Study
Last Changed
1
NCT04030351
Recruiting
Effect of Dried Fruit Intake on Acid-base Balance
Conditions: Acid-Base Balance Disorder
Intervention: Food - Dried Fruit
July 22, 2019
2
NCT04030338
Recruiting
Prostate-Specific Membrane Antigen (PSMA) PET Scans in People Prostate Cancer
Conditions: Prostate Cancer; Prostate Neoplasm; Prostate Adenocarcinoma; Prostate Cancer Metastatic; Metastatic Prostate Cancer
Intervention: 18F-DCFPyL-iPSMA, 68Ga-HBED-iPSMA, PET/CT Scan
July 22, 2019
3
NCT04030325
Not yet recruiting
Motivating Campus Change Study
Conditions: Drinking Behavior
Intervention: Sequential Post Feedback Intervention Delivery, Simultaneous Post Feedback Intervention Delivery, Text Message Boosters
July 22, 2019
4
NCT04030312
Not yet recruiting
Effectiveness of Donor Human Milk Supplementation for the Treatment of Hypoglycemia in the Breastfed Infant
Conditions: Neonatal Hypoglycemia
Intervention: Bottle Supplementation--Pasteurized Donor Human Milk, Bottle Supplementation--Standard Infant Formula
July 22, 2019
5
NCT04030299
Not yet recruiting
Longitudinal Outcomes of Hearing Aids
Conditions: Presbycusis
Intervention: Over-the-counter Fitting
July 22, 2019
6
NCT04030286
Completed
Evaluation of Malondialdehyde in Periodontal and Cardiovascular Disease
Conditions: Metabolic Disease
Intervention: Observation
July 19, 2019
7
NCT04030273
Not yet recruiting
Prevalence of Intrauterine Adhesions After Abdominal Myomectomy
Conditions: Myoma;Uterus
Intervention: Diagnostic Hysteroscopy
July 19, 2019
8
NCT04030260
Recruiting
Regorafenib and Nivolumab in Combination With Radiotherapy for pMMR/MSS Metastatic Colorectal Cancer
Conditions: Colorectal Cancer Metastatic; MSS
Intervention: Regorafenib And Nivolumab In Combination With Radiotherapy, Radiation Therapy
July 19, 2019
9
NCT04030247
Not yet recruiting
The Effects of Plant Sterol Supplementation on LDL Levels in Intermediate Cardiovascular Risk Individuals
Conditions: Cardiovascular Risk Factor
Intervention: Plant Sterol
July 19, 2019
10
NCT04030234
Not yet recruiting
Effects of Intensive Systolic Blood Pressure Lowering Treatment in Reducing RIsk of Vascular evenTs (ESPRIT) Study
Conditions: Hypertension
Intervention: Intensive BP Treatment Group, Standard BP Treatment Group
July 21, 2019
11
NCT04030221
Not yet recruiting
Pressure Gradient for Venous Return in Predicting Fluid Responsiveness in Patients Undergoing Laparoscopic Surgery
Conditions: Fluid Responsiveness
Intervention: Fluid Infusion
July 19, 2019
12
NCT04030208
Recruiting
Evaluating Safety and Efficacy of Umbulizer in Patients Requiring Intermittent Positive Pressure Ventilation
Conditions: Respiratory Failure; Respiratory Insufficiency; Respiratory Arrest
Intervention: Umbulizer, Traditional Mechanical Ventilator
July 21, 2019
13
NCT04030195
Not yet recruiting
To Evaluate the Safety and Tolerability, Find an Appropriate Dose to Optimize Safety and Efficacy, and Evaluate Clinical Activity of PBCAR20A in Subjects With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) or r/r Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)
Conditions: Non-Hodgkin's Lymphoma, Relapsed; Chronic Lymphoid Leukemia in Relapse; Non-Hodgkin's Lymphoma Refractory; Chronic Lymphocytic Leukemia; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic; B-cell Chronic Lymphocytic Leukemia; B-cell Non Hodgkin Lymphoma
Intervention: PBCAR20A, Fludarabine, Cyclophosphamide
July 22, 2019
14
NCT04030182
Not yet recruiting
Vitamin D Deficit in Women With Uterine Fibroids
Conditions: Leiomyoma; Vitamin D Deficiency; Fibroid Uterus
Intervention: Level Of Vitamin D
July 22, 2019
15
NCT04030169
Not yet recruiting
Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD With Optional fMRI Sub-Study
Conditions: PTSD
Intervention: Methylenedioxymethamphetamine
July 22, 2019
16
NCT04030156
Completed
ASSESMENT OF TONSIL VOLUME WITH TRANSCERVICAL ULTRASONOGRAPHY
Conditions: OSAS; Recurrent Tonsillitis
Intervention: Tonsillectomy
July 19, 2019
17
NCT04030143
Not yet recruiting
A Trial of Multiple-doses of Aripiprazole in Adults With Schizophrenia or Bipolar 1 Disorder
Conditions: Schizophrenia; Bipolar I Disorder
Intervention: Aripiprazole, Aripiprazole
July 19, 2019
18
NCT04030130
Not yet recruiting
Navigation vs Usual Care for Timely Adjuvant Therapy for Patients With Locally Advanced HNSCC
Conditions: Squamous Cell Carcinoma of Head and Neck
Intervention: NDURE
July 19, 2019
19
NCT04030117
Not yet recruiting
Class II Restoration Using Bioactive Restorative Material vs Polyacid Modified Composite Resin in Primary Molars
Conditions: Class II Dental Caries
Intervention: ACTIVA Bioactive Restoration, Compomer Restoration
July 19, 2019
20
NCT04030104
Not yet recruiting
Optoacoustic Images Versus Imagio® Ultrasound
Conditions: Breast Cancer
Intervention: Optoacoustic Imaging - Reader Study
July 18, 2019
21
NCT04030091
Not yet recruiting
Pulsatile Insulin Infusion Therapy in Patients With Type 1 and Type 2 Diabetes Mellitus
Conditions: Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 1
Intervention: 3 Hours Humulin R 100 IU/mL PIT, 2 Hours Humulin R 100 IU/mL PIT
July 18, 2019
22
NCT04030078
Not yet recruiting
A Central and Eastern European Survey On PEEP Titration and Alveolar Recruitment Manoeuvres During Surgery
Conditions: Ventilator-Induced Lung Injury; Positive End-Expiratory Pressure; Alveolar Recruitment Manoeuvres
Intervention: Survey
July 18, 2019
23
NCT04030065
Recruiting
Study to Assess the Effect of Intravenous Supplementation of Omega-3 Fatty Acids on Outcome of Recipients in Living Donor Liver Transplantation
Conditions: Liver Transplantation
Intervention: Omega 3 Fatty Acid
July 21, 2019
24
NCT04030052
Not yet recruiting
Emicizumab PUPs and Nuwiq ITI Study
Conditions: Hemophilia A
Intervention: Nuwiq (low Dose Protocol), Emicizumab, Nuwiq (Atlanta Protocol)
July 21, 2019
25
NCT04030039
Recruiting
Cohort Study of Clinical Outcomes in Chronic HBV Infection Patients With Low HBsAg Under Unplanned Intervention
Conditions: Chronic Hepatitis B Infection
Intervention: Interferon, Nucleoside Analogues
July 20, 2019
26
NCT04030026
Not yet recruiting
A Study of Nalbuphine (Extended Release) ER in Idiopathic Pulmonary Fibrosis (IPF) for Treatment of Cough
Conditions: Nalbuphine; Idiopathic Pulmonary Fibrosis; Cough
Intervention: Nalbuphine ER, Placebo Oral Tablet
July 22, 2019
27
NCT04030013
Completed
"Outcome of Diabetes Education Among Renal Transplant Recipients With New Onset Diabetes After Transplantation (NODAT)"
Conditions: New Onset Diabetes After Transplant; Diabetes Mellitus
Intervention: Group Education
July 20, 2019
28
NCT04030000
Not yet recruiting
Uterine Serous Carcinoma and Adjuvant Combined Intraperitoneal Chemotherapy and Radiation
Conditions: Uterine Carcinoma
Intervention: Paclitaxel/Carboplatin, Pelvic Radiation Therapy
July 19, 2019
29
NCT04029987
Recruiting
Bilateral Ultrasound-Guided Intra Muscular Quadratus Lumborum Block Versus Trans Muscular Quadratus Lumborum Block for Peri-Operative Analgesia in Abdominal Surgeries in Pediatric Patients. A Comparative Controlled Randomized Study.
Conditions: Pain, Acute
Intervention: Bilateral Ultrasound-Guided Transmuscular Quadratus Lumborum Block., Bilateral Ultrasound-Guided Intra Smuscular Quadratus Lumborum Block., Control
July 20, 2019
30
NCT04029974
Not yet recruiting
Speed of Robotic Leg Movements and Orthostatic Hypotension in Subacute SCI
Conditions: Spinal Cord Injuries; Orthostatic Hypotension
Intervention: ErigoPro
July 19, 2019
31
NCT04029961
Not yet recruiting
A Virtual Reality-based Radiation Therapy Education Program
Conditions: Anxiety; Stress; Satisfaction, Patient; Preparedness; Informational Needs
Intervention: Video Education, VR-based Education
July 19, 2019
32
NCT04029948
Recruiting
Laser vs. Electorsurgical Enbloc Resection of Bladder Tumours
Conditions: Urinary Bladder Neoplasm
Intervention: Laser En Bloc Resection Of Bladder Tumor, Electro-surgical En Bloc Resection Of Bladder Tumor
July 20, 2019
33
NCT04029935
Enrolling by invitation
The Effect of Physical Fatigue on Lower Limb Functional Performance Tests in a Healthy Population
Conditions: Physical Fatigue; Return to Sport; Injury Prevention; Functional Performance
Intervention: Physical Fatigue, Control
July 22, 2019
34
NCT04029922
Not yet recruiting
Study of MT-5111 in HER2-positive Solid Tumors
Conditions: HER2-positive Solid Cancers
Intervention: MT-5111 (experimental Study Drug)
July 19, 2019
35
NCT04029909
Recruiting
A Clinical Study of Gimatecan in Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer
Conditions: Ovarian Epithelial Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer
Intervention: Gimatecan 0.6mg/m2/d, 0.8mg/m2/d, 0.4mg/m2/d
July 21, 2019
36
NCT04029896
Available
"Individual Patient Expanded Access Protocol of Autologous HB-adMSC's for the Treatment of Cerebral Palsy"
Conditions: Cerebral Palsy
Intervention: HBadMSCs
July 19, 2019
37
NCT04029883
Not yet recruiting
Hypertension Control and Remote Blood Pressure Monitoring
Conditions: Hypertension
Intervention: Remote BP Monitoring
July 19, 2019
38
NCT04029870
Recruiting
Psychological Determinants of the Therapeutic Observance of Osteoporotic Patients
Conditions: Osteoporosis, Postmenopausal
July 19, 2019
39
NCT04029857
Not yet recruiting
Nutritional Supplementation in Reducing Complications in Patients With Locally Advanced Esophageal Cancer Undergoing Chemotherapy, Radiation Therapy, and/or Surgery
Conditions: Clinical Stage III Esophageal Adenocarcinoma AJCC v8; Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8; Pathologic Stage III Esophageal Adenocarcinoma AJCC v8; Pathologic Stage III Esophageal Squamous Cell Carcinoma AJCC v8; Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8; Pathologic Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8; Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8; Pathologic Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8; Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8; Postneoadjuvant Therapy Stage III Esophageal Squamous Cell Carcinoma AJCC v8; Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8; Postneoadjuvant Therapy Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8; Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8; Postneoadjuvant Therapy Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8; Resectable Mass
Intervention: Nutritional Supplement Drink, Nutritional Supplementation
July 19, 2019
40
NCT04029844
Not yet recruiting
Colibri Transcatheter Aortic Heart Valve System Study
Conditions: Severe Aortic Stenosis
Intervention: Colibri TAVI System
July 19, 2019
41
NCT04029831
Not yet recruiting
Comparison of Different Ratio of Ketofol (6:1 vs. 4:1) for Sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP)
Conditions: Analgesia
Intervention: Propofol And Ketamine Mixture (Ketofol)
July 19, 2019
42
NCT04029818
Active, not recruiting
Evaluation of a Probiotic on LDL-cholesterol Levels
Conditions: Cardiovascular Diseases; LDL-cholesterol
Intervention: Bifidobacterium BSL_PS404, Placebo
July 22, 2019
43
NCT04029805
Recruiting
Evaluation of a Combination of a Plant Extract and a Probiotic on Glucidic Metabolism in Women With PCOS and High Insulin Levels
Conditions: Polycystic Ovarian Syndrome; Insulin Resistance
Intervention: Combination Of A Plant Extract (BSL_EP044) And Lactobacillus BSL_PS6, Placebo
July 22, 2019
44
NCT04029792
Not yet recruiting
Evaluation of a Combination of Plant Extracts (BSL_EP028) on Joint Mobility
Conditions: Joint Diseases
Intervention: Combination Of Plant Extracts (BSL_EP028), Placebo
July 22, 2019
45
NCT04029779
Enrolling by invitation
Evaluation of Immediately Placed Dental Implants With Local Application of Injectable PRF in Periodontally Compromised Sites
Conditions: Bone Density; Bone Loss, Alveolar
Intervention: I-PRF
July 22, 2019
46
NCT04029766
Completed
A Study Evaluating Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of HSK3486 Single Bolus Dose Followed With a 30 Minute Constant Infusion in Healthy Male Subjects
Conditions: Anesthesia; Sedation
Intervention: HSK3486
July 20, 2019
47
NCT04029753
Not yet recruiting
Patients Undergoing Laparoscopic Radical Gastrectomy Walk Out From Operating Room After Surgery ( WOFOR-G-01 )
Conditions: Laparoscopic Radical Gastrectomy; Enhanced Recovery After Surgery
Intervention: Walk Out From Operating Room
July 20, 2019
48
NCT04029740
Recruiting
Exosomal microRNAs as a Biomarker in Panic Disorder and in Response to CBT
Conditions: Panic Disorder
Intervention: CBT- Both Internet And Face To Face, No Intervention
July 18, 2019
49
NCT04029727
Active, not recruiting
Effect of the Combination of Plant Extracts (BSL_EP025) in Cardiovascular Health
Conditions: Cardiovascular Disease
Intervention: Combination Of Plant Extracts (BSL_EP025), Placebo
July 22, 2019
50
NCT04029714
Not yet recruiting
Prostate Cancer Active Surveillance Trigger Trial (PCASTT-UK): Comparing Current Practice for Men With Prostate Cancer on Active Surveillance (AS) to an AS Protocol With Standardised Triggers for Transitioning to Curative Treatment
Conditions: Prostate Cancer
Intervention: Active Surveillance
July 22, 2019

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Last Updated

The last updated date is the most recent date when changes to a clinical trial were submitted to ClinicalTrials.gov. There is often a delay of a few days before the updated trial is available on the clinical trials website.

Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.

Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.

First Received

The first received date is the date when the clinical trial was first submitted to ClinicalTrials.gov. There is often a delay of a few days before the trial is available on the clinical trials website.

Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.

Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.

Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.

Safety Issue

If selected, restricts search results to those studies which have an outcome measure designated as a safety issue. Note that this is a poor estimate of the safety of a treatment or intervention, but it is all we have now.

Funded By

Studies are supported by one or more organizations called sponsors. Support includes contributions of facilities, expertise, and/or financial resources. All sponsors in the database have been assigned one of the following organization types:

National Institutes of Health (NIH)

Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.

Industry - the pharmaceutical companies

University/Organization - all others, including community-based organizations

Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.

Study Phase

Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions that study is seeking to answer:

In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.

In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.

In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.

In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.

These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.

Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.

Age Group

Studies may be designed for participants of particular ages:

Children (birth-17 yrs old)

Adults (18-65 yrs old)

Senior (66+ yrs old)

Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.

Gender

Searches can be restricted to studies which accept female or male participants.
Location Terms

If you are interested in a specific city (such as Los Angeles) or facility name (such as the Mayo Clinic), enter it as a location term. Not all studies include this level of detail, but if they do, this will find them.

Countries and States

Trials are often conducted at many locations around the world. Select up to three locations to find trials conducted in specific countries. Some countries (currently limited to the United States, Canada, and Australia), locations can be narrowed further by selecting a state.

Study IDs

Each trial is assigned one or more identification numbers by the institute, agency, or organization sponsoring the trial. In addition, clinical trials assigns a unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit. Use this box to search for a trial by NCT identifier or any other study identification numbers.

Examples:

NCT00001789
97-h-0197
ia0006
actg 076

Sponsor (Lead)

Use this box to specify the name of an institute, organization, or company that is conducting a trial.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.

A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.

When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Examples:

National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators

Use this box to specify institutes, organizations, or companies that are conducting or otherwise supporting a trial.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.

Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.

When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Examples:

National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb

Outcome Measures

Outcome measures are used to evaluate trial results. For example, an obesity treatment might be evaluated by a measure of weight loss after 6 months. Measures can also be used to quantify side effects, such as number of myocardial infarctions, number of patients with heart arrhythmia, number of suicides, etc.

Use this box to specify an outcome measure used to evaluate trial results.

Examples:

weight loss
heart failure
suicide

Interventions

Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied. Interventions can also include less intrusive possibilities such as surveys, education, and interviews.

Use this box to specify drugs, devices, procedures, or vaccines used in a trial.

Examples:

clofibrate
cyclosporine
vitamin e

Conditions

Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov, conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.

Use this box to specify the conditions being studied.

Examples:

lupus
heart attack
leukemia
risk factors for breast cancer

Study Type

There are three types of studies available in ClinicalTrials.gov:

Interventional:

Studies where individuals are assigned to receive specific interventions. Participants may receive diagnostic, therapeutic or other types of interventions. Assignment of the intervention may or may not be random. Individuals are tracked and biomedical and/or health outcomes are assessed.

Observational:

Studies without an intervention. Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals. Participants may receive diagnostic, therapeutic, or other interventions, but the investigator does not assign specific interventions to the participants of the study.

Expanded Access:

Records describing the procedure for obtaining an experimental drug or device for patients who are failing on currently available treatments for their condition and also are unable to participate in ongoing clinical trials. Expanded Access records are used to register all types of non-protocol access to experimental treatments, including protocol exception, single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.

Study Results

Searches can be restricted to studies with or without results.

The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.

Recruitment Status

Also known as Enrollment Status.

Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.

If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.

Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.

Full list of all possible recruitment status values:

Open recruitment status values:

Recruiting,
Not yet recruiting, or
Available for expanded access.

Closed recruitment status values:

Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.

Values are color coded (as shown) in the search results.

Search Terms

Use this box to specify general search terms found anywhere in the trial record.

Multiple terms can be separated by an AND (all uppercase).

Examples:

type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study


Help for Searching clinical trials

Help Topics:
Basic Search
Advanced Search
Refine Search
Search Expressions


Basic Search:

On the Basic Search page, enter a word or word(s) that you want to use to find studies. These may include diseases, interventions, and/or locations.

Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks

A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.


Advanced Search:

Many searches are a single term and can be performed with a few words in the search box. But, sometimes you need more control. Click on the Advanced Search tab (if starting a new search) or Refine Search tab (if modifying an existing search) to show additional search fields.

The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.

Search Terms:
Performs a general search in all sections of the study record, including title, description, conditions, interventions, locations, etc. Terms in this field are searched the same as Basic Search.

Recruitment:
Limits search results to studies that are open or closed. New volunteers may be able to participate in open studies, but not closed studies.

Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.

Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.

Values are color coded (as shown) in the search results.

Study Results:
Limits search results based on whether the study has results or not:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov. Only a few studies have results available.

Study Type:
Limits search results to any of the following study types:
Interventional,
Observational, or
Expanded Access

Conditions:
Performs a search on fields describing the diseases or conditions being studied.

Interventions:
Performs a search on fields listing the drugs or interventions being studied.

Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.

Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.

When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Sponsor (Lead):
Performs a search on the sponsor field of a study.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.

When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Study IDs:
Performs a search on fields listing ID numbers.

Country/State:
Trials are often conducted at many locations around the world. Select up to three locations to find trials conducted in specific countries. Some countries (currently limited to the United States, Canada, and Australia), locations can be narrowed further by selecting a state (e.g., United States, Alabama).

Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic). Not all studies include this level of detail, but if they do, this will find them.

Gender:
Limits search results to those studies that accept female or male participants.

Age Group:
Limits search results to those studies that include at least one of the specified age ranges. More than one age group can be selected.

Phase:
Limits search results to studies that are labeled with at least one of the specified phases. More than one Phase can be selected.

Funded By:
Limits search results to studies that have at least one sponsor of the specified types. More than one sponsor type can be selected.

Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.

First Received:
Limits search results to studies that were received by clinical trials within a specified date range. The "From" or "To" field can be left blank.

Last Updated:
Limits search results to studies that were modified within a specified date range. The "From" or "To" field can be left blank.


Refine Search:

Searches display a list of studies found (List Results tab). If you are not content with the search results, click on the Refine Search tab at the top of the list to modify your search.

Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.

For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California

When you are done making changes, click Search to display the new results.


Search Expressions:

Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California

Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack

Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS

Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )

Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.

To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.

Conditions

Alphabetic (A-Z)
By Category

Rare Diseases

Alphabetic (A-Z)

Drug
Interventions

Alphabetic (A-Z)
By Category

Dietary
Supplements

Alphabetic (A-Z)
By Category

Sponsor/
Collaborators

Alphabetic (A-Z)
By Category

Locations

Alphabetic (A-Z)
By Category