Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] AREA[ConditionSearch] Disease
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Completed
Conditions: Classical Kaposi's Sarcoma
Intervention: Indinavir
Completed
Conditions: Recurrent Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma
Intervention: Bevacizumab, Laboratory Biomarker Analysis, Temsirolimus, Therapeutic Conventional Surgery
Unknown status
Conditions: Melanoma (Skin); Non-melanomatous Skin Cancer
Intervention: Bioelectric Field Imaging, Biopsy, Histopathologic Examination
Completed
Conditions: Recurrent Melanoma; Stage III Skin Melanoma; Stage IV Skin Melanoma
Intervention: Bevacizumab, Laboratory Biomarker Analysis, Pharmacological Study, Sorafenib Tosylate
Completed
Conditions: Kaposi s Sarcoma (KS)
Completed
Conditions: Kaposi's Sarcoma
Active, not recruiting
Conditions: Thymoma; Thymic Carcinoma; Clinical Masaoka Stage II to IVA
Intervention: Cetuximab, Cisplatin, Doxorubicin & Cyclophosphamide
Completed
Conditions: Cervical Intraepithelial Neoplasia; Papillomavirus Infection
Intervention: GSK Biologicals' HPV-16/18 Vaccine (Cervarix™), Havrix™
Terminated
Conditions: Thymic Carcinoma
Intervention: Milciclib Maleate
Completed
Conditions: Sarcoma
Intervention: Nicotine
Completed
Conditions: Stage IV Melanoma
Intervention: Coxsackievirus A21
Terminated
Conditions: Kaposi's Sarcoma; HHV-8; KSHV
Intervention: BAY 43-9006
Completed
Conditions: Melanoma
Intervention: JX-594
Completed
Conditions: Carcinoma of Unknown Primary; Head and Neck Cancer; Non-melanomatous Skin Cancer
Intervention: Semaxanib
Completed
Conditions: Thymoma; Thymic Carcinoma; Thymic Carcinoid; Thymic Neuroendocrine Tumors
Intervention: IMC-12
Terminated
Conditions: Sarcoma
Intervention: Diagnostic Imaging
Completed
Conditions: Melanoma (Skin); Non-melanomatous Skin Cancer
Intervention: LMB-2 Immunotoxin, MART-1 Antigen, Gp100 Antigen, Incomplete Freund's Adjuvant
Unknown status
Conditions: Melanoma (Skin); Non-melanomatous Skin Cancer
Intervention: Educational Intervention, Internet-based Intervention
Unknown status
Conditions: Choroidal Melanoma; Melanoma; Eye Neoplasms
Intervention: Ibuprofen, Tramadol
Terminated
Conditions: Pressure Ulcers; Bacteremia
Completed
Conditions: Melanoma; Unresectable Metatstatic Cutaneous Melanoma
Intervention: 852A
Terminated
Conditions: Thymoma; Thymic Carcinoma
Intervention: Paclitaxel And Cisplatin
Completed
Conditions: Diphtheria; Tetanus; Pertussis; Haemophilus Influenzae Type B
Intervention: DTaP//PRP-T Combined Vaccine, DTaP//PRP-T Combined Vaccine, DTaP Combined Vaccine And PRP-Tetanus Conjugate Vaccine
Completed
Conditions: Mucosal Melanoma; Recurrent Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma
Intervention: Carboplatin, Laboratory Biomarker Analysis, Paclitaxel, Pharmacological Study, Placebo, Sorafenib Tosylate
Terminated
Conditions: Invasive Thymoma and Thymic Carcinoma; Recurrent Thymoma and Thymic Carcinoma; Stage III Thymoma; Stage IVA Thymoma; Stage IVB Thymoma
Intervention: Saracatinib
Completed
Conditions: Low Birth Weight Infant; Enteral Nutrition
Intervention: Oral Rehydration Therapy, Classical Hydration Via Intravenous Infusion
Completed
Conditions: Sarcoma
Intervention: Valganciclovir
Completed
Conditions: Malignant Melanoma
Intervention: Coxsackievirus A21
Completed
Conditions: Chickenpox; Rubella; Rubeola; Mumps
Completed
Conditions: Sarcoma
Intervention: Imatinib Mesylate
Completed
Conditions: Sarcoma
Intervention: Semaxanib
Completed
Conditions: Melanoma
Intervention: Intranodal Immunization With A Recombinant Vaccinia Virus Expressing 5 Transgenes, Intranodal Booster Immunizations With Synthetic Melanoma Associated Epitopes
Completed
Conditions: Melanoma; Skin Neoplasms
Intervention: Axitinib [AG-013736]
Completed
Conditions: Sarcoma
Intervention: Semaxanib
Completed
Conditions: Thymoma; Thymic Carcinoma
Intervention: Belinostat (PDX101)
Terminated
Conditions: Sarcoma
Intervention: Cilengitide
Completed
Conditions: Sarcoma
Intervention: Daunorubicin Hydrochloride, Pegylated Liposomal Doxorubicin Hydrochloride
Completed
Conditions: Sarcoma
Intervention: Cidofovir
Completed
Conditions: Sarcoma
Intervention: Thalidomide
Completed
Conditions: Melanoma; Skin Cancer
Intervention: Talabostat (PT-100) Tablets, Cisplatin
Completed
Conditions: Melanoma; Skin Cancer
Intervention: Talabostat (PT-100) Tablets
Completed
Conditions: Sarcoma; Unspecified Adult Solid Tumor, Protocol Specific
Intervention: Pegylated Liposomal Doxorubicin Hydrochloride, PSC 833
Completed
Conditions: Sarcoma
Intervention: Valproic Acid
Completed
Conditions: Melanoma
Intervention: Questionnaire
Completed
Conditions: Melanoma (Skin); Non-melanomatous Skin Cancer
Intervention: Isotretinoin
Enrolling by invitation
Conditions: Concussion Post Syndrome
Intervention: Blood Flow Restriction Training With Exercise
Withdrawn
Conditions: Hallux Valgus; Postoperative Pain
Intervention: Etoricoxib, Diclofenac
Completed
Conditions: Sarcoma
Intervention: Rebimastat
Completed
Conditions: Malignant Neoplasms of Eye, Brain and Other Parts of Central Nervous System
Intervention: Carmustine, Radiation Therapy, O6-Benzylguanine
Completed
Conditions: AIDS-related Kaposi Sarcoma
Intervention: Paclitaxel, Pegylated Liposomal Doxorubicin Hydrochloride, Laboratory Biomarker Analysis, Quality-of-life Assessment
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Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Examples:
97-h-0197
ia0006
actg 076
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
There are three types of studies available in ClinicalTrials.gov:
Observational:
Expanded Access:
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help Topics:
Basic Search:
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Open recruitment status values:
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Studies With Results, or
Studies Without Results
Observational, or
Expanded Access
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
Refine Search:
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
For example:
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.